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Nutritional composition, ultrastructural characterization, and peptidome profile of antioxidant hemp protein hydrolysates

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FOOD BIOSCIENCE 2023年第3期53卷 783-793页

作者： Montserrat-de la Paz, Sergio Rivero-Pino, Fernando Villanueva, Alvaro Toscano-sanchez, Rocio Martin, Maria E. Millan, Francisco Millan-Linares, Maria C. Univ Seville Sch Med Dept Med Biochem Mol Biol & Immunol Seville Spain CSIC Inst Grasa Dept Food & Hlth Ctra Utrera Km 1 Seville 41013 Spain Univ Seville Fac Biol Dept Cell Biol Seville Spain Univ Seville Sch Med Dept Med Biochem Mol Biol Av Sanchez Pizjuan S-N Seville 41009 Spain

Hemp is the term commonly used to refer to the variety of Cannabis sativa L. cultivated for industrial purposes. The seeds have gained interest in recent years as functional foods due to their nutritional composition and high content of protein and bioactive compounds. In this study, ten hemp protein hydrolysates (HPHs) were obtained by enzymatic hydrolysis with Alcalase and Flavourzyme from hemp protein isolate (HPI) and their antioxidant properties (DPPH radical scavenging activity, beta-carotene activity and ferric ion reducing antioxidant power (FRAP)) were evaluated. Shorter peptide sequences, mainly obtained with Flavourzyme, were found to react with free radicals more easily. The peptidome of all the hydrolysates was characterized, identifying, and quantifying the peptides. Furthermore, 19 unique peptides were assessed by in silico tools to hypothesize those that could be responsible of the bioactivity reported for the hydrolysates. From the identified peptides, based on the molecular features and the predictions, the peptides KNAIYTPH, EERPGHF, and KNGMMAPH, among others, are proposed to be highly contributing to the antioxidant activity of the hydrolysates.

关键词： Bioeconomy Bioactive peptides Cannabis sativa Peptidomics Proteomic profile

高水溶性7-(3-氨基-1-吡咯烷基)喹诺酮氨基酸前药的合成和构效关系

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国外医药（抗生素分册） 1993年第5期14卷 353-357页

作者： sanchez jP 韦舜雄

许多研究所仍在继续寻找理想的喹诺酮抗菌剂,即既具抗革兰氏阳性和阴性菌的广谱抗菌活性,又具抗分枝杆菌和厌氧菌活性,同时,副作用小,水溶性好,且口服有效。现已批准上市或已进入人体试验的喹诺酮(诺氟沙星,伊诺沙星、氧氟沙星、环丙沙... 详细信息

许多研究所仍在继续寻找理想的喹诺酮抗菌剂,即既具抗革兰氏阳性和阴性菌的广谱抗菌活性,又具抗分枝杆菌和厌氧菌活性,同时,副作用小,水溶性好,且口服有效。现已批准上市或已进入人体试验的喹诺酮(诺氟沙星,伊诺沙星、氧氟沙星、环丙沙星、洛美沙星、妥舒沙星、司帕沙星、WIN57273、Elinafloxacin)(图1)仍在继续增加。在这领域中已积累了许多经验,从而揭示了作用机理、构效关系、毒副作用等。并发现在喹诺酮7位上可用三种有效的碱性基因取代。许多喹诺酮在7位上都有1-哌嗪基。

关键词：喹诺酮合成构效关系

Projected effectiveness of HIV detection during early infection and rapid ART initiation among MSM and transgender women in Peru: A modeling study

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Infectious Disease Modelling 2019年第1期4卷 73-82页

作者： Dobromir Dimitrov Daniel Wood Angela Ulrich David A.Swan Blythe Adamson javier R.Lama jorge sanchez Ann Duerr Vaccine and Infectious Diseases Division Fred Hutchinson Cancer Research CenterSeattleWAUSA Department of Global Health University of WashingtonSeattleWAUSA Comparative Health Outcomes Policy&Economics(CHOICE)InstituteUniversity of WashingtonSeattleWAUSA Asociacion Civil Impacta Salud y Educacion LimaPeru Centro de Investigaciones Tecnologicas Biomedicas y MedioambientalesUniversidad Mayor de San MarcosLimaPeru

Background:The Sabes study,a treatment as prevention intervention in Peru,tested the hypothesis that initiating antiretroviral therapy(ART)early in HIV infection when viral load is high,would markedly reduce onward HIV transmission among high-risk men who have sex with men(MSM)and transgender women(TW).We investigated the potential population-level benefits of detection of HIV early after acquisition and rapid initiation of ***:We designed a transmission dynamic model to simulate the HIV epidemic among MSM and TW in Peru,calibrated to data on HIV prevalence and ART coverage from 2004 to *** assessed the impact of an intervention starting in 2018 in which up to 50%of the new infections were diagnosed within three months of acquisition and initiated on ART within 1 month of *** estimated the impact of the intervention over 20 years using the cumulative prevented fraction of new HIV infections compared to scenarios without ***:Our model suggests that only 19%of the infected MSM and TW are virally suppressed in 2018 and 35%e40%of the new HIV infections are transmitted from contacts with acutely-infected *** intervention reaching 10%of all acutely infected MSM and TW is projected to prevent 13.3%[Uncertainty interval:11.9%e14.3%]of the new infections over 20 years and reduce HIV incidence in 2038 by 24%.Reaching 50%of all acutely infected MSM and TWwill increase the prevalence of viral suppression in 2038 to 59%and prevent 41%of expected infections over 20 *** 50%of the high-risk MSM and TW in acute phase would reduce HIV incidence in 2038 by 60%and prevent 36%of new infections between 2018 and ***:Early detection of HIV infections and rapid initiation of ART among MSM is desirable as it would increase the effectiveness of the HIV prevention program in *** high-risk MSM and TW will be highly efficient.

关键词： Mathematical model Antiretroviral therapy HIV incidence HIV prevention

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WINDOWS图形编程

Comparison between type-2 and type-1 myocardial infarction：clinical features, treatment strategies and outcomes

2000年

作者：（美）（j.桑切斯）julio sanchez （美）（M.P.坎顿）Maria P.Canton 罗骏等译

本书分Windows API编程、API图形、Direct Draw编程及DirectX图形支持四部分，讲述了如何使用C++语言进行Windows编程及Windows图形处理。

ISBN: (纸本)7900625445

本书分Windows API编程、API图形、Direct Draw编程及DirectX图形支持四部分，讲述了如何使用C++语言进行Windows编程及Windows图形处理。

关键词：窗口软件 C语言程序设计图形语言

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journal of Geriatric Cardiology 2016年第1期13卷 15-22页

作者： Angel Lopez-Cuenca Miriam Gomez-Molina Pedro j Flores-Blanco Marianela sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-Gomez Maria j Sainchez-Galian Esther Guerrero-Perez Mariano Valdes Sergio Manzano-Femandez Department of Internal Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Division of Cardiology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain Department of lnternal Medicine University of Murcia Murcia Spain

Objective To assess the differences in incidence, clinical features, current treatment strategies and outcome in patients with type-2vs. type-1 acute myocardial infarction （AMI）.Methods We included 824 consecutive patients with a diagnosis of type-1 or type-2 AMI. Dur-ing index hospitalization, clinical features and treatment strategies were collected in detail. At 1-year follow-up, mortality, stroke, non-fatal myocardial infarction and major bleeding were ***-1 AMI was present in 707 （86%） of the cases while 117 （14%） were classified as type-2. Patients with type-2 AMI were more frequently female and had higher co-morbidities such as diabetes, previous non-ST segment elevation acute coronary syndromes, impaired renal function, anaemia, atrial fibrillation and malignancy. However, preserved left ventricular ejection fraction and normal coronary arteries were more frequently seen, an invasive treatment was less common, and anti-platelet medications, statins and beta-blockers were less prescribed in patients with type-2 AMI. At 1-year follow-up, type-2 AMI was associated with a higher crude mortality risk （HR： 1.75, 95% CI： 1.14-2.68;P = 0.001）, but this association did not remain significant after multivariable adjustment （P = 0.785）. Furthermore, we did not find type-2 AMI to be associated with other clinical *** In this real-life population, compared with type-1, type-2 AMI were predominantly women and had more co-morbidities. Invasive treatment strategies and cardioprotective medications were less used in type-2, while the 1-year clinical outcomes were similar.

关键词： Coronary vessels Follow-up studies Myocardial infarction

Magnetic resonance imaging findings of spontaneous pyomyoma in a premenopausal woman managed with myomectomy:A case report

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World journal of Radiology 2023年第3期15卷 83-88页

作者： David Martínez Gustavo E sanchez jhonatan Gómez Luis j Sonda Luis D Suárez Carlos S López juan j Vega Daniel A Cepeda Department of Radiology Hospital Christus MuguerzaPuebla 72501PueblaMexico Department of Radiology Hospital Regional Dr.Juan Graham CasasùsVillahermosa 86126TabascoMexico Department of Radiology Hospital de Especialidades 5 de MayoPuebla 72550PueblaMexico

BACKGROUND Acute fibroid complications are ***,failure to recognize and treat acute complications expeditiously when they occur can lead to catastrophic,even deadly,*** is a rare but potentially fatal condition resulting from infarction and infection of a fibroid through bacterial seeding and direct,hematogenous,or lymphatic *** though the diagnosis is established through clinical and laboratory findings,imaging is an important complementary method to support the suspected *** SUMMARY Herein,we report a case of a pyomyoma in a nulliparous woman previously diagnosed with uterine leiomyomatosis according to ultrasound *** patient had previously attended the emergency room due to hypogastric pain unresponsive to *** a week of persistent pain,she developed sepsis without any identifiable *** resonance imaging revealed findings compatible with uterine myomatosis with red degeneration,and a possible diagnosis of a pyomyoma was made according to the imaging findings along with the patient’s clinical *** decided to perform myomectomy(which is an infrequently performed surgical treatment due to the procedure’s intrinsic implic-ations)due to the patient’s desire to preserve *** results revealed a uterine leiomyoma with coagulative and liquefactive necrosis,while the tissue culture showed gram-negative cocci bacteria,which were successfully treated using antibiotic *** patient’s health status improved after several *** The main diagnostic tools to evaluate pyomyomas are the clinical and laboratory findings as well as tissue ***,magnetic resonance imaging can help to corroborate these findings as well as to better characterize myomas with its different complications.

关键词： Diffusion-weighted images Apparent diffusion coefficient Leiomyoma Sepsis Magnetic resonance imaging Case report

Properdin deficiency associated with systemic meningococcal disease due to a novel ***337Arg pathogenic variant

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Genes & Diseases 2024年第6期11卷 43-46页

作者： Laura Gonzalez-sanchez Ana Mei Agudo Anne Van Den Rym Maria Isabel Begiristain Alazne Saizar Rebeca Perez de Diego Pilar Nozal Alberto Lopez-Lera Margarita Lopez-Trascasa Fernando Corvillo Complement Research Group Hospital La Paz Institute for Health Research(ldiPAZ)La Paz University HospitalMadrid 28046Spain Center for Biomedical Network Research on Rare Diseases MadridSpain Laboratory of Immunogenetics of Human Diseases IdiPAz Institute for Health ResearchLa Paz University HospitalMadrid 28046Spain Ormaiztegui Clinic Guipuzcoa 20216Spain Immunology Unit La Paz University HospitalMadrid 28046Spain Departamento de Medicina Universidad Autonoma de MadridMadrid28029Spain

Properdin(FP)is a soluble glycoprotein with a key role in the regulation of the alternative pathway(AP)of the complement system.1 Neutrophils are the main source of FP,although monocytes,bone marrow progenitors,and T cells also synthesize this complement *** is codified by the gene CFP,located at Xp11.23-p11.3,and formed by 10 exons,of which exons 2 to 10 are translated conforming six thrombospondin type 1 repeats(TSR1-6).

关键词： Xp11.2 glycoprotein progenitor

Breaking paradigms: Long non-coding RNAs forming gene fusions with potential implications in cancer

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Genes & Diseases 2024年第3期11卷 311-323页

作者： David sanchez-Marin Macrina Beatriz Silva-Cazares Fany Iris Porras-Reyes Rebeca Garcia-Roman Alma D.Campos-Parra Posgrado en Ciencias Biologicas Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad de MexicoC.P.04360Mexico Unidad Academica Multidisciplinaria Region Altiplano Universidad Autonoma de San Luis Potost(UASLP)Carretera a Cedral Km 5+600Ejido San Jose de la TrojesMatehualaSan Luis PotosiC.P.78760Mexico Servicio de Anatomia Patologica Instituto Nacional de Cancerologia(INCan)Nino JesuisTlalpanCiudaddeMexicoC.P.14080Mexico Instituto de Salud Publica Universidad Veracruzana(UV)Av.Dr LuisDr.Castelazo Ayala s/nCol.Industrial AnimasXalapaVeracruzC.P.91190Mexico

Long non-coding RNAs(lncRNAs)are non-coding RNAs longer than 200 nucleotides with dynamic regulatory *** interact with a wide range of molecules such as DNA,RNA,and proteins to modulate diverse cellular functions through several mechanisms and,if deregulated,they can lead to cancer development and ***,it has been described that IncRNAs are susceptible to form gene fusions with mRNAs or other IncRNAs,breaking the paradigm of gene fusions consisting mainly of protein-coding ***,their biological significance in the tumor phenotype is still ***,their recent identification opens a new line of research to study their biological role in tumor-igenesis,and their potential as biomarkers with clinical relevance or as therapeutic *** present study aimed to review the IncRNA fusions identified so far and to know which of them have been associated with a potential *** address the current challenges to deepen their study as well as the reasons why they represent a future therapeutic window incancer.

关键词： Cancer Genefusions IncRNAs ncRNAs Therapy

Fiber laser with simultaneous multi-wavelength Er/Yb passively Q-switched and single-wavelength Tm gain-switched operations

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Photonics Research 2019年第6期7卷 608-614页

作者： j.ALANIZ-BAYLON M.DURAN-sanchez R.I.ALVAREZ-TAMAYO B.POSADA-RAMIREZ M.BELLO-jIMENEZ B.IBARRA-ESCAMILLA A.A.CASTILLO-GUZMAN E.A.KUZIN Instituto Nacional de Astrofísica óptica y Electrónica (INAOE)L. E. Erro 1 Sta. Ma. Tonantzintla Pue. 72824 Mexico CONACyT-Instituto Nacional de Astrofísica óptica y ElectrónicaA. P. 51 y 216 Pue. 72000 Mexico CONACyT-Universidad Autónoma de Nuevo León Av.Universidad S/NSan Nicolas de los Garza N. L. 66451 Mexico Instituto de Investigación en Comunicación óptica Universidad Autónoma de San Luis Potosí Av. Karakorum 1470 S. L. P. 78210 Mexico Universidad Autónoma de Nuevo León Av.Universidad S/NSan Nicolas de los Garza N. L. 66451 Mexico

We report the experimental investigation of an all-fiber multi-wavelength passively Q-switched Er/Yb laser with simultaneous gain-switched pulsed operation by using a thulium-doped fiber as a saturable *** emission is obtained in three wavelength regions with central peaks at around 1546 nm, 1561 nm, and1862 nm. Multi-wavelength emission with separation of approximately 1 nm is obtained around the wavelength regions of 1546 nm and 1561 nm. Stable laser pulses are generated in the pump power range from 3.6 W to7.3 W.

关键词： Fiber laser multi-wavelength