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Journal of Materials Science & Technology 2021年第8期67卷 127-134页

作者： Mei-jun Liu Guan-jun yang State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an fiaotong UniversityXi’anShaanxi710049PR China

Plasma spray-physical vapor deposition(PS-PVD)has exhibited the potential ability to prepare columnar structures for advanced thermal barrier coatings(TBCs).The coating structure is nominally affected by operating parameters,but it is controlled by the type of deposition unit actually and *** order to realize the columnar structure deposited by gaseous phase units,the transition behavior of gaseous phase units to clusters must be fundamentally *** work investigated the transport process of gaseous phase units in the PS-PVD near-substrate boundary layer along with the condensation *** Monte Carlo method was used to examine the transport process and condensation behavior of gaseous phase units under different scale boundary *** results show that it is easier to form more numerous larger clusters at the edge of the plasma jet than at the *** on the understanding of the changes in deposition unit caused by the condensation of gaseous phase in the near-substrate boundary layer of PS-PVD,an outlook towards TBCs with different structures is *** it is in good agreement with the experimental data.

关键词： Condensation behavior Transport process Cluster Boundary layer PS-PVD

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural regeneration research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong yangping Zhuang Jiali Wu Yu Wang Hanlin Huang jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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基于π型谐波控制网络的高效功率放大器设计

现代电子技术 2025年第2期48卷 9-13页

作者：汪雅婷杨苹王俊白天华中师范大学物理科学与技术学院PLAC实验室湖北武汉430079 中信科移动通信技术股份有限公司湖北武汉430205

为了提高通信系统的工作效率,提出一种基于F类理论的π型谐波控制网络。该网络利用直流偏置电路引入二次谐波短路点,从而降低谐波控制电路的复杂度;同时,能够确保二次、三次谐波阻抗不受后续基波匹配电路的影响。为避免寄生参数对晶体... 详细信息

为了提高通信系统的工作效率,提出一种基于F类理论的π型谐波控制网络。该网络利用直流偏置电路引入二次谐波短路点,从而降低谐波控制电路的复杂度;同时,能够确保二次、三次谐波阻抗不受后续基波匹配电路的影响。为避免寄生参数对晶体管芯漏极阻抗的影响,在π型谐波控制网络与晶体管之间引入L型寄生补偿电路,实现二次谐波阻抗趋近零、三次谐波阻抗趋近无穷大。为验证所设计网络的可行性,设计一款高效率F类功率放大器并进行仿真测试,结果表明在1.8~2.1 GHz工作频带内,饱和输出功率为43.21~44.84 dBm,增益为13.21~14.84 dB,功率附加效率为69.59%~73.54%。由此证明了所提出的π型谐波控制网络在高效率放大器设计中能够很好地满足各项性能指标。

关键词： F类功率放大器工作效率 π型谐波控制网络谐波阻抗 L型寄生补偿电路联合仿真

Foldcore Structures with Origami Initiators for Energy-Absorbing Sandwich Panels

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Acta Mechanica Solida Sinica 2023年第4期36卷 491-505页

作者： jun Cheng yang Li The Institute of Technological Sciences Wuhan UniversityWuhan 430072China Wuhan University Shenzhen research Institute Shenzhen 518057China

Origami foldcore structures can be used in thin-walled sandwich panels to provide unique advantages over traditional honey-comb *** instance,their continuously connected space is available for flowing through cooling liquid or compact pipeline ***,origami foldcores suffer from relatively low-energy *** paper proposes a new design of energy-absorbing foldcore structures for sandwich panels,including the geometric design,experimental tests,numerical parametric study,and theoretical estimation of energy *** initiators are introduced to the Miura foldcores to induce a failure mode with more transverse folds,which is not common for regular foldcore *** a result,60%higher energy absorption and tunable load uniformity can be achieved.

关键词： Thin-walled structures Sandwich panels Energy absorption Origami Foldcores

An Adaptive Time-Domain Kalman Filtering Approach to Acoustic Feedback Cancellation for Hearing Aids

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Chinese Journal of Electronics 2020年第1期29卷 139-146页

作者： LU Caixia yang Feiran yang jun Key Laboratory of Noise and Vibration research Institute of Acoustics of Chinese Academy of Science University of Chinese Academy of Science

The adaptive filtering approach has been widely used for acoustic feedback control in the hearing aids due to its excellent performance. The commonly used adaptive filtering algorithms employ a fixed step-size,which has to compromise between the initial convergence and the steady-state misalignment. Many variable stepsize adaptive algorithms have been proposed to handle this problem. In this paper, we propose a broadband Kalman filter to resolve this problem. The acoustic feedback path is modelled by a first-order Markov model,and the observation equation is constructed using more past data vector. A major issue in the hearing aids is the computational complexity. We thus present a simplified version to reduce the complexity, which bridges between the exact Kalman filter and the affine projection algorithm. The estimation of the process and measurement noise variance is discussed in detail. A two-feedbackpath model is adopted to improve the algorithm’s lack of re-convergence. Simulation results confirm the proposed algorithm clearly outperforms the other variable step-size adaptive filtering approaches.

关键词： Acoustic feedback cancellation Kalman filter Convergence rate Tracking capability

Frequency　response　of　tiltmeters　and　tidal　factor

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Acta Seismologica Sinica(English Edition) 1998年第4期11卷 455-465页

作者： jun yang Seismological Bureau of Jiangsu Province Nanjing China

ＦｒｅｑｕｅｎｃｙｒｅｓｐｏｎｓｅｏｆｔｉｌｔｍｅｔｅｒｓａｎｄｔｉｄａｌｆａｃｔｏｒＪＵＮＹＡＮＧ（杨军）ＳｅｉｓｍｏｌｏｇｉｃａｌＢｕｒｅａｕｏｆＪｉａｎｇｓｕＰｒｏｖｉｎｃｅ，Ｎａｎｊｉｎｇ２１００１４．Ｃｈｉ... 详细信息

ＦｒｅｑｕｅｎｃｙｒｅｓｐｏｎｓｅｏｆｔｉｌｔｍｅｔｅｒｓａｎｄｔｉｄａｌｆａｃｔｏｒＪＵＮＹＡＮＧ（杨军）ＳｅｉｓｍｏｌｏｇｉｃａｌＢｕｒｅａｕｏｆＪｉａｎｇｓｕＰｒｏｖｉｎｃｅ，Ｎａｎｊｉｎｇ２１００１４．ＣｈｉｎａＡｂｓｔｒａｃｔＴｈｅｒｅｌａ...

关键词： tiltmeters and factor response Frequency

Nogo-A aggravates oxidative damage in oligodendrocytes

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Neural regeneration research 2021年第1期16卷 179-185页

作者： yang-yang Wang Na Han Dao-jun Hong jun Zhang Department of Neurology Peking University People’s HospitalBeijingChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Nogo-A is considered one of the most important inhibitors of myelin-associated axonal regeneration in the central nervous *** is mainly expressed by *** previous studies have found regulatory roles for Nogo-A in neurite outgrowth inhibition,neuronal homeostasis,precursor migration,plasticity,and neurodegeneration,its functions in the process of oxidative injury are largely *** this study,oligodendrocytes were extracted from the cerebral cortex of newborn Sprague-Dawley *** used hydrogen peroxide(H2O2)to induce an in vitro oligodendrocyte oxidative damage model and found that endogenously expressed Nogo-A is significantly upregulated in *** recombinant virus Ad-ZsGreen-rat Nogo-A infection of oligodendrocytes,Nogo-A expression was increased,and the infected oligodendrocytes were more susceptible to acute oxidative insults and exhibited a markedly elevated rate of cell ***,knockdown of Nogo-A expression in oligodendrocytes by Ad-ZsGreen-shrNA-Nogo-A almost completely protected against oxidative stress induced by exogenous *** with a Nogo-66 antibody,a LINGO1 blocker,or Y27632,an inhibitor in the Nogo-66-Ngr/p75/LINGO-1-rhoA-rOCK pathway,did not affect the death of ***-ZsGreen-shrNA-Nogo-A also increased the levels of phosphorylated extracellular signal-regulated kinase 1/2 and inhibited BCL2 expression in *** conclusion,Nogo-A aggravated reactive oxygen species damage in oligodendrocytes,and phosphorylated extracellular signal-regulated kinase 1/2 and BCL2 might be involved in this *** study was approved by the Ethics Committee of Peking University People’s Hospital,China(approval No.2018PHC081)on December 18,2018.

关键词： BCL2 H2O2 LINGO1 Ngr Nogo-A oligodendrocytes phosphorylated extracellular signal-regulated kinase 1/2 reactive oxygen species

Photothermal probiotics delivery of photodynamic agents for enhanced immunogenic cell death within hypoxia center of solid tumors

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Nano research 2025年第1期18卷 642-652页

作者： Wen Luo Shiyu Du Yateng Jiang Bangshun He jun Tang Jingjing yang Yujun Song Jiangsu Key Laboratory of Artificial Functional Materials State Key Laboratory of Analytical Chemistry for Life ScienceNational Laboratory of Solid State MicrostructuresCollege of Engineering and Applied SciencesNanjing UniversityNanjing 210023China Department of Laboratory Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006China Department of Anesthesiology Jinling HospitalMedical School of Nanjing UniversityNanjing 210000China Department of Biochemistry and Molecular Biology School of Medicine&Holistic Integrative MedicineJiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China

resulting from harsh hypoxic environmental conditions,central cells in the core of solid tumors are usually more aggressive and malignant with a less stable ***,therapeutic agents with improved penetration for the activation of immunity in tumor centers exhibit promising potential in ***,polydopamine-coated Escherichia coli Nissle 1917(EcN)bearing chlorin e6(Ce6)-loaded and polyethyleneimine(PEI)-coated hollow manganese dioxide(shorted as EP-ChP)are applied for enhanced immunotherapy in deep *** accumulation in tumor center through hypoxia targeting,manganese dioxide is degradated under the tumor microenvironment with released Ce6 and thus generates reactive oxygen species(rOS)upon 660 nm laser irradiation,which can further lower thermalresistance of cancer cells via HSP90α*** to that,heating induced by polydopamine upon 808 nm laser irradiation can achieve effective tumor *** upon dual laser induces enhanced immunogenic cell death,while bacterial infections in tumor tissues also trigger innate *** bacteria-based approach provides enhanced antitumor immune responses in deep tumors with great potential in the reshaping of immunosuppression tumor microenvironment.

关键词： bacteria phototherapies immunotherapy hypoxia targeting tumor penetration

Model and algorithm of flow interception problem with multi-type of flows

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Journal of Systems Engineering and Electronics 2009年第4期20卷 755-761页

作者： Hu Dandan yang Chao yang jun Dept. of Management Science and Engineering Huazhong Univ. of Science and Technology Wuhan 430074 P. R. China

To study simultaneous location of different kinds of facilities, a new model of flow interception problem with multi-type of flows is proposed, with the consideration of multi-purpose flows and the influence of facilities on each other. To be more practical, the objective is to maximize the benefits from flow-by customers instead of maximizing flows in the past. Since this problem is NP-hard and there is no optimal solution for large network, greedy and improved greedy heuristic algorithms are proposed. A computational example is presented to show that the optimal location decisions are proved to be strongly dependent on the influence coefficients and average profits by one customer and different types of facilities are almost co-located. Finally the results of sensitivity analysis are reported.

关键词： location flow interception greedy heuristic multi-purpose influence coefficient

Influence of pile spacing on seismic response of piled raft in soft clay: centrifuge modeling

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Earthquake Engineering and Engineering Vibration 2019年第4期18卷 719-733页

作者： yang jun yang Min Chen Haibing Guangzhou Municipal Engineering Testing Co. Ltd Guangzhou 510060 China School of Civil Engineering and Transportation South China University of Technology Guangzhou 510641 China Department of Geotechnical Engineering Tongji University Shanghai 200092 China Institute of Foundation and Structure Technologies Zhejiang Sci-Tech University Hangzhou 310018 China

In order to study the infl uence of pile spacing on the seismic response of piled raft in soft clay, a series of shaking table tests were conducted by using a geotechnical centrifuge. The dynamic behavior of acceleration, displacement and internal forces was examined. The test results indicate that the seismic acceleration responses of models are generally greater than the surrounding soil surface in the period ranges of 2–10 seconds. Foundation instant settlements for 4×4 and 3×3 piled raft (with pile spacing equal to 4 and 6 times pile diameter) are somewhat close to each other at the end of the earthquake, but reconsolidation settlements are greater for 3×3 piled raft. The seismic acceleration of superstructure, the uneven settlement of the foundation and the maximum bending moment of pile are relatively lower for 3×3 piled raft. Successive earthquakes lead to the softening behavior of soft clay, which causes a reduction of the pile bearing capacity and thus loads are transferred from the pile group to the raft. For the case of a 3×3 piled raft, there is relatively smaller change of the load sharing ratio of the pile group and raft after the earthquake and the distribution of maximum bending moments at the pile head is more uniform.

关键词： piled raft pile spacing soft clay dynamic centrifuge model test seismic response subsidence load sharing bending moment