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Role of neoadjuvant therapy for nonmetastatic pancreatic cancer:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2023年第6期15卷 911-924页

作者： Gianluca Cassese Ho-Seong Han Yoo-Seok Yoon jun suh lee Boram lee Antonio Cubisino Fabrizio Panaro Roberto Ivan Troisi Department of Clinical Medicine and Surgery Division of Minimally Invasive HPB Surgery and Transplantation ServiceFederico II University HospitalNaples 80131Italy Department of Surgery Seoul National University College of MedicineSeongnam 13620Gyeonggi-doSouth Korea Department of HPB Surgery and Transplantation Beaujon HospitalClichy 92110France Department of Digestive Surgery and Liver Transplantation CHU MontpellierMontpellier 34100France

Pancreatic adenocarcinoma(PDAC)is one of the most common and lethal human cancers *** followed by adjuvant chemotherapy offers the best chance of a long-term survival for patients with PDAC,although only approximately 20%of the patients have resectable tumors when *** chemotherapy(NACT)is recommended for borderline resectable pancreatic *** studies have investigated the role of NACT in treating resectable tumors based on the recent advances in PDAC biology,as NACT provides the potential benefit of selecting patients with favorable tumor biology and controls potential micro-metastases in high-risk patients with resectable *** such challenging cases,new potential tools,such as ct-DNA and molecular targeted therapy,are emerging as novel therapeutic options that may improve old *** review aims to summarize the current evidence regarding the role of NACT in treating non-metastatic pancreatic cancer while focusing on future perspectives in light of recent evidence.

关键词： Pancreatic cancer Pancreatic duct adenocarcinoma Neoadjuvant chemotherapy Borderline resectable Locally advanced pancreatic cancer

Laparoscopic anatomical versus non-anatomical liver resection for hepatocellular carcinoma in the posterosuperior segments:a propensity score matched analysis

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 824-834,I0001页

作者： Boram lee Jai Young Cho Ho-Seong Han Yoo-Seok Yoon Hae Won lee jun suh lee Moonhwan Kim Yeongsoo Jo Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnamKorea

Background:Since laparoscopic anatomical resection(LAR)for tumors,especially located in the posterosuperior(PS)segments of the liver remains difficult,laparoscopic non-anatomical resection(LNAR)are generally *** compare the clinical outcomes between LAR and LNAR for hepatocellular carcinoma(HCC)located in the PS ***:We retrospectively reviewed the data for 1,029 patients who underwent hepatectomy for HCC between 2004 and *** 167 patients who underwent laparoscopic hepatectomy for HCC in PS segments,64 underwent LNAR and 103 underwent *** were matched one-to-one using propensity score matching(46:46).Results:LNAR was associated with significantly shorter operation time(P=0.001),lower estimated blood loss(P=0.001),lower transfusion rate(P=0.006)and shorter hospital stay(P=0.012)than *** respective 1-,3-,and 5-year overall survival rates(LAR:95.3%,87.1%,and 77.8%;LNAR:96.7%,91.6%,and 85.0%;P=0.262)and recurrence-free survival rates(LAR:75.7%,70.3%,and 68.9%;LNAR:81.8%,58.3%,and 55.3%;P=0.879)were *** intrahepatic recurrence rate was significantly higher in LNAR group than in LAR group(78.6%vs.57.1%,P=0.023),but the post-recurrence treatments differed significantly between the two groups(P=0.016);the re-resection rate was much greater in the LNAR group(45.0%vs.0%)*** respective 1-,3-,and 5-year post-recurrence survival rates were similar in the LAR and LNAR groups(P=0.212).After recurrence,survival in re-resection group was significantly greater than not(P=0.026).Conclusions:LNAR is safe and feasible for HCC located in PS segments,and provided acceptable oncologic outcomes that are comparable to those of *** can be considered for patient with tumor located in PS segment when LAR is not feasible.

关键词： Laparoscopy hepatectomy carcinoma,hepatocellular recurrence

Intra-arterial lipo-prostaglandin E1 infusion for arterial spasm in liver transplantation:A case report

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World Journal of Clinical Cases 2023年第34期11卷 8153-8157页

作者： Moonhwan Kim Hae Won lee Chang Jin Yoon Boram lee Yeongsoo Jo Jai Young Cho Yoo-Seok Yoon jun suh lee Ho-Seong Han Department of Surgery Seoul National University Bundang HospitalSeoul National University College of MedicineSeongnam-si 13620Gyeonggi-doSouth Korea Department of Radiology Seoul National UniversitySeongnam 463-707South Korea

BACKGROUND Hepatic artery obstruction is a critical consideration in graft outcomes after living donor liver *** report a case of diffuse arterial vasospasm that developed immediately after anastomosis and was managed with an intra-arterial infusion of lipo-prostaglandin E1(PGE1).CASE SUMMARY A 57-year-old male with hepatitis B virus-related liver cirrhosis and hepatocellular carcinoma underwent ABO-incompatible living donor liver *** grafted hepatic artery was first anastomosed to the recipient’s right hepatic artery ***,the arterial pulse immediately *** a new anastomosis was performed using the right gastroepiploic artery,the patient’s arterial pulse rate remained *** attempted angiographic intervention immediately after the operation;it showed diffuse arterial vasospasms like‘beads on a string’.We attempted continuous infusion of lipo-PGE1 overnight via an intra-arterial *** next day,arterial flow improved without any spasms or *** patient had no additional arterial complications or related sequelae at the time of writing,1-year post-liver *** Angiographic evaluation is helpful in cases of repetitive arterial obstruction,and intra-arterial infusion of lipo-PGE1 may be effective in treating diffuse arterial spasms.

关键词： Liver transplantation Hepatic artery Vasospasm Prostaglandin E1 Intervention Case report

Quantitative analysis of mechanical properties associated with aging treatment and microstructure in Mg-Al-Zn alloys through machine learning

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Journal of Materials Science & Technology 2022年第12期107卷 52-63页

作者： Joung Sik suh Byeong-Chan suh Sang Eun lee jun Ho Bae Byoung Gi Moon Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

The present study proposes a methodology for predicting the mechanical properties of AZ61 and AZ91alloys associated with microstructure,texture and aging parameters and estimating predictor *** this,we investigate quantitative correlations between microstructure,texture and mechanical properties of aged AZ61 and AZ91 rods through machine *** regression analysis focuses on the precipitation behavior of Mg17Al12as the main second phase of Mg-Al-Zn alloys with respect to aging *** simplify data generation,only SEM images were used to quantify the features of discontinuous and continuous *** overcome the lack of data and make the most of the measured data,we devised a method to extend the existing dataset by a factor of 9 using the mean and standard deviation of the measured *** neural networks predicted tensile and compressive yield strengths and resultant yield asymmetry with a high accuracy of over 98%using 11 predictors for a total of *** tree learning quantitatively assessed the importance of predictors in determining the mechanical properties of aged AZ61 and AZ91 rods.

关键词： Magnesium alloy Aging treatment Microstructure Mechanical properties Machine learning

Temperature and moisture sensitivities of CO_(2) efflux from lowland and alpine meadow soils

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Journal of Plant Ecology 2009年第4期2卷 225-231页

作者： Sanguk suh Eunhye lee Jaeseok lee Department of Biological Science College of ScienceKonkuk UniversityHwayang-dong 1Gwangjin-guSeoul 143-701Korea

Aims This study was conducted to(i)determine if soil CO_(2) efflux is more sensitive to temperature changes in alpine areas than in lowland grasslands,(ii)examine the effects of temperature and moisture on soil respiration,and(iii)evaluate the potential for change in soil carbon storage in response to global warming in different grasslands in East *** We collected soil samples from two different temperate grasslands,an alpine meadow on the Qinghai-Tibetan plateau,China,and a lowland grassland in Tsukuba,*** CO_(2) emission rate was then measured for these soil samples after they were incubated at 25℃ and 60%of the water holding capacity for 7 *** Findings(i)The soil respiration rate was more sensitive to temperature change in the alpine soil than in the lowland *** average Q_(10) was 7.6 for the alpine meadow soil but only 5.9 for the lowland *** increased sensitivity appears to be due,at least in part,to the soil organic carbon content and/or soil carbon to nitrogen ratio,especially in the surface layer.(ii)The relationship between the CO_(2) emission rate and the soil moisture content revealed that the alpine meadow had a more clear response than the lowland soil.(iii)This study suggests that changes in soil moisture and soil temperature may have larger impacts on soil CO_(2) efflux in the alpine meadow than in the lowland grassland evaluated here.

关键词： alpine meadow global warming grassland Q_(10) soil respiration

Recent Advances in Cuticular Wax Biosynthesis and Its Regulation in Arabidopsis

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Molecular Plant 2013年第2期6卷 246-249页

作者： Saet Buyl lee Mi Chung suh Department of Bioenergy Science and Technology Chonnam National University Gwangju Korea

The aerial parts of land plants are covered with cuticu- lar waxes that limit non-stomatal water loss and gaseous exchanges, and protect plants from ultraviolet radiation and pathogen attacks. They are composed of very-long-chain fatty acids （VLCFAs; C20 to C34） in addition to their deriva-tives, aldehydes, alkanes, primary and secondary alcohols, and wax esters. Due to their physical properties, such as solid-ity at room temperature and a translucency ranging from transparent to opaque, plant waxes have been used as raw materials in the production of cosmetics, detergents, plas-tics, soaps, paints, drugs, lubricants, and high-value renew-able fuels. Many genes involved in cuticular wax biosynthesis and export have been characterized by forward and reverse genetic approaches as well as by stem epidermis transcrip-tome analysis. The regulatory mechanisms of cuticular wax biosynthesis have been reported at the transcriptional, post- transcriptional, and translational levels. Recent advances in cuticular wax biosynthesis and its regulation are reviewed in this paper.

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Hopf Hypersurfaces in Complex Two-Plane Grassmannians with Generalized Tanaka–Webster D-Parallel Shape Operator

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Acta Mathematica Sinica,English Series 2017年第1期33卷 61-70页

作者： Hyunjin lee Eunmi PAK Young Jin suh Research Institute of Real&Complex Manifolds Kyungpook National UniversityDaegu 41566Republic of Korea Department of Mathematics Kyungpook National UniversityDaegu 41566Republic of Korea

In this paper, we consider a new notion of generalized Tanaka Webster З-parallel shape operator for a real hypersurface in a complex two-plane Grassrnannian and prove a non-existence theorem of a real hypersurface.

关键词： Complex two-plane Grassmannians real hypersurfaces generalized Tanaka-Webster con-nection parallel shape operator З-parallel shape operator

Long-range-interacting topological photonic lattices breaking channel-bandwidth limit

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Light(Science & Applications) 2024年第10期13卷 2367-2375页

作者： Gyunghun Kim Joseph suh Dayeong lee Namkyoo Park Sunkyu Yu Department of Electrical and Computer Engineering Intelligent Wave Systems LaboratorySeoul National UniversitySeoul 08826Korea Department of Electrical and Computer Engineering Photonic Systems LaboratorySeoul National UniversitySeoul 08826Korea

The presence of long-range interactions is crucial in distinguishing between abstract complex networks and wave *** photonics,because electromagnetic interactions between optical elements generally decay rapidly with spatial distance,most wave phenomena are modeled with neighboring interactions,which account for only a small part of conceptually possible ***,we explore the impact of substantial long-range interactions in topological *** demonstrate that a crystalline structure,characterized by long-range interactions in the absence of neighboring ones,can be interpreted as an overlapped *** overlap model facilitates the realization of higher values of topological invariants while maintaining bandgap width in photonic topological *** breaking of topology-bandgap tradeoff enables topologically protected multichannel signal processing with broad *** practically accessible system parameters,the result paves the way to the extension of topological physics to network science.

关键词： topological breaking neighboring

Influences of the Welding Heat Input and the Repeated Repair Welding on Ti–3Al–2.5V Titanium Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第6期28卷 684-691页

作者： Hui-jun Yi Yong-jun lee Kwang-O lee School of Mechanical Engineering Pusan National University

The primary purpose of this study was to determine the effects of gas tungsten arc welding heat input on the high-temperature tensile properties, toughness, and microstructural features of titanium alloy Ti-3A1-2.5V. The secondary objective was to examine the effect of the repeated repair welding on the properties of the alloy. It was also found that the mechanical properties progressively decreased with increasing the repair welding cycles, especially in the case of the weldment after the first welding repair. It was observed that the sizes of the acicular and prior β grain boundaries as well as the volume fraction of the acicular phases increased with increasing the welding heat input. In addition, the amount and size of the acicular a1 phases were found to increase with increasing the repair welding cycles.

关键词： Ti-3AI-2.5V Repair welding Heat input Tensile properties Microstructure