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Statistic Analysis on Quantitative Characteristics for Developing the DUS Test Guideline of Ranunculus asiaticus L.

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Journal of Integrative Agriculture 2013年第6期12卷 971-978页

作者： LIU Yan-fang ZHANG Jian-hua Lü Bo3 YANG Xiao-hong LI Yan-gang WANG Ye WANG Jiang-min ZHANG Hui guan jun-jiao Institute of Quality Standard and Testing Technology Research Yunnan Academy of Agricultural Sciences Kunming DUS Test Station Ministry of Agriculture Division of Plant Variety Management Seed Management Administration Ministry of Agriculture Faculty of Agriculture and Biological Sciences Dali College

Selection of quantitative characteristics, division of their expression ranges, and selection of example varieties are key issues on developing DUS Test Guidelines, which are more crucial for quantitative characteristics since their expressions vary in different degrees. Taking the development of DUS Test Guideline of Ranunculus asiaticus L. as an example, this paper applied statistic-based approaches for the analyses of quantitative characteristics. We selected 9 quantitative characteristics from 18 pre-selected characteristics, based on within-variety uniformity, stability between different growing cycles, and correlation among characteristics, by the analyses of coefficient of variation, paired-samples t-test and partial correlation. The expression ranges of the 9 selected quantitative characteristics were divided into different states using descriptive statistics and distribution frequency of varieties. Eight of the 9 selected quantitative characteristics were categorized as standard characteristics as they showed one peak in distribution frequency of 120 varieties in various expressions of the characteristics, whereas, plant height can be categorized as grouping characteristic since it gave two peaks, and can group the varieties into pot and cut varieties. Finally, box-plot was applied to visually select the example varieties, and varieties 7, 12, and 28 were determined as the example varieties for plant height. The methods described in this paper are effective for the selection of quantitative characteristics, division of expression ranges, and selection of example varieties in Ranunculus asiaticus L. for DUS test, and may also be interest for other plant genera.

关键词： DUS Test Guideline quantitative characteristic statistic analysis expression range of characteristic example variety

Optimal concentration and time window for proliferation and differentiation of neural stem cells from embryonic cerebral cortex: 5% oxygen preconditioning for 72 hours

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Neural Regeneration Research 2015年第9期10卷 1516-1522页

作者： Li-li Yuan Ying-jun guan Deng-dian Ma Hong-mei Du Department of Histology and Embryology Academy of Basic Medicine Jining Medical University Department of Histology and Embryology Academy of Basic Medicine Weifang Medical University Department of Otorhinolaryngology Affiliated Hospital of Jining Medical University

Hypoxia promotes proliferation and differentiation of neural stem cells from embryonic day 12 rat brain tissue, but the concentration and time of hypoxic preconditioning are controversial. To address this, we cultured neural stem cells isolated from embryonic day 14 rat cerebral cortex in 5% and 10% oxygen in vitro. MTT assay, neurosphere number, and immunofluorescent staining found that 5% or 10% oxygen preconditioning for 72 hours improved neural stem cell viability and proliferation. With prolonged hypoxic duration （120 hours）, the proportion of apoptotic cells increased. Thus, 5% oxygen preconditioning for 72 hours promotes neural stem cell prolif- eration and neuronal differentiation. Our findings indicate that the optimal concentration and duration of hypoxic preconditioning for promoting proliferation and differentiation of neural stem cells from the cerebral cortex are 5% oxygen for 72 hours.

关键词： nerve regeneration brain injury neural stem cells low oxygen cerebral cortex apoptosis differentiation microtubule-associated protein 2 glial fibrillary acidic protein caspase-3 neuralregeneration

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国有企业改制相关会计问题探讨

财经问题研究 2001年第4期 61-63页

作者：关君大连市房地产发展集团辽宁大连116011

本文通过对国有企业股份制改造过程中股本的确定、净资产折股以及股票市价的确定等问题的论述 ,证明了国有企业股份制改造在会计方面的可行性。

关键词：国有企业股份制改造会计问题中国

资本体现式和非体现式技术进步的经济驱动力比较——基于能源技术进步的视角

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北京工商大学学报（社会科学版） 2013年第4期28卷 122-126页

作者：关峻北京工业大学经济与管理学院北京100124

科学技术进步是经济社会发展的推动力,而资本体现式技术进步和非体现式技术进步对经济增长的驱动力是不平衡的。为了论证其潜在的不平衡性,文章基于卡尔曼滤波算法和Solow模型,构建了时变参数状态空间模型,以能源技术进步为基准,分别对... 详细信息

科学技术进步是经济社会发展的推动力,而资本体现式技术进步和非体现式技术进步对经济增长的驱动力是不平衡的。为了论证其潜在的不平衡性,文章基于卡尔曼滤波算法和Solow模型,构建了时变参数状态空间模型,以能源技术进步为基准,分别对资本体现式和非体现式技术进步的水平值进行测度,进而比较了两种技术进步方式对经济增长驱动力的差别。

关键词：技术进步驱动力卡尔曼滤波状态空间模型

A high-throughput model for screening anti-tumor agents capable of promoting polymerization of tubulin in vitro

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Acta Pharmacologica Sinica 2004年第6期25卷 73-80页

作者： Wei HU, Hui DONG, Yue-zhong LI2, Xi-tao HU, guan-jun HAN, Yin-bo QU State KeyLaboratory of Microbial Technology, School of Life Science, Shandong University, Ji-nan 250100, China State Key Laboratory of Microbial Technology School of Life Science Shandong University Ji-nan 250100 China

AIM: To establish a high-throughput model for screening anti-tumor agents capable of promoting the polymeriza- tion of tubulin in vitro. METHODS: Tubulin was prepared in different purity for two screening steps. The first step was a high-throughput screening (HTS) for a set of 1500 samples using the GTP-containing tubulin and the end-reading method. The second step was performed on 119 hits from the first screening by a kinetic assay with GTP-lacking tubulin. RESULTS: The HTS for 1500 samples was accomplished in less than 3 h. From the screening, 108 samples were identified with >20 % promotion activity at 10 mg/L. Five of 108 were further confirmed by the kinetic assay using the purified tubulin subsequently. Three of the hit compounds were Epothilone A or its analogs, the other two compounds had new structures with a common pharmacophore for cytotoxic natural products that stabilize microtubules. In an MTT test, the five selected samples from the screening showed a minimal IC50 at0.28±0.06 nmol/Lto Helacells. CONCLUTION: The two-stepscreening methodis a high-throughtput, cost-effective, and efficient approach to identify microtubule-stabilizing agents.

关键词： antitumor drug screening assays tubulin polymerization promotor microtubules

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对独立电厂调度管理的思考

中国电力 2000年第8期33卷 28-30页

作者：王官君华北电力调度局北京100761

针对华北电网独立电厂逐渐占据主导地位的实际情况，对独立电厂的调度管理包括其并网条件及协议、“三公”调度的含义及其实施、日常运行管理原则以及存在的问题展开分析讨论，并提出一些解决问题的初步设想。

关键词：独立电厂调度管理电力生产企业

Annual review of Chinese Journal of Traumatology 2019

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Chinese Journal of Traumatology 2020年第1期23卷 1-4页

作者： Wen-jun Zhao jun-jun guan Gui-E Liu Yuan Tian Lei Li Research Institute of Surgery Daping HospitalArmy Medical UniversityChongqing 400042China College of Foreign Languages Chongqing Medical UniversityChongqing 400016China

Trauma is the leading cause of death in people under the age of 45 years,and it has gained wide attention from academics ***,more and more studies have reported on trauma and related fields in recent *** 2019,Chinese Journal of Traumatology(CJTEE)published 69 articles covering traffic medicine,wound healing,bone trauma,emergency care,and other hot topics of *** we reviewed a series of articles published in CJTEE on the topics mentioned above,try to give a brief introduction of progress in trauma field.

关键词： mentioned gained healing

Mistaken Oophorectomy in an Adolescent with McCune-Albright Syndrome: A Case Report and Literature Review

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Reproductive and Developmental Medicine 2018年第4期2卷 252-255页

作者： jun guan Hai-Yun guan Lu Wang Wei Zhang Department of Gynecology Campus Virchow ClinicCharite Medical University of BerlinCorporate Member of Free University of BerlinHumboldt University of Berlinand Berlin Institute of HealthBerlinGermany Tumor Bank Ovarian Cancer Network BerlinGermany Department of Gynecological Endocrinology Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China

McCune-Albright syndrome(MAS)is a rare disease characterized by caféau lait spots,bone fibrous dysplasia,and precocious *** MAS cases are diagnosed before ***,we reported an adolescent girl underwent mistaken oophorectomy for suspected ovarian tumor,and later,she was diagnosed with *** 11-year-old girl was found to have an irregular pelvic mass measuring 9.74 cm×9.01 cm×7.30 cm with a cyst-solid component and a clear boundary by magnetic resonance *** underwent right oophorectomy for the suspected ovarian ***,histopathological examination showed ovarian tissue with many antral *** week after the surgery,ultrasonography revealed a left pelvic irregular echo-free mass measuring 60 mm×53 mm×48 *** patient was then examined by endocrine specialists,and caféau lait spots were found predominantly located on the right side of her waist,hip,and *** had her first period before the surgery,and her serum concentrations of sex hormones were ***,MAS was *** patient has been taking dydrogesterone 20 mg/d for 10 days from the 14th day of her period for 2 *** performed every 3-6 months revealed no enlargement of her left *** of MAS and careful physical and imaging examination should be emphasized,even in the absence of full classic triad of ***,unnecessary oophorectomy and irreversible loss of fertility potential can be avoided in these patients.

关键词： Adolescent with McCune-Albright Syndrome Caféau lait Spots Diagnosis Mistaken Oophorectomy

Support-Vector-Machine-Based False Alarm Filter of Mechatronic Built-in Test

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International Journal of Plant Engineering and Management 2005年第4期10卷 189-195页

作者： LIU Xin-min LIU guan-jun QIU Jing College of Mechatronics Engineering and Automation National University of Defense Technology Changsha 410073 P. R. China

Diagnosing intermittent fault is an important approach to reduce built-in test（BIT） false alarms. Aiming at solving the shortcoming of the present diagnostic method of intermittent fault, and according to the merit of support vector machines （ SVM） which can be trained with a small-sample, an SVM-based diagnostic model of 3 states that include OK state, intermittent state and faulty state is presented. With the features based on the reflection coefficients of an alarm rate （ AR ） model extracted from small vibration samples, these models are trained to diagnose intermittent faults. The experimental results show that this method can diagnose multiple intermittent faults accurately with small training samples and BIT false alarms are reduced.

关键词： support vector machine intermittent fault false alarm built-in test