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Management of Pregnancy with Ankylosing Spondylitis

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Chinese Medical Sciences Journal 2012年第1期27卷 46-49页

作者： Qian Zhou Xu-ming Bian jun-tao liu Department of Obestetric and Gynecology Peking Union Medical College Hospita Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To discuss the interaction between pregnancy and ankylosing spondylitis, and the management of pregnancy with ankylosing spondylitis. Methods Twelve cases of pregnancy with ankylosing spondylitis in Peking Union Medical College Hospital from September 2004 to July 2011 were analyzed retrospectively, focusing on the arteritis condition, pregnancy complications, and outcomes. Results All the 12 patients had full-term pregnancy. Five cases gave birth naturally, and 7 cases received cesarean section for maternity factors. No adverse pregnancy outcomes were encountered. Waist pain appeared in 2 cases in the second trimester, for both of which medication failed. One of the 2 cases had natural childbirth, while the other maintained pregnancy smoothly to cesarean section. Conclusions Pregnancy monitoring can help obtain favorable pregnancy outcomes. Attention should be paid to postpartum change of the illness.

关键词： ankylosing spondylitis pregnancy pregnancy outcome

Phases and microstructures of high Zn-containing Al–Zn–Mg–Cu alloys

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Rare Metals 2016年第5期35卷 380-384页

作者： jun-tao liu Yong-An Zhang Xi-Wu Li Zhi-Hui Li Bai-Qing Xiong Ji-Shan Zhang State Key Laboratory of Nonferrous Metals and Process General Research Institute for Nonferrous Metals State Key Laboratory for Advanced Metals and Materials University of Science and Technology

Phases and microstructures of three high Zncontaining Al–Zn–Mg–Cu alloys were investigated by means of thermodynamic calculation method, optica microscopy（OM）, scanning electron microscopy（SEM）energy dispersive spectroscopy（EDS）, X-ray diffraction（XRD）, and differential scanning calorimetry（DSC） analysis. The results indicate that similar dendritic network morphologies are found in these three Al–Zn–Mg–Cu alloys. The as-cast 7056 aluminum alloy consists of aluminum solid solution, coarse Al/Mg（Cu, Zn, Al）2 eutectic phases, and fine intermetallic compounds g（MgZn2）. Both of as-cast 7095 and 7136 aluminum alloys involve a（Al）eutectic Al/Mg（Cu, Zn, Al）2, intermetallic g（MgZn2）, and h（Al2Cu）. During homogenization at 450 ℃, fine g（MgZn2） can dissolve into matrix absolutely. After homogenization at 450 ℃ for 24 h, Mg（Cu, Zn, Al）2 phase in 7136 alloy transforms into S（Al2Cu Mg） while no change is found in 7056 and 7095 alloys. The thermodynamic calculation can be used to predict the phases in high Zncontaining Al–Zn–Mg–Cu alloys.

关键词： Al–Zn–Mg–Cu alloy High Zn Microstructure Homogenization

Cytogenetic and Clinical Analysis of 340 Chinese Patients with Primary Amenorrhea

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Chinese Medical Sciences Journal 2011年第3期26卷 163-167页

作者： Hong Yu Xun-min Bian jun-tao liu Na Hao Jing Zhou Shan-ying liu Department of Obstetric and Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences ＆ Peking Union Medical CollegeBeijing 100730China the Reproduction CenterHunan Provincial Maternal and Child Health HospitalChangshaChina.

Objective To analyze the relationship between karyotypes and clinic features of patients with primary *** G banding was done for 340 patients with primary amenorrhea to facilitate individual chromosome identification,and if specific staining for certain portions of the chromosome was necessary,C banding was *** clinical data were recorded by physical examination and ultrasound *** Karyotype analysis of the 340 patients revealed that 180(52.94%) patients had normal female karyotypes and 160(47.06%) patients had abnormal *** abnormal karyotypes included abnormal X chromosome(150 patients),mosaic X-Y chromosome(4 patients),abnormal autosome(5 patients),and X-autosome translocation(1 patient).The main clinical manifestations in patients with primary amenorrhea were primordial or absent uterus(95.9%),invisible secondary sex features(68.8%),little or absent ovary(62.6%),and short stature(30.0%).The incidence of short stature in patients with X chromosome aberration(46%,69/150) was significangly higher that in patients with 46,XX(9.44%,17/180) as well as 46,XY(6.67%,3/45;χ2=146.25,P=0.000).All primary amenorrhea patients with deletion or break-point at Xp11.1-11.4 were short *** One of the main reasons of primary amenorrhea is choromosome abnormality,especially heterosome *** implies the need to routinely screen chromosomal anomalies for such *** might be relationship between Xp11.1-11.4 integrity and height improvement.

关键词： primary amenorrhea Turner Syndrome karyotype

Spatio-temporally resolved measurement of quantal exocytosis from single cells using microelectrode array modified with poly L-lysine and poly dopamine

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Chinese Chemical Letters 2016年第5期27卷 738-744页

作者： Li Wang Sheng-Wei Xu Hui-Ren Xu Yi-Lin Song jun-tao liu Jin-Ping Luo Xin-Xia Cai State Key Laboratory of Transducer Technology Institute of Electronics Chinese Academy of Sciences Beijing 100190 China University of Chinese Academy of Sciences Beijing 100190 China

The subsecond, temporal, vesicular exocytosis is ubiquitous, but difficult detecting in communication mechanisms of cells. A microelectrode array （MEA）, fabricated by MEMS technology, was applied successfully for real-time monitoring of quantal exocytosis from single pheochromocytoma （PC12） cell, The developed MEA was evaluated by dopamine （DA） using electrochemical methods and the results revealed that the sensitivity of DA was improved to 12659.24 p.A L mmol 1 cm 2. The modified MEA was used to detect in vitro vesicular exocytosis of DA from single PCI 2 cells stimulated by concentrated 100 mmol L-1 K＋ cell solution. A total of 592 spikes were measured and analyzed by three parameters and the statistical results revealed the population of each parameter was an approximate Gaussian distribution, and on average, 1.31 × 106 ± 9.25× 104 oxidizable molecules were released in each quantal exocytosis. In addition, results also indicate that a single PC12 cell probably releases the spikes with T ranging from 25.6 ms to 35.4 ms corresponding to/max ranging from 45.6 pA to 65.2 pA. The devices, including a homemade computer interface and the MEA modified with polymer film, provides a new means for further research on the neural, intercellular, communication mechanism.

关键词： Microelectrode array Quantal exocytosis Dopamine Parameter

Clinical Analysis of Placenta Previa Complicated with Previous Caesarean Section

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Chinese Medical Sciences Journal 2012年第3期27卷 129-133页

作者： Liang-kun Ma Na Han Jian-qiu Yang Xu-ming Bian jun-tao liu Department of Obstetrics&Gynecology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Obstetrics&Gynecology Tongzhou District Maternal and Child Health HospitalBeijing 101101China

Objective To investigate the clinical features and treatment of placenta previa complicated with previous caesarean section. Methods The clinical data of 29 patients with placenta previa complicated with a previous caesarean section (RCS group) admitted in Peking Union Medical College Hospital during a period from 2003 to 2011 were retrospectively reviewed and compared with those of 243 patients with placenta previa without a previous caesarean section (FCS group) during the same period. Results There was no difference in the mean age (28.9±3.6 vs. 28.1±4.5 years) and the average gravidity (2.35±1.48 vs. 2.21±1.53) between RCS group and FCS group (all P>0.05). The RCS group had more preterm births (24.1% vs. 13.2%), complete placenta previa (55.2% vs. 4.9%), placenta accreta (34.5% vs. 2.5%), more blood loss during caesarean section (1412±602 vs. 648±265 mL), blood transfusion (51.7% vs. 4.9%), disseminated intravascular coagulation (13.8% vs. 2.1%), and obstetric hysterectomy (13.8% vs. 0.8%) than the FCS group (all P<0.05). The preterm infant rate (30.0% vs. 13.0%), neonatal asphyxia rate (10.0% vs. 4.9%), and perinatal mortality rate (6.7% vs. 0.4%) of the RCS group were higher than those of the FCS group (all P<0.05). Conclusions More patients had complete placenta previa and placenta accreta, postpartum hemorrhage, transfusion, uterine packing, obstetric hysterectomy, and perinatal morbidity in the placenta previa patients with previous caesarean section. The patient should be informed of the risk and unnecessary first cesarean sections should be avoided.

关键词： placenta previa previous caesarean section perinatal complications

Indirect ELISA with Recombinant GP5 for Detecting Antibodies to Porcine Reproductive and Respiratory Syndrome Virus

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Virologica Sinica 2011年第1期26卷 61-66页

作者： Yan Chen Hong Tian Jian-Hui He Jin-Yin Wu You-jun Shang Xiang-tao liu Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Animal Virology of Ministry of Agriculture Lanzhou 730046 China

Porcine reproductive and respiratory syndrome is caused by the PRRS virus (PRRSV),which has six structural proteins (GP2,GP3,GP4,GP5,M and N). GP5 and N protein are important targets for serological detection by enzyme-linked immunosorbent assay (ELISA) and other methods. Toward this goal,we developed an indirect ELISA with recombinant GP5 antigens and this method was validated by comparison to the LSI PRRSV-Ab ELISA kit. The results indicated that the optimal concentration of coated recombinant antigen was 0.2 μg/well for a serum dilution of 1:40. The rate of agreement with the LSI PRRSV-Ab kit was 88.7% (266/300). These results support the potential use of recombinant GP5 as an antigen for indirect ELISA to detect PRRSV antibodies in pigs.

关键词： Porcine reproductive and respiratory syndromevirus (PRRSV) GP5 protein Indirect ELISA

Application of GP5 Protein to Develop Monoclonal Antibody against Porcine Reproductive and Respiratory Syndrome Virus

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Virologica Sinica 2011年第4期26卷 267-272页

作者： Hong Tian Yan Cheng Jin-yang Wu Jian-hui He You-jun Shang Xiang-tao liu State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference Laboratory Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 China

In this study, a panel of monoclonal antibodies （mAbs） against Porcine reproductive and respiratory syndrome virus（PRRSV）, named as 8C9 and4B4, were produced by fusing SP2/0 myeloma cells and spleen cells of BALB/c mice immunized with the PRRSV （TCID50=5.5）, screened by the indirect ELISA and subjected to several limiting dilutions, mAbs were then identified by biological characterization. Among the two fusion cell strains, 8C9 belonged to the IgG1 subclass and 4B4 belonged to the IgG2a subclass. The titers in cell culture supematant and abdomen liquor reached to 1：104and 1：105, respectively. The specificity test indicated that the two cells had specific reactions for the PRRSV and GP5 protein respectively, and no reaction with Classical swine fever virus （CSFV） or Swine vesicular disease virus （SVDV）. The molecular weights of the heavy chain and light chain were about 45.0 kDa and 25.0 kDa, respectively. In neutralization activity tests, the results showed that the prepared mAb 4B4 can protect 50% of cells with no CPE in dilution up to 1：512, but mAB 8C9 has no neutralization activities to PRRSV.

关键词： Porcine reproductive and respiratory syndrome virus (PRRSV) Recombinant GP5 protein Monoclonal antibody

Pregnancy Outcomes of Repeat Cesarean Section in Peking Union Medical College Hospital

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Chinese Medical Sciences Journal 2009年第3期24卷 147-150页

作者： Liang-kun Ma Na liu Xu-ming Bian Li-rong Teng Hong Qi Xiao-ming Gong jun-tao liu Jian-qiu Yang Department of Obstetrics and Gynecology Academy of Medical Sciences ＆ Peking Peking Union Medical College Hospital Chinese Union Medical College Beijing 100730 China

Objective To evaluate the effect of elective repeat cesarean section on the maternal and neonatal outcomes. Methods A retrospective clinic- and hospital-based survey was designed for comparing the maternal and neonatal outcomes of elective repeat cesarean section [RCS group （one previous cesarean section） and MRCS group （two or more previous cesarean sections）] and primary cesarean section （FCS group） at Peking Union Medical College Hospital from January 1998 to December 2007. Results The incidence of repeat cesarean section increased from 1.26% to 7.32%. The mean gestational age at delivery in RCS group （38.1±1.8 weeks） and MRCS group （37.3±2.5 weeks） were significantly shorter than that in FCS group （38.9±2.1 weeks, all P〈0.01）. The incidence of complication was 33.8% and 33.3% in RCS group and MRCS group respectively, and was significantly higher than that in FCS group （7.9%, P〈0.05）. Dense adhesion （13.5% vs. 0.4%, OR=7.156, 95% CI： 1.7-30.7, P〈0.01） and uterine rupture （1.0% vs. O,P〈0.05） were commoner in RCS group compared with FCS group. Neonatal morbidity was similar among three groups （P〉0.05）. Conclusions Repeat cesarean section is associated with more complicated surgery technique and increased frequency of maternal morbidity. However, the incidence of neonatal morbidity is similar to primary cesarean section.

关键词： repeat cesarean section pregnancy outcomes

Obstetric Outcomes in Chinese Women with Endometriosis： A Retrospective Cohort Study

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Chinese Medical Journal 2015年第4期128卷 455-458页

作者： Hong Lin Jin-Hua Leng jun-tao liu Jing-He Lang Department of Obstetrics and Gynecology Peking Union Medical College Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100730 China

Background：The effect of endometriosis on obstetric outcomes is still *** aim of our study was to determine the association between endometriosis and adverse obstetric outcomes in a cohort of Chinese ***：A retrospective cohort study was undertaken to compare obstetric outcomes between 249 women with endometriosis and 249 women without *** women were nulliparous and achieved singleton pregnancies *** with endometriosis were diagnosed during surgery and confirmed *** ratios （ORs） and 95％ confidence intervals （CIs） of measures of obstetric outcomes were ***：Women with endometriosis showed significantly increased risks of preterm labor （adjusted OR,2.42; 95％ CI,1.05-5.57）,placenta previa （adjusted OR,4.51; 95％ CI,1.23-16.50）,and cesarean section （adjusted OR,1.93; 95％ CI,1.31-2.84）.No significant differences were observed in the incidence of pregnancy-induced hypertension,fetal growth restriction,small for gestational age,placental abruption,or luteal support in the first trimester between the two ***：Women with endometriosis are at a higher risk of preterm labor,placenta previa,and cesarean section during pregnancy and need additional care.

关键词： Endometriosis Pregnancy Outcome Premature Birth