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Cancer nanomedicine in preoperative therapeutics:Nanotechnology-enabled neoadjuvant chemotherapy,radiotherapy,immunotherapy,and phototherapy

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Bioactive Materials 2023年第6期24卷 136-152页

作者： Xiaogang Qu Dong Zhou Jianpu Lu Duotian Qin jun Zhou hai-jun liu Department of General Surgery Changshu Hospital Affiliated to Nanjing University of Chinese MedicineChangshu215500China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA02115USA

Surgical resection remains a mainstay in the treatment of malignant solid ***,the use of neoadjuvant treatments,including chemotherapy,radiotherapy,phototherapy,and immunotherapy,either alone or in combination,as a preoperative intervention regimen,have attracted increasing attention in the last *** randomized,controlled trials in some tumor settings have not shown a significant difference between the survival rates in long-term neoadjuvant therapy and adjuvant ***,this has not hampered the increasing use of neoadjuvant treatments in clinical practice,due to its evident downstaging of primary tumors to delineate the surgical margin,tailoring systemic therapy response as a clinical tool to optimize subsequent therapeutic regimens,and decreasing the need for surgery,with its potential for increased *** recent expansion of nanotechnology-based nanomedicine and related medical technologies provides a new approach to address the current challenges of neoadjuvant therapy for preoperative *** review not only summarizes how nanomedicine plays an important role in a range of neoadjuvant therapeutic modalities,but also highlights the potential use of nanomedicine as neoadjuvant therapy in preclinical and clinic settings for tumor management.

关键词： Neoadjuvant treatment Preoperative preparation Surgical resection Nanotechnology

Climate change trend and its effects on reference evapotranspiration at Linhe Station, Hetao Irrigation District

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Water Science and Engineering 2014年第3期7卷 250-266页

作者： Xu-ming WANG hai-jun liu Li-wei ZHANG Rui-hao ZHANG College of Water Sciences Beijing Normal University

Linhe National Meteorological Station, a representative weather station in the Hetao Irrigation District of China, was selected as the research site for the present study. Changes in climatic variables and reference evapotranspiration （ET0 ）（estimated by the Penman-Monteith method） were detected using Mann-Kendall tests and Sen＇s slope estimator, respectively. The authors analyzed the relationship between the ET0 change and each climatic variable＇s change. From 1954 to 2012, the air temperature showed a significant increasing trend, whereas relative humidity and wind speed decreased dramatically. These changes resulted in a slight increase in ETo. The radiative component of total ET0 increased from 50% to 57%, indicating that this component made a greater contribution to the increase in total ETo than the aerodynamic component, especially during the crop growing season （from April to October）. The sensitivity analysis showed that ETo in Hetao is most sensitive to mean daily air temperature （11.8%）, followed by wind speed （-7.3%） and relative humidity （4.8%）. Changes in sunshine duration had only a minor effect on ET0 over the past 59 years.

关键词： climatic variables reference evapotranspiration change trend Mann-Kendall test sensitivity analysis

Effect of Carbon Content on Stacking Fault Energy of Fe-20Mn-3Cu TWIP Steel

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Journal of Iron and Steel Research International 2014年第1期21卷 116-120页

作者： Xian PENG Ding-yi ZHU Zhen-ming HU Ming-jie WANG Long-long liu hai-jun liu College of Materials Science and Engineering Fuzhou University Chengdu Aircraft Industrial(Group)Co. Ltd.AVIC Fujian San Ming Iron and Steel Group Co. Ltd. College of Materials Science and Engineering Fujian University of Technology

The influence of carbon content on the stacking fault energy （SFE） of Fe-20Mn-3Cu twinning-induced plasticity （TWIP） steel was investigated by means of X-ray diffraction peak-shift method and thermodynamic modeling. The experimental result indicated that the stacking fault probability decreases with increasing carbon addition, the SFE increases linearly when the carbon content in mass percent is between 0.23 M and 1.41%. The thermody namic calculation results showed that the SFE varied from 22.40 to 29.64 mJ ~ m 2 when the carbon content in mass percent changes from 0.23 % to 1.41%. The XRD analysis revealed that all steels were fully austenitic before and after deformation, which suggested that TWIP effect is the predominant mechanism during the tensile deformation process of Fe-20Mn-3Cu-XC steels.

关键词： stacking fault energy carbon content peak-shift method thermodynamic modeling TWIP steel

0D-2D Schottky heterostructure coupling of FeS nanosheets and Co_(9)S_(8)nanoparticles for long-term industrial-level water oxidation

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Nano Research 2023年第4期16卷 5929-5937页

作者： hai-jun liu Ning Yu Xiao-Qing Yuan Hui-Ying Zhao Xin-Yu Zhang Yong-Ming Chai Bin Dong State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

The effective electron and interface/structural coupling for heterostructure electrocatalyst is the key to regulating the intrinsic activity and stability for oxygen evolution reaction(OER).Herein,a facile strategy is developed to fabricate well-dispersed zerodimensional(0D)metallic Co_(9)S_(8)nanoparticles on two-dimensional(2D)FeS nanosheets,forming FeS-Co_(9)S_(8)Schottky heterostructures with abundant heterointerfaces as OER *** strong electronic coupling between FeS and Co_(9)S_(8)expedites electrons flow from Fe atoms in FeS nanosheets to Co atoms in tetrahedron sites(CoTd),thereby leading to the structural integrity of the heterostructure and the constant exposure of active *** Raman spectroscopy also indicates the Co sites in the FeS-Co_(9)S_(8)Schottky heterostructure are OER active ***,FeS-Co_(9)S_(8)heterostructure supported by iron foam(FeS-Co_(9)S_(8)/IF)shows the remarkable activity and durability,achieving an industrial-level 500 mA·cm^(−2)current density at an overpotential of only 332 mV and maintaining for 100 *** work demonstrates that constructing Schottky heterostructure interface with strong coupling effect may be a good strategy for excellent catalytic performances.

关键词： Schottky heterostructure strong electronic coupling electron rearrangement operando Raman oxygen evolution reaction

Passive Q-Switching of a Yb:LuVO_4 Laser with Cr^(4+):YAG:Approaching the Intrinsic Upper Limit of Repetition Rate

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Chinese Physics Letters 2018年第6期35卷 28-32页

作者： Xiao-Dan Dou Jing-Nan Yang Yan-jun Ma Wen-Juan Han Hong-nao Xu jun-hai liu College of Physics Qingdao University

We demonstrate a diode pumped Yb：LuVO4 laser that can be passively Q-switched by a Cr^（4＋）：YAG saturable absorber having an initial transmission as high as 99.3%.A maximum pulsed output power of 2.35 W is generated at a repetition rate of 285.7 kHz,approaching or very near the intrinsic upper limit imposed by the recovery time of the Cr^（4＋）：YAG saturable absorber,and the resulting pulse energy,duration and peak power are,respectively,8.2μJ,39.2ns and 0.209kW.

关键词： YAG:Approaching the Intrinsic Upper Limit of Repetition Rate Yb Passive Q-Switching of a Yb:LuVO4 Laser with Cr

Theoretical study on the effect of H_(2)O on the formation mechanism of NO_(x) precursors during indole pyrolysis

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 99-112页

作者： Ziqi Wang jun Shen Xuesong liu Sha Wang Shengxiang Deng hai Zhang Yun Guo School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The incineration technology of kitchen waste is one of the effective technologies to achieve the resource utilization of municipal solid *** is an important stage of *** is a rich initial product in the pyrolysis process of kitchen waste,and the presence of H_(2)O has a significant impact on the decomposition of indole to form NO_(x) ***,this study uses density functional theory method to study the effect of H_(2)O on the thermal decomposition of indole to produce NH_(3),HNCO,and *** H_(2)O participates in the reaction,it can provide oxidative groups to generate a new product HNCO,which is different from the previous findings by indole pyrolysis without the presence of H_(2)***,this study theoretically proves that NH_(3) is easier to form than *** is consistent with the phenomenon that NH_(3) release is higher than HCN release in pyrolysis *** addition,compared with the individual pyrolysis of indole,the participation of H_(2)O reduces the energy barriers for the formation of NH_(3) and HCN during indole pyrolysis,thereby promoting the formation of NH_(3) and HCN.

关键词： indole pyrolysis H_(2)O NO_(x)precursors DFT

Characterization of Uniform PL-convexity of Complex Banach Space by Functions with Two Variables

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Wuhan University Journal of Natural Sciences 1999年第4期4卷 399-403页

作者： HUANG hai jun,liu Pei de (College of Mathematics and Computer Science, Wuhan University, Wuhan 430072,China) Wuhan University College of Mathematics and Computer Science Wuhan China (GRID:grid.49470.3e) (ISNI:***)

We give a new characterization ofq-uniform PL-convexity of complex Banach space by using the existence of a kind of functions with two variables and then prove a sharp weak (1, 1)-type inequality for analytic martinga... 详细信息

关键词： analytic martingale uniform PL convexity mean square operator

Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model

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Nano-Micro Letters 2021年第11期13卷 1-17页

作者： hai‑Yi Feng Yihang Yuan Yunpeng Zhang hai‑jun liu Xiao Dong Si‑Cong Yang Xue‑Liang liu Xing Lai Mao‑Hua Zhu Jue Wang Qin Lu Quanjun Lin Hong‑Zhuan Chen Jonathan F.Lovell Peng Sun Chao Fang Hongqiao International Institute of Medicine Tongren Hospital and State Key Laboratory of Oncogenes and Related GenesDepartment of Pharmacology and Chemical BiologyShanghai Jiao Tong University School of Medicine(SJTU-SM)Shanghai 200025People’s Republic of China Department of General Surgery Tongren HospitalSJTU-SMShanghai 200336People’s Republic of China Institute of Interdisciplinary Integrative Biomedical Research Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203People’s Republic of China Department of Biomedical Engineering University at BuffaloState University of New YorkBuffaloNY 14260USA

Tumor lymph node(LN)metastasis seriously affects the treatment *** have shown that nanoparticles with size of sub-50 nm can directly penetrate into LN metastases after intravenous ***,we speculate through introducing targeting capacity,the nanoparticle accumulation in LN metastases would be further enhanced for improved local treatment such as photothermal *** micelles(<50 nm)were formulated using a unique surfactantstripping approach that yielded concentrated phthalocyanines with strong near-infrared *** micellar phthalocyanine(T-MP)was an effective photothermal transducer and ablated HT-29 cells in vitro.A HER2-expressing colorectal cancer cell line(HT-29)was used to establish an orthotopic mouse model that developed metastatic disease in mesenteric sentinel LN.T-MP accumulated more in the LN metastases compared to the micelles conjugated with control *** surgical resection of the primary tumor,minimally invasive photothermal treatment of the metastatic LN with T-MP,but not the control micelles,extended mouse *** findings demonstrate for the first time that targeted small-sized nanoparticles have potential to enable superior paradigms for dealing with LN metastases.

关键词： Lymph node metastasis Photothermal therapy Trastuzumab Phthalocyanine Micelles

Microwave-assisted molybdenum-nickel alloy for efficient water electrolysis under large current density through spillover and Fe doping

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Nano Research 2022年第7期15卷 5873-5883页

作者： Ya-Nan Zhou hai-jun liu Zhuo-Ning Shi Jian-Cheng Zhou Bin Dong Hui-Ying Zhao Feng-Ge Wang JianFeng Yu Yong-Ming Chai State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China

The development of high-efficiency electrocatalysts for overall water splitting under large current density is significant and ***,a high-performing Fe-doped MoNi alloy catalyst(M-H-MoNiFe-50)abundant with flower-like nanorods assemblies has been prepared by high-pressure microwave reaction and hydrogen ***,Fe doped NiMoO_(4) precursor(M-MoNiFe-50)was synthesized by microwave fast heating,ensuring the robustness of nanorods,which owns larger area and improved catalytic activity than that by conventional hydrothermal ***,M-MoNiFe-50 was reduced in H_(2)/Ar to fabricate Fe-incorporated MoNi_(4) alloys(M-H-MoNiFe-50),greatly enhancing the conductivity and facilitating hydrogen/oxygen *** final M-H-MoNiFe-50 exhibits remarkable activity for alkaline/acidic hydrogen evolution reaction and oxygen evolution reaction with low overpotential of 208(alkaline),254(acid)and 347 mV at 1,000 mA·cm^(−2).Moreover,an alkaline water electrolyzer is established using M-H-MoNiFe-50 as anode and cathode,generating a current density of 100 mA·cm^(−2) at 1.58 V with encouraging durability of 50 h at 1,000 mA·cm^(−2).The extraordinary water splitting performance can be chalked up to the large surface area,favorable charge transfer,modified electron distribution,intrinsic robustness as well as an efficient gas spillover of *** final electrocatalyst has great prospects for practical application and confirms the significance of Fe doping,microwave method and spillover effect for catalytic performance improvement.

关键词： high-pressure microwave Fe doping MoNi_(4) spillover overall water splitting