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Selective inhibition of cell growth by activin in SNU-16 cells

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World Journal of Gastroenterology 2006年第19期12卷 3000-3005页

作者： young Il Kim Hee Joo Lee Inkoo Khang Byung-Nam Cho ha Kyu Lee East-West Medical Research Institute Kyung Hee University SeoulSouth Korea Department of Laboratory Medicine Kyung Hee University College of MedicineSeoulSouth Korea School of Biological Sciences Seoul National University SeoulSouth Korea Department of Life Sciences The Catholic University of Korea PuchonSouth Korea

AIM： To investigate whether activin regulates the cell proliferation of human gastric cancer cell line SNU-16 through the mRNA changes in activin receptors, Smads and p21^CIP1/WAF1. METHODS： The human gastric cancer cell lines were cultured, RNAs were purified, and RT-PCRs were carried out with specifically designed primer for each gene. Among them, the two cell lines SNU-5 and SNU-16 were cultured with activin A for 24, 48 and 72 h. The cell proliferation was measured by MTT assay. For SNU-16, changes in ActRIA, ActRIB, ActRIIA, ActRIIB, Smad2, Smad4, Smad7, and p21^CIP1/WAF1 mRNAs were detected with RT-PCR after the cells were cultured with activin A for 24, 48 and 72 h. RESULTS： The proliferation of SNU-16 cells was down regulated by activin A whereas other cells showed no change. Basal level of inhibin/activin subunits, activin receptors, Smads, and p21^CIP1/WAF1 except for activin βB mRNAs was observed to have differential expression patterns in the human gastric cancer cell lines, AGS, KATO III, SNU-1, SNU-5, SNU-16, SNU-484, SNU-601, SNU-638, SNU-668, and SNU-719. Interestingly, significantly higher expressions of ActR IIA and IIB mRNAs were observed in SNU-16 cells when compared to other cells. After activin treatment, ActR IA, IB, and IIA mRNA levels were decreased whereas ActR IIB mRNA level increased in SNU-16 cells. Smad4 mRNA increased for up to 48 h whereas Smad7 mRNA increased sharply at 24 h and returned to the initial level at 48 h in SNU-16 cells. In addition, expression of the p21^CIP1/WAF1 the mitotic inhibitor, peaked at 72 h after activin treatment in SNU-16 cells. CONCLUSION： Our results suggest that inhibition of cell growth by activin is regulated by the negative feedback effect of Smad7 on the activin signaling pathway, and is mediated through p21^CIP1/WAF1 activation in SNU-16 cells.

关键词： Human gastric cancer cell lines, Activin A Cell proliferation Activin receptors Smads p21^CIP1/WAF1

Single omental metastasis of renal cell carcinoma after radical nephrectomy:A case report

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World Journal of Clinical Cases 2023年第25期11卷 5994-5999页

作者： Jae-Wook Chung jun-Koo Kang Eun Hye Lee So young Chun Yun-Sok ha jun Nyung Lee Tae-Hwan Kim Tae Gyun Kwon Ghil Suk Yoon Department of Urology Kyungpook National University HospitalDaegu 41404South Korea Department of Urology School of MedicineKyungpook National UniversityDaegu 41404South Korea Biomedical Research Institute Kyungpook National UniversityDaegu 41404South Korea Joint Institute for Regenerative Medicine Kyungpook National UniversityDaegu 41404South Korea Department of Pathology Kyungpook National University HospitalDaegu 41404South Korea Department of Pathology School of MedicineKyungpook National UniversityDaegu 41404South Korea

BACKGROUND Renal cell carcinoma(RCC)is the third most common malignancy in the genitourinary *** lungs,bone,lymph nodes,liver,and brain are common metastatic sites of ***,there is limited literature on single omental metastasis of *** SUMMARY We present the case of a 44-year-old man with single omental metastasis of RCC after laparoscopic radical *** diagnosis of the resected left kidney revealed pT3a clear cell RCC(Fuhrman grade III).At 6 mo postoperatively,abdominal computed tomography revealed a 12-mm enhancing nodule in the left lower *** 7 mo after initial operation,laparoscopic removal of the left omental nodule was *** pathological results indicated metastatic clear cell ***,the patient is being treated with adjuvant *** Omental metastasis of RCC owing to laparoscopic radical nephrectomy is *** should be aware of the diverse nature of RCC.

关键词： Metastasis Omentum Renal cell carcinoma Radical nephrectomy Case report

Allele-specific PCR genotyping of the HSP70 gene polymorphism discriminating the green and red color variants sea cucumber (Apostichopus japonicus)

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Journal of Genetics and Genomics 2011年第8期38卷 351-355页

作者： jung-ha Kang Ki Hwan Yu jung-Youn Park Chul-Min An Je-Cheon jun Sang-jun Lee Biotechnology Research Division NFRDIBusan 619-705Republic of Korea Aquaculture Management Division NFRDIBusan 619-705Republic of Korea

Color variation is a well-known feature of sea cucumbers （Apostichopus japonicus）, which are classified into three groups based on their colors of red, green and black. It is also one of the most important traits related to how they taste, and it thereby affects their market price. Attempts were made to identify single-nucleotide polymorphisms （SNPs） and to analyze differences associated with SNP genotypes between green and red color variants using HSP70 as the target gene. The HSP70 gene, which is found universally in organisms from bacteria to humans, is one of the most evolutionarily conserved genes and the most widely studied biomarker of stress response. DNA fragments of 1074 bp covering a partial sequence of the sea cucumber HSP70 gene, were amplified from both red and green variants, and subsequently analyzed for the presence of SNPs. Twenty-seven polymorphic sites in total, including heterozygous sites, were observed. Of these, six sites were found to be significantly different SNP genotypes between green and red variants. Furthermore, PCR with an internal primer designed to include an allelespecific SNP at the 3＇ end （site 443） showed differentiation between the two variants, 100% and 4.2% amplification in green and red variants, respectively. The validated SNPs may serve as informative genetic markers that can be used to distinguish variants at the early developmental stage, prior to color differentiation.

关键词： Sea cucumber HSP70 SNP Color variant

High-temperature Oxidation Behavior of Zircaloy-4 and Zirlo in Steam Ambient

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Journal of Materials Science & Technology 2010年第9期26卷 827-832页

作者： Hyung Hoon Kim jun Ho Kim Jin young Moon Ho Seong Lee Jeong Joo Kim young Suck Chai School of Materials Science and Engineering Kyungpook National University School of Mechanical Engineering Yeungnam University214-1 Dae-dongGyeongsan-si

The oxidation characteristics for Zircaloy-4 and Zirlo in the temperature range of 700-1200°C under steam supply condition were investigated by using a modified thermo-gravimetric *** specimens were oxidized for 3600 s at each temperature and then quenched in a *** oxidation rate constants were measured from the weight gains to evaluate the oxidation behavior in Zircaloy-4 and *** weight gain rates of Zirlo were lower than those of Zircaloy-4,leading to the low rate *** different oxidation behaviors between both cladding materials were considered to be due to the difference in their chemical compositions.

关键词： Zircaloy-4 Zirlo Oxidation

Preparation and Characterization of Porous PVdF-HFP/clay Nanocomposite Membranes

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Journal of Materials Science & Technology 2010年第7期26卷 633-638页

作者： Mi Jin Koh hae young Hwang Deuk Ju Kim Hyeng jun Kim young Taik Hong Sang Yong Nam School of Materials Science and Engineering Engineering Research Institutei-Cube CenterGyeongsang National UniversityJinjuKorea Fuel Cell Research Center Korea Institute of Science and TechnologySeoul 136-791Korea Energy Material Research Center Korea Research Institute of Chemical TechnologyDaejeon 305-600Korea

Polyvinylidene fluoride-hexafluoropropylene （PVdF-HFP） / clay nanocomposite membranes were prepared by phase inversion method through controlling retention time to apply for a lithium ion secondary batteries. Increased membrane porosity with macrovoids was observed at increasing retention time. Partially intercalated structures of PVdF-HFP/clay nanocomposite membranes were confirmed by X-ray diffraction （XRD） analysis. PVdF-HFP membranes containing various kind of clay showed the increase of membrane modulus compared to the pristine PVdF-HFP membrane.

关键词： PVdF-HFP Porosity Mechanical properties Clay Separator

THEORY AND NUMERICAL ANALYSIS OF THE INTERACTION BETWEEN TURBULENCE AND SUSPENDED SEDIMENT

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Journal of Hydrodynamics 2005年第5期17卷 532-538页

作者： LIANG Bing-chen EEE Dong-young LI Hua-jun LI Lei-yan Engineering College Ocean University of China Qingdao 266071 China Coastal and harbour Engineering Research Center Korea Ocean Research and Development InstituteAnsan Korea

The coupled hydrodynamical-ecological model for Regional and Shelf Seas Coherens was modified through introducing sediment model in order to simulate suspended sediment transport and account for the interaction between turbulence and sediment. To discuss the effects of sediment on vertical eddy viscosity and diffusion coefficients, the damping function of sediment on turbulence was introduced into one equation k-ε turbulence closure model. Moreover, it is assumed that local equilibrium among turbulence production, dissipation and buoyancy destruction exist near the bottom. The local equilibrium assumption is introduced into the one equation k-ε model and the specific formulation of local equilihrium for one equation k-ε was derived. The tidal current was calculated for youngkwang Bay near the west coast of Korea. Meanwhile, the suspended sediment was also simulated with the local equilibrium assumption and damping function of sediment on turbulence. It is found that the damping function of sediment reduces vertical eddy viscosity and diffusion coefficients. The local equilibrium assumption changes obviously bottom layer turhulence intensity and sediment concentration.

关键词： damping turbulence sediment Coherens

Effect of Palladium Nanoparticles on Photocatalytic Characteristics of N doped Titania Catalyst

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Journal of Materials Science & Technology 2015年第6期31卷 664-669页

作者： Jong-Ho Lee Jeong-Il Youn young-Jig Kim han-jun Oh Department of Chemistry Hanseo University School of Advanced Materials Engineering Sungkyunkwan University Department of Materials Science Hanseo University

To improve the photocatalytic efficiency of TiO2nanotubular catalyst,N doped and Pd decorated titania nanotubes was successfully synthesized via anodizing,hydrazine hydrate treatment and photoreduction of Pd *** small Pd nanoparticles were precipitated on TiO2nanotubes through photoreduction of Pd ions,and its distribution is relatively *** X-ray photoelectron spectrometry（XPS） result,the N 1s spectrum represents two peaks with binding energy at 399.7 and 400.7 eV,which suggests that the nitrogen elements doped by hydrazine hydrate treatment are located in interstitial sites of the TiO2crystalline *** N doped TiO2nanotubes with Pd particles,a high photocurrent was detected due to increase of interface charge carrier separation ***,N doped and Pd decorated TiO2nanotubes exhibited much higher dye destruction efficiency and rate constant due to the synergistic effect of the N dopant and the Pd deposition on TiO2nanotubes.

关键词： Pd nanoparticle Titania nanotube Anodizing Dye dec

Effects of acupuncture stimulation on brain activation induced by cue-elicited alcohol craving

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Neural Regeneration Research 2022年第5期17卷 1059-1064页

作者： Hyeok Gyu Kwon Seong Hun Choi Joon Ho Seo Chae ha Yang Mi young Lee Department of Physical Therapy College of Health ScienceEulji UniversityGyeonggiRepublic of Korea Department of Anatomy and Histology College of Oriental MedicineDaegu Haany UniversityGyeongsanRepublic of Korea Department of Rehabilitation Gyeongbuk Regional Rehabilitation HospitalGyeongsanRepublic of Korea Department of Physiology College of Korean MedicineDaegu Haany UniversityDaeguRepublic of Korea Department of Physical Therapy College of Biomedical ScienceDaegu Haany UniversityGyeongsanRepublic of Korea

Acupuncture has been shown to be effective on alcohol use ***,the underlying mechanism remains poorly *** investigate the effects of Shenmen(HT7)acupoint on brain activation induced by cue-elicited alcohol craving,30 right-handed healthy light to moderate alcohol drinkers were recruited from the *** were randomly assigned to undergo acupuncture either at HT7(experimental acupoint,n=15)or Jingqu(LU8,control acupoint,n=15)*** randomized controlled study was performed in Daegu haany University and Daegu-Gyeongbuk Medical Innovation Foundation,Republic of *** and data collection were conducted from December 2018 to May *** results showed that after acupuncture at HT7 acupoint,the activation of orbitofrontal cortex and dorsolateral prefrontal cortex was greatly increased,while the activation of dorsolateral prefrontal cortex was obviously reduced,and subject's craving for alcohol was reduced when he/she seeing alcohol-related video clips involving various alcohols(beer,wine,or soju)or drinking *** at HT7 more greatly reduced subject's alcohol cravings than acupuncture at LU8 *** findings suggest that acupuncture can improve the self-control of mild to moderate social drinkers through the activation of the orbitofrontal cortex and dorsolateral prefrontal cortex,thereby reducing the craving for *** study protocol was approved by the Institutional Review Board of Daegu haany University Korean Medicine Hospital,Republic of Korea(approval ***-D-18026-PRO-02)on November 30,2018.

关键词： acupuncture addiction alcohol brain activation craving cue functional MRI Shenmen(HT7)acupoint

MXene-based hybrid materials for electrochemical and photoelectrochemical H_(2) generation

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Journal of Energy Chemistry 2024年第6期93卷 111-125,I0004页

作者： jun young Kim Seung Hun Roh Chengkai Xia Uk Sim jung Kyu Kim School of Material Science and Engineering North University of ChinaTaiyuan 030051China School of Chemical Engineering Sungkyunkwan University(SKKU)2066Seobu-roJangan-guSuwon 16419Republic of Korea Hydrogen Energy Technology Laboratory Korea Institute of Energy Technology(KENTECH)NajuJeollanamdo 58330Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan University(SKKU)2066Seobu-roJangan-guSuwon 16419Republic of Korea

The conversion of solar energy to produce clean hydrogen fuel through water splitting is an emerging strategy for efficiently storing solar energy in the form of solar *** aligns with the increasing global demand for the development of an ideal energy alternative to fossil fuels that does not emit greenhouse ***(EC) and photoelectrochemical(PEC) water splitting technologies have garnered significant attention worldwide for advanced hydrogen solar fuel production in recent *** achieve sustainable green H_(2) production,it is essential to create efficient catalyst materials that are low-cost and can replace expensive noble metal-based *** characteristics make them an ideal catalyst material for the ***-dimensional MXenes with M_(n+1)X_(n) structure have been identified as a promising option for EC and PEC water splitting due to their superior hydrophilicity,metal-like conductivity,large surface area,and adjustable surface ***,we present a summary of recent advancements in the synthesis and performance enhancement methods for MXene hybrid materials in hydrogen production through EC and PEC water ***,we examine the challenges and insights associated with the rational design of MXene-based hybrid materials to facilitate efficient water splitting for sustainable solar fuel production.

关键词： MXene Hybrid materials EC PEC HER OER Water splitting