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World Journal of Gastrointestinal Endoscopy 2012年第7期4卷 335-338页

作者： Kazuhiro Fukatsu Kazuki Ueda Hiroki Maeda Yasunobu Yamashita Masahiro Itonaga Yoshiyuki Mori Kosaku Moribata Naoki Shingaki Hisanobu Deguchi Shotaro Enomoto Izumi Inoue Takao Maekita Mikitaka Iguchi Hideyuki Tamai jun kato Masao Ichinose Second Department of Internal Medicine Wakayama Medical University811-1 Kimiidera Wakayama City Wakayama 641-0012 Japan

Endoscopic ultrasonography (EUS) was performed on a patient being treated for chronic pancreatitis because a submucosal tumor was observed in the stomach during gastrointestinal endoscopy. As internal pulsa- tile blood flow on Doppler was present, the diagnosis of an aneurysm was made. The pseudoaneurysm of the left gastric artery was embolized with histoacryl and lipiodol and the splenic artery was embolized with coils at the location of the pseudoaneurysm to prevent hemorrhage. Follow up EUS confirmed the cessation of blood flow from the pseudoaneurysm. Clinicians encountering a gastric submucosal tumor-like protrusion in a patient with chronic pancreatitis should use EUS to investigate the possibility of a pseudoaneurysm, which must be treated as quickly as possible once identified.

关键词： Chronic pancreatitis Endoscopic ultraso- nography Pseudoaneurysm

Significance of timing of therapeutic line on effectiveness of nivolumab for metastatic renal cell carcinoma

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Current Urology 2023年第1期17卷 52-57页

作者： jun Teishima Daiki Murata Kazuma Yukihiro Yohei Sekino Shogo Inoue Tetsutaro Hayashi Koji Mita Yasuhisa Hasegawa Masao kato Mitsuru Kajiwara Masanobu Shigeta Satoshi Maruyama Hiroyuki Moriyama Seiji Fujiwara Akio Matsubara Department of Urology Graduate School of Biomedical and Health SciencesHiroshima UniversityHiroshimaJapan Department of Urology Hiroshima-City Asa Citizens HospitalHiroshimaJapan Department of Urology Fukuyama Medical CenterFukuyamaJapan Department of Urology Hiroshima General HospitalHatsukaichiJapan Department of Urology Hiroshima Prefectural HospitalHiroshimaJapan Department of Urology Kure Medical Center and Chugoku Cancer CenterKureJapan Department of Urology Miyoshi Central HospitalMiyoshiJapan Department of Urology Onomichi General HospitalOnomichiJapan Department of Urology Higashi-Hiroshima Medical Center Higashi-HiroshimaJapan

Objectives:This study aimed to clarify the significance of therapeutic timing on the effectiveness of nivolumab for treating metastatic renal cell *** and methods:Fifty-eight patients with metastatic renal cell carcinoma treated with nivolumab monotherapy were retrospectively *** who were treated with nivolumab as second-line therapy were included in the second-line group,while the others were included in the later-line *** clinicopathological characteristics,effects of nivolumab,and prognoses of these groups were ***:Twenty and thirty-eight patients were included in the second-line and later-line groups,*** were no significant differences in the distribution of International Metastatic Renal Cell Carcinoma Database Consotium risk and other clinicopathological characteristics between the 2 *** proportion of patients whose objective best response was progressive disease in the second-line group was significantly lower than that in the later-line group(15%vs.50%,p=0.0090).The 50%progression-free survival with nivolumab in the second-line group was significantly better than that in the later-line group(not reached and 5 months,p=0.0018).Multivariate analysis showed that the second-line setting was an independent predictive factor for better progression-free survival(p=0.0028,hazard ratio=0.108).The 50%overall survival after starting nivolumab in the second-line and later-line groups was not reached and 27.8 months,respectively(p=0.2652).Conclusions:The therapeutic efficacy of nivolumab as second-line therapy is expected to be better than that of later therapy.

关键词： Immune checkpoint inhibitor Metastatic renal cell carcinoma Nivolumab Prognostic factor Second-line treatment

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios alone or combined with prostate-specific antigen for the diagnosis of prostate cancer and clinically significant prostate cancer

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Asian Journal of Urology 2023年第2期10卷 158-165页

作者： Sat Prasad Nepal Takehiko Nakasato Takashi Fukagai Yoshio Ogawa Yoshihiro Nakagami Takeshi Shichijo jun Morita Yoshiko Maeda Kazuhiko Oshinomi Tsutomu Unoki Tetsuo Noguchi Tatsuki Inoue Ryosuke kato Satoshi Amano Moyuru Mizunuma Masahiro Kurokawa Yoshiki Tsunokawa Sou Yasuda Department of Urology Department of MedicineShowa University School of Medicine1-5-8 HatanodaiShinagawa-kuTokyoJapan

Objective:We evaluated whether the blood parameters before prostate biopsy can diagnose prostate cancer(PCa)and clinically significant PCa(Gleason score[GS]7)in our ***:This study included patients with increased prostate-specific antigen(PSA)up to 20 ng/*** associations of neutrophil-to-lymphocyte ratio(NLR)and platelet-tolymphocyte ratio(PLR)alone or with PSA with PCa and clinically significant PCa were ***:We included 365 patients,of whom 52.9%(193)had PCa including 66.8%(129)with GS of≥*** density(PSAD)and PSA had better the area under the curve(AUC)of 0.722 and 0.585,respectively with pZ0.001 for detecting PCa compared with other blood *** combined with PLR(PsPLR)and PSA with NLR(PsNLR)had better AUC of 0.608 and 0.610,respectively with p<0.05,for diagnosing GS≥7 population,compared with PSA,free/total PSA,NLR,PLR,and PsNPLR(PSA combined with NLR and PLR).NLR and PLR did not predict PCa on multivariate *** GS≥7 cancer detection,in the multivariate analysis,separate models with PSA and NLR(Model 1:PsNLRþbaseline parameters)or PSA and PLR(Moder 2:PsPLRþbaseline parameters)were *** parameters comprised age,digital rectal exam-positive lesions,PSA density,free/total PSA,and magnetic resonance *** 2 containing PsPLR was statistically significant(odds ratio:2.862,95% confidence interval:1.174-6.975,p=0.021)in finding aggressive *** predictive accuracy of Model 2 was increased(AUC:0.734,p<0.001)than that when only baseline parameters were used(AUC:0.693,p<0.001).Conclusion:NLR or PLR,either alone or combined with PSA,did not detect ***,the combined use of PSA with PLR could find the differences between clinically significant and insignificant PCa in our retrospective study limited by the small number of samples.

关键词： Blood parameter Gleason score Neutrophil-tolymphocyte ratio Platelet-tolymphocyte ratio Prostate cancer

Usefulness of continuous suction mouthpiece during esophagogastroduodenoscopy: A single-center, prospective,randomized study

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World Journal of Gastrointestinal Endoscopy 2013年第10期5卷 508-513页

作者： Takao Maekita jun kato Yukihiko Nakatani Shotaro Enomoto Ema Takano Masahiro Tsuji Tsuyoshi Nakaya Kosaku Moribata Yosuke Muraki Naoki Shingaki Toru Niwa Hisanobu Deguchi Kazuki Ueda Izumi Inoue Mikitaka Iguchi Hideyuki Tamai Masao Ichinose Department of Gastroen-terology School of Medicine Wakayama Medical UniversityWakayama Department of Internal Medicine Nakaya HospitalWakayama

AIM: To develop a new continuous suction mouthpiece(CSM) and evaluate its usefulness for screening esophagogastroduodenoscopy(EGD).METHODS: A total of 196 patients who were scheduled to undergo screening EGD were assigned to one of two groups: a group using the CSM and a group using a conventional mouthpiece. Extent of salivary flow,frequency of saliva suction, number of choking episodesduring the examination, and incidence of aspiration pneumonia after the examination were evaluated and compared between the two groups. Adverse events during and after EGD were also examined. In addition, the oral cavity was meticulously examined after the ***: The same number of patients was randomly allocated to each group. There were no significant differences between the two groups in sex, age,biopsy procedure, duration of procedure and depth of sedation. Aspiration pneumonia and other significant adverse events were not observed in either group. The grade of extent of salivary flow was significantly lower in patients with the CSM than in patients with the conventional mouthpiece(P < 0.001). Although there was no significant difference, less frequent suctioning and fewer choking episodes were observed in patients with the CSM than in patients with the conventional mouthpiece(P = 0.082 and P = 0.084, respectively). In addition, there were no patients in the CSM group who required saliva suctioning during the ***: Use of the CSM during screening EGD can reduce the extent of salivary flow. The device is expected to reduce complications and contamination with saliva.

关键词： Mouthpiece Esophagogastroduodenoscopy Aspiration Saliva Suction

Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome

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World Journal of Gastroenterology 2012年第13期18卷 1508-1516页

作者： Masahide Hamaguchi Noriyuki Takeda Takao Kojima Akihiro Ohbora Takahiro kato Hiroshi Sarui Michiaki Fukui Chisato Nagata jun Takeda Immunology Frontier Research Center at Osaka University Osaka 5650871Japan Department of Endocrinology and Metabo lism Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Gastroenterology Murakami Memorial HospitalAsahi UniversityGifu 5008523Japan Department of Endocrinology and Metabolism Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 6028566Japan Department of Epidemiology and Preventive Medicine Graduate School of MedicineGifu UniversityGifu 5008523Japan Department of Diabetes and Endocrinology Division of Molecule and StructureGraduate School of MedicineGifu UniversityGifu 5008523Japan

AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal *** study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of *** was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of *** revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic ***:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in *** NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic *** sensitivity of the definition"at least 1 criterion"was as good as 84.8%in men and 86.6%in *** subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome.

关键词：代谢综合征脂肪肝病酒精性标准个人识别诊断肝疾病肝脏疾病

Paradoxical reduction of cerebral blood flow after acetazolamide loading:a hemodynamic and metabolic study with ^(15)O PET

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Neuroscience Bulletin 2014年第5期30卷 845-856页

作者： Tadashi Watabe Eku Shimosegawa Hiroki kato Kayako Isohashi Mana Ishibashi Mitsuaki Tatsumi Kazuo Kitagawa Toshiyuki Fujinaka Toshiki Yoshimine jun Hatazawa Department of Molecular Imaging in Medicine Department of Nuclear Medicine Department of Nuclear Medicine and Tracer Kinetics Stroke Center Osaka University Hospital Department of Radiology Department of Neurology Department of Neurosurgery Osaka University Graduate School of Medicine

Paradoxical reduction of cerebral blood flow （CBF） after administration of the vasodilator acetazolamide is the most severe stage of cerebrovascular reactivity failure and is often associated with an increased oxygen extraction fraction （OEF）. In this study, we aimed to reveal the mechanism underlying this phenomenon by focusing on the ratio of CBF to cerebral blood volume （CBV） as a marker of regional cerebral perfusion pressure （CPP）. In 37 patients with unilateral internal carotid or middle cerebral arterial （MCA） steno-occlusive disease and 8 normal controls, the baseline CBF （CBFb）, CBV, OEF, cerebral oxygen metabolic rate （CMRO2）, and CBF after acetazolamide loading in the anterior and posterior MCA territories were measured by （15）~O positron emission tomography. Paradoxical CBF reduction was found in 28 of 74 regions （18 of 37 patients） in the ipsilateral hemisphere. High CBFb （〉47.6 mL/100 mL/min, n = 7） was associated with normal CBFb/CBV, increased CBV, decreased OEF, and normal CMRO2. Low CBFb （〈31.8 mL/100 mL/min, n = 9） was associated with decreased CBFb/CBV, increased CBV, increased OEF, and decreased CMRO2. These findings demonstrated that paradoxical CBF reduction is not always associated with reduction of CPP, but partly includes high- CBFb regions with normal CPP, which has not been described in previous studies.

关键词： acetazolamide cerebral blood flowparadoxical reduction positron emission tomographyvasodilatation

Rice Stomatal Closure Requires Guard Cell Plasma Membrane ATP-Binding Cassette Transporter RCN1/OsABCG5

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Molecular Plant 2016年第3期9卷 417-427页

作者： Shuichi Matsuda Sho Takano Moeko Sato Kaoru Furukawa Hidetaka Nagasawa Shoko Yoshikawa jun Kasuga Yoshihiko Tokuji Kazufumi Yazaki Mikio Nakazono Itsuro Takamure Kiyoaki kato Department of Agro-environmental Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Department of Food Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Research Institute for Sustainable Humanosphere Kyoto University Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa Nagoya Aichi 464-8601 Japan Graduate School of Agriculture Hokkaido University Kita 9 Nishi 9 Kita-ku Sapporo Hokkaido 060-8589 Japan

Water stress is one of the major environmental stresses that affect agricultural production worldwide. Water loss from plants occurs primarily through stomatal pores. Here, we report that an Oryza sativa half-size ATP-binding cassette （ABC） subfamily G protein, RCN 1/OsABCG5, is involved in stomatal closure mediated by phytohormone abscisic acid （ABA） accumulation in guard cells. We found that the GFP-RCN1/ OsABCG5-fusion protein was localized at the plasma membrane in guard cells. The percentage of guard cell pairs containing both ABA and GFP-RCN1/OsABCG5 increased after exogenous ABA treatment, whereas they were co-localized in guard cell pairs regardless of whether exogenous ABA was applied. ABA application resulted in a smaller increase in the percentage of guard cell pairs containing ABA in rcnl mutant （A684P） and RCN1-RNAi than in wild-type plants. Furthermore, polyethylene glycol （drought stress）-inducible ABA accumulation in guard cells did not occur in rcnl mutants. Stomata closure mediated by exogenous ABA application was strongly reduced in rcnl mutants. Finally, rcnl mutant plants had more rapid water loss from detached leaves than the wild-type plants. These results indicate that in response to drought stress, RCN1/OsABCG5 is involved in accumulation of ABA in guard cells, which is indispensable for stomatal closure.

关键词： stomatal closure abscisic acid ABC transporter rice drought stress

Spinous process plate fixation for cervical spinal fusion after spinal trauma:two case reports

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第9期14卷 855-858页

作者： Hiroki HIRABAYASHI jun TAKAHASHI Hiroyuki HASHIDATE Nobuhide OGIHARA Keijiro MUKAIYAMA Shugo KURAISHI Masayuki SHIMIZU Hiroyuki NAKAGAWA Renzo MATSUE Hiroyuki kato Department of Orthopedic Surgery Shinshu University School of Medicine

Posterior cervical fixation with various forms of instrumentation has been used for reconstruction in cases of traumatic disorders and degenerative or tumor-related dysfunction of the cervical spine. Recently, posterior plate and rod techniques using lateral mass screws or pedicle screws have been reported to show excellent fusion rates (Xu et al.,2010).

关键词：病例报告脊柱融合脊髓损伤颈椎椎弓根螺钉钢板功能障碍外伤性

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湖南省永兴县人体重点肠道蠕虫感染监测分析

中国媒介生物学及控制杂志 2024年第1期35卷 85-88,114页

作者：朱韩武阳慧何德彪黄军校郴州市疾病预防控制中心地方病寄生虫病防治科湖南郴州423000 永兴县疾病预防控制中心湖南永兴423300

目的分析湖南省永兴县人体重点肠道蠕虫感染情况,为寄生虫病防控提供科学依据。方法 2016-2020年在湖南省永兴县按东、西、南、北、中5个方位分别随机抽取1个乡镇的1个行政村,连续5年开展监测,每个监测点每年调查3周岁及以上常住居民至... 详细信息

目的分析湖南省永兴县人体重点肠道蠕虫感染情况,为寄生虫病防控提供科学依据。方法 2016-2020年在湖南省永兴县按东、西、南、北、中5个方位分别随机抽取1个乡镇的1个行政村,连续5年开展监测,每个监测点每年调查3周岁及以上常住居民至少200人;采用改良加藤厚涂片法检测肠道蠕虫虫卵,试管滤纸培养法鉴定钩虫虫种,透明胶纸肛拭法检测3~9岁儿童蛲虫卵。采用WPS Excel 2021软件建立数据库,SPSS 20.0软件进行统计学分析,感染率的差异比较采用χ^(2)检验。结果粪检5 066人,检出人体重点肠道蠕虫感染136人,感染率为2.68%,其中蛔虫感染率为1.99%、钩虫0.24%、蛲虫0.20%、鞭虫0.18%和肝吸虫0.08%,未检出混合感染。钩蚴培养12份,结果均为美洲钩虫。透明胶纸肛拭法检查3~9岁儿童1 500人,蛲虫感染率为0.33%。2016-2020年永兴县人体重点肠道蠕虫总感染率分别为4.08%、1.97%、3.24%、1.10%和3.00%。结论湖南省永兴县人体重点肠道蠕虫感染处于低流行水平,但感染因素依然存在,仍需加强分类监测和寄生虫病防治知识宣传教育。

关键词：人体肠道蠕虫感染监测分析永兴县

Solar power sail mission of OKEANOS

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Astrodynamics 2020年第3期4卷 233-248页

作者： Osamu Mori jun Matsumoto Toshihiro Chujo Masanori Matsushita Hideki kato Takanao Saiki Yuichi Tsuda jun'ichiro Kawaguchi Fuyuto Terui Yuya Mimasu Go Ono Naoko Ogawa Yuki Takao Yuki Kubo Kaoru Ohashi Ahmed Kiyoshi Sugihara Tatsuaki Okada Takahiro Iwata Hajime Yano Japan Aerospace Exploration Agency Sagarmihara 252-5210Japan Tokyo Institute of Technology Tokyo 152-8550Japan The University of Tokyo Tokyo 113-8654Japan Patchedconics LLCSagarmihara 252-5210Japan

The solar power sail is an original Japanese concept in which electric power is generated by thin-film solar cells attached on the solar sail *** Aerospace Exploration Agency(JAXA)successfully demonstrated the world’s first solar power sail technology through IKAROS(Interplanetary Kite-craft Accelerated by Radiation of the Sun)mission in *** demonstrated photon propulsion and power generation using thin-film solar cells during its interplanetary *** up,solar power sails can generate enough power to drive high specific impulse ion thrusters in the outer planetary *** this concept,we propose a landing or sample return mission to directly explore a Jupiter Trojan asteroid using solar power sail-craft OKEANOS(Oversize Kite-craft for Exploration and AstroNautics in the Outer Solar System).After rendezvousing with a Trojan asteroid,a lander separates from OKEANOS to collect samples,and perform in-situ analyses in three proposed mission sequences,including sending samples back to *** paper proposes a system design for OKEANOS and includes analyses of the latest mission.

关键词： solar power sail Trojan asteroid landing in-situ analysis outer solar system OKEANOS