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Androgen-deprivation therapy alone versus combined with radiation therapy or chemotherapy For nonlocalized prostate cancer： a systematic review and meta-analysis

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Asian Journal of Andrology 2016年第1期18卷 102-107页

作者： jun-hao lei Liang-Ren Liu Qiang Wei Tu-Run Song Lu Yang Yang Meng Ping Han Department of Urology West China Hospital Sichuan University Guoxue Xiang #37 Chengdu 610041 Sichuan China

In this paper, we reviewed the long-term survival outcomes, safety, and quality-of-life of androgen-deprivation therapy （ADT） alone versus combined with radiation therapy （RT） or chemotherapy for locally advanced and metastatic prostate cancer （PCa）. A literature search was performed using OvidSP. Randomized controlled trials （RCTs） that met the following criteria were included： including locally advanced or metastatic PCa, comparing ADT alone versus combined with any treatment method and reporting quantitative data of disease control or survival outcomes. Finally, eight RCTs met the inclusion criteria. Among these, three compared ADT versus ADT plus RT （n = 2344） and one compared ADT versus ADT plus docetaxel-estramustine （n = 413） in locally advanced PCa; two compared ADT versus ADT plus docetaxel （n = 1175） and two compared ADT versus ADT plus estramustine （n = 114） in metastatic PCa. For locally advanced PCa, the addition of RT to long-term ADT can improve the outcomes of survival and tumor control with fully acceptable adverse effects. Specially, the pooled odds ratio （OR） of overall survival （OS） was 1.43 （95% confidence interval 1.20-1.71） when compared ADT plus RT with ADT alone （P 〈 0.0001）. For metastatic hormonally sensitive PCa, the concurrent use of docetaxel plus ADT was effective and safe （pooled OR of OS： 1.29 [1.01-1.65]： P = 0.04）. In all, long-term ADT plus RT and long-term ADT plus docetaxel should be considered as proper treatment option in locally advanced and metastatic hormonally sensitive PCa, respectively. The major limitation for the paper was that only eight RCTs were available.

关键词： androgen-deprivation chemotherapy prostate cancer quality-of-life radiation therapy

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Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway

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World Journal of Stem Cells 2020年第6期12卷 500-513页

作者： jun-hao lei Wen Yan Chun-Hua Luo Yu-Ming Guo Yang-Yang Zhang Xing-Huan Wang Xin-jun Su Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan 430071Hubei ProvinceChina Center for Evidence-based and Translational Medicine Wuhan UniversityWuhan 430071Hubei ProvinceChina

BACKGROUND With continuous advancement of industrial society,environmental pollution has become more and more *** has been an increase in infertility caused by environmental ***(NP)is a stable degradation product widely used in daily life and production and has been proven to affect male ***,the underlying mechanisms therein are ***,it is necessary to study the effect and mechanism of NP on spermatogonial stem cells(SSCs).AIM To investigate the cytotoxic effect of NP on SSCs via the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin(PI3K/AKT/mTOR)*** SSCs were treated with NP at 0,10,20 or 30μ*** assay was performed to evaluate the effect of NP on the proliferation of *** cytometry was conducted to measure SSC *** expression of Bad,Bcl-2,cytochrome-c,pro-Caspase 9,SOX-2,OCT-4,Nanog,Nanos3,Stra8,Scp3,GFRα1,CD90,VASA,Nanos2,KIT,PLZF and PI3K/AKT/mTOR-related proteins was observed by western blot,and the mRNA expression of SOX-2,OCT-4 and Nanog was detected by quantitative reverse transcription polymerase chain *** Compared with untreated cells(0μmol NP),SSCs treated with NP at all concentrations showed a decrease in cell proliferation and expression of Bcl-2,Nanog,OCT-4,SOX-2,Nanos3,Stra8,Scp3,GFRα1,CD90,VASA,Nanos2,KIT,and PLZF(P<0.05),whereas the expression of Bad,cytochrome-c,and pro-Caspase 9 increased significantly(P<0.05).We further examined the PI3K/AKT/mTOR pathway and found that the phosphorylation of PI3K,AKT,mTORC1,and S6K was significantly decreased by NP at all concentrations compared to that in untreated SSCs(P<0.05).NP exerted the greatest effect at 30μmol among all NP *** NP attenuated the proliferation,differentiation and stemness maintenance of SSCs while promoting apoptosis and oxidative *** associated mechanism may be related to the PI3K/AKT/mTOR pathway.

关键词： Spermatogonial stem cells Nonylphenol Cytotoxicity Phosphatidylinositol-3-kinase Protein kinase B Mammalian target of rapamycin

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Circumcision with ＂no-flip Shang Ring＂ and ＂Dorsal Slit＂ methods for adult males： a single-centered, prospective, clinical study

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Asian Journal of Andrology 2016年第5期18卷 798-802页

作者： jun-hao lei Liang-Ren Liu Qiang Wei Wen-Ben Xue Tu-Run Song Shi-Bing Yan Lu Yang Ping Han Yu-Chun Zhu Department of Urology West China Hospital Sichuan University Chengdu China Department of Urology Dujiangyan Medical Center/The Affiliated Hospital of ChengduUniversity Dujiangyan China

This paper was aimed to compare the clinical effectiveness and safety of adult male circumcision using the Shang RingTM （SR） with the no-flip technique compared with Dorsal Slit （DS） surgical method, A single-centered, prospective study was conducted at the West China Hospital, where patients were circumcised using the no-flip SR （n = 408） or the DS （n = 94） procedure. The adverse events （AEs） and satisfaction were recorded for both groups, and ring-removal time and percentage of delayed removals were recorded for the SR group. Finally, complete follow-up data were collected for 76.1% of patients （SR： n = 306; DS： n = 76）. The average ring-removal time for the SR group was 17.62 ± 6.30 days. The operation time （P 〈 0.001）, pain scores during the procedure （P 〈 0.001） and at 24 h postoperatively （P 〈 0.001）, bleeding （P = 0.001）, infection （P = 0.034）, and satisfaction with penile appearance （P 〈 0.001） in the SR group were superior to those in the DS group. After two postoperative weeks, the percentage of patients with edema in the SR group （P = 0.029） was higher but no differences were found at 4 weeks （P = 0, 185） between the two groups. In conclusions, the no-flip SR method was found to be superior to the DS method for its short operation time （〈5 min）, involving less pain, bleeding, infection, and resulting in a satisfactory appearance. However, the time for recovery from edema took longer, and patients may wear device for 2-3 weeks after the procedure.

关键词： Chinese Shang Ring circumcision Dorsal Slit phimosis redundant prepuce

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少模光纤的不同模式布里渊散射特性

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物理学报 2017年第2期66卷 176-182页

作者：张燕君高浩雷付兴虎田永胜燕山大学信息科学与工程学院河北省特种光纤与光纤传感重点实验室秦皇岛066004

少模光纤可以传输有限的正交模式,具有模间干涉小、模式易于控制等优点.基于少模光纤的布里渊散射传感器能够有效地减小多参量测量过程中的交叉敏感,实现多物理量的测量.本文基于波动光学理论对阶跃型少模光纤各个模式布里渊散射谱的频... 详细信息

少模光纤可以传输有限的正交模式,具有模间干涉小、模式易于控制等优点.基于少模光纤的布里渊散射传感器能够有效地减小多参量测量过程中的交叉敏感,实现多物理量的测量.本文基于波动光学理论对阶跃型少模光纤各个模式布里渊散射谱的频移、线宽、峰值增益等参数进行了分析.首先对少模光纤进行了模式分析,其次分析了少模光纤不同模式的频移、线宽、增益的数学模型,以及不同模式叠加的布里渊散射谱频移、线宽、增益.结果表明:少模光纤各模式布里渊散射谱的频移在10.19—10.23 GHz范围内,且随模式阶数的减小而增加;各模式布里渊散射谱的线宽在32—34 MHz,且随模式阶数的减小而增加;各模式布里渊散射增益谱相对幅度因为模式阶数的减小而增大.少模光纤中各个模式布里渊增益谱和多模式联运布里渊增益谱均符合洛伦兹曲线分布,多模式联运导致布里渊增益谱线宽展宽,且多模式联运布里渊增益谱相对振幅一般小于单个模式的布里渊相对振幅.

关键词：少模光纤布里渊散射波动光学布里渊增益谱

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun haoyan Li Dongqing Sun Shaliu Fu lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang Xing jun Wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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城市天然气利用工程中储气方式的优选

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新疆石油学院学报 2002年第3期14卷 74-77,54页

作者：何绍军赫春蕾中国石油天然气管道工程有限公司河北廊房065000

城市燃气有低压储气、高压储气、管线末端储气、地下储气库储气等多种储气形式。但对于城市天然气利用工程 ,由于输送天然气压力较高 ,解决日和周的不均衡用气 ,应充分利用干线和市内高压管网的储气能力进行储气 ,不建或少建储罐 ,以降... 详细信息

城市燃气有低压储气、高压储气、管线末端储气、地下储气库储气等多种储气形式。但对于城市天然气利用工程 ,由于输送天然气压力较高 ,解决日和周的不均衡用气 ,应充分利用干线和市内高压管网的储气能力进行储气 ,不建或少建储罐 ,以降低工程投资 ,又能安全、平稳供气。

关键词：城市天然气利用工程储气方式优选

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智能制造企业应对新型安全威胁“勒索软件”探讨

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网络空间安全 2017年第8期8卷 6-11页

作者：徐金伟郝军雷刘权峰潘鲁中国人民解放军总参谋部某研究所北京100091 北京科能腾达信息技术股份有限公司北京100041

2017年5月12日,随着名为"Wanna Cry"的勒索病毒大规模爆发,一种新型的具备自我传播特性的勒索软件及其变种,成为了全球互联网的新型安全威胁。伴随着"中国制造2025"发展战略的推进,制造企业"深度两化融合"工作的开展,智能制造企业也不... 详细信息

2017年5月12日,随着名为"Wanna Cry"的勒索病毒大规模爆发,一种新型的具备自我传播特性的勒索软件及其变种,成为了全球互联网的新型安全威胁。伴随着"中国制造2025"发展战略的推进,制造企业"深度两化融合"工作的开展,智能制造企业也不可避免地面临恶意勒索软件的威胁。论文以智能制造企业如何应对恶意勒索软件的入侵和攻击展开初步探讨,以期对从事信息安全建设的单位和同行有所借鉴。

关键词：恶意勒索软件智能制造企业安全策略

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Studies on State and Structure of Noble Metals in Electrocatalyst Made by Coprecipitation Method

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Chemical Research in Chinese Universities 2003年第1期19卷 89-93页

作者： HOU Zhong-jun lei hao FuelCellR&DCenter DalianinstituteofChemicalPhysicsCASDalian116023China StateKeyLaboratoryofCatalysis DalianInstituteofChemicalPhysicsCASDalian116023China

The electrocatalysts of Pt/C, PtRu/C and Ru/C were prepared by the impregnation method. The facet characterization, the dispersion and the particle size for the catalysts were determined by means of X ray diffraction and transmission electron microscopy. X ray photoelectron spectroscopy was also used to analyze the state and the valency of the noble metals. The results show that the particle size was in nanometer range and the binary metals have come into being an alloy. The platinum in the catalysts existed in zero valency. The valency of the ruthenium on the surface is different from that in the body, while the ruthenium on the surface existed in oxide form. PtRu/C and Pt/C are of good activity to the electrooxidation of hydrogen except Ru/C. PtRu/C is more tolerant of CO than Pt/C, and CO is only adsorbed on Pt.

关键词： Proton exchange membrane fuel cell Coprecipitation method Electrocatalyst PtRu/C XPS

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An novel energy dissipator with self-recovery capability after deformation for structurally energy-dissipating rock-shed

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Journal of Mountain Science 2021年第11期18卷 3058-3068页

作者： XIE Qi-jun SU Li-jun BAI hao TANG hao ZHANG Chong-lei YU Fang-wei Key Laboratory of Mountain Hazards and Earth Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Sichuan Expressway Construction&Development Group CO. LTD.Chengdu 610041China China-Pakistan joint Research Center on Earth Sciences CAS-HECIslamabad 45320Pakistan University of Chinese Academy of Sciences Beijing 100049China College of Environment and Civil Engineering in Chengdu University of Technology Chengdu 610051China

Theperformanceof a structurally dissipating rock-shed(SDR)depends largely onthecapacityofitsenergy *** present,mostenergy dissipatorsare made of metals,which dissipateenergy by unrecoverable plastic ***,they are not able to recover their energy-dissipation capacity after deformation under rockfall ***,a rockfall usually disintegrates into pieces when it rolls down from a higher position and results in multiple rockfall *** energy dissipator with self-recovery capability is therefore more suitable for ensuring the safety of *** metal with polyurethane(a hyperelastic material with remarkable self-recovery capability)can provide self-recovery capability for energy dissipators,making them more suitable for resisting multiple rockfall *** this work,polyurethane was manufactured into twotypes ofenergy dissipators:cylindrical and ***-scale falling rock impact testsand dynamic numerical simulationswereconducted to study the mechanical response of the energy *** addition,in order to ensure the accuracy of the simulation,the dynamic mechanical properties of the polyurethanewere tested and its dynamic constitutive model was *** experimental and simulation tests have clarified the advantages of the polyurethane energy *** also summarized the practical considerations in the design of energy dissipators.

关键词： Recoverableenergy dissipator Dynamic constitutive model Rockfall test Numerical simulation Resist multiple impacts

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Development of a 1200 fine group nuclear data library for advanced nuclear systems

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Nuclear Science and Techniques 2017年第5期28卷 48-52页

作者： jun Zou lei-Ming Shang Fang Wang Li-Juan hao Key Laboratory of Neutronics and Radiation Safety Institute of Nuclear Energy Safety Technology Chinese Academy of Sciences Hefei 230031 China

Accurate and reliable nuclear data libraries are essential for calculation and design of advanced nuclea systems. A 1200 fine group nuclear data library Hybrid Evaluated Nuclear Data Library/Fine Group(HENDL/FG with neutrons of up to 150 Me V has been developed to improve the accuracy of neutronics calculations and anal ysis. Corrections of Doppler, resonance self-shielding, and thermal upscatter effects were done for HENDL/FG Shielding and critical safety benchmarks were performed to test the accuracy and reliability of the library. The dis crepancy between calculated and measured nuclea parameters fell into a reasonable range.

关键词： Advanced nuclear system Fine group nuclear data library Effective multiplication factor

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