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Photoionization and Dissociative Photoionization Study of Cholesterol by I R Laser Desorption/Tunable Synchrotron VUV Photoionization Mass Spectrometry

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Chinese Journal of Chemical Physics 2009年第2期22卷 129-133页

作者： Yang Pan Li-dong Zhang hui-jun guo Hao Yin Fei Qi National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230029 China Hefei National Laboratory for Physical Sciences at Microscale University of Science and Technology of China Hefei 230026 China

Elementary cholesterol was analyzed with IR laser desorption/tunable synchrotron vacuum ultraviolet photoionization mass spectrometry. An exclusive molecular ion of cholesterol is observed by near threshold single-photon ionization with high efficiency. Fragments are yielded with the increase of photon energy. The structures of various fragments are determined with commercial electron ionization time-of-flight mass spectrometry. Dominant fragmentation pathways are discussed in detail with the aid of ab initio calculations.

关键词： Cholesterol Mass spectrometry Laser desorption Photoionization Ab initio

CFD SIMULATION OF 3D FLOW IN LARGE-BORE AXIAL-FLOW PUMP WITH HALF-ELBOW SUCTION SUMP

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Journal of Hydrodynamics 2006年第2期18卷 243-247页

作者： WANG Fu-jun LI Yao-jun CONG guo-hui WANG Wen-e WANG Hai-song College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China

Numerical simulations of 3D turbulent flow in a large-bore axial-flow pump coupled with half-elbow suction sump were perlbrmed by using CFD approach. The numerical model and velocity and pressure distributions in entire flow passage were presented. The obvious backflow in half-elbow suction sump and strong flow nonuniformity at suction sump outlet were observed, whereas these phenomena were not observed in existing studies performed for a separate suction sump by either experimental or numerical approach. This result indicates that the interaction between half-elbow suction sump and impeller has significant effect on the flow distribution in the pump passage. The change of pump efficiency caused by the interaction was discussed,

关键词： axial flow pump half elbow suction sump,CFD

Proteomic profiling of fetal esophageal epithelium, esophageal cancer, and tumor-adjacent esophageal epithelium and immunohistochemical characterization of a representative differential protein, PRX6

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World Journal of Gastroenterology 2017年第8期23卷 1434-1442页

作者： jun-hui guo guo-Lan Xing Xin-hui Fang hui-Fang Wu Bo Zhang Jin-Zhong Yu Zong-Min Fan Li-Dong Wang Henan Province Hospital of TCM The Second Affiliated Hospital of Henan University of Chinese Medicine Henan Key Lab For Esophageal Cancer Res The First Affiliated Hospital of Zhengzhou University Henan Province People’s Hospital The Second Affiliated Hospital of Zhengzhou University

AIM To understand the molecular mechanism of esophageal cancer development and provide molecular markers for screening high-risk populations and early diagnosis. METHODS Two-dimensional electrophoresis combined with mass spectrometry were adopted to screen differentially expressed proteins in nine cases of fetal esophageal epithelium, eight cases of esophageal cancer, and eight cases of tumor-adjacent normal esophageal epithelium collected from fetuses of different gestational age, or esophageal cancer patients from a high-risk area of esophageal cancer in China. Immunohistochemistry(avidin-biotin-horseradish peroxidase complex method) was used to detect the expression of peroxiredoxin(PRX)6 in 91 cases of esophageal cancer, tumoradjacent normal esophageal tissue, basal cell hyperplasia, dysplasia, and carcinoma in situ, as well as 65 cases of esophageal epithelium from fetuses at a gestational age of 3-9 *** After peptide mass fingerprint analysis and search of protein databases, 21 differential proteins were identified; some of which represent a protein isoform. Varying degrees of expression of PRX6 protein, which was localized mainly in the cytoplasm, were detected in adult and fetal normal esophageal tissues, precancerous lesions, and esophageal cancer. With the progression of esophageal lesions, PRX6 protein expression showed a declining trend(P < 0.05). In fetal epithelium from fetuses at gestational age 3-6 mo, PRX6 protein expression showed a declining trend with age(P < 0.05). PRX6 protein expression was significantly higher in well-differentiated esophageal cancer tissues than in poorly differentiated esophageal cancer tissues(P < 0.05).CONCLUSION Development and progression of esophageal cancer result from interactions of genetic changes(accumulation or superposition). PRX6 protein is associated with fetal esophageal development and cancer differentiation.

关键词： Fetal esophageal epithelium Esophageal squamous cell carcinoma Tumor-adjacent esophageal epithelium Proteomics

The misfit mitral valve

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Journal of Geriatric Cardiology 2021年第10期18卷 855-856页

作者： Sebastian Alejandro Mikulic JoséRamón Rivas hui-jun guo Khadeeja Esmail Internal Medicine University of Florida Health JacksonvilleFloridaUSA Division of Cardiology University of Florida Health JacksonvilleFloridaUSA

A 70-year-old female with history of rheumatic fever as a child with resultant surgical mitral valve replacement with bioprosthetic valve ten years prior presented to the hospital with worsening shortness of breath of two days *** symptoms included orthopnea,dry cough,and lower extremity *** the Emergency Room,the patient was afebrile and hemodynamically stable;however,she was tachypneic and hypoxic requiring non-rebreather.

关键词： valve mitral breath

Clinical effects of apatinib mesylate for treatment of multiple brain micrometastases:Two case reports

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World Journal of Clinical Cases 2020年第7期8卷 1326-1336页

作者： jun-hui guo Yuan-Yuan Wang Jiang-Wei Zhang Pei-Min Liu Yan-jun Hao Hai-Rui Duan Department of Oncology The Second Affiliated Hospital of Henan University of Chinese MedicineHenan Province Hospital of TCMZhengzhou 450002Henan ProvinceChina

BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase *** has demonstrated encouraging antitumor *** study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain *** SUMMARY We report two patients with multiple brain micrometastases after failure of second-line *** patients had extracerebral *** the patients took 250 mg/d apatinib orally,the intracerebral lesions *** extracerebral lesions were partially *** patients had a progressionfree survival of more than 12 mo and were still *** safety was *** main adverse events(AEs)were mild hypertension and proteinuria,which could be *** Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.

关键词： Esophageal squamous cell carcinoma Cervical adenocarcinoma Brain micrometastases Apatinib Tyrosine kinase inhibitor Vascular endothelial growth factor

Treatment of 43 Cases of Enuresis by Acupuncture

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Journal of Acupuncture and Tuina Science 2003年第6期1卷 26-27页

作者： DING hui-jun HUANG guo-qi Chinese Medicine Hospital of Guanyun County Jiangsu China 222200

By classification with syndrome differentiation into the three patterns of deficient cold in the lower energizer, qi deficiency in the spleen and lung and damp heat in the Liver Meridian, 43 cases of enuresis were treated by puncturing Baihui (GV 20), Guanyuan (CV 4) and Shanyinjiao (SP 6). After two courses of the treatment, the results showed cure in 28 cases, improvement in 13 cases and failure in 2 cases. Key Words Enuresis - Acupuncture Therapy - Syndrome Differ Classification Translator: HUANG guo-qi

关键词： Enuresis Acupuncture Therapy Syndrome Differ Classification

Honoring a legend: Celebrating the life and legacy of Professor Heng Li

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Plant Diversity 2023年第3期45卷 239-240页

作者： hui-jun guo Jin-Ling Huang Yun-Heng Ji Rong Li Chun-Lin Long Qin-Er Yang Yong-Ping Yang Ting-Shuang Yi National Plateau Wetlands Research Center Southwest Forestry UniversityKunming 650224YunnanChina Department of Biology East Carolina UniversityGreenville 27858NCUSA CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina Key Laboratory of Ecology and Environment in Minority Areas(Minzu University of China) National Ethnic Affairs CommissionBeijing 100081China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China CAS Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenChinese Academy of SciencesGuangzhou 510650GuangdongChina CAS Key Laboratory of Tropical Plant Resources and Sustainable Use Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesXishuangbanna 666303YunnanChina Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina

Professor Heng Li(李恒,March 9,1929-January 12,2023)was a legendary plant taxonomist and phytogeographer at the Kunming Institute of Botany,Chinese Academy of Sciences(Fig.1).She made important contributions to our understanding of China's flora,including the biodiversity and biogeography of Dulong Valley and the Gaoligong Mountains,as well as the vegetation of plateau lakes and wetlands in Southwest *** Heng Li received her Bachelor's degree in Russian from Beijing Foreign Studies University in 1956 and immediately joined the Institute of Geography(now Institute of Geographic Sciences and Natural Resources Research),Chinese Academy of Sciences,as a Russian *** 1961,Prof.

关键词： translator plateau Hen

Basaloid squamous carcinoma of esophagus:a clinicopathological,immunohistochemical and electron microscopic study of sixteen cases

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World Journal of Gastroenterology 1998年第5期4卷 34-40页

作者： ZHANG Xin Hua, SUN Gui Qin, ZHOU Xiao jun, guo hui Fang and ZHANG Tai He

AIM To further clarify the clinicopathological, immunohistochemical and electron microscopic features, and prognostic aspect of basaloid squamous carcinoma (BSC), a rare esophageal *** We reviewed 763 documented cases of esophageal malignancies from year (1977-1996) from our hospital, and discovered 16 (2.1%) cases of BSC. The clinicopathological features of these cases were evaluated. Immunohistochemistry (S-P method), histochemical stains, and electron microscopy were used to further characterize the *** The tumors were classified into stages Ⅰ (n=1), ⅡA (n=6), ⅡB (n=2), Ⅲ (n=5), and Ⅳ (n=2) according to the criteria of the UICC TNM classification system of malignant tumors (1987). Most neoplasms were located in the mid third of the esophagus. Grossly, they had a similar appearance of conventional esophageal carcinoma, but showed a typical cytoarchitectural pattern of BSC histologically. The most important histologic feature of this tumor is carcinoma with a basaloid pattern, intimately associated with squamous cell carcinoma, dysplasia, or focal squamous differentiation. The basaloid cells were round to oval in shape with scant cytoplasm, arranged mainly in the form of solid, smooth-contoured lobules with peripheral palisading. A panel of immunostains were used for the basaloid component of the tumor with the following results: CK(Pan) 14/16 (+); EMA 16/16 (+); Vimentin 4/16 (+); S-100 protein 7/16 (+). CEA and smooth muscle actin were negative. Electron microscopy (EM) revealed that the basaloid cells were poorly differentiated, with a few desmosomes and fibrils, and numerous free and polyribosome. Of the 11 patients with adequate follow-up 8 died within 2 years, with an average survival time of 16.2 months. No stage Ⅱ, Ⅲ or Ⅳ cases survived beyond 5 years. The one-year survival rate was 60% and two-year 20%.CONCLUSION The BSC of esophagus is a distinct clinicopathological entity with poor prognosis. The cellular differentiation and bi

关键词： esophageal neoplasms/pathology esophageal neoplasms/ultrastructure carcinoma, squamous cell/pathology carcinoma, squamous cell/ultrastructure

Arthroscopic release of the deltoid contracture

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Chinese Medical Journal 2010年第22期123卷 3243-3246页

作者： WANG Hai-jun YAN hui CUI guo-qing AO Ying-fang Institute of Sports Medicine Peking University Third Hospital Beijing 100191 China

Background The deltoid contracture is an uncommon disorder. Long-standing contracture produces winged scapula, abduction and extension contracture of the shoulder. Surgical release has been considered the treatment of choice. However, the method of approach has not been well defined. The purpose of this study was to evaluate the results of arthroscopic release of the deltoid contracture. Methods A retrospective study was undertaken to evaluate the results of arthroscopic release in six patients （seven shoulders） who had a contracture of the deltoid muscle. All patients had arthroscopJc release. The abduction-contracture and horizontal-adduction angle was measured after operation. The average duration of follow-up was 16 months （range, from 4 to 41 months）. Results The preoperative abduction contracture resolved completely in three shoulders. Two had a residual abduction contracture of 5° to 7° and two had a poor result with 15° abduction-contracture angle. The average postoperative abduction-contracture angle was 6° （range, 0° to 15°）. The preoperative horizontal-adduction contracture was corrected, permitting at least 130° of adduction, in five shoulders. The remaining two shoulders had a postoperative horizontal-adduction angle of 120° and 110°. Overall, the average postoperative horizontal-adduction angle was 130° （range, 110° to 140°）. Conclusion Arthroscopic release is an effective surgical technique to treat the deltoid contracture.

关键词： deltoid contracture arthroscopy surgical release