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Marker Ki-67 is a potential biomarker for the diagnosis and prognosis of prostate cancer based on two cohorts

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World Journal of Clinical Cases 2024年第1期12卷 32-41页

作者： Zhen Song Qi zhou Jiang-Lei Zhang {1. Ouyang Zhi-Yu Zhang Department of Urology Taixing People’s HospitalTaizhou 225400Jiangsu ProvinceChina Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Reproductive Medicine Center The First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Prostate cancer(PCa)is a widespread malignancy,predominantly affecting elderly males,and current methods for diagnosis and treatment of this disease continue to fall *** marker Ki-67(MKI67)has been previously demonstrated to correlate with the proliferation and metastasis of various cancer cells,including those of ***,verifying the association between MKI67 and the diagnosis and prognosis of PCa,using bioinformatics databases and clinical data analysis,carries significant clinical *** To explore the diagnostic and prognostic efficacy of antigens identified by MKI67 expression in *** For cohort 1.the efficacy of MKI67 diagnosis was evaluated using data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)*** cohort 2,the diagnostic and prognostic power of MKI67 expression was further validated using data from 271.patients with clinical *** In cohort 1.MKI67 expression was correlated with prostate-specific antigen(PSA),Gleason Score,T stage,and N *** receiver operating characteristic(ROC)curve showed a strong diagnostic ability,and the Kaplan-Meier method demonstrated that MKI67 expression was negatively associated with the progression-free interval(PFI).The time-ROC curve displayed a weak prognostic capability for MKI67 expression in *** cohort 2,MKI67 expression was significantly related to the Gleason Score,T stage,and N stage;however,it was negatively associated with the *** time-ROC curve revealed the stronger prognostic capability of MKI67 in patients with *** COX regression analysis was performed to select risk factors,including PSA level,N stage,and MKI67 expression.A nomogram was established to predict the 3-year *** MKI67 expression was positively associated with the Gleason Score,T stage,and N stage and showed a strong diagnostic and prognostic ability in PCa.

关键词： Marker Ki-67 Prostate cancer Biomarker Diagnosis Prognosis

Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain

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Rare Metals 2024年第7期43卷 3370-3382页

作者： Min zhou Hong-Hui Wu Yuan Wu Hui Wang Xiong-{1. Liu Sui-He Jiang Xiao-Bin Zhang Zhao-Ping Lu Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083Cnina Institute for Carbon Neutrality University of Science and TechnologyBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Ab st ra ct Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary(GB) ***,this high-density characteristic induces grain coarsening at elevated temperatures,thereby limiting the widespread application of nanocrystalline *** experimental observations revealed that GB segregation and second-phase pinning effectively hinder GB migration,thereby improving the stability of nanocry stalline *** this study,a mouified phase-field model that integrates mismatch strain,solute segregation and precipitation was developed to evaluate the influence of lattice misfit on the thermal stability of nanocrystalline *** simulation results indicated that introducing a suitable mismatch strain can effectively enhance the microstructural stability of nanocrystalline *** synergizing precipitation with an appropriate lattice misfit,the formation of second-phase particles in the bulk grains can be suppressed,thereby facilitating solute segregation/precipitation at the *** concentrated solute segregation and precipitation at the GBs effectively hinders grain migration,thereby preventing grain *** findings provide a new perspective on the design and regulation of nanocrystalline alloys with enhanced thermal stability.

关键词： Phase field model Mismatch strain Second-phase precipitation Grain boundary segregation Nanocrystalline alloys

Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films

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Chinese Journal of Polymer Science 2024年第6期42卷 805-814页

作者： Hong-Tao Shan Jia-Xin He Bing-Yan Zhu Xue-Ting Cao Ying-Ying Yan Jian-jun {1. Hong Huo Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing100875China

In this work,poly(3-hexylthiophene)(P3HT)ultrathin films(P3HT-T)were prepared by spin-coating a dilute P3HT solution(in a toluene:o-dichlorobenzene(Tol:ODCB)blend with a volume ratio of 80:20)with ultrasonication and the addition of the nucleating agent bicycle[2.2.1.heptane-2,3-dicarboxylic acid disodium salt(HPN-68L)on glass,Si wafers and indium tin oxide(ITO)*** electrical and mechanical properties of the P3HT-T ultrathin films were investigated,and it was found that the conductivity and crack onset strain(COS)were simultaneously improved in comparison with those of the corresponding pristine P3HT film(P3HT-0,without ultrasonication and nucleating agent)on the same substrate,regardless of what substrate was ***,the conductivity of P3HT-T ultrathin films on different substrates was similar(varying from 3.7 S·cm^(-1.to 4.4 S·cm^(-1.),yet the COS increased from 97%to 1.8%by varying the substrate from a Si wafer to *** grazing-incidence wide-angle X-ray diffraction(GIXRD),UV-visible(UV-Vis)spectroscopy and atomic force microscopy(AFM),we found that the solid order and crystallinity of the P3HT-T ultrathin film on the Si wafer are highest,followed by those on glass,and much lower on ***,the surface energy and roughness of three substrates were investigated,and it was found that the polar component of the surface energyγp plays a critical role in determining the crystalline microstructures of P3HT ultrathin films on different *** work indicates that the P3HT ultrathin film can obviously improve the stretchability and simultaneously retain similar electrical performance when a suitable substrate is *** findings offer a new direction for research on stretchable CP ultrathin films to facilitate future practical applications.

关键词： P3HT ultrathin film Substrate Crystalline microstructures Polar component of the surface energy Electrical and stretchable performances

Regulating intramolecular hydrogen bonds of p-phenylenediimidazole-based small-molecule compounds towards the enhanced lithium storage capacity

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Journal of Energy Chemistry 2024年第9期96卷 406-413页

作者： Liping Zheng Bei Wang Jianze Zhang Wenjie zhou Jiayi Ren Huige Ma Rui Li Chengming Li Ming{1. Hu {1. Yang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China College of Chemistry Nankai UniversityTianjin 300071China School of Materials Science and Engineering Beihang UniversityBeijing 100191China ShenSi Lab Shenzhen Institute for Advanced StudyUniversity of Electronic Science and Technology of ChinaShenzhen 518110GuangdongChina

The use of redox-active organic electrode materials in energy storage is restricted due to their inferior solvent resistance,abysmal conductivity,and the resultant low practical *** address these issues,a class of bipolar p-phenylenediimidazole-based small-molecule compounds are designed and ***π-conjugated backbone of these small molecules allows for electron delocalization on a big conjugation plane,endowing them with good conductivity and reaction ***,when the para-positions of phenylene are occupied by hydroxyl groups,as-formed intramolecular hydrogen bonds(N-H...O)between phenolic hydroxyl groups and the–NH groups of imidazole rings further enhance the structural planarity,resulting in higherπ-conjugation degree and better conductivity,and thus higher utilization of active sites and electrode capacity,proved by both experimental results and theoretical *** optimized composite electrode DBNQ@rGO-45 shows a high specific capacity(∼308 mA h g^(−1.at 1.0 mA g^(−1.)and a long cycling stability(1.2.9 mA h g^(−1.after 6000 cycles at 2000 mA g^(−1.).The significantly better electrochemical properties for hydroxyl group-containing compounds than those without hydroxyl groups attributed to intramolecular hydrogen bond-induced conjugation enhancement will inspire the structure design of organic electrodes for better energy storage.

关键词： Bipolar P-phenylenedimidazole Intramolecular hydrogenbonds Planarity and conjugationd egree High capacity

Engineering a high-barrier d-f single-molecule magnet centered with hexagonal bipyramidal Dy(Ⅲ)unit

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Science China Chemistry 2024年第10期67卷 3291-3298页

作者： Wei Deng Chan-Ying Yao Yan-Cong Chen Ying-Qian zhou Shan-Nan Du {1.-Liang Liu Ming-Liang Tong Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of ChemistryInstitute of Green Chemistry and Molecular EngineeringGuangdong Basic Research Center of Excellence for Functional Molecular EngineeringSun Yat-sen UniversityGuangzhou 510006China

In the pursuit of high-performance single-molecule magnets(SMMs),incorporating intramolecular magnetic coupling emerges as a pivotal *** these,d-f SMMs have garnered significant attention due to their remarkable versatility,which lies in their ability to tune coordination environments and facilely substitute metal ***,achieving performance-centric d-f SMMs through the synergistic interplay between highly anisotropic f ions and d-f magnetic interactions remains a formidable *** mononuclear hexagonal bipyramidal(D_(6h))Dy^(Ⅲ)SMMs have been successfully isolated,the exploration of d-f SMMs featuring D_(6h)-lanthanide metal centers remains uncharted *** this study,we employed planar bipodal ligands in conjunction with“staple-like”axial phenoxide ligands to synthesize the first hexagonal bipyramidal d-f ***,this compound exhibits alternating-current magnetic susceptibilities peaking up to 68 K with an energy barrier surpassing 1.200 K,thus establishing a new benchmark within the heterometallic d-f SMM landscape inclusive of complexes with diamagnetic d metals and paramagnetic f ***,the ferromagnetic interaction at the d-f sites engenders oscillating relaxation times contingent on the magnetic field—a characteristic distinct from mononuclear *** findings shed light on a deliberate design approach for d-f SMMs,emphasizing the cooperative utilization of high-barrier lanthanide modules alongside d ions through magnetic *** synergy significantly enhances and diversifies the magnetic dynamics of these intriguing molecular systems.

关键词： single-molecule magnets magnetic coupling crystal engineering hexagonal bipyramid energy barrier

Dissolution kinetics and reaction mechanism of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag

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Journal of Iron and Steel Research International 2024年第4期31卷 861-869页

作者： Yao-xin Du Yan-wu Dong zhou-hua Jiang Ganna Stovpchenko Yu-shuo Li {1. Huang Xin-wei Wang Yu-xiao Liu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina E.O.Paton Electric Welding Institute of the National Academy of Science of Ukraine Kiev 03115Ukraine

The dissolution behavior of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag,a basic slag system of electroslag remelting process,was investigated by rotating cylinder method using corundum rods to simulate Al_(2)O_(3) inclusions in *** experimental results show that the dissolution rate of Al_(2)O_(3);rods in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in rotating speed and temperature,and the rate-controlling step is the mass transfer in the *** dissolution rate of Al_(2)O,in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in the ratio of CaO to Al_(2)O_(3),which is due to the increase in dissolution driving force and the decrease in slag *** apparent activation energy of the mass transfer of AlOs in slag C is calculated to be 222.86 kJ mol^(-1..During the dissolution of Al_(2)0,inclusions in the slag,it reacts with F in liquid slag at first,then reacts with CaO to form the intermediate compounds of xCaO-yAl_(2)O_(3) system,and finally dissolves in molten *** dissolution rate of Al_(2)O_(3) inclusions in CaF_(2)-CaO-Al_(2)O_(3) slag for electroslag remelting is positively correlated with the ratio of the dissolution driving force and slag viscosity,and the correlation coeficient is 2.487×1.^(-1.).

关键词： Inclusion Electroslag remelting Mass transfer:Dissolution rate-Dissolution driving force

Annealing-induced gradient nanostructured FeCrAlTiMo high-entropy alloy coatings with significantly enhanced wear resistance

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Tungsten 2024年第3期6卷 544-548页

作者： Jian Yang Ming-Yang zhou Ji-{1. Yang Key Laboratory of Radiation Physics and Technology of Ministry of Education Institute of Nuclear Science and Technology Sichuan University Science and Technology on Reactor System Design Technology Laboratory Nuclear Power Institute of China

Recently, the amorphous high-entropy alloy(HEA) coatings exhibit an impressive resistance to the lead–bismuth eutectic(LBE) corrosion and ion irradiation, showing great application potential for lead-cooled fast reac...

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Boosting High-Voltage Practical Lithium Metal Batteries with Tailored Additives

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Nano-Micro Letters 2024年第12期16卷 23-41页

作者： Jinhai You Qiong Wang Runhong Wei Li Deng Yiyang Hu Li Niu Jingkai Wang Xiaomei Zheng junwei Li Yao {1. jun-Tao Li College of Energy Xiamen UniversityXiamen 361005People’s Republic of China Magnetism Key Laboratory of Zhejiang Province College of Materials and ChemistryChina Jiliang UniversityHangzhou 310018People’s Republic of China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium State Key Lab of Physical Chemistry of Solid Surface College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005People’s Republic of China Department of Chemical Engineering KU LeuvenCelestijnenlaan 200F3001 LeuvenBelgium College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuPeople’s Republic of China

The lithium(Li)metal anode is widely regarded as an ideal anode material for high-energy-density ***,uncontrolled Li dendrite growth often leads to unfavorable interfaces and low Coulombic efficiency(CE),limiting its broader ***,an ether-based electrolyte(termed FGN-1.2)is formulated,exhibiting ultra-stable Li metal anodes through the incorporation of LiFSI and LiNO3 as dual *** synergistic effect of the dual salts facilitates the formation of a highly robust SEI film with fast Li+transport ***,Li||Cu half cells exhibit an average CE reaching up to 99.56%.In particular,pouch cells equipped with high-loading lithium cobalt oxide(LCO,3 mAh cm^(-2))cathodes,ultrathin Li chips(25μm),and lean electrolytes(5 g Ah-1.demonstrate outstanding cycling performance,retaining 80%capacity after 1.5 *** address the gas issue in the cathode under high voltage,cathode additives 1.3,6-tricyanohexane is incorporated with FGN-1.2;the resulting high-voltage LCO||Li(4.4 V)pouch cells can cycle steadily over 93 *** study demonstrates that,even with the use of ether-based electrolytes,it is possible to simultaneously achieve significant improvements in both high Li utilization and electrolyte tolerance to high voltage by exploring appropriate functional additives for both the cathode and anode.

关键词： Li metal anode Li dendrites LiNO_(3) 1.3,6-tricyanohexane Pouch cells

Semi-synthetic chondroitin sulfate CS-semi5 upregulates miR-1.2-5p,conferring a therapeutic effect on osteoarthritis via the p38/MMP1. pathway

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3528-3542页

作者： Xiang Li Ya zhou Xuefeng Chen Hong{1. Wang Shuang Yang {1. Yang Yunfeng Song Zhehui Zhao Haijing Zhang Lianqiu Wu State Key Laboratory of Digestive Health Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Tide Pharmaceutical Co. Ltd.Beijing 100176China Camford Royal School Beijing 100093China

Osteoarthritis(OA)is an aging-associated disease characterized by joint stiffness pain and destroyed articular *** treatments for OA are limited to alleviating various OA *** is a lack of drugs available in clinical practice that can truly repair cartilage ***,we developed the chondroitin sulfate analog CS-semi5,semi-synthesized from chondroitin sulfate *** vivo,CS-semi5 alleviated inflammation,provided analgesic effects,and protected cartilage in the modified Hulth OA rat model and papain-induced OA rat model.A bioinformatics analysis was performed on samples from OA patients and an exosome analysis on papain-induced OA rats,revealing miR-1.2-5p as the key regulator associated with CS-semi5 in OA *** prediction revealed that miR-1.2-5p acted on the 30-untranslated region of p38 mitogen-activated protein kinase,which was related to MMP1. *** in vitro experiments revealed that CS-semi5 effectively reduced cartilage degeneration and maintained matrix homeostasis by inhibiting matrix breakdown through the miR-1.2-5p/p38/MMP1. axis,which was further validated in the articular cartilage of OA *** is the first study to investigate the semi-synthesized chondroitin sulfate CS-semi5,revealing its cartilageprotecting,anti-inflammatory,and analgesic properties that show promising therapeutic effects in OA via the miR-1.2-5p/p38/MMP1. pathway.

关键词： Chondroitin sulfate Cartilage Osteoarthritis Extracellular matrix Inflammation miRNA p38 MMP1.