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Journal of Integrative Agriculture 2017年第2期16卷 471-477页

作者： HE Jin-gang CHENG Yu-dou guan jun-feng GE Wen-ya ZHAO Zhe Institute of Genetics and Physiology Hebei Academy of Agricultural and Forestry Science Shijiazhuang 050051 P.R. China Plant Genetic Engineering Center of Hebei Province Shijiazhuang 050051 P.R. China

According to synthetic pathway of plant chlorogenic acid （CGA）, the expression patterns of genes encoding enzymes that are associated with CGA synthesis were studied in normally developed Xuehua pear fruit. The study demonstrated that CGA content in peel and flesh of Xuehua pear decreased as fruit development progressed, with a higher level in peel. The expression levels of PbPAL 1, PbPAL2, PbC3H, PbC4H, Pb4CL 1, Pb4CL2, Pb4CL6, PbHC T1 and PbHC T3 genes decreased in fruit, which was consistent with the pattern of variation in CGA content. That indicated that these genes might be key genes for influencing fruit CGA synthesis in Xuehua pear. However, Pb4CL7 gene expression profile is not consistent with variation of CGA content, hence, it may not be a key gene involved in CGA synthesis.

关键词： cinnamate 4-hydroxylase gene hydroxy cinnamoyl CoA shikimate/quinic acid hydroxycinnamoyl transferasegene p-coumarate 3'-hydroxylase gene 4-hydroxycinnamoyl-CoA ligase gene phenylalanine ammonia lyasegene Xuehua pear

Synthesis of pyridine-based poly(N-arylenebenzimidazole sulfone)

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Chinese Chemical Letters 2012年第7期23卷 871-874页

作者： Ye Wei Xu Jie Tang guan jun Chang Fang Hua Zhu Lin Zhang Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang 621900China School of Chemistry and Chemical Engineering Mianyang Normal UniversityMianyang 621000China

Poly（N-arylenebenzimidazole pyridine sulfone）（PNABIPS） has been prepared via the aromatic nucleophilic displacement reaction of 2,6-bis（2-benzimidazoly）pyridine（BBP） with bis（4-fluorophenyl） *** was synthesized by reaction of 2,6- pyridinedicarboxylic acid with 1,2-phenylenediamine in polyphosphoric *** chemical structure of BBP was confirmed by FTIR, HRMS,^1H NMR and ^13C *** characterization of the polymer was performed with FT-IR,^1H NMR,elemental analysis, GPC,XRD,DSC,TGA and solubility *** polymer was obtained in quantitative yield with M_n value 12,600 and M_w value 28,300,*** and TGA measurements show that the glass transition temperature（T_g） is 312℃ and 5%weight loss temperature is 434℃ in nitrogen and 545℃ in air,*** addition,the novel polymer exhibits good solubility,which can be dissolved in common organic solvent at room temperature.

关键词： Polybenzimidazoles Poly(N-arylenebenzimidazole pyridine sulfone) Thermal properties Solubility

The immunological roles in acute-on-chronic liver failure:An update

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Hepatobiliary & Pancreatic Diseases International 2019年第5期18卷 403-411页

作者： Ping Chen Yun-Yun Wang Chao Chen jun guan Hai-Hong Zhu Zhi Chen State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated Hospital Zhejiang University School of Medicine

Background: Acute-on-chronic liver failure (ACLF) refers to the acute deterioration of liver function that occurs in patients with chronic liver disease. ACLF is characterized by acute decompensation, organ failure and high short-term mortality. Numerous studies have been conducted and remarkable progress has been made regarding the pathophysiology and pathogenesis of this disease in the last decade. The present review was to summarize the advances in this field. Data sources: A comprehensive search in PubMed and EMBASE was conducted using the medical subject words “acute-on-chronic liver failure”,“ACLF”,“pathogenesis”,“predictors”, and “immunotherapy” combined with free text terms such as “systemic inflammation” and “immune paralysis”. Relevant papers published before October 31, 2018, were included. Results: ACLF has two marked pathophysiological features, namely, excessive systemic inflammation and susceptibility to infection. The systemic inflammation is mainly manifested by a significant increase in the levels of plasma pro-inflammatory factors, leukocyte count and C-reactive protein. The underlying mechanisms are unclear and may be associated with decreased immune inhibitory cells, abnormal expression of cell surface molecules and intracellular regulatory pathways in immune cells and increased damageassociated molecular patterns in circulation. However, the main cause of susceptibility to infection is immune paralysis. Immunological paralysis is characterized by an attenuated activity of immune cells. The mechanisms are related to elevations of immune inhibitory cells and the concentration of plasma antiinflammatory molecules. Some immune biological indicators, such as soluble CD163, are used to explore the pathogenesis and prognosis of the disease, and some immunotherapies, such as glucocorticoids and granulocyte colony-stimulating factor, are effective on ACLF. Conclusions: Overwhelming systemic inflammation and susceptibility to infection are two key featur

关键词： Acute-on-chronic liver failure Pathogenesis Predictors Immunotherapy

Fingerprinting Analysis of Saposhnikovia divaricata using ~1H Nuclear Magnetic Resonance Spectroscopy and High Performance Liquid Chromatography

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Journal of Integrative Plant Biology 2010年第9期52卷 782-792页

作者： Yue-Yang Xin An-jun Deng guan-Hua Du Jin-Lan Zhang Hai-Lin Qin Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education & Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

The 1H nuclear magnetic resonance （1H NMR） fingerprints of fractionated non-polar and polar extracts （control substance for plant drug [CSPD] A and B） from the roots of 12 specimens of Saposhnikovia divaricata （Turcz.） Schischk were achieved with Fourier Transform （FT）-NMR spectrometer and assigned by comparison to each other and to the 1H NMR spectra of the isolated individual compounds. These fingerprints were found to be uniform in terms of the specificity for the implication of all 12 specimens being systematically of the same origin. The uniformity was further affirmed by high performance liquid chromatography （HPLC）, which also revealed exactly identical specificity for the identified S. divaricata species with the 1H NMR appearances of corresponding CSPD on the part of the composition of characteristic constituents when comparing to corresponding individual compounds. This investigation unambiguously shows that the specific signals from the chemotaxonomically significant compounds of chromones and coumarins in S. divaricata are exhibited distinctively in the composite features of both 1H NMR fingerprints and HPLC profiles. The 1H NMR and HPLC profiles established can successfully be used as reference for the authentication of the origin of S. divaricata species as well as for chemotaxonomic studies.

关键词： FINGERPRINTS NUCLEAR magnetic resonance spectroscopy HIGH performance liquid chromatography COUMARINS CHEMOTAXONOMY

Infrared Photodissociation Spectroscopy of Ti＋（CO2）2Ar and Ti＋（CO2）n （n=3-7） Complexes

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Chinese Journal of Chemical Physics 2013年第6期26卷 687-693,I0004页

作者： Xiao-peng Xing guan-jun Wang Cai-xia Wang Ming-fei Zhou Department of Chemistry Tongji University Shanghai 200092 China Department of Chemistry Shanghai Key Laboratory of Molecular Catalysts and Innovative MaterialsFudan University Shanghai 200433 China

Ti＋（CO2）2Ar and Ti＋（CO2）n （n=3-7） complexes are produced by laser vaporization in a pulsed supersonic expansion. The ion complexes of interest are each mass-selected in a time- of-flight spectrometer, and studied with infrared photodissociation spectroscopy. For each complex, a sharp band in the CO stretching frequency region is observed, which confirms the formation of the OTi＋CO（CO2）~_l oxide-carbonyl species. Small OTi＋CO（CO2）~_1 complexes （n_〈5） exhibit CO stretching and antisymmetric CO2 stretching vibrational bands that are blue-shifted from those of free CO and CO2. The experimental observations indicate that the coordination number of CO and CO2 molecules around TiO＋ is five. Evidence is also observed for the presence of another electrostatic bonding Ti＋（CO2）2 structural isomer for the Ti＋（CO2）2Ar complex, which is characterized to have a bent OCO-Ti＋-OCO structure stabilized by argon coordination.

关键词： Infrared photodissociation spectroscopy Carbon dioxide complex Titanium Insertion reaction Density functional calculation

U-series Dating of Ganqian Cave in guangxi and Its Anthropological Implications

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人类学学报 2002年第S1期21卷 78-87页

作者： SHEN guan-jun SHI Li WANG Wei WANG Qian Institute for Coastal and Quaternary Studies Nanjing Normal UniversityNanjing 210097China Natural History Museum of guangxi Zhuang Autonomous Region Nanning 530012China Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesBeijing 100044China

From Ganqian (Tubo) Cave a total of 17 hominid teeth attributed to late Homo sapiens has been collected along with an abundance of mammalian fossils. The fossiliferous deposits are bracketed by the capping and second flowstone layers, which yielded 230 Th/ 234 U dates of ～93 and ～220 ka, marking the minimum and maximum age of the hominid teeth respectively. Two U series methods performed on two mammalian teeth gave dates in the range of 85 and 139 ka, lending support to the stratigraphic order of the depositional sequence. The results presented in this paper point to an occurrence of modern Homo sapiens in southern China much earlier than has been thought, which is supported by the dating of nearby Liujiang and Bailiandong hominid sites. Taken together, these data suggest that China should not be considered as a backwater in recent human evolution where all the previous populations were replaced.

关键词： Tubo hominid Ganqian Cave U series dating Speleothem calcite Anatomically modern Homo sapiens

Feature and Tendency of Technology Transfer in Z-Park Patent Cooperation Network:From the Perspective of Global Optimal Path

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Journal of Data and Information Science 2021年第4期6卷 111-138页

作者： jun guan Jingying Xu Yu Han Dawei Wang Lizhi Xing School of Economics and Management Beijing University of TechnologyBeijing 100124China

Purpose:This study aims to provide a new framework for analyzing the path of technology diffusion in the innovation network at the regional level and industrial level respectively,which is conducive to the integration of innovation resources,the coordinated development of innovative subjects,and the improvement of innovation ***/methodology/approach:Based on the Z-Park patent cooperation data,we establish Inter-Enterprise Technology Transfer Network model and apply the concept of Pivotability to describe the key links of technology diffusion and quantify the importance of innovative *** measuring the topologically structural characteristics in the levels of branch park and the technosphere,this paper demonstrates how technology spreads and promotes overall innovation activities within the innovation ***:The results indicate that:(1)Patent cooperation network of the Z-Park displays heterogeneity and the connections between the innovative subjects distribute extremely uneven.(2)Haidian park owns the highest pivotability in the IETTN model,yet the related inter-enterprise patent cooperation is mainly concentrated in its internal,failing to facilitate the technology diffusion across multiple branch parks.(3)Such fields as“electronics and information”and“advanced manufacturing”are prominent in the cross-technosphere cooperation,while fields such as“new energy”and“environmental protection technology”can better promote industrial *** limitations:Only the part of the joint patent application is taken into account while establishing the patent cooperation *** other factors that influence the mechanism of technology diffusion in the innovation network need to be further studied,such as financial capital,market competition,and personnel mobility,*** implications:The findings of this paper will provide useful information and suggestions for the administration and policy-making of high-tech ***

关键词： Patent Cooperation Innovation Network Industrial Integration Z-Park

Highly Site-and Enantioselective N-H Functionalization of N-Monosubstituted Aniline Derivatives Affording Pyrazolones Bearing a Quaternary Stereocenter

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Chinese Journal of Chemistry 2022年第10期40卷 1144-1148页

作者： guan-jun Wang Shu-Yu Zhang Zhen-Liang Sun Peng Li Tong-Mei Ding School of Chemistry and Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Southern Medical University Affiliated Fengxian Hospital Shanghai 201499China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China

Chiral phosphoric acid catalyzed the regio-and enantioselective N-H functionalization of N-alkylaniline with pyrazolones derived ketimines as electrophiles,providing a variety of chiral pyrazolones containing a tetrasubstituted stereocenter bearing a new N,N'-acetal motif in excellent yields and high *** strategy was featured by low catalyst loading,mild conditions,and high efficiency and selectivity.

关键词： Asymmetric synthesis Enantioselectivity Alkylation Nitrogen heterocycles Quaternary stereocenter

Lightweight epoxy-based abradable seal coating with high bonding strength

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Journal of Materials Science & Technology 2021年第10期69卷 129-137页

作者： Yun-Qi Tong Qiu-Sheng Shi Mei-jun Liu guang-Rong Li Chang-Jiu Li guan-jun Yang State Key Laboratory for Mechanical Behavior o f Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an710049China

To gain high efficiency and low fuel consumption, aluminum-based abradable seal coatings had been widely used in the compressor casing of aero engines or gas turbines owing to the low elastic modulus. However, the adhesive transfer phenomenon frequently occurs when the radial rubbing generates between titanium alloy blade tips and aluminum-based coating. It tends to increase scratch force and results in blades vibration and even engine jam. To eliminate this problem, a new lightweight epoxy-based abradable seal coating with high bonding strength was developed by an effective and porosity controllable mixing process that distributes spherical pores uniformly in the continuous matrix. A lightweight coating of 63% porosity with a hardness of 33.1(HR15 Y) can be reached when the content of hollow microspheres is 31 wt.%. The coating density is 0.5 g/cm3 and the bonding strength is as high as 18 *** performance of the epoxy-based coating is comprehensively better than aluminum-based coatings in five essential indices. This study is expected to provide a new technical path for obtaining high-quality abradable seal coatings to guarantee the efficient and safe operation of compressors.

关键词： Epoxy-based seal coating Porosity HR15Y Lightweight High bonding strength

Bimodal TBCs with low thermal conductivity deposited by a powder-suspension co-spray process

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Journal of Materials Science & Technology 2018年第8期34卷 1293-1304页

作者： Wei-Wei Zhang guang-Rong Li Qiang Zhang guan-jun Yang Guo-Wang Zhang Hong-Min Mu State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi'an Jiaotong UniversityXi'an 710049China School of Materials Science and Engineering Chang'an UniversityXi'an 710064China Institute of Publication Science Chang'an UniversityXi'an 710064China AECC Beijing Institute of Aeronautical Material Beijing 100095China

Advanced thermal harrier coatings （TBCs） with better thermal barrier performance are required by both advanced gas turbine and air engine. In this work, novel bimodal TBCs with low thermal conductivity were deposited and characterized by a novel co-spray approach with both solid powder and suspension. Experimental and finite element analyses were used to optimize the process parameters to prepare the specific morphology nanostructure features. With a comprehensive understanding on the influence of spraying parameters on the morphology ofnano-particles, homogeneous nano-particle heaps with a large aspect ratio were introduced to conventional layered coatings by plasma co-spraying with suspension and solid powder. Co-sprayed bimodal microstructure composite coatings resulted from both wet suspension droplets and molten particle droplets exhibited low thermal conductivity. The thermal conductivity of the composite coating was 1/5 lower than that of the counterpart coatings by conventional plasma spraying with solid powder. This study sheds light to the structural tailoring towards the advanced TBCs with low thermal conductivity.

关键词： Thermal barrier coatings Aspect ratioBimodal microstructure Thermal conductivity Co-spray process