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Ischemic colitis during interferon-ribavirin therapy for chronic hepatitis C:A case report

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World Journal of Gastroenterology 2012年第31期18卷 4233-4236页

作者： Su jung Baik Tae Hun Kim Kwon yoo il Hwan Moon Min-Sun Cho Department of Gastroenterology Health Promotion CenterYonsei University Gangnam Severance HospitalSeoul 158-050South Korea Department of Internal Medicine Ewha Medical Research InstituteEwha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea Department of Pathology Ewha University Mokdong HospitalEwha Womans University School of MedicineSeoul 158-710South Korea

Ischemic colitis is a rare complication of interferon *** 9 cases in 6 reports have been described *** report describes a case of ischemic colitis during pegylated interferon and ribavirin treatment for chronic hepatitis C,and includes a review of the relevant literature.A 48-year-old woman was treated with pegylated interferon-2a and ribavirin for chronic hepatitis C,genotype *** 19 wk of treatment,the patient complained of severe afebrile abdominal pain with *** signs were stable and serum white blood cell count was within the normal *** computed tomography showed diffuse colonic wall thickening from the splenic flexure to the proximal sigmoid colon,which is the most vulnerable area for the development of ischemic *** revealed an acute mucosal hyperemic change,with edema and ulcerations extending from the proximal descending colon to the sigmoid *** mucosal biopsy revealed acute exudative *** chain reaction and culture for Mycobacterium tuberculosis were negative and the cultures for cytomegalovirus,Salmonella and Shigella species were *** discontinuation of interferon and ribavirin therapy,abdominal pain and hematochezia subsided and,following colonoscopy showed improvement of the mucosal *** colitis cases during interferon therapy in patients with chronic hepatitis C reported so far have all involved the descending *** colitis is a rarely encountered complication of interferon administration in patients with chronic hepatitis C and should be considered when a patient complains of abdominal pain and hematochezia.

关键词： Ischemia Hepatitis C Interferon

Obesity and novel management of inflammatory bowel disease

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World Journal of Gastroenterology 2023年第12期29卷 1779-1794页

作者： Jee Hyun Kim Chang-Myung Oh jun Hwan yoo Department of Gastroenterology CHA Bundang Medical CenterCHA University School of MedicineSeongnam 13496South Korea Department of Biomedical Science and Engineering Gwangju Institute of Science and TechnologyGwangju 62465South Korea Institute of Basic Medical Sciences CHA University School of MedicineSeongnam 13496South Korea

Obesity is prevalent within the inflammatory bowel disease(IBD)population,particularly in newly developed *** epidemiological studies have suggested that 15%-40%of IBD patients are obese,and there is a potential role of obesity in the pathogenesis of *** dysfunction of mesenteric fat worsens the inflammatory course of Crohn’s disease and may induce formation of strictures or ***,obesity may affect the disease course or treatment response of *** the increasing data supporting the pathophysiologic and epidemiologic relationship between obesity and IBD,obesity control is being suggested as a novel management for ***,this review aimed to describe the influence of obesity on the outcomes of IBD treatment and to present the current status of pharmacologic or surgical anti-obesity treatments in IBD patients.

关键词： Obesity Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Molecular approaches for the detection and monitoring of microbial communities in bioaerosols:A review

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Journal of Environmental Sciences 2017年第1期29卷 234-247页

作者： Keunje yoo Tae Kwon Lee Eun Joo Choi Jihoon Yang Sudheer Kumar Shukla Sang-il Hwang Joonhong Park Department of Civil and Environmental Engineering Yonsei UniversitySeoul 03722South Korea Department of Environmental Engineering Yonsei UniversityWonju 26493South Korea Department of Systems Biology Yonsei UniversitySeoul 03722South Korea Department of Built and Natural Environment Caledonian College of EngineeringSultanate of Oman Division of Natural Resources Conservation Korea Environment InstituteSejong-si 30147South Korea

Bioaerosols significantly affect atmospheric processes while they undergo long-range vertical and horizontal transport and influence atmospheric chemistry and physics and climate *** evidence suggests that exposure to bioaerosols may cause adverse health effects,including severe *** of bioaerosols have primarily focused on their chemical composition and largely neglected their biological composition and the negative effects of biological composition on ecosystems and human ***,current molecular methods for the identification,quantification,and distribution of bioaerosol agents are *** developments in environmental microbiology technology would be favorable in elucidation of microbial temporal and spatial distribution in the atmosphere at high *** addition,these provide additional supports for growing evidence that microbial diversity or composition in the bioaerosol is an indispensable environmental aspect linking with public health.

关键词： Bioaerosol Airborne microbial community Molecular methods Metagenomics

Materials and devices for flexible and stretchable photodetectors and light-emitting diodes

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Nano Research 2021年第9期14卷 2919-2937页

作者： jun-Kyul Song Min Sung Kim Seungwon yoo Ja Hoon Koo Dae-Hyeong Kim Center for Nanoparticle Research Institute for Basic Science(IBS)Seoul 08826Republic of Korea School of Chemical and Biological Engineering and Institute of Chemical Processes Seoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Program for Bioengineering Seoul National UniversitySeoul 08826Republic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea

Recently,significant efforts have been directed at overcoming the limitations of conventional rigid optoelectronic devices,particularly their poor mechanical stability under bending,folding,and stretching *** of major approaches for rendering optoelectronic devices mechanically deformable is to replace the conventional electronic/optoelectronic materials with functional nanomaterials or organic materials that are intrinsically flexible/***,advanced device designs and unconventional fabrication methods have also contributed to the development of soft optoelectronic ***,new devices such as bio-inspired curved image sensors,wearable light emitting devices,and deformable bio-integrated optoelectronic devices have been *** this review,recent progress in the development of soft optoelectronic materials and devices is ***,various materials such as nanomaterials,organic materials,and their hybrids that are suitable for developing deformable photodetectors,are ***,the nanomaterials and organic/polymeric materials that are applicable in deformable light-emitting diodes are ***,representative system-level applications of flexible and stretchable photodetectors and light-emitting diodes are reviewed,and future prospects are discussed.

关键词： nanomaterial organic material photodetector light-emitting diode flexible optoelectronics stretchable optoelectronics

Outcome of laparoscopic cholecystectomy is not influenced by chronological age in the elderly

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World Journal of Gastroenterology 2009年第6期15卷 722-726页

作者： Hyung Ook Kim jung Won Yun jun Ho Shin Sang il Hwang Yong Kyun Cho Byung Ho Son Chang Hak yoo Yong Lai Park Hungdai Kim Departments of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of MedicineSeoul 110-746 South Korea Departments of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoul 110-746South Korea

AIM:To evaluate the outcome of laparoscopic cholecystectomy(LC)in patients aged 80 years and older. METHODS:A total of 353 patients aged 65 to 79 years(group 1)and 35 patients aged 80 years and older(group 2)underwent *** were further classified into two other groups:those with uncomplicated gallbladder disease(group A)or those with complicated gallbladder disease(group B). RESULTS:There were no significant differences between the age groups(groups 1 and 2)with respect to clinical characteristics such as age,gender,comorbid disease,or disease *** operative time,conversion rate,and the incidence of major postoperative complications were similar in groups 1 and ***,the percentage of high-risk patients was significantly higher in group 2 than in group 1 (20.0%vs 5.7%,P<0.01).Group A comprised 322 patients with a mean age of 71.0±5.3 years,and group B comprised 51 patients with a mean age of 69.9±4.8 *** group B,mean operative time (78.4±49.3 min vs 58.3±35.8 min,P<0.01),mean postoperative hospital stay(7.9±6.5 d vs 5.0±3.7 d, P<0.01),and the incidence of major postoperative complications(9.8%vs 3.1%,P<0.05)were significantly greater than in group *** conversion rate tended to be higher in group B,but this difference was not significant. CONCLUSION:Perioperative outcomes in elderly patients who underwent LC seem to be influenced by the severity of gallbladder disease,and not by chronologic *** octogenarians,LC should be performed at an earlier,uncomplicated stage of the disease whenever possible to improve perioperative outcomes.

关键词： Elderly Laparoscopic cholecystectomy Octogenarians Gallbladder Cholecystitis

Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam Hun Park Hyeonkyeong Kim Jiseon Shin jungseok Choi Sungmin Park Ji-Yun Moon Kwanbyung Chae Jeil jung Jae-Hyun Lee Youngdong yoo Ji-Yong Park Kwang jun Ahn Dong-il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

Comparison of ring 1 parameters in 37-segment multifocal electroretinography between onset and offset conditions of ring 2 to 4 in normal subjects

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International Journal of Ophthalmology(English edition) 2019年第1期12卷 73-78页

作者： jun Ho yoo Cheolmin Yun Jaeryung Oh Seong-Woo Kim Department of Ophthalmology Korea University College of Medicine

AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. METHODS: Prospective, observational study. Thirty healthy subjects were included in this study. mfERG recordings were performed according to two protocols: stimulus with 37 hexagonal elements(protocol 1), and stimulus with a single central element created by deactivating the other 36 hexagonal elements(protocol 2). We compared differences between ring 1 parameters in each protocol. RESULTS: In protocol 1, the first positive component(P1) implicit time and P1 amplitude were 37.8±1.8 ms and 6.3±2.7 μV. After single element stimulation(protocol 2), double positive waves appeared. The implicit time and amplitude of P1 were 40.7±2.4 ms(P<0.001) and 9.1±3.3 μV(P=0.001), respectively. The implicit time and amplitude of the second positive component(P2) were 68.0±4.5 ms(P<0.001, compared with P1 in protocol 1) and 12.3±4.7 μV(P<0.001, compared with P1 in protocol 1), respectively. The amplitude of P2 in protocol 2 was about two times higher than that of P1 in protocol 1. CONCLUSION: mfERG responses of a central hexagonal element in a single element stimulation protocol are different from those of multiple element stimulation. The positive wave is more enhanced compared to that of the conventional protocol and it elongated into two wavelets.

关键词： multifocal electroretinography focal electroretinography macular function single element stimulation stray light effect

Investigation of transient and heterogeneous micro-climate around a human body in an enclosed personalized work environment

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能源与人工环境(英文) 2020年第4期1卷 423-431页

作者： Chong Wang Sung-jun yoo Shin-ichi Tanabe Kazuhide Ito Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityJapan Faculty of Engineering Sciences Kyushu UniversityJapan Faculty of Science and Engineering Waseda UniversityJapan

Heterogeneous distribution of indoor environmental quality is known to have a great impact on human health,comfort,and productivity.A personalized work environment,that creates a localized and independent environ-ment with capsules or partitions,is being developed worldwide to provide workers with a space that enables undisturbed concentration on studying and ***,the minimized interior space of a personalized work environment can immediately cause adverse health impacts for occupant if the air quality and thermal en-vironment in the personalized work environment is not controlled ***,constant breathing can sharply increase the CO 2 concentrations in an interior space with an insufficient ventilation *** order to design a healthy and comfortable indoor environment,especially in a personalized work environment,it is important to predict precisely and comprehensively the transient and heterogeneous structure of the indoor envi-ronment formed around a human *** this background,we have developed an in silico human model that integrates a computational human model(virtual manikin combined with thermoregulation models)and respi-ratory model(virtual airway)for estimating indoor environmental quality,targeting the microclimate around a human body and breathing zone with high *** this study,we report the applicability of a comprehensive in silico human model to estimate the environ-mental quality in a personalized work environment.A coupled analysis of heat and contaminant transfer with computational fluid dynamics was conducted targeting the space around the in silico human model installed in a virtual personalized work *** informative data including human thermal comfort and breathing air quality were obtained,potentially forming the basis for the development of a digital twin of the personalized work environment and contributing to the design of a healthy,comfortable,and productive personalized work environme

关键词： Microclimate Indoor environment Digital twin Personalized work environment Computational fluid dynamics in silico human model

Decreasing inhaled contaminant dose of a factory worker through a hybrid Emergency Ventilation System:Performance evaluation in worst-case scenario

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能源与人工环境(英文) 2020年第3期1卷 319-326页

作者： Alicia Murga Zhengwei Long Sung-jun yoo Eisaku Sumiyoshi Kazuhide Ito Faculty of Engineering Sciences Kyushu UniversityJapan School of Environmental Science and Engineering Tianjin UniversityChina Technical Research Institute Obayashi CorporationJapan

Air pollution is detrimental to human health,causing several human *** industrial microenvironment generates high levels of indoor airborne pollutants,becoming a pervasive issue for *** is essential to im-prove the indoor air quality in this workplace by applying enhanced ventilation systems to minimize inhalation *** ventilation is used in industrial buildings because of its stratified air distribution and low ***,in case of accidental pollutant release,an enhancement is needed to minimize inhalation *** study proposes a hybrid emergency ventilation system using localized push-pull ventilation to improve the installed displacement ventilation system of a representative *** fluid dynamics was ap-plied to calculate steady-state indoor air flow and volume-averaged pollutant *** performance was evaluated in terms of source position;a computer simulated person was integrated to the building to confirm effectiveness against personal *** showed marked improvement in performance when push-pull technique was used:room-averaged concentration diminished up to 91%while ventilation rate only increased 4%.Inhaled pollutant mitigation was achieved but performance dependence against leakage source and personal position was confirmed.

关键词： Computational fluid dynamics Hybrid ventilation Industrial environment Computer simulated person Inhalation exposure