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MANAGEMENT OF CEREBROSPINAL FLUID LEAKAGE FOLLOWING CERVICAL SPINE SURGERY

Chinese Medical Sciences Journal 2008年第2期23卷 121-125页

作者： Ye Tian Ke-yi Yu Yi-peng Wang jun Qian Gui-xing Qiu Department of Orthopaedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100730

Objective To investigate the management and outcome of cerebrospinal fluid leakage(CSFL)after cervical *** Medical records of 642 patients who underwent cervical surgery between December 1999 and December 2005 at our hospital were retrospectively *** patients complicated by CSFL after surgery were enrolled,of which 4 cases were complicated after ossified posterior longitudinal ligament or posterior vertebral osteophyte resection directly injuring the dura,and 1 case after posterior cervical double-door laminoplasty without observed dural injury during *** the 5 CSFL cases,4 cases occurred at 1-3 days after operation and 1 case at 9 days after *** 5 postoperative CSFL cases were treated through wound drainage removal,wound sutures,prophylactic antibiotics,and continuous subarachnoid drainage in the elevated head *** All 5 CSFL cases experienced leakage cessation within 1-3 days and wound healing within 4-8 days,and subarachnoid drainage lasted 11-16 days with an average volume of 320 mL(range,150-410 mL).Four cases experienced headache,nausea and vomiting,1 case suffered from somnolence and hyponatremia,and symptoms subsided after symptomatic treatment and intravenous fluid *** patients were followed up for an average of 32 months(range,22-50 months).No occurrence of cerebrospinal fluid cyst or wound infection was *** produced no significant negative effects upon neuromuscular function *** Continuous subarachnoid cavity drainage in combination with elevated head position is a simple and safe non-surgical method in treatment of CSFL following cervical surgery.

关键词： cervical vertebra cerebrospinal fluid leakage subarachnoid drainage

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Comparative analysis and phylogenetic and evolutionary implications of mitogenomes of Chinese Sinocyclocheilus cavefish(Cypriniformes:Cyprinidae)

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Zoological Research 2023年第4期44卷 779-781页

作者： Wan-Sheng Jiang Jie Li Hong-Mei Xiang Chao Sun Jian-Bo Chang jun-xing Yang Hunan Engineering Laboratory for Chinese Giant Salamander’s Resource Protection and Comprehensive Utilization and Key Laboratory of Hunan Forest Products and Chemical Industry EngineeringJishou UniversityZhangjiajieHunan 427000China College of Biology and Environmental Sciences Jishou UniversityJishouHunan 416000China Hubei Fisheries Science Research Institute WuhanHubei 430071China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China State Key Laboratory of Water Resources Engineering and Management School of Water Resources and Hydropower EngineeringWuhan UniversityWuhanHubei 430072China

DEAR EDITOR,Cavefish are of considerable interest due to the remarkable morphological changes that occurred during their adaptation to cave or subterranean river *** changes are thought to involve trade-offs in metabolic requirements and energy *** play a vital role in oxygen use and energy metabolism;thus,mitochondrial genes are likely to have experienced specific selective pressures during cavefish *** this study,we assembled and annotated the mitogenome of Sinocyclocheilus sanxiaensis,a typical cavefish species in *** this sequence and other available mitogenomes from the NCBI database,we reconstructed an updated phylogeny of Sinocyclocheilus based on 29 *** species groups were revealed,with the recently erected *** species group *** determine whether divergent selective pressures have acted on the protein-coding genes(PCGs)of the 29 Sinocyclocheilus species exhibiting different morphological features(including eye shape and body color),the fish were classified into three groups according to their cave-related *** branch model test revealed higher nonsynonymous/synonymous substitution ratios(ω)in the cave-dwelling groups,potentially resulting from a balance between adaptive selection and relaxed functional *** analysis using site and branch-site models identified 24 highly credible positive selection sites located on nine PCGs,with most sites also showing radical changes in amino acid *** study sheds light on the phylogeny and mitogenomic evolution of Sinocyclocheilus cavefish,highlighting their successful adaptation and survival in subterranean environments.

关键词： fish phylogeny habitat

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Determination of urinary 8-hydroxy-2′-deoxyguanosine by capillary electrophoresis with molecularly imprinted monolith in-tube solid phase microextraction

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Chinese Chemical Letters 2010年第1期21卷 85-88页

作者： Zhang, Shao Wen Zou, Cun Jie Luo, Nan Weng, Qian Feng Cai, Ling Shuang Wu, Cai Ying xing, jun Wuhan Univ Coll Chem & Mol Sci Wuhan 430072 Peoples R China Luoyang Inst Sci & Technol Dept Chem & Environm Engn Luoyang 471023 Peoples R China Liaoning Normal Univ Coll Chem & Chem Engn Dalian 116029 Peoples R China

Urinary 8-hydroxy-2 -deoxyguanosine(8-OHdG) is an excellent marker of oxidative DNA *** this study,employing guanosine as dummy template a novel molecularly imprinted(MIP) monolithic capillary column had been synthesized,and that was used as medium of in-tube solid phase microextraction(SPME).Coupled with capillary electrophoresis-electrochemical detection(CE-ECD),the system of extraction and detection of 8-OHdG in urinary sample had been *** of its greater phase ratio combined with conv...

关键词： Molecularly imprinted monolith In-tube solid phase microextraction 8-Hydroxy-2 -deoxyguanosine(8-OHdG) Electrophoresis Urine

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Qinggan Huoxue Recipe suppresses epithelial-tomesenchymal transition in alcoholic liver fibrosis through TGF-β1/Smad signaling pathway

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World Journal of Gastroenterology 2016年第19期22卷 4695-4706页

作者： Tao Wu jun-Ming Chen Tie-Gang Xiao Xiang-Bing Shu Han-Chen Xu Li-Li Yang Lian-jun xing Pei-Yong Zheng Guang Ji Center of Chinese Medical Therapy and Systems Biology Shanghai University of Traditional Chinese Medicine Institute of Digestive Disease Longhua Hospital Shanghai University of Traditional Chinese Medicine Department of Traditional Chinese Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital E-institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine

AIM: To investigate the mechanism by which Qinggan Huoxue Recipe (QGHXR) inhibits epithelial-to-mesenchymal transition (EMT) in rats with alcoholic liver fibrosis (ALF).METHODS: A total of 75 male SD rats were used to induce ALF. Serum biochemical indicators, including alanine aminotransferase, aspartate aminotransferase, laminin and hyaluronidase, were measured. Liver histopathological changes were evaluated using hematoxylin-eosin and Sirius red staining. EMT was examined by analyzing the expression of the epithelial marker E-cadherin and the mesenchymal markers vimentin and fibronectin using RT-PCR and Western blot. The inhibitory effect of QGHXR on EMT markers, as well as its effect on molecules associated with the transforming growth factor (TGF)-β1/Smad signaling pathway, including TGF-β1, Smad3, snail, occludin, ZO-1 and claudin, was also ***: Compared with normal control rats, ALF rats exhibited a decrease in E-cadherin levels (mRNA: ALF 0.16 ± 0.05 vs control 1.00 ± 0.08; protein: ALF 0.09 ± 0.05 vs control 0.70 ± 0.17, P < 0.01) and an increase in vimentin and fibronectin levels (mRNA: 11.43 ± 0.39 vs 1.00 ± 0.19 and 9.91 ± 0.34 vs 1.00 ± 0.44, respectively, P < 0.01; protein: 1.13 ± 0.42 vs 0.09 ± 0.03 and 1.16 ± 0.43 vs 0.09 ± 0.00, respectively, P < 0.01). This indicates that EMT occurred in ALF rats. In addition, the TGF-β1/Smad signaling pathway was activated in ALF rats, as evidenced by the increase in TGF-β1 and snail levels (mRNA: 1.76 ± 0.12 vs 1.00 ± 0.05 and 6.98 ± 0.41 vs 1.00 ± 0.10, respectively, P < 0.01; protein: 1.43 ± 0.05 vs 0.12 ± 0.03 and 1.07 ± 0.29 vs 0.07 ± 0.02, respectively, P < 0.01) and the decrease in Smad3 levels (mRNA: 0.05 ± 0.01 vs 1.00 ± 0.12, P < 0.01; prote

关键词： Alcoholic liver fibrosis QGHXR Epithelial-to-mesenchymal transition Snail Transforming growth factor-β 1/Smad

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Side-stream smoking reduces intestinal inflammation and increases expression of tight junction proteins

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World Journal of Gastroenterology 2012年第18期18卷 2180-2187页

作者： Hui Wang jun-xing Zhao Nan Hu jun Ren Min Du Mei-jun Zhu Department of Animal Science University of Wyoming Laramie WY82071 United States School of Pharmacy University of Wyoming Laramie WY 82071 United States

AIM:To investigate the effect of side-stream smoking on gut microflora composition,intestinal inflammation and expression of tight junction ***:C57BL/6 mice were exposed to side-stream cigarette smoking for one hour daily over eight *** contents were collected for microbial composition *** intestine was collected for immunoblotting and quantitative reverse transcriptase polymerase chain reaction analyses of the inflammatory pathway and tight junction ***:Side-stream smoking induced significant changes in the gut microbiota with increased mouse intestinal bacteria,Clostridium but decreased Fermicutes(Lactoccoci and Ruminococcus),Enterobacteriaceae family and Segmented filamentous baceteria compared to the control ***,side-stream smoking inhibited the nuclear factor-κB pathway with reduced phosphorylation of p65 and IκBα,accompanied with unchanged mRNA expression of tumor necrosis factor-α or *** contents of tight junction proteins,claudin3 and ZO2 were up-regulated in the large intestine of mice exposed side-stream *** addition,side-stream smoking increased c-jun N-terminal kinase and p38 MAPK kinase signaling,while inhibiting AMPactivated protein kinase in the large ***:Side-stream smoking altered gut microflora composition and reduced the inflammatory response,which was associated with increased expression of tight junction proteins.

关键词： Inflammation Microbiota Tight junction protein Side-stream smoking Intestine

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Wide reflected angle DBR red light LED

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Optoelectronics Letters 2007年第6期3卷 420-422页

作者： HAN jun LI Jlan-jun DENG jun xing Yan-hui YU Xiao-dong LIN Wei-zhi LIU Ying SHEN Guang-dl Beijing Optoelectronic Technology Lab Beijing University of Technology Be（iing 100022 China

The coupled DBR LED with one DBR for reflecting normal incidence light and the other for reflecting inclined incidence light has been grown by MOCVD. For improving the conventional DBR which was used to increase light extraction efficiency in AIG-alnP red light LED is analyzed. At 20 mADc injection current, the LED peak wave length is 630 nm, and the light intensity of on axis is 137 mcd. The output light power is 2.32 mW. The light intensity and output light power have been improved compared with the conventional LEDs.

关键词：反射范围灯光发光二极管技术性能

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Fabrication and property analysis of AlGaInP red light LED with high bright

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Optoelectronics Letters 2007年第6期3卷 417-419页

作者： HAN jun LI Jian-jun DENG jun xing Yan-hui YU Xiao-dong LIN Wei-zhi LIU Ying SHEN Guang-di Beijing Optoelectronic Technology Lab Beijing University of Technology Beijing 100022 China

The LED with DBR and enhancing transmission film was grown by MOCVD. At 20 mA DC injection current, the LED peak wavelength was 623 nm, the light intensity was 200 mcd, and the output light power was 2.14 mW. The ligh... 详细信息

关键词：高亮度灯发光二极管技术性能产品制造

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聚丙烯材料环境适应性行为规律

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高分子材料科学与工程 2005年第3期21卷 145-147页

作者：胡行俊广州合成材料研究院广东广州510665

研究了聚丙烯材料通过稳定剂改性后的熔体状态与在热或光照环境下的老化行为规律。研究结果表明,当聚丙烯熔体中仅掺入抗氧剂时,熔体稳定性只说明材料的可加工性,并不能完全代表它长期耐热效果;当熔体中掺入了光稳定剂和抗氧剂的协同组... 详细信息

研究了聚丙烯材料通过稳定剂改性后的熔体状态与在热或光照环境下的老化行为规律。研究结果表明,当聚丙烯熔体中仅掺入抗氧剂时,熔体稳定性只说明材料的可加工性,并不能完全代表它长期耐热效果;当熔体中掺入了光稳定剂和抗氧剂的协同组合体系,不仅熔体状态稳定,且长期耐光老化效果优良,所以聚丙烯的树脂-加工-材料-老化行为是一个整体过程,不仅取决于配合体系的协同效应,还取决于材料加工时的熔体状态。本研究系统跟踪了4组试样在进行人工光(氙灯)加速试验过程中羰基指数变化与试样所接受的紫外辐射累积能量值之间的关联性。结果表明,在聚丙烯光氧老化过程中羰基,选取羰基指数来表征聚丙烯材料光氧老化程度既准确又可靠。

关键词：聚丙烯环境适应羰基指数行为规律

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Improvement of Plant Regeneration from Immature Embryos of Wheat Infected by Agrobacterium tumefaciens

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Agricultural Sciences in China 2011年第3期10卷 317-326页

作者： TAO Li-li YIN Gui-xiang DU Li-pu SHI Zheng-yuan SHE Mao-yun XU Hui-jun YE xing-guo National Key Facility of Crop Gene Resources and Genetic Improvement Key Laboratory of Crop Genetics and Breeding Ministry ofAgriculture~Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

Wheat, one of the most important food crops, has been extensively studied with respects to plant regeneration and transformation employing the immature embryos as recipient tissues. However, the transformed tissues often become severely necrotic after co-cultivation with Agrobacterium, which is one of the major obstacles in gene delivery. In this study, wheat varieties CB037, Kenong 199, Xinchun 9, Lunxuan 987, and Shi 4185 showed desirable culture potential or high infection ability in Agrobacterium-mediated transformation. Similarly, optimal regeneration conditions were determined by testing their ability to inhibit the cell necrosis and cell death phenotype. Two auxins of 2,4-dichlorophenoxyacetic acid （2,4-D） and 3,6-dichloro-o-anisic acid （dicamba） were evaluated for highly significant effect on both callus and plantlet production, although they were genotype-dependent in wheat. Substitution of 2,4-D by dicamba enhanced the growth and regeneration ability of callus from the immature embryos of most genotypes tested. The callus growth state couldn’t be modified by adding antioxidants such as ascorbic acid, cysteine, and silver nitrate or organic additives such as thiamine HCl and asparagine to the media. On the contrary, the best tissue statement and plant regeneration was achieved by employing the media containing the simplest MS （Murashige and Skoog） components and dicamba without organic components and vitamins. Thereby, our results are thought to inhibit wheat cell necrosis effectively and suggested to be used for more wheat genotypes.

关键词： wheat immature embryos Agrobacterium tumefaciens transformation genotypes plant regeneration

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Bladder preservation in complicated invasive urothelial carcinoma following treatment with cisplatin/gemcitabine plus tislelizumab:A case report

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World Journal of Clinical Cases 2023年第5期11卷 1165-1174页

作者： Rui Yang jun-xing Chen Shu-Hang Luo Ting-Ting Chen Ling-Wu Chen Bin Huang Department of Urology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080Guangdong ProvinceChina The Medical Department 3D Medicines Inc.Shanghai 200120China

BACKGROUND Invasive urothelial carcinoma(UC)with squamous and glandular differentiation is a highly malignant and complicated pathological subtype,and the standard care is radical cystectomy(RC).However,urinary diversion after RC significantly reduces patient quality of life,thus bladder-sparing therapy has become a research hotspot in this ***,five immune checkpoint inhibitors have been approved for systemic therapy of locally advanced or metastatic bladder cancer by the Food and Drug Administration,but the efficacy of immunotherapy combined with chemotherapy for invasive UC is still unknown,especially for pathological subtypes with squamous and glandular *** SUMMARY We report the case of a 60-year-old male who complained of repetitive painless gross hematuria and was diagnosed with muscle-invasive bladder cancer with squamous and glandular differentiation,defined as cT3N1M0 according to the American Joint Committee on Cancer,who had a strong desire to preserve the *** staining revealed that programmed cell deathligand 1(PD-L1)expression in the tumor was ***,a transurethral resection to maximize removal of the bladder tumor was performed under cystoscopy,and the patient subsequently received a combination of chemotherapy(cisplatin/gemcitabine)and immunotherapy(tislelizumab)*** tumor recurrence in the bladder was observed following pathological and imaging examination after 2 cycles and 4 cycles of treatment,*** patient achieved bladder preservation and has been tumor-free for more than two *** This case shows that the combination of chemotherapy and immunotherapy might be an effective and safe treatment strategy for PD-L1 expression positive UC with divergent histologic differentiation.

关键词： Invasive urothelial carcinoma Immunotherapy Chemotherapy Squamous and glandular differentiation Tislelizumab Case report

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