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Molecular Plant 2016年第3期9卷 428-436页

作者： J. Bohm S. Scherzer S. Shabala E. Krol E. Neher t.D. Mueller R. Hedrich julius-yon-Sachs Institute Department for Molecular Plant Physiology and Biophysics University of Wurzburg Julius-von-Sachs Platz 2 97082 Wurzburg Germany School of Land and Food University of Tasmania Hobart TAS 7001 Australia Zoology Department College of Science King Saud University PO Box 2455 Riyadh 11451 Saudi Arabia Department for Membrane Biophysics Max Planck Institute for Biophysical Chemistry 37077 Goettingen Germany

the animal diet of the carnivorous Venus flytrap, Dionaea muscipula, contains a sodium load that enters the capture organ via an HKt1-type sodium channel, expressed in special epithelia cells on the inner trap lobe surface. DmHKt1 expression and sodium uptake activity is induced upon prey contact. Here, we analyzed the HKt1 properties required for prey sodium osmolyte management of carnivorous Dionaea. Analyses were based on homology modeling, generation of model-derived point mutants, and their functional testing in Xenopus oocytes. We showed that the wild-type HKt1 and its Na^＋- and K^＋-permeable mutants function as ion channels rather than K^＋ transporters driven by proton or sodium gradients. these structural and biophysical features of a high-capacity, Na^＋-selective ion channel enable Dionaea glands to manage prey-derived sodium loads without confounding the action potential-based information management of the flytrap.

关键词： sodium channel HKt1 Dionaea muscipula action potential glands sodium uptake

POLIII-derived non-coding RNAs acting as scaffolds and decoys

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Journal of Molecular Cell Biology 2019年第10期11卷 880-885页

作者： Hendriktauber Stefan Huttelmaier Marcel Kohn Institute of Molecular Medicine Section for Molecular Cell BiologyFaculty of MedicineMartin Luther University Halle-WittenbergCharles Tan ford Protein CentreKurt-Mothes-Str.3a06120 HalleGermany julius Bernstein Institute of Physiology Faculty of MedicineMartin Luther University Halle-WittenbergCharles Tan ford Protein CentreKurt-Mothes-Str.3a06120 HalleGermany

A large variety of eukaryotic small structured POLIII-derived non-coding RNAs(ncRNAs)have been described in the ***,for only few,e.g.7SL and H1/MRP families,cellular functions are well *** the vast majority of these transcripts,cellular functions remain *** findings on the role ofY RNAs and other POLIII-derived ncRNAs suggest an evolutionarily conserved function of these ncRNAs in the assembly and function of ribonucleoprotein complexes(RNPs).these RNPs provide cellular‘machineries’,which are essential for guiding the fate and function of a variety of *** this review,we summarize current knowledge on the role of POLIII-derived ncRNAs in the assembly and function of *** propose that these ncRNAs serve as scaffolding factors that‘chaperone’RNA-binding proteins(RBPs)to form functional *** addition or associated with this role,some small ncRNAs act as molecular decoys impairing the RBP-guided control of RNA fate by competing with other RNA *** suggests that POLIII-derived ncRNAs serve essential and conserved roles in the assembly of larger RNPs and thus the control of gene expression by indirectly guiding the fate of mRNAs and IncRNAs.

关键词： ncRNA POLIII RBP scaffold RBP decoy

Virtual Australia:its key elementsknow,think,communicate

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International Journal of Digital Earth 2008年第1期1卷 66-87,I0005页

作者： B.thompson t.O.Cha R.Slee P.Kinne A.Jahshan P.Woodgate I.Bishop D.McKenzie Spatial Information Infrastructure Department of Sustainability and EnvironmentLevel 13Marland House570 Bourke StreetMelbourne Victoria 3000Australia Oracle Fusion Middleware Sales Oracle Corporation Asia Pacific4 Julius AvenueNorth Ryde NSW 2113Australia Open Spatial technologies Pty Ltd 433 Logan RoadStones Corner QLD 4120Australia Australian Cooperative Research Centre for Spatial Information 723 Swanston StreetUniversity of MelbourneVictoria 3010Australia Department of Geomatics The University of Melbourne VictoriaAustralia

Virtual Australia is not a well-defined or agreed *** discussion paper conceptualises Virtual Australia as a‘virtual[digital]model containing and representing all non-trivial objects and their contextual environmentfrom blue sky to bedrockin real world Australia’.It describes a scenario for Virtual Australia,one or two decades from now,in which the locations and conditions of non-trivial objects and their environment are updated automatically through a combination of remote sensing and wireless communication technologies in support of a‘Supranet’.It then examines the concept of the‘Supranet’a pervasive information network based largely on wireless technology linking the physical world to a virtual model in real timeand develops and discusses three principal characteristics of the Supranet:the ability to have or collect specific information(know);the ability to process information(think);and the ability to communicate that ***,in the near future,any or all non-trivial devices are to some extent able to know,think and communicate,the potential for object autonomy will be realised.

关键词： virtual spatial supranet digital information sensors motes innovation Australia

高血压患者心电图左心室肥厚消退与新发房颤发生率下降

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美国医学会杂志（中文版） 2007年第5期26卷 265-270页

作者： Peter M. Okin Kristian Wachtell Richard B. Devereux Katherine E. Harris Sverker Jern Sverre E. Kjeldsen Stevo julius Lars H. Lindholm Markku S. Nieminen Jonathan M. Edelman t Darcy A. Hille Bjoern Dahloef 阮雯（译）沈卫峰（校） Greenberg Division of Cardiology Weill Medical College of Comell University New York NY Departrnent of Medicine Glostrup University Hospital Glostrup Denmark Merck Research Laboratories West Point Pa Sahlgrenska University Hospital/Oestra GoeteborgSweden University of Oslo Uileval Hospital OsloNorway University of Michigan Medical Center Ann Arbor Umea University Umea Sweden Division of Cardiology Department of MedicineHelsinki University Central HospitalHelsinkiFinland Umea university and merck＆co Inc Whitehouse Station.Nu 不详

背景：心房纤颤（简称房颤）与死亡和心血管事件（特别是卒中）危险性增加相关，因此，预防新发房颤是一个重要的临床问题。虽然心电图左心室肥厚（electrocardiographic left ventricular hypertrophy，LVH）的存在及其严重程度可以预... 详细信息

背景：心房纤颤（简称房颤）与死亡和心血管事件（特别是卒中）危险性增加相关，因此，预防新发房颤是一个重要的临床问题。虽然心电图左心室肥厚（electrocardiographic left ventricular hypertrophy，LVH）的存在及其严重程度可以预测房颤的发生，但是心电图LVH消退是否与房颤发生率下降相关尚不清楚。目的：验证降压治疗期间心电图LVH消退或持续消失与房颤发生率下降相关且独立于血压水平及治疗模式的假设。设计、方法及参试者：1995～2001年于8831例男性和女性高血压患者中进行双盲、随机、平行分组研究。患者年龄55～80岁（中位数，67岁），均根据心电图Comell电压-间期乘积或Sokolow—Lyon电压标准诊断LVH。患者无房颤史，基线心电图无房颤，已入选氯沙坦干预降低终点事件高血压研究。干预：氯沙坦或阿替洛尔治疗方案，6个月时进行随访评估，之后每年随访，直至患者死亡或试验终止。主要观测指标：基线及随访各时点心电图LVH与新发房颤的相关性。心电图LVH的测量使用性别校正的Comell乘积标准（{RavL＋Sv3[女性＋6mm]}×QRS间期）。结果：经过平均（SD）4．7（1．1）年的随访，治疗期间心电图Comell乘积标准LVH消退或持续消失的患者有290例新发房颤（发生率为14．9／1000病人-年）；而心电图LVH持续或进展的患者则有411例新发房颤（19．0／1000病人-年）。时间依赖Cox分析显示，在校正治疗效果、基线房颤危险因素差异、基线及治疗期间血压以及基线LVH严重程度后，治疗期间Comell乘积标准LVH降低作为一种时间变异协变量与新发房颤下降相关。Comell乘积每下降1050mm×msec（每个SD），新发房颤就下降12．4％（校正风险比[hazard ratio，HR]，0．88；95％可信区间[confidence interval，CI]0．80～0．97；P=0．007）；氯沙坦减少高血压患者发生房颤的益处优于阿替洛尔（HR，0．83；95％CI，0．71～0．97；P=0．01）。结论：原发性高血压患者在降压治疗期间，心电图Comell乘积标准LVH消退与新发房颤下降相关，而且独立于血压和治疗方案。这些发现提示，以降低或预防心电图LVH为目标的降压治疗可以降低新发房颤的发生率。

关键词：原发性高血压患者左心室肥厚心电图发生率房颤消退标准诊断降压治疗

添加硒和限饲对妊娠母羊母体和胎儿体重、内脏器官重量及细胞构成、空肠血流量的影响

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饲料博览（技术版） 2007年第12期 60-60页

作者： Reed J J Ward M A Vonnahme K A Neville t L julius S L Borowicz P P

检测营养限饲和日粮硒对母体和胎儿内脏组织的影响。36只妊娠塔尔基杂交母羊随机分到1个处理的4个重复中，采用2×2因子设计。各试验组的营养基础为：母羊最低营养需要量（对照组）和对照组的60％（限饲组）；日粮硒以硒浓缩酵母形式添... 详细信息

检测营养限饲和日粮硒对母体和胎儿内脏组织的影响。36只妊娠塔尔基杂交母羊随机分到1个处理的4个重复中，采用2×2因子设计。各试验组的营养基础为：母羊最低营养需要量（对照组）和对照组的60％（限饲组）；日粮硒以硒浓缩酵母形式添加，硒水平为：适量硒（6μg·kg^-1Bw）和高硒（80μg·kg^-1Bw）。硒处理组在分娩前21天时开始添加硒，妊娠第64天时开始限饲。日粮粗蛋白水平为16％，代谢能水平为8.87MJ·kg^-1干物质（DM），对照组和限饲组添加不同数量饲粮。在妊娠的第（135±5）d（平均值±变异范围）时，屠宰母羊并采集内脏器官。营养和硒的互作对母体空肠RNA：DNA有显著影响（P=0．02）；在母体测定时。没有检测到其他互作。与对照组母羊相比，限饲组母体体重、胃复合体、小肠、大肠、肝脏和肾脏重极显著减小（P≤0．01）。限饲组母羊与对照组相比，高硒组与适量硒组相比，肺脏重量（g·kg^-1净膛重）增加（P=0．09）。限饲组母羊与对照组相比，母体空肠蛋白含量和蛋白：DNA极显著降低（P≤0．002）。对照组母体空肠DNA和RNA浓度，总增生的空肠细胞不受影响（P≥0．11）。限饲组母羊与对照组相比，总空肠和黏膜血流量（mL）极显著降低（P≤0．01）。与对照组相比，限饲组母羊的胎儿体重和空屠体重减小（P=0．06），坐高显著减小（P=0．03），肝脏重极显著减小（P=0．01），胰脏重减小（P=0．07），肾脂肪囊重显著减小（P=0.02），小肠重极显著减小（P=0．007），脾脏重显著减小（P=0．03）。与适量硒组相比，高硒组母羊的胎儿体重，空屠体、心脏、肺脏、脾脏、总内脏和大肠重增加（P≤0．09）。养分限饲极显著降低胎儿空肠蛋白含量（mg，P=0．01），蛋白：DNA降低（P=0．06）。与其他试验组相比。添加高硒的限饲母羊的胎儿肌肉DNA含量（营养和硒互作，P=0．04）显著增加（P〈0．05）。高硒对适量硒组母羊，胎儿肌肉RNA浓度极显著升高（P=0．01），肝脏RNA含量显著升高（P=0.04）。试验结果表明：母体日粮硒能改变胎儿应答，由更大的胎儿心脏，肺脏。脾脏和体重显示。

关键词：胎儿母体养分限饲妊娠硒

Rhizosphere microbial communities associated to rose replant disease:links to plant growth and root metabolites

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Horticulture Research 2020年第1期7卷 1031-1046页

作者： B.Yim A.Baumann G.Grunewaldt-Stöcker B.Liu L.Beerhues S.Zühlke M.Sapp J.Nesme S.J.Sørensen K.Smalla t.Winkelmann Institute of Horticultural Production Systems Leibniz Universität Hannover30419 HannoverGermany julius Kühn-Institut(JKI) Institute for Epidemiology and Pathogen Diagnostics38104 BraunschweigGermany Institute of Pharmaceutical Biology Technische Universität Braunschweig38106 BraunschweigGermany Faculty of Chemistry and Chemical Biology(CCB) Technische Universität Dortmund44227 DortmundGermany Cluster of Excellence on Plant Sciences(CEPLAS) Institute for Population GeneticsHeinrich Heine University40225 DüsseldorfGermany Section of Microbiology Department of BiologyUniversity of Copenhagen2100 CopenhagenDenmark

Growth depression of Rosa plants at sites previously used to cultivate the same or closely related species is a typical symptom of rose replant disease(RRD).Currently,limited information is available on the causes and the etiology of RRD compared to apple replant disease(ARD).thus,this study aimed at analyzing growth characteristics,root morphology,and root metabolites,as well as microbial communities in the rhizosphere of the susceptible rootstock Rosa corymbifera‘Laxa’grown in RRD-affected soil from two sites(Heidgraben and Sangerhausen),either untreated or disinfected byγ-*** a greenhouse bioassay,plants developed significantly more biomass in theγ-irradiated than in the untreated soils of both *** plant metabolites detected in ***‘Laxa’roots were site-and *** aloesin was recorded in significantly higher concentrations in untreated than inγ-irradiated soils from Heidgraben,the concentrations of phenylalanine were significantly lower in roots from untreated soil of both *** microbial communities of 8-week-old plants were studied by sequencing of 16S rRNA,ItS,and cox gene fragments amplified from total community *** by microscopic observations,sequences affiliated to the bacterial genus Streptomyces and the fungal genus Nectria were identified as potential causal agents of RRD in the soils *** relative abundance of oomycetes belonging to the genus Pythiogeton showed a negative correlation to the growth of the ***,the RRD symptoms,the effects of soil treatments on the composition of the rhizosphere microbial community revealed striking similarities to findings related to ARD.

关键词： soil roots plant

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岩石工程的理论与实践(一)

矿业工程 1988年第10期 27-34页

作者： E.t.布朗蔡■经

本文作者系国际岩石力学学会主席,著名的岩石力学专家、教授。本文是作者在英国矿冶学会第19届julius Wernher爵士纪念会的讲稿,系统地阐述了岩石工程的理论与实践及其相互关系,现特全文译登,以飨读者。

关键词：原岩应力场影响范围水平应力岩石工程开挖工程采场巷道岩体特性岩柱垂直应力三维应力分析采矿工程师理论与实践

利用常规胸部Ct偶发异常影像辨识未来心血管事件高危个体

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国际医学放射学杂志 2014年第6期 573-574页

作者： P.M.Jairam M.J.A.Gondrie D.E.Grobbee W.P.t.M.Mali P.C.A.Jacobs Y.van der Graaf 杨君 julius Center for Health Sciences and Primary Care and Department of Radiology University Medical Center UtrechtUniversiteitsweg 100PO Box 85500Room E 1163584 CG Utrechtthe Netherlands

摘要目的推导并验证基于Ct影像的预测规则,研究胸部Ct偶发异常影像对发现心血管病(CVD)高危病人的作用。材料与方法本研究经伦理审查委员会的批准,免除签署

关键词：胸部躯干心血管 Ct

心脏病风险决定绝经年龄而非绝经年龄决定心脏病风险

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 50-50页

作者： Kok H.S. van Asselt K.M. van der Schouw Y.t. 郭俊 julius Center for Health Sciences and Primary Care Utrecht University Utrecht Netherlands Dr.

Objectives: the purpose of this study was to investigate whether a harmful cardiovascular risk profile accelerates menopause. Background: Women with an early menopause are at an increased risk of cardiovascular disease. Although increased cardiovascular risk has been proposed as consequence of menopause, the alternative hypothesis, that increased premenopausal cardiovascular risk promotes early menopause, needs to be examined. Methods: We used data from the Framingham Heart Study cohort. this study started in 1948 and has followed up participants biennially since then. Women who were premenopausal at study entry and who reached natural menopause after at least two examination rounds were included in the study(n=695). Premenopausal age-independent levels of serum total cholesterol, relative weight, blood pressure, and Framingham risk score were determined, as well as premenopausal changes in cholesterol, body weight, and blood pressure. Results: A higher premenopausal serum total cholesterol level was statistically significantly associated with an earlier age at menopause, as were increases in total serum cholesterol, relative weight, and blood pressure in the premenopausal period. A decrease in total serum cholesterol during premenopause was statistically significantly associated with later age at menopause. Decreasing blood pressure was associated with a later menopausal age, but this association was not statistically significant. A decrease in relative weight was associated with a significant earlier age at menopause. Each 1%higher premenopausal Framingham risk score was associated with a decrease in menopausal age of 1.8 years(95%confidence interval -2.72 to-0.92). Conclusions: the findings support the view that heart disease risk determines age at menopause. this offers a novel explanation for the inconsistent findings on cardiovascular disease rate and its relationship to menopausal age and effects of hormone replacement therapy.

关键词：绝经年龄绝经前期早绝经心血管风险血清总胆固醇心血管疾病自然绝经激素替代治疗

腺样体切除术在反复上呼吸道感染儿童中的疗效：开放随机对照研究

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英国医学杂志中文版 2011年第6期14卷 359-359页

作者： van den Aardweg M t A Boonacker C W B Rovers M M Hoes A W Schilder A G M 郑远征(译者) 杜忠东(审校者) Department of Otorhinolaryngology University Medical Centre Utrecht Netherlands julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht Department of Otorhinolaryngology University Medical Centre Utrecht Netherlands julius Centre for Health Sciences and Primary Care University Medical Centre Utrecht 首都医科大学附属北京儿童医院儿内科

目的评价腺样体切除术在反复上呼吸道感染儿童中的效果。设计开放随机对照研究。地点11所综合医院和2所大学医学中心。研究对象111例1～6岁患反复上呼吸道感染被选择进行腺样体切除术儿童。研究方法一种干预策略是即刻进行腺样体切除术... 详细信息

目的评价腺样体切除术在反复上呼吸道感染儿童中的效果。设计开放随机对照研究。地点11所综合医院和2所大学医学中心。研究对象111例1～6岁患反复上呼吸道感染被选择进行腺样体切除术儿童。研究方法一种干预策略是即刻进行腺样体切除术伴或不伴骨膜切开术，另一种策略是保守治疗。主要评价指标主要评价指标为从总随访数据（最长24个月）中计算每年每人上呼吸道感染总次数；次要评价指标包括每年每人患上呼吸道感染的天数、伴发热的中耳并发症次数及天数、发热天数、上呼吸道感染的患病率及健康相关的生活质量。结果在随访的中位数24个月期间，腺样体切除术组每年有7．91人次发生上呼吸道感染，而保守治疗组为7．84人次（发病率差别为0．07，95％可信区间为-0．70～0．85）。两组在上呼吸道感染的天数、伴发热的中耳并发症的发生次数及天数、健康相关的生活质量方面也没有显著差异。随时间的进展，两组上呼吸道感染的患病率均有所下降。腺样体切除术组儿童发热天数比保守治疗组显著增多，两例患儿发生了手术相关并发症。结论在被选择做腺样体切除术的反复上呼吸道感染的儿童中，与保守治疗组比较即刻手术组没有更多的临床受益。

关键词：反复上呼吸道感染腺样体切除术随机对照研究儿童中耳并发症保守治疗疗效大学医学中心