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PROGRESS IN STUDIES ON ICE ACCUMULATION IN RIVER BENDS

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Journal of Hydrodynamics 2011年第6期23卷 737-744页

作者： WANG jun CHEN pang-pang SUI Jue-yi School of Civil Engineering Hefei University of Technology Heifei 230029 China Environmental Engineering Program University of Northern British Columbia Prince George British ColumbiaCanada V2N 4V9

River ice is an important hydraulic element in temperate and polar environments and would affect hydrodynamic conditions of rivers through changes both in the boundary conditions and the thermal regime. The river bend has been reported as the common location for the initiation of ice jams because the water flow along a river bend is markedly affected by the channel curvature. In this article, the experimental studies about the ice accumulation in a river bend are reviewed. Based on experiments conducted so far, the criteria for the formation of ice jams in the river bend, the mechanisms of the ice accumulation in the river bend and the thickness profile of the ice accumulation in the river bend are discussed. The two-equation turbulence model is used to simulate the ice accumulation under an ice cover along a river bend. A formula is proposed for describing the deformation of the ice jam bottom. Our results indicate that all simulated thickness of the ice accumulation agrees reasonably well with the measured thickness of the ice accumulation in the laboratory.

关键词： experiment ice jam/accumulation bend channel thickness profile

Sensitivity analysis of spacecraft in micrometeoroids and orbital debris environment based on panel method

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Defence Technology（防务技术） 2023年第1期19卷 126-142页

作者： Di-qi Hu Run-qiang Chi Yu-yan Liu Bao-jun pang Hypervelocity Impact Research Center Harbin Institute of Technology150080HarbinChina

To reduce the risk of mission failure caused by the MM/OD impact of the spacecraft,it is necessary to optimize the design of the *** survivability assessment is the key technology in the optimal design of *** survivability assessment includes spacecraft impact sensitivity analysis and spacecraft component vulnerability analysis under MM/OD *** impact sensitivity refers to the probability of a spacecraft encountering an MM/OD impact while in *** refers to the probability that each component of a spacecraft may fail or malfunction when impacted by space *** this paper mainly analyzes the impact sensitivity and proposes a spacecraft sensitivity assessment method under the MM/OD environment based on a panel *** this panel method,a spacecraft geometric model is discretized into small panels,and whether they are impacted by MM/OD or not is determined through the analysis of the shielding or shadowing relationships between *** number of impacts on each panel is obtained through calculation,and accordingly the probability of each spacecraft component encountering MM/OD impact can be acquired,thus generating the impact *** paper extracts data from the NASA’s ORDEM2000,the ESA’s MASTER8 as well as the SDEEM2015(Space Debris Environmental Engineering Model developed by HIT),and uses the PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)method to interpolate and fit the size-flux relationship of space *** with linear interpolation and cubic spline interpolation,the fitting results through the method are relatively more *** feasibility of this method is also demonstrated through two actual examples shown in this paper,whose results are close to those from ESABASE,although there are some minor errors mainly due to different debris data *** the cross-check by three risk assessment software-BUMPER,MDPANTO and MODAOST-under standard operating condit

关键词： Shielding algorithm Panel method Spacecraft Sensitivity

Model checking with fairness assumptions using PAT

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Frontiers of Computer Science 2014年第1期8卷 1-16页

作者： Yuanjie SI jun SUN Yang LIU Jin Song DONG jun pang Shao Jie ZHANG Xiaohu YANG College of Computer Science Zhejiang University Hangzhou 310027 China Information System Technology and Design Singapore University of Technology and Design Singapore 138682 Singapore School of Computer Engineering Nanyang Technological University Singapore 639798 5ingapore School of Computing National University of Singapore Singapore 117417 Singapore Faculty of Science Technology and Communication University of Luxembourg Luxembourg L- 1359 Luxembourg

Recent development on distributed systems has shown that a variety of fairness constraints （some of which are only recently defined） play vital roles in designing self- stabilizing population protocols. Existing model checkers are deficient in verifying the systems as only limited kinds of fair- ness are supported with limited verification efficiency. In this work, we support model checking of distributed systems in the toolkit PAT （process analysis toolkit）, with a variety of fairness constraints （e.g., process-level weak/strong fairness, event-level weak/strong fairness, strong global fairness）. It performs on-the-fly verification against linear temporal prop- erties. We show through empirical evaluation （on recent pop- ulation protocols as well as benchmark systems） that PAT has advantage in model checking with fairness. Previously un- known bugs have been revealed against systems which are designed to function only with strong global fairness.

关键词： model checking fairness PAT verification tool,formal methods

高危型HPV感染对宫颈阴道微生态、miR-149-3p、CYBRD1表达的影响

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中国计划生育学杂志 2024年第9期32卷 2141-2145页

作者：李琼谢林峻庞君陈稀文四川省成都市第七人民医院 610044

目的:探讨宫颈炎患者高危型HPV(HR-HPV)感染对宫颈阴道微生态、miR-149-3p、CYBRD1表达的影响。方法:选取2020年12月-2022年12月因宫颈炎就诊于本院的102例临床资料,根据是否感染HR-HPV分入高危HPV阴性组(n=65)与阳性组(n=37)。检测HPV... 详细信息

目的:探讨宫颈炎患者高危型HPV(HR-HPV)感染对宫颈阴道微生态、miR-149-3p、CYBRD1表达的影响。方法:选取2020年12月-2022年12月因宫颈炎就诊于本院的102例临床资料,根据是否感染HR-HPV分入高危HPV阴性组(n=65)与阳性组(n=37)。检测HPV阳性患者HPV感染亚型,比较两组阴道微生态改变及阴道微生态平衡状态;采用荧光定量PCR法检测宫颈脱落细胞miR-149-3p、CYBRD1水平;Spearman法分析宫颈阴道微生态与宫颈脱落细胞miR-149-3p、CYBRD1水平的相关性;采用多因素logistic逐步回归分析HR-HPV感染影响因素。结果:HR-HPV阳性组宫颈病变严重程度高于阴性组,阳性组中HPV16亚型检出率最高(51.0%),其次为HPV18(18.6%);阳性组阴道微生态失衡、解脲脲原体阳性率、乳酸杆菌异常率均高于阴性组,miR-149-3p(0.53±0.12)低于阴性组(1.67±0.23),CYBRD1相对表达量(1.29±0.27)高于阴性组(0.46±0.10)(均P<0.05);HR-HPV感染与宫颈脱落细胞miR-149-3p表达呈负相关、与CYBRD1表达、阴道微生态失衡、解脲脲原体阳性率及乳酸杆菌异常率呈正相关(均P<0.05)。HR-HPV阳性组不良孕产史占比高于阴性组(P<0.05)。多因素分析显示:解脲脲原体阳性率、乳酸杆菌异常率、不良孕产史、阴道微生态失衡、miR-149-3p降低、CYBRD1升高是HR-HPV感染影响因素(均P<0.05)。结论:HR-HPV感染者宫颈脱落细胞中miR-149-3p低表达、CYBRD1高表达,亚型检出以HPV16、HPV18为主,且HR-HPV感染会影响患者宫颈阴道微生态失衡,增加宫颈病变严重程度。

关键词：高危型人乳头瘤病毒 miR-149-3p 人细胞色素b还原酶1 宫颈阴道微生态相关性影响因素

秦岭南坡不同林分类型枯落物层和土壤层水文功能综合评价

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西北林学院学报 2024年第3期39卷 50-58页

作者：王亚萍刘庆安庞军柱张淑兰王昕婕安康学院旅游与资源环境学院陕西安康725000 安康天长工程建设集团有限公司陕西安康725000 西北农林科技大学林学院陕西杨陵712100

为探究秦岭地区典型林分下枯落物层和土壤层水文功能差异,采用室内浸水法、环刀法定量研究秦岭火地塘林区油松林、锐齿栎林和华北落叶松林下枯落物层和土壤层持水特征,并借助主成分分析法、熵权法综合评价其水文功能。结果表明:1)3个林... 详细信息

为探究秦岭地区典型林分下枯落物层和土壤层水文功能差异,采用室内浸水法、环刀法定量研究秦岭火地塘林区油松林、锐齿栎林和华北落叶松林下枯落物层和土壤层持水特征,并借助主成分分析法、熵权法综合评价其水文功能。结果表明:1)3个林分下枯落物层厚度和蓄积量分别为3.11~7.44 cm和5.58~10.02 t·hm^(-2),其中锐齿栎林枯落物厚度最大,而华北落叶松林蓄积量最高;2)枯落物层自然含水率、最大持水率、最大持水量和有效拦蓄量分别为12.54%~102.59%、185.93%~557.7%、14.41~17.8 t·hm^(-2)和7.66~14.34 t·hm^(-2),其中锐齿栎林的最大持水量和有效拦蓄量最大,华北落叶松林则在枯落物自然含水率及最大持水率上表现最佳;3)3个林分下土壤容重均随着土层深度的增加而增加,其值为0.89~1.21 g·cm^(-3),油松林的土壤储水量最低,华北落叶松林下的土壤总孔隙度和毛管孔隙度则最大,0~40 cm土层最大持水量依次为华北落叶松林(257 mm)>锐齿栎林(234 mm)>油松林(231 mm)。通过熵权法综合评价,锐齿栎林在枯落物拦蓄能力方面表现最佳,而华北落叶松林土壤层的持水功能最优,因此建议在今后的森林管理中合理优化树种配置,以更好地发挥其水源涵养功能。

关键词：枯落物层土壤层持水功能熵权法秦岭

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Impact of Poly(Ester Amide) Structure on Properties and Drug Delivery for Prostate Cancer Therapy

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Biomedical Engineering Frontiers 2023年第1期4卷 42-51页

作者： junfu Zhang Liying Wang Mengting Ding Xinru You jun Wu jun pang Department of Urology Kidney and Urology CenterPelvic Floor Disorders CenterThe Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Department of Hematology The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women's HospitalHarvard Medical SchoolBostonMA 02115USA Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)NanshaGuangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong Kong SARChina

Objective:We aim to develop a polymer library consisting of phenylalanine-based poly(ester amide)s(Phe-PEAs)for cancer therapy and investigate the structure–property relationship of these polymers to understand their impact on the drug delivery efficiency of corresponding nanoparticles(NPs).Impact Statement:Our study provides insights into the structure–property relationship of polymers in NP-based drug delivery applications and offers a potential polymer library and NP platform for enhancing cancer ***:Polymer NP-based drug delivery systems have demonstrated substantial potential in cancer therapy by improving drug efficacy and minimizing systemic ***,successful design and optimization of these systems require a comprehensive understanding of the relationship between polymer structure and physicochemical properties,which directly influence the drug delivery efficiency of the corresponding ***:A series of Phe-PEAs with tunable structures was synthesized by varying the length of the methylene group in the diol part of the ***,Phe-PEAs were formulated into NPs for doxorubicin(DOX)delivery in prostate cancer ***:Small adjustments in polymer structure induced the changes in the hydrophobicity and thermal properties of the PEAs,consequently NP size,drug loading capacity,cellular uptake efficacy,and ***,DOXloaded Phe-PEA NPs demonstrated enhanced tumor suppression and reduced side effects in prostate tumor-bearing ***:Phe-PEAs,with their finely tunable structures,show great promise as effective and customizable nanocarriers for cancer therapy.

关键词： Impact loaded property

Survivability assessment of spacecraft impacted by orbit debris

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Defence Technology（防务技术） 2021年第3期17卷 961-970页

作者： Di-qi Hu Bao-jun pang Run-qiang Chi Zhang-chi Song Hao Wu Hypervelocity Impact Research Center Harbin Institute of Technology150080HarbinChina Beijing Institute of Aerospace Automatic Control 100854BeijingChina Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences130033ChangchunChina

To help optimize the spacecraft design and reduce the risk of spacecraft mission failure, a new approach to assess the survivability of spacecraft in orbit is presented here, including the following three steps: 1)Sensitivity Analysis of spacecraft. A new sensitivity analysis method, a ray method based on virtual outer wall, is presented here. Using rays to simulate the debris cloud can effectively address the component shadowing issues. 2) Component Vulnerability analysis of spacecraft. A function "Component functional reduction degree-Component physical damage degree" is provided here to clearly describe the component functional reduction. 3) System-level Survivability Assessment of spacecraft. A new method based on expert knowledge reasoning, instead of traditional artificial failure tree method, is presented here to greatly improve the efficiency and accuracy of calculation.

关键词： Survivability Hypervelocity impact Orbit debris Ray method

Omics Approaches for Exploring Pneumoconiosis:A Review

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Biomedical and Environmental Sciences 2021年第1期34卷 71-82页

作者： LUO Ya QI Xian Mei pang jun Ling WANG Jing WANG Chen State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PathophysiologyPeking Union Medical CollegeBeijing 100730China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesDepartment of PhysiologyPeking Union Medical CollegeBeijing 100730China

Pneumoconiosis,a fatal lung disease caused by dust inhalation and deposition,is one of the leading occupational diseases worldwide[1].The dust is primarily inorganic particles,such as silica particles,coal dust,and asbestos *** the diameter of dust is less than 5μm,it is defined as‘respirable dust’that can easily reach the distal airways and alveoli[2].

关键词： lung diseases occupational

药学类专业“有机化学”课程“五位一体”教学模式初探——以北京城市学院为例

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教育教学论坛 2024年第18期 153-156页

作者：焦晓林田婧庞俊兰厉妲北京城市学院生物医药学部北京100094

“有机化学”是高等院校药学类专业的一门重要基础课程,为后续专业课学习提供重要支撑。针对“有机化学”传统教学模式下存在的痛点,构建了“理论具象、应用导向、思政融合、线上贯穿、线下联动”相融合的“五位一体”混合教学新模式,... 详细信息

“有机化学”是高等院校药学类专业的一门重要基础课程,为后续专业课学习提供重要支撑。针对“有机化学”传统教学模式下存在的痛点,构建了“理论具象、应用导向、思政融合、线上贯穿、线下联动”相融合的“五位一体”混合教学新模式,从教学目标、教学内容、教学形式及教学效果四个方面对教学模式的应用进行了总结与讨论。实践表明,有机化学“五位一体”教学模式提升了学生成绩,受到了学生好评,取得了较好成效。

关键词：药学专业中药学专业有机化学 “五位一体”