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Chinese Journal of Integrative Medicine 2016年第7期22卷 490-495页

作者： hyun jun park Sangmin Choe Nam Cheol park Department of Urology Pusan National University School of MedicineBusan(602-739)Republic of Korea Medical Research Institute of Pusan National University Hospital Busan(602-739)Republic of Korea Division of Clinical Pharmacology Clinical Trial CenterPusan National University HospitalBusan(602-739)Republic of Korea

Objective： To investigate the effects of Korean red ginseng （KRG） on semen parameters in male infertility patients in a randomized, double-blind, placebo-controlled study. Methods： A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups： non-varicocelectomy （V）＋placebo （P） group, V＋P group, non-V＋KRG group （1.5-g KRG daily）, and V＋KGR group （1.5-g KRG daily）. Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. Results： All groups but not the non-V＋P group, showed significant improvements in sperm concentrations, motility, morphology, and viability at the end of the study. However, there were no significant differences in serum follicle-stimulating hormone, luteinizing hormone, and testosterone among groups. The incidence of adverse events was low, and all events were assumed to be unrelated to the treatments administered. Conclusions： Although the exact mechanism by which KRG improves spermatogenesis remains unclear, KRG may be a useful agent for the treatment of male infertility. Nevertheless, additional studies to evaluate the optimal dose and duration of treatment are needed.

关键词： Panax ginseng male infertility spermatogenesis

Expression of E-cadherin and α-catenin in a varicocele-induced infertility rat model

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Asian Journal of Andrology 2011年第3期13卷 470-475,514页

作者： Hong Koo Ha hyun jun park Nam Cheol park Department of Urology Pusan National University School of Medicine Busan 602739 Korea Medical Research Institute Pusan National University Hospital Busan 602739 Korea

The roles of E-cadherin and α-catenin were evaluated in the development of varicocele-induced infertility. Analysis of the association between the expression of E-cadherinla-catenin and clinical/pathological parameters was performed. Thirty lO-week-old male rats （experimental group） were used for the experiments; the left renal vein was ligated to form a varicocele. The abdomen was incised in 30 rats （control group） and no procedure was performed on 10 rats （baseline group）. The weights of the left testis, serum reactive oxygen species （ROS）, testosterone, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and degenerative changes in the seminiferous tubules after 4 and 8 weeks were recorded. The expression of E-cadherin and α-catenin was evaluated by immunohistochemical （IHC） staining and Western blot analysis. The ROS increased in the 8-week experimental group, compared with the baseline and control groups （P〈0.001 for both）. Additionally, FSH significantly increased in the 4- and 8-week experimental group compared with the control groups （P= 0.013 and P= 0.032, respectively）. The ratio of degenerative changes in the seminiferous tubules of the experimental groups increased. The IHC staining showed that the expression of E-cadherin and a-catenin decreased in the 4- and 8-week experimental groups. Similar to the IHC staining, the experimental group had decreased reactivity on Western blot analysis. The expression of E-cadherin and a-catenin was significantly associated with the ROS and degenerative changes in the seminiferous tubules. The results of this study suggest that damage to the blood-testis barrier （BTB） is associated with varicocele-induced male infertility, and that ROS may cause damage to the BTB.

关键词： α-catenin blood-testis barrier E-cadherin varicocele infertility

Predictors of pain resolution after varicocelectomy for painful varicocele

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Asian Journal of Andrology 2011年第5期13卷 754-758页

作者： hyun jun park Seung Soo Lee Nam Cheol park Department of Urology Pusan National University School of MedicineMedical Research InstitutePusan National University.Busan 602-739Korea

Varioocelectomny is a management option for patients with painful varicocele. In this study, we assessed the effectiveness of varicocelectomy for painful varicocele and examined the factors that might be predictive of outcome. All patients who underwent a varicocelectomy for pain between February 2007 and July 2009 were includecL A review of patient medical records was conducted; patient age,body mass index （BMI）, uede, iocatien of the vericocele, tasticular volume, duration and quality of the pain （dull, draaing, throbbing or sharp） and surgical technique （ingulnal versus subinguinal） were documented. All parameters were compared with the rasolution of pain （complete, partial or failure）. We followed up on 53 of 104 patients （51.0%）. Complete postopanntive resolution of pain was reported by 28 patients （52.8%）, whereas 22 （41.5%） reported partial resolution, Only three patients （5.7%） mpaded failure. No relationship was observed between postoperative pain resolution and age, BMI, grade of varicoceio, location of varicocele, ipsilateral testicular, quality of pain or surgical technique. The duration of pain before surllery was the only factor that correlated with postopaative pain resolution （univariate, P=-0.004; multivariate, P=0.002）. Our rasults indicatethat varicocelectomy isan effective treatmentfar painful varicocele in properly selected patients, and that duration of pain before surgery may be predictive of outcome.

关键词： duration pain testis vadcocele vadcocelectemy

Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 361-369页

作者： Ja Yoon Ku Min jung park hyun jun park Nam Cheol park Bo Sun Joo Department of Urology Pusan National University HospitalPusan National University School of MedicineBusan(49241)Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan(49241)Republic of Korea The Korea Institute for Public Sperm Bank Busan(49241)Republic of Korea

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng(KRG) water(HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young(3 month-old) and aged(12 month-old) male mice were randomly assigned to 4 groups(n=10 per group) including control group, hydrogen-rich water(HRW) group(10 m L/kg daily), KRG group(50 mg/kg daily) and HRGW group(10 m L/kg HRW and 50 mg/kg KRG daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone, and reactive oxygen species(ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation(PPx3, PPx4, GSTm5 and GPx4), spermatogenesis(inhibin-α, neptin-2 and CREM), antiaging(SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor(VEGF)] related genes were examined through realtime polymerase chain reaction. Results: HRW and KRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility(P<0.05). These effects were strengthened synergistically by a HRGW mixture(P<0.05 or P<0.01). HRGW greatly increased the expressions of antioxidation, antiaging, spermatogenesis related genes and VEGF especially in aged mice(P<0.05). Serum testosterone and FSH levels also increased, while serum ROS level decreased(all P<0.05). Conclusion: HRGW increases sperm production and motility by enhancing antioxidation and stimulating spermatogenesis and sex hormone production, particularly in aged mice.

关键词： aging ginseng infertlit mineral waters sperm mtility

Free radical scavenger effect of rebamipide in sperm processing and cryopreservation

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Asian Journal of Andrology 2003年第3期5卷 195-201页

作者： Nam Cheol park hyun jun park Kyeong Mi Lee Dong Gil Shin Department of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 KoreaDepartment of Urology College of Medicine Pusan National University Busan 602 739 Korea

Aim: To study the effect of rebamipide added to semen samples and cryoprotectant on reactive oxygen species (ROS) production. Methods: Semen samples from 30 fertile and healthy volunteers were collected by masturbation after 2 days - 3 days of abstinence. After liquefaction, the specimens were diluted with sperm wash media to a uniform density of 20×106/mL. Rebamipide was added to semen samples and cryoprotectant to a final concentration of 10 μmol/L, 30 μmol/L, 100 μmol/L or 300 μmol/L. Specimens were incubated at 37 ℃ in a 0.5 % CO2 incubator for 1 h or cryopreserved at -196 ℃ LN2 for 3 days. The sperm motility and viability and the levels of ROS and lipid peroxidation of sperm membrance were assessed before and after incubation and cryopreservation by means of computer assisted semen analyzer, eosin-nigrosin stain, chemiluminescence and thiobarbituric acid assay, respectively. Results: The sperm motility was significantly increased after incubation with 100 μmol/L and 300 μmol/L rebamipide (P0.05). The levels of ROS and lipid peroxidation in semen were significantly decreased in proportion to the concentrations of rebamipide both after incubation and cryopreservation (P<0.05). Conclusion: Rebamipide is an effective free radical scavenger in semen in vitro.

关键词： male infertility reactive oxygen species rebamipide

Prevalence of premature ejaculation in young and middle-aged men in Korea： a multicenter intemet-based survey from the Korean Andrological Society

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Asian Journal of Andrology 2010年第6期12卷 880-889页

作者： hyun jun park Jong Kwan park Kwangsung park Sung Won Lee Sae-Woong Kim Dae Yul Yang DU Geon Moon Kweon-Sik Min Ki-Hak Moon Sang-Kuk Yang Jae Seog hyun Nam Cheol park Deparment of Urology Pusan National University School of medicine Busan 602739 Korea Deparment of Urology Chonbuk National University Medical School Jeonju 561712 Korea Deparment of Urology Chonnam National University Medical School Gwangju 501746 Korea Deparment of Urology Sungkyunkwan Univer＆ty School of Medicine Seou1135 710 Korea Deparment of Urology Catholic University College of Medicine Seoul 137701 Korea Deparment of Urology Hallym University College of Medicine Seoul 13 7701 Korea Deparment of Urology Korea University College of Medicine Seoul 152703 Korea Deparment of Urology lnje University College of Medicine Busan 614735 Korea Deparment of Urology Yeungnam University College of Medicine Daegu 705717 Korea Deparment of Urology Konkuk University School of Medicine Chungju 380704 Korea Deparment of Urology Gyeongsang National University School of Medicine Jinju 660702 Korea

In this study, we aimed to investigate the prevalence and perception of premature ejaculation （PE） in young and middle-aged Korean men. The study was conducted using an Internet-assisted questionnaire. A total of 2 037 Korean male adults, aged 20 years or older, were randomly sampled based on age and residency. The questionnaire developed by the PE Study Group of the Korean Andrological Society includes four categories （overall sexual function, symptoms, distress and treatment） with a total of 16 questions. For each question, symptoms were evaluated by a scale ranging from 0 to 10. Intravaginal ejaculation latency time was ‘5-10 min＇ in 38.6%, followed by ‘longer than 10 min＇ in 2919%, ‘2-5 min＇ in 23.6%, ‘1-2 min＇ in 5.4% and ‘shorter than 1 min＇ in 2.5%. In our series, 27.5% of respondents reported having PE. Control over ejaculation within a recent 3-month period was 6.2 points on average. Respondent complaints of PE-related stress averaged 7.1 points and stress-related complaints from sexual partners averaged 7.1 points. The effect of PE on sexual life was 6.8 points. Of the respondents determined as having PE, 42.6% responded that they were inclined to receive treatment. Results from this study suggest that the prevalence of PE diagnosed by the respondent on his own was approximately 27.5% in young and middle-aged men in Korea. PE-related stress had a significant effect on the stress, sexual activity and quality of life of the respondent and his sexual partner.

关键词： epidemiology premature ejaculation questionnaire sexual dysfunction

2D MoS2 Helical Liquid Crystalline Fibers for Multifunctional Wearable Sensors

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Advanced Fiber Materials 2024年第6期6卷 1813-1824页

作者： jun hyun park Jang Hwan Kim Su Eon Lee Hyokyeong Kim Heo Yeon Lim Ji Sung park Taeyeong Yun Jinyong Lee Simon Kim Ho jun Jin Kyeong jun park Heemin Kang Hoe Joon Kim Hyeong Min Jin Jiwoong Kim Sang Ouk Kim Bong Hoon Kim Department of Robotics and Mechatronics Engineering DGISTDaegu 42988Republic of Korea Present Address:Platform Technology R&D Center LG ChemistrySeoul 07795Republic of Korea Department of Materials Science and Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Organic Materials and Fiber Engineering Soongsil UniversitySeoul 06978Republic of Korea Nano Convergence Technology Research Center Korea Electronics Technology Institute(KETI)Gyeonggi‑do 13509Republic of Korea Department of Green Chemistry and Materials Engineering Soongsil UniversitySeoul 06978Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Materials Science and Engineering National Creative Research Initiative Center for Multi‑Dimensional Directed Nanoscale AssemblyKAIST Institute for NanocenturyKAISTDaejeon 34141Republic of Korea Department of Organic Materials Engineering Chungnam National UniversityDaejeon 34134Republic of Korea Department of Materials Science and Engineering Chungnam National University99 Daehak‑roYuseong‑guDaejeon 34134Republic of Korea

Fiber-based material systems are emerging as key elements for next-generation wearable devices due to their remarkable advantages,including large mechanical deformability,breathability,and high ***,greatly improved mechani-cal stability has been established in functional fiber systems by introducing atomic-thick two-dimensional(2D)*** development of intelligent fibers that can respond to various external stimuli is strongly needed for versatile *** this work,helical-shaped semiconductive fibers capable of multifunctional sensing are obtained by wet-spinning MoS2 liquid crystal(LC)*** mechanical properties of the MoS2 fibers were improved by exploiting high-purity LC dispersions consisting of uniformly-sized MoS2 ***,three-dimensional(3D)helical fibers with structural chirality were successfully constructed by controlling the wet-spinning process *** helical fibers exhibited multifunctional sensing characteristics,including(1)photodetection,(2)pH monitoring,(3)gas detection,and(4)3D strain sensing.2D materials with semiconducting properties as well as abundant surface reactive sites enable smart multifunctionalities in one-dimensional(1D)and helical fiber geometry,which is potentially useful for diverse applications such as wearable internet of things(IoT)devices and soft robotics.

关键词： Molybdenum disulfide(MoS2) Liquid crystal(LC) Two-dimensional(2D)material Sensor Fiber

Refractory lipoatrophy treated with autologous whole blood injection:A case report

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World Journal of Clinical Cases 2025年第2期13卷 33-38页

作者： Wonnam Kim jun Su park En hyung Kim Department of Pharmacology School of Korean MedicinePusan National UniversityYangsan 50612GyeongnamSouth Korea Department of Dermatology College of MedicineChungbuk National UniversityCheongju 28644ChungbukSouth Korea Department of Dermatology Chungbuk National University HospitalCheongju 28644ChungbukSouth Korea

BACKGROUND Intramuscular corticosteroid injection may cause adverse effects such as dermal and/or subcutaneous atrophy,alopecia,hypopigmentation,and *** cutaneous atrophy can spontaneously resolve,several treatment options have been suggested for this *** SUMMARY In this paper,we report a case of corticosteroid injection induced lipoatrophy treated with autologous whole blood(AWB)injection,as the condition had been unresponsive to fractional laser therapy.A 29-year-old female patient visited the dermatology clinic complaining of skin depression on her right buttock area,which had appeared six months *** had been only subtle improvement at the margins after fractional CO_(2) laser treatment;therefore,after obtaining informed consent from the patient,AWB treatment was *** month after the first AWB injection,the size and depth of the lesion had noticeably improved,and a slight improvement was also observed in *** Close observation is the initial treatment of choice for steroid induced skin atrophy;however,for patients in need of immediate cosmetic improvement,AWB injection may be a safe and cost-effective alternative.

关键词： Atrophy Corticosteroid Subcutaneous fat Autologous whole blood injection Laser therapy Case report

Secondary endoscopic submucosal dissection for locally recurrent or incompletely resected gastric neoplasms

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World Journal of Gastroenterology 2018年第33期24卷 3776-3785页

作者： Da hyun jung Young Hoon Youn Jie-hyun Kim Jae jun park Hyojin park Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To investigate the feasibility and safety of secondary endoscopic submucosal dissection(ESD) for residual or locally recurrent gastric tumors. METHODS Between 2010 and 2017, 1623 consecutive patients underwent ESD for gastric neoplasms at a single tertiary referral center. Among these, 28 patients underwent secondary ESD for a residual or locally recurrent tumor. Our analysis compared clinicopathologic factors between primary ESD and secondary ESD groups. RESULTS The en bloc resection and curative rate of resection of secondary ESD were 92.9% and 89.3%, respectively. The average procedure time of secondary ESD was significantly longer than primary ESD(78.2 min vs 55.1 min, P = 0.004), and the adverse events rate was not significantly different but trended slightly higher in the secondary ESD group compared to the primary ESD group(10.7% vs 3.8%, P = 0.095). Patients who received secondary ESD had favorable outcomes without severe adverse events. During a mean follow-up period, no local recurrence occurred in patients who received secondary ESD. CONCLUSION Secondary ESD of residual or locally recurrent gastric tumors appears to be a feasible and curative treatment though it requires greater technical efficiency and longer procedure time.

关键词： Secondary endoscopic submucosal dissection Endoscopic submucosal dissection Gastric neoplasms Residual tumors Recurrent tumors

Adverse events related to colonoscopy: Global trends and future challenges

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World Journal of Gastroenterology 2019年第2期25卷 190-204页

作者： Su Young Kim hyun-Soo Kim Hong jun park Department of Internal Medicine Yonsei University Wonju College of Medicine

Colonoscopy is a widely used method for diagnosing and treating colonic disease. The number of colonoscopies is increasing worldwide, and concerns about associated adverse events are growing. Large-scale studies using big data for post-colonoscopy complications have been reported. A colon perforation is a severe complication with a relatively high mortality rate. The perforation rate, as reported in large studies(≥ 50,000 colonoscopies) published since 2000, ranges from 0.005-0.085%. The trend in the overall perforation rate in the past 15 years has not changed significantly. Bleeding is a more common adverse event than perforation. Recent large studies(≥ 50,000 colonoscopies) have reported postcolonoscopy bleeding occurring in 0.001-0.687% of cases. Most studies about adverse events related to colonoscopy were performed in the West, and relatively few studies have been conducted in the East. The incidence of post-colonoscopy complications increases in elderly patients or patients with inflammatory bowel diseases. It is important to use a unified definition and refined data to overcome the limitations of previous studies. In addition, a structured training program for endoscopists and a systematic national management program are needed to reduce post-colonoscopy complications. In this review, we discuss the current trends in colonoscopy related to adverse events, as well as the challenges to be addressed through future research.

关键词： Colonoscopy Adverse events Perforation Bleeding Post-colonoscopy