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Neuroscience Bulletin 2022年第4期38卷 373-385页

作者： Seong-Ah Kim jun ho jang Wheedong Kim Pa Reum Lee Yong ho Kim Hue Vang Kihwan Lee Seog Bae Oh Department of Neurobiology and Physiology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 03080Republic of Korea Department of Brain and Cognitive Sciences College of Natural SciencesSeoul National UniversitySeoul 08826Republic of Korea Gachon Pain Center and Department of Physiology College of MedicineGachon UniversityIncheon 21999Republic of Korea Tooth-Periodontium Complex Medical Research Center School of DentistrySeoul National UniversitySeoul 03080Republic of Korea

Mitochondrial reactive oxygen species(mROS)that are overproduced by mitochondrial dysfunction are linked to pathological conditions including sensory ***,we explored whether mROS overproduction induces itch through transient receptor potential canonical 3(TRPC3),which is sensitive to *** injection of antimycin A(AA),a selective inhibitor of mitochondrial electron transport chain complex III for mROS overproduction,produced robust scratching behavior in naïve mice,which was suppressed by MitoTEMPO,a mitochondria-selective ROS scavenger,and Pyr10,a TRPC3-specific blocker,but not by blockers of TRPA1 or *** activated subsets of trigeminal ganglion neurons and also induced inward currents,which were blocked by MitoTEMPO and ***,dry skin-induced chronic scratching was relieved by MitoTEMPO and Pyr10,and also by resveratrol,an *** together,our results suggest that mROS elicit itch through TRPC3,which may underlie chronic itch,representing a potential therapeutic target for chronic itch.

关键词： Mitochondria Reactive oxygen species TRPC3 Itch Dry skin Trigeminal ganglia

Impact of high-resolution HLA matching on outcomes of unrelated donor hematopoietic stem cell transplantation

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Impact of high-resolution HLA matching on outcomes of unrela...

Endothelial progenitor cell differentiation using cryopreserved,umbilical cord blood-derived mononuclear cells

第十届亚太国际骨髓移植会议

作者： Seok Yun Kang Hyun Woo Lee jun ho jang Joon Seong Park Jin Hyuk Choi ho Young Lim Hugh Chul Kim Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea Department of Hematology-Oncology Ajou University School of Medicine SuwonKorea

＜正＞Objective: We assessed the impact of high-resolution genotypic results of human leukocyte antigen （HLA） for all major class Ⅰand Ⅱloci between donors and recipients in the outcome of unrelated hematopoietic stem cell transplantation （HSCT）. Method: Between 1999 and 2005, high-resolution genotyping for HLA-A, -B, -C and -DRB1 was performed for 23 unrelated HSCT. All the patients were typed as HLA identical by serologic technique and then they were also typed HLA identical by high resolution technique. Unrelated bone marrow

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Acta Pharmacologica Sinica 2007年第3期28卷 367-374页

作者： jun-ho jang~(2,5) Sun-kyung KIM~(3,5) Jeong-eun ChoI~3 Young-jin KIM~3 Hyun-woo LEE~2 Seok-yun KANG~2 Joon-seong PARK~2 Jin-hyuk ChoI~2 ho-yeong LIM~4 Hugh C KIM~(2,6)2 Department of Hematalogy-Oncology,Ajou University,School of Medicine,Suwon 442749,Korea 3 Biomedical Research Institute,LifeCord,Suwon 442749,Korea 4 Division of Hematology-Ontology,Department of Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul 135710,Korea Department of Hematology-Oncology Ajou University School of Medicine Suwon Korea Department of Biomedical Research Institute Suwon Korea Division of Hematology-Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea

Aim:To investigate the endothelial differentiation potentiality of umbilical cordblood(UCB),we induced the differentiation of endothelial progenitor cells(EPC)from cryopreserved UCB-derived mononuclear cells(MNC).Methods:MNC fromcryopreserved UCB and peripheral blood(PB)were cultured in M199 medium withendothelial cell growth supplements for 14 *** were characterized by RT-PCR,flow cytometry,and immunocytochemistry *** proliferation of differen-tiated EPC was studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazoliumbromide(MTT)assay,and vascular endothelial growth factor(VEGF)concentra-tion was measured using an ELISA *** of UCB-derived EPC werecompared with those of PB-derived ***:A number of round-shapedcells were loosely attached to the bottom after 24 h culture,and numerous spindle-shaped cells began to appear from the round-shaped ones on d *** cellsexpressed endothelial markers such as,Flt-1/VEGFR-1,ecNOS,VE-cadherin,vonWillebrand factor,and secreted VEGE The patterns of endothelial markers of EPCfrom PB and UCB did not show striking *** results of the prolifera-tion and secretion of VEGF were also ***:We successfully cul-tured UCB cells stored at -196℃ into cells with the quality of endothelial *** EPC could be used for angiogenic therapeutics by activating adjacentendothelial cells and enhancing angiogenesis.

关键词： cord blood endothelial cells cryopreserved

Central post-stroke pain due to injury of the spinothalamic tract in patients with cerebral infarction： a diffusion tensor tractography imaging study

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Neural Regeneration Research 2017年第12期12卷 2021-2024页

作者： Sung ho jang jun Lee Sang Seok Yeo Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Namku Daegu Republic of Korea Department of Neurology College of Medicine Yeungnam University Namku Daegu Republic of Korea Department of Physical Therapy College of Health Sciences Dankook University Chungnam Republic of Korea

Many studies using diffusion tensor tractography（DTT） have demonstrated that injury of the spinothalamic tract（STT） is the pathogenetic mechanism of central post-stroke pain（CPSP） in intracerebral hemorrhage; however, there is no DTT study reporting the pathogenetic mechanism of CPSP in cerebral infarction. In this study, we investigated injury of the STT in patients with CPSP following cerebral infarction, using DTT. Five patients with CPSP following cerebral infarction and eight age-and sex-matched healthy control subjects were recruited for this study. STT was examined using DTT. Among DTT parameters of the affected STT, fractional anisotropy and tract volume were decreased by more than two standard deviations in two patients（patients 1 and 2） and three patients（patients 3, 4, and 5）, respectively, compared with those of the control subjects, while mean diffusivity value was increased by more than two standard deviations in one patient（patient 2）. Regarding DTT configuration, all affected STTs passed through adjacent part of the infarct and three STTs showed narrowing. These findings suggest that injury of the STT might be a pathogenetic etiology of CPSP in patients with cerebral infarction.

关键词： nerve regeneration central post-stroke pain cerebral infarction spinothalamic tract diffusion tensorimaging neural regeneration

Recovery mechanisms of somatosensory function in stroke patients: implications of brain imaging studies

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Neuroscience Bulletin 2013年第3期29卷 366-372页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Somatosensory dysfunction is associated with a high incidence of functional impairment and safety in patients with stroke. With developments in brain mapping techniques, many studies have addressed the recovery of various functions in such patients. however, relatively little is known about the mechanisms of recovery of somatosensory function. Based on the previous human studies, a review of 11 relevant studies on the mecha- nisms underlying the recovery of somatosensory function in stroke patients was conducted based on the fol- lowing topics：（1） recovery of an injured somatosensory pathway, （2） peri-lesional reorganization, （3） contribu- tion of the unaffected somatosensory cortex, （4） contribution of the secondary somatosensory cortex, and （5） mechanisms of recovery in patients with thalamic lesions. We believe that further studies in this field using combinations of diffusion tensor imaging, functional neuroimaging, and magnetoencephalography are needed. In addition, the clinical significance, critical period, and facilitatory strategies for each recovery mechanism should be clarified.

关键词： stroke somatosensory recovery brain mapping brain plasticity

Perilesional reorganization of motor function in stroke patients

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Neural Regeneration Research 2010年第21期5卷 1668-1672页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Perilesional reorganization is an important recovery mechanism for stroke patients because it yields good motor outcomes. however, perilesional reorganization remains poorly understood. The scientific basis for stroke rehabilitation can be established when detailed mechanisms of recovery are clarified. In addition, studies at the subcortical level remain in the early stages. Therefore, the present study suggested that additional investigations should focus on perilesional reorganization at the subcortical level, identifying the critical period for this mechanism and determining treatment strategies and modalities to facilitate development. The present study reviews literature focused on perilesional reorganization in stroke patients with regard to demonstration, clinical characteristics, and rehabilitative aspects, as well as previous studies of perilesional reorganization at cortical and subcortical levels.

关键词： stroke motor recovery functional MRI diffusion tensor imaging brain plasticity reorganization

Unusual long-term motor recovery in a patient with corona radiata infarct

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Neural Regeneration Research 2010年第17期5卷 1353-1356页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityDaegu 705-717Republic of Korea

The majority of motor recovery following stroke occurs within 6 months after *** present study examined a patient with a corona radiata infarct,who exhibited an unusual long-term recovery（24 months after onset）.The patient was a 64-year-old female,who presented with severe paralysis of the left extremities resulting from a corona radiate *** recovery from the weakness progressed slowly over a 24-month period following onset,even at 6-12 months after *** tensor tractography at 2 weeks from onset showed disruption of the corticospinal tract of the affected hemisphere resulting from the ***,at 12 and 24 months after onset,the corticospinal tract was elongated to the cortex level,as shown by diffusion tensor tractography.A 2-week transcranial magnetic stimulation showed no motor-evoked potential for the affected hemisphere,but a motor-evoked potential of the corticospinal tract was observed at12 and 24 *** results suggest that motor function recovery in cerebral infarct patients can occur at least up to 24 months after stroke onset.

关键词： stroke motor recovery cerebral infarct diffusion tensor tractography transcranial magnetic stimulation diffusion tensor imaging

Reduced graphene oxide-based materials for electrochemical energy conversion reactions

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Carbon Energy 2019年第1期1卷 85-108页

作者： Seokhoon Choi Changyeon Kim jun Min Suh ho Won jang Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea

There have been ever-growing demands to develop advanced electrocatalysts for renewable energy conversion over the past *** a promising platform for advanced electrocatalysts,reduced graphene oxide(rGO)has attracted substantial research interests in a variety of electrochemical energy conversion *** versatile utility is mainly attributed to unique physical and chemical properties,such as high specific surface area,tunable electronic structure,and the feasibility of structural modification and ***,a comprehensive discussion is provided upon recent advances in the material preparation,characterization,and the catalytic activity of rGO-based electrocatalysts for various electrochemical energy conversion reactions(water splitting,CO2 reduction reaction,N2 reduction reaction,and O2 reduction reaction).Major advantages of rGO and the related challenges for enhancing their catalytic performance are addressed.

关键词： CO2 reduction reaction electrocatalysis N2 reduction reaction O2 reduction reaction reduced graphene oxide water splitting

Isolated corticospinal tract in a patient with intracerebral hemorrhage A diffusion tensor tractography and transcranial magnetic stimulation study

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Neural Regeneration Research 2011年第7期6卷 558-560页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University

Diffusion tensor tractography allows visualization of the corticospinal tract （CST） in three dimensions. Transcranial magnetic stimulation offers a unique advantage in that it can distinguish between the corticospinal tract and the non-CST by analyzing the characteristics of a motor-evoked potential. A 15 year-old female showed right hemiparesis, due to intracerebral hemorrhage in the left corona radiata, and the posterior limb of the internal capsule. Diffusion tensor tractography revealed that the tracts of both hemispheres originated from the precentral gyrus, and descended through the known CST pathway. Specifically, the tract of the affected hemisphere descended through an isolated area in the leukomalactic lesion at the posterior limb level. In addition, the characteristics of the motor-evoked potential obtained from the right hand when stimulating the hot spot of the left motor cortex corresponded to a CST. In conclusion, we report on a patient with intracerebral hemorrhage who showed an isolated CST in a leukomalactic lesion. This result suggests the importance of saving the adjacent area or penumbra around a hematoma after an intracerebral hemorrhage.

关键词： stroke motor recovery corticospinal tract magnetic stimulation diffusion tensor im-aging

Spared integrity of corticospinal tract within a pontine infarct A diffusion tensor tractography study

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Neural Regeneration Research 2010年第20期5卷 1552-1554页

作者： Sung ho jang Department of Physical Medicine and Rehabilitation College of Medicine Yeungnam University Daegu 705-717 Republic of Korea

Integrity of the corticospinal tract is mandatory for good recovery of impaired motor function in patients who have suffered a stroke.A 67-year-old left hemiparetic female showed an infarct in the right *** months after onset,motor function of the affected extremities recovered rapidly to a nearly complete *** tensor tractography of both hemispheres showed that the corticospinal tract originated from the primary sensori-motor cortex and descended through the known corticospinal tract *** tract of the affected（right）hemisphere descended through an area within the pontine *** diffusion tensor tractography results suggest that from the onset,the integrity of the corticospinal tract appears to have been spared within the pontine infarct.

关键词： pontine infarct diffusion tensor imaging corticospinal tract stroke motor recovery