检索结果-南通市图书馆

Complement activation targeted inhibitor C2-FH ameliorates acetaminophen-induced liver injury in mice

World Journal of Hepatology 2024年第10期16卷 1188-1198页

作者： Chun-Mei Li Tian Sun Mou-Jie Yang Zhi Yang Qing Li Jia-Lin Shi Chong Zhang jun-fei Jin Guangxi Key Laboratory of Molecular Medicine in Liver Injury and Repair the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Guangxi Health Commission Key Laboratory of Basic Research in Sphingolipid Metabolism Related Diseases the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina China-United States Lipids in Health and Disease Research Center Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina Laboratory of Hepatobiliary and Pancreatic Surgery the Affiliated Hospital of Guilin Medical UniversityGuilin 541001Guangxi Zhuang Autonomous RegionChina

BACKGROUND Complement activation is recognized as an important factor in the progression of liver damage caused by acetaminophen(APAP).However,the role of the complement inhibitor C2-FH in APAP-induced liver injury remains *** To explore C2-FH in protecting against APAP-induced liver injury by inhibiting complement *** A model of APAP-induced liver injury was used to study the protective effect of C2-FH on liver injury.C2-FH was administered through intraperitoneal injection 30 minutes after APAP *** detected the effects of C2-FH on liver function,inflammatory response and complement ***,RNA-sequencing(RNA-Seq)analysis was conducted to understand the mechanism through which C2-FH provides protection against APAP-induced liver *** C2-FH inhibited the increase in serum alanine aminotransferase activity,aspartate aminotransferase activity and lactate dehydrogenase,and reduced liver tissue necrosis caused by ***,it attenuated the inflammatory response and inhibited complement activation in APAP-induced liver ***-Seq analysis provided additional explanations for the protective role of C2-FH against APAP-induced liver *** C2-FH attenuates APAP-induced liver injury by inhibiting complement activation.

关键词： C2-FH Complement Complement activation Acetaminophen-induced liver injury Inflammation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

微分Haar-Gaussian小波变换在大景深物体边缘测量中的应用

引用

光学技术 2006年第3期32卷 403-405页

作者：范玲宋菲君北京邮电大学电子工程学院北京100876 北京交通大学理学院物理系北京100044

提出了微分Haar_Gaussian小波变换算法并将其应用于边缘检测,在空域和频域中进行变换,并应用带宽匹配方法和远心测量光学系统,提高了运算速度,通过对实际大景深物体离焦像的边缘测量,得到了准确的结果。

关键词：光学测量小波变换边缘测量自动检测远心系统

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of long-lasting therapeutic effects between succimer and penicillamine on hepatolenticular degeneration

引用

World Journal of Gastroenterology 1998年第6期4卷 75-77页

作者： REN Ming Shan, ZHANG Zhi, WU jun Xia, LI fei, XUE Ben Chun and YANG Ren Min

AIM To compare the long term effect of succimer (Suc) with that of penicillamine (Pen) in treating hepatolenticular degeneration (HLD). METHODS One hundred and twenty patients with HLD were divided into 2 groups. Group A ( n =60) received Suc 750mg , po. bid. Group B ( n =60) received Pen 250mg , po. qid. The period of maintenance treatment varied from 6 months to 3 years, averaging 1 5 years. Symptoms and therapeutic effects were evaluated by modified Goldstein scale. RESULTS The total effectiveness of group A in two different periods of treatment were 80% and 85% respectively, higher than those of group B (58% and 59% respectively) ( P <0 05). Suc also had obvious curative effects for the patients who failed in the use of Pen. There were fewer side effect in group A than in group B ( P <0 05). Suc and Pen could increase urinary copper excretion effectively and continually. CONCLUSION Suc is more effective and safer than Pen. Clinically, it can replace Pen as first choice drug for long term maintenance therapy of HLD.

关键词： hepatolenticular degeneration/drug therapy succimer/therapeutic use penicillamine/therapeutic use

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Poland＇s syndrome in women： 24 cases study and literature review

引用

Chinese Medical Journal 2012年第18期125卷 3283-3287页

作者： ZHU Lin ZENG Ang WANG Xiao-jun LIU Zhi-fei ZHANG Hai-lin Plastic Surgery Department Peking Union Medical CollegeHospital Chinese Academy of Medical SciencesChina Beijing 100032

Background Since its first description in 1841, numerous variations and treatments of Poland＇s syndrome （congenital deficiency of the pectoralis major muscle associated with brachysyndactyly） have been reported. None of the reports, however, involved female Chinese patients. Methods A retrospective study of 24 female patients was conducted to guide the selection of methods of surgical reconstruction. The patients were divided into three groups according to the degree of thoracic tissue development. Type I （mild）： Limited tissue loss which can be treated with simple filling with autologous fat and/or an artificial breast implant. Type II （moderate）： Moderate thoracic tissue hypoplasia where the breast parenchyma can still offer adequate implant coverage. Mammoplasty using a latissimus dorsi muscular flap with an implant was performed in this group. The flap was used to fill the infraclavicular hollow, and the implant was placed in the dual-plane pocket. Type Ⅲ （severe）： Severe thoracic tissue hypoplasia, without sufficient parenchyma to offer implant coverage. A latissimus dorsi muscular flap was used to form a total submuscular pocket in which an implant was placed. Results The numbers of Type Ⅰ, Ⅱ, and Ⅲ patients were 15, 3, and 6, respectively. All of the flaps and injected fat demonstrated good survival. Satisfactory cosmetic results were exhibited during the follow-up period of 1 to 9 years. Conclusions Although this group of patients showed varied conditions, they can be roughly divided into three types according to the degree of thoracic tissue development. In our experience, this classification is simple and useful in choosing the breast reconstruction options.

关键词： Poland's syndrome pectoralis major muscle aplasia congenital breast malformation latissimus dorsi muscular flap

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

活性污泥法污水处理过程动态仿真研究

引用

系统仿真学报 2008年第8期20卷 2156-2160页

作者：乔俊飞张颖北京工业大学电子信息与控制工程学院北京100022 北京工业大学424信箱北京100022

根据污水处理过程的实际需要,在国际公认的活性污泥模型ASM1模型的基础上,获得了能够反映污水处理系统出水水质的简化模型。利用LabVIEW软件平台,开发出了基于该模型的污水处理过程动态特性的仿真系统。系统具有反映污水处理过程动态信... 详细信息

根据污水处理过程的实际需要,在国际公认的活性污泥模型ASM1模型的基础上,获得了能够反映污水处理系统出水水质的简化模型。利用LabVIEW软件平台,开发出了基于该模型的污水处理过程动态特性的仿真系统。系统具有反映污水处理过程动态信息量大、直观性好、人机交互方便等特点。通过对污水关键水质参数COD、BOD5、SS进行仿真,证明了该仿真系统的有效性。

关键词：仿真活性污泥法曝气池二沉池

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Liver Dysfunction and Its Association with the Risk of Death in COVID-19 Patients:A Prospective Cohort Study

引用

Journal of Clinical and Translational Hepatology 2020年第3期8卷 246-254页

作者： Lin Fu jun fei Shen Xu Hui-Xian Xiang Ying Xiang Biao Hu Meng-Die Li Fang-Fang Liu Ying Li Xiu-Yong Li Hui Zhao De-Xiang Xu Second Affiliated Hospital Anhui Medical UniversityHefeiAnhuiChina School of Public Health Anhui Medical UniversityHefeiAnhuiChina Union Hospital Huazhong University of Science and TechnologyWuhanHubeiChina The Second People’s Hospital of Fuyang City FuyangAnhuiChina

Background and Aims:Coronavirus disease 2019(COVID-19)is a new respiratory infectious disease caused by severe acute respiratory syndrome coronavirus-2(commonly known as SARS-CoV-2)with multiple organ *** aim of this study was to analyze COVID-19-associated liver dysfunction(LD),its association with the risk of death and prognosis after ***:Three-hundred and fifty-five COVID-19 patients were *** data were collected from electronic medical *** was evaluated and its prognosis was *** association between LD and the risk of death was ***:Of the 355 COVID-19 patients,211 had mild disease,88 had severe disease,and 51 had critically ill *** admission,223(62.8%)patients presented with hypoproteinemia,151(42.5%)with cholestasis,and 101(28.5%)with hepatocellular *** expected,LD was more common in critically ill *** multivariate logistic regression,male sex,older age and lymphopenia were three important independent risk factors predicting LD among COVID-19 *** of death analysis showed that the fatality rate was higher in patients with hypoproteinemia than in those without hypoproteinemia(relative risk=9.471,p<0.01).Moreover,the fatality rate was higher in patients with cholestasis than those without cholestasis(relative risk=2.182,p<0.05).Follow-up observation found that more than one hepatic functional index of two-third patients remained abnormal at 14 days after ***:LD at early disease stage elevates the risk of death of COVID-19 ***-19-associated LD does not recover completely by 14 days after discharge.

关键词： Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) liver dysfunction(LD) Hepatocellular Hypoproteinemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment of 120 Cases of Lumber Intervertebral Disk Displacement by Electroacupuncture plus Movable Cupping and Traction

引用

Journal of Acupuncture and Tuina Science 2003年第2期1卷 50-51页

作者： LU Guo-ping LONG Jia-jun WU Xue-fei Xuanwu District TCM Hospital of Nanjing Jiangsu 210018 China Xuanwu district Peoples' hospital of Nanjing Jiangsu 210018 China

Ashi points, movable cupping and traction were employed to treat 120 cases of prolapase of lumber intervertebral disk, and the total effective rate was 95.6%. Key Words Lumber Vertebrae - Electroacupuncture - Cupping Therapy - Acupuncture-moxibustion - Traction - Intervertebral Disk Dislacement Author: Lü Guo-ping (1958-), female, attending physicianTranslator: WU Xue-fei

关键词： Lumber Vertebrae Electroacupuncture Cupping Therapy Acupuncture-moxibustion Traction Intervertebral Disk Dislacement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

引用

中国园林 2007年第7期 28-29页

作者： XIE jun-fei, LI Yan-ming, LI Shu-hua

1 Preface In urban green space system, urban parks, with wide space, perfect facilities, low density of building, can provide excellent emergency shelter condition. Due to

关键词： The Layout Study on the Emergency and Disaster-prevention Functions of the Green Space of Beijing City Parks

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

An Analysis of the Text Arrivals

引用

海外英语 2019年第21期 214-215页

作者：彭俊菲华中师范大学本科生院外国语学院翻译系

This paper presents the analysis of the text Arrivals,which serves as the first chapter in Rana Dasgupta's fiction Tokyo *** analysis mainly focuses on the role of literature devices including foregrounding,metaphor,and *** advantages and limitations of the devices are concerned in the ***,with the skillful use of the literature techniques,the charm of the text is enhanced through lines.

关键词： literature text analysis foregrounding metaphor voice

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of misdiagnosis in patients with multiple trauma

引用

Chinese Journal of Traumatology 2011年第1期14卷 20-24页

作者： YANG Fan BAI Xiang-jun LI Zhan-fei Department of Traumatic Surgery Tongji HospitalTongji Medical College Huazhong University of Science and Technology Wuhan 430030 China

Objective： To explore the features, treatment outcomes and reasons for misdiagnosis in patients with multiple trauma, so as to decrease the incidence of ***： A total of 3 163 patients with multiple trauma who were admitted in our department from August 1997 to August 2008, were retrospectively studied to compare the features of diagnosis and treatment. There were 2 117 males （66.93%） and 1 046 females （33.07%） with the mean age of 36.46 years （range, 14-80 years）. Parameters such as general status, traumatic condition, diagnosis and treatment situation, prognosis and mortality were analyzed. The differences between misdiagnosis group and correct diagnosis group were compared in terms of severity of injury, complications and treatment outcomes to elucidate the cause and prevention of ***： The misdiagnosis rate of multiple trauma in this study was 16.19%. The major anatomic sites misdiagnosed were limbs and pelvis （299 positions, 39.50%）, abdominal region and pelvic organ （148 positions, 19.55%）,and thoracic region （109 positions, 14.40%）. In misdiagnosis group, ISS, length of hospital stay, rates of disturbance of consciousness, critical cases and shock cases were 33.78± 19.64, （23.59±7.26） days, 49.22%, 33.01% and 47.46%,respectively, which were significantly higher than those of the correct diagnosis group （P〈0.01）. And the data showed that the more serious the injury was, the higher the rate of misdiagnosis would be. The rate of primary diagnosis by trauma surgeons in correct diagnosis group was 75.78%, significantly higher than that of the misdiagnosis group （ x2=382.01,P〈0.01）. The mortality rate of the mi sdiagnosis group was 2.93%, which was significantly higher than that for all patients （ x2=5.22, P〈0.05）.Conclusions： The results indicated that patients with severe multiple trauma are at high risk of misdiagnosis in early treatment. The mortality rate of misdiagnosed patients is higher than the correctly-diagnosed patients.

关键词： Delayed diagnosis Diagnostic errors Multiple trauma Prevention and control Treatment outcome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：