检索结果-南通市图书馆

Liver tissue engineering using decellularized scaffolds:Current progress,challenges,and opportunities

Bioactive Materials 2024年第10期40卷 280-305页

作者： Kamal H.Hussein Boyukkhanim Ahmadzada julio Cisneros Correa Ahmer Sultan Silvana Wilken Bruce Amiot Scott L.Nyberg Department of Surgery Mayo ClinicRochesterMNUnited States William J.von Liebig Center for Transplantation and Clinical Regeneration Mayo ClinicRochesterMNUnited States Department of Surgery Anesthesiologyand RadiologyCollege of Veterinary MedicineAssiut UniversityAssiutEgypt

Liver transplantation represents the only definitive treatment for patients with end-stage liver ***,the shortage of liver donors provokes a dramatic gap between available grafts and patients on the waiting *** liver bioengineering,an emerging field of tissue engineering,holds great potential to overcome this *** approach involves two main steps;the first is liver decellularization and the second is *** decellularization aims to remove cellular and nuclear materials from the organ,leaving behind extracellular matrices containing different structural proteins and growth factors while retaining both the vascular and biliary *** involves repopulating the decellularized liver with appropriate cells,theoretically from the recipient patient,to reconstruct the parenchyma,vascular tree,and biliary *** aim of this review is to identify the major advances in decellularization and recellularization strategies and investigate obstacles for the clinical application of bioengineered liver,including immunogenicity of the designed liver extracellular matrices,the need for standardization of scaffold fabrication techniques,selection of suitable cell sources for parenchymal repopulation,vascular,and biliary tree *** vivo transplantation models are also summarized for evaluating the functionality of bioengineered ***,the regulatory measures and future directions for confirming the safety and efficacy of bioengineered liver are also *** these challenges in whole liver bioengineering may offer new solutions to meet the demand for liver transplantation and improve patient outcomes.

关键词： Bioengineered liver Decellularization Recellularization Reendothelialization Biliary reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Growth plasticity of conifers did not avoid declining resilience to soil and atmospheric droughts during the 20th century

引用

Forest Ecosystems 2023年第2期10卷 238-251页

作者： Tong Zheng Jordi Martínez-Vilalta Raúl García-Valdés Antonio Gazol J.julio Camarero Changcheng Mu Maurizio Mencuccini Northeast Forestry University Harbin150040China CREAF E08193 Bellaterra(Cerdanyola del Vallès)CataloniaSpain Universitat Autònoma de Barcelona E08193 Bellaterra(Cerdanyola del Vallès)CataloniaSpain Centre de Ciència i Tecnologia Forestal de Catalunya(CTFC) E-25280SolsonaSpain Department of Biology GeologyPhysics and Inorganic ChemistryRey Juan Carlos University28933MóstolesMadridSpain Instituto Pirenaico de Ecologia(IPE-CSIC) Zaragoza50059Spain ICREA 08010BarcelonaSpain

Background:Plasticity in response to environmental drivers can help trees cope with ***,our understanding of the importance of plasticity and physiological adjustments in trees under global change is ***:We used the International Tree-Ring Data Bank(ITRDB)to examine 20th century growth responses in conifer trees during(resistance)and following(resilience)years of severe soil and atmospheric droughts occurring in isolation or as compound *** resilience indices were calculated using observed growth divided by expected growth to avoid spurious correlations,in which the expected values were obtained by the autoregressive moving average(ARIMA)*** used high atmospheric vapour pressure deficit(VPD)to select years of atmospheric drought and low annual values of the Standardized Precipitation-Evapotranspiration Index(SPEI)to select years with soil *** acquired the sensitivities(i.e.,the slopes of the relationships)by fitting the resilience indices as a function of environmental drivers,and assessed how these sensitivities changed over time for different types of drought events using linear mixed *** also checked whether plasticity in growth responses was sufficient to prevent long-term trends of growth reductions during or after severe *** acknowledge that by focusing on the response of surviving trees from the ITRDB we are potentially biasing our results towards higher resilience,as stand level responses(e.g.,mortality)may result in lowered competition after the disturbance ***:Sensitivities of resilience to VPD and SPEI changed throughout the 20th century,with the directions of these changes often reversing in the second half of the *** the 1961–2010 period,changing sensitivities had positive effects on resilience,especially following years of high-VPD and compound events,avoiding growth losses that would have occurred if sensitivities had remained *** sensitivity changes,resilience

关键词： Tree rings Growth Drought Vapor pressure deficit Plasticity Acclimation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NTR/NRX Define a New Thioredoxin System in the Nucleus of Arabidopsis thaliana Cells

引用

Molecular Plant 2014年第1期7卷 30-44页

作者： Corinne Marchal Valerie Delorme-Hinoux Laetitia Bariat Wafi Siala Christophe Belin julio Saez-Vasquez Christophe Riondet Jean-Philippe Reichheld Universite Perpignan Via Domitia CNRS Laboratoire Genome et Developpement des Plantes UMR 5096 58 Avenue Paul Alduy-Bat T F-66860 Perpignan France Pharmacologie cellulaire et moleculaire Louvain Drug Research Institute Universite catholique de Louvain Brussels Belgium

Thioredoxins （TRX） are key components of cellular redox balance, regulating many target proteins through thiol/disulfide exchange reactions. In higher plants, TRX constitute a complex multigenic family whose members have been found in almost all cellular compartments. Although chloroplastic and cytosolic TRX systems have been largely studied, the presence of a nuclear TRX system has been elusive for a long time. Nucleoredoxins （NRX） are potential nuclear TRX found in most eukaryotic organisms. In contrast to mammals, which harbor a unique NRX, angiosperms gen- erally possess multiple NRX organized in three subfamilies. Here, we show thatArabidopsis thaliana has two NRXgenes （AtNRX1 and AtNRX2）, respectively, belonging to subgroups I and III. While NRX1 harbors typical TRX active sites （WCG/ PPC）, NRX2 has atypical active sites （WCRPC and WCPPF）. Nevertheless, both NRXl and NRX2 have disulfide reduction capacities, although NRX1 alone can be reduced by the thioredoxin reductase NTRA. We also show that both NRX1 and NRX2 have a dual nuclear/cytosolic localization. Interestingly, we found that NTRA, previously identified as a cytosolic protein, is also partially localized in the nucleus, suggesting that a complete TRX system is functional in the nucleus. We show that NRX1 is mainly found as a dimer in vivo. nrxl and nrx2 knockout mutant plants exhibit no phenotypic perturbations under standard growth conditions. However, the nrxl mutant shows a reduced pollen fertility phenotype, suggesting a specific role of NRX1 at the haploid phase.

关键词： thioredoxin nucleoredoxin nucleus Arabidopsis.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats

引用

Asian Journal of Andrology 2003年第4期5卷 349-352页

作者： Gustavo F. Gonzales julio Rubio Arturo Chung Manuel Gasco León Villegas Department of Biological and physiological Sciences Faculty of Sciences and Philosophy and Instituto de Investigaciones de la Altura Department of Biochemistry Molecular Biology and Pharmacology Universidad Peruana Cayetano HerediaLima Peru

Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats. Methods: In Holtzman rats, Maca alcoholic extract (5%) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats.

关键词： Lepidium meyenii transillumination spermatogenesis sperm count

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neuroprotective effect of Neuro-EPO in neurodegenerative diseases:“Alea jacta est”

引用

Neural Regeneration Research 2019年第9期14卷 1519-1521页

作者： Ramón Rama Fernando Garzón Yamila Rodríguez-Cruz Tangui Maurice julio-César García-Rodríguez Department of Cell Biology Physiology and ImmunologyUniversity of BarcelonaBarcelonaSpain Department of Animal Health University of NarinoPastoNarinoColombia Department of Histology University of Medical SciencesHavanaCuba MMDN Univ MontpellierINSERMEPHEUMR_S1198MontpellierFrance CENPALAB National Center for Animals BreedingHavanaCuba

Our common home,planet Earth,is inhabited by more than 7 billion human *** average life expectancy currently estimated for men is^69 years,with strong differences among ***,neurodegenerative diseases are currently the leading cause of death and disability *** clinical use and neuroscience research,a solution for an effective diagnosis is in progress,but a prophylactic treatment to counteract this long-lasting plague for humanity is still unidentified.

关键词： Our common home neurodegenerative still unidentified

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-pressure scheelite-type polymorph of SmCrO_4: synthesis, structural characterization and magnetic properties

引用

Journal of Rare Earths 2010年第6期28卷 936-939页

作者： Regino Sáez-Puche Mahmoud Gamal Rabie julio Romero de Paz José-Manuel Gallardo-Amores Esteban Climent Pascual Department of Inorganic Chemistry Faculty of Chemical Sciences Complutense University of Madrid Ciudad Universitaria

The new scheelite form of SmCrO4 oxide was obtained by heating the zircon-type SmCrO4 oxide at 4 GPa and 803 K. X-ray diffraction revealed that this scheelite SmCrO4 phase crystallized with tetragonal symmetry, S.G. I41/a and lattice parameters: a=0.50776(3) nm and c=1.15606(2) nm. This structural phase transition from zircon to scheelite involved a decreasing of around 10% in the unit cell volume. Although the Cr-O and Sm-O distances did not change very much in both zircon and scheelite polymorphs, the changes occurred in the bond angles were remarkable that appear to support the proposed reconstructive model to explain this structural zircon-scheelite phase transition. Magnetic susceptibility and magnetization measurements revealed that the scheelite SmCrO4 oxide behaved an antiferromagnetic material, where the Sm3+ and Cr5+ were simultaneously ordered. The estimated Néel temperature, TN, was 16 K and the critical field at 12 K associated with the metamagnetic transition was 3.2 T.

关键词： scheelite-type structure zircon-type structure high pressure synthesis antiferromagnetic behaviour metamagnetic transition rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease:A systematic review and meta-analysis

引用

Journal of Sport and Health Science 2021年第6期10卷 609-619,F0003页

作者： Yasmin Ezzatvar MikelIzquierdo julio Núñez Joaquín Calatayud Robinson Ramírez-Vélez Antonio García-Hermoso Exercise Intervention for Health Research Group(EXINH-RG) Department of PhysiotherapyUniversitat de ValènciaValencia 46010Spain Navarrabiomed Navarra Hospital Complex(CHN)Public University of Navarra(UPNA)Navarra Medical Research Institute(IdiSNA)Pamplona 31008Spain CIBER of Frailty and Healthy Aging(CIBERFES) Instituto de Salud Carlos IIIMadrid 28029Spain Department of Cardiology Valencia University HospitalBiomedical Research Institute(INCLIVA)Valencia 46010Spain CIBER in Cardiovascular Diseases(CIBERCV) Madrid 28029Spain Sciences of Physical Activity Sports and Health SchoolUniversity of Santiago of Chile(USACH)Santiago 71783-5Chile

Background Cardiorespiratory fitness(CRF)is inversely associated with mortality in apparently healthy subjects and in some clinical populations,but evidence for the association between CRF and all-cause and/or cardiovascular disease(CVD)mortality in patients with established CVD is *** study aimed to quantify this *** We searched for prospective cohort studies that measured CRF with cardiopulmonary exercise testing in patients with CVD and that examined all-cause and CVD mortality with at least 6 months of *** hazard ratios(HRs)were calculated using random-effect inverse-variance *** Data were obtained from 21 studies and included 159,352 patients diagnosed with CVD(38.1%female).Pooled HRs for all-cause and CVD mortality comparing the highest *** category of CRF were 0.42(95%confidence interval(95%CI):0.28–0.61)and 0.27(95%CI:0.16–0.48),*** HRs per 1 metabolic equivalent(1-MET)increment were significant for all-cause mortality(HR=0.81;95%CI:0.74–0.88)but not for CVD mortality(HR=0.75;95%CI:0.48–1.18).Coronary artery disease patients with high CRF had a lower risk of all-cause mortality(HR=0.32;95%CI:0.26–0.41)than did their unfit *** 1-MET increase was associated with lower all-cause mortality risk among coronary artery disease patients(HR=0.83;95%CI:0.76–0.91)but not lower among those with heart failure(HR=0.69;95%CI:0.36–1.32).Conclusion A better CRF was associated with lower risk of all-cause mortality and *** study supports the use of CRF as a powerful predictor of mortality in this population.

关键词： Cardiopulmonary fitness Coronary artery disease Exercise capacity Heart failure Survival

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clinical heterogeneity in autoimmune acute liver failure

引用

World Journal of Gastroenterology 2007年第12期13卷 1824-1827页

作者： Norberto C Chavez-Tapia julio Martinez-Salgado julio Granados Misael Uribe Felix I Tellez-Avila Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City MexicoJulio Granados Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico

AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.

关键词： Autoimmune hepatitis Acute liver failure Corticosteroids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New therapeutic strategy with extracorporeal membrane oxygenation for refractory hepatopulmonary syndrome after liver transplant: A case report

引用

World Journal of Transplantation 2024年第1期14卷 210-214页

作者： Belinda Sánchez Pérez María Pérez Reyes Jose Aranda Narvaez julio Santoyo Villalba Jose Antonio Perez Daga Claudia Sanchez-Gonzalez julio Santoyo-Santoyo Hepatobiliary and Trasplantation Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Department of General and Digestive Surgery Regional University Hospital of MalagaMalaga 29010Spain

BACKGROUND Due to the lack of published literature about treatment of refractory hepatopulmonary syndrome(HPS)after liver transplant(LT),this case adds information and experience on this issue along with a treatment with positive *** is a complication of end-stage liver disease,with a 10%-30%incidence in cirrhotic *** can reverse the physiopathology of this process and restore normal ***,in some cases,refractory hypoxemia persists,and extracorporeal membrane oxygenation(ECMO)can be used as a rescue therapy with good *** SUMMARY A 59-year-old patient with alcohol-related liver cirrhosis and portal hypertension was included in the LT waiting list for *** had good liver function(Model for End-Stage Liver Disease score 12,Child-Pugh class B7).He had pulmonary fibrosis and a mild restrictive respiratory pattern with a basal oxygen saturation of 82%.The macroaggregated albumin test result was>*** demonstrated a forced expiratory volume in one second(FEV1)of 78%,forced vital capacity(FVC)of 74%,FEV1/FVC ratio of 81%,diffusion capacity for carbon monoxide of 42%,and carbon monoxide transfer coefficient of 57%.He required domiciliary oxygen at 2 L/min(16 h/d).The patient was admitted to the intensive care unit(ICU)and extubated in the first 24 h,needing high-flow therapy and non-invasive ventilation and inhaled nitric oxide *** was needed after 72 *** to the non-response to supportive therapies,installation of ECMO was decided with progressive recovery after 9 *** was possible on the tenth day,maintaining a high-flow nasal cannula and de-escalating to conventional oxygen therapy after 48 *** was discharged from ICU on postoperative day(POD)20 with a 90%-92%oxygen *** recycling was needed twice for acute *** patient was discharged from hospital on POD 27 with no symptoms,with an 89%-90%oxygen *** Due to the favorable results observed,ECMO could bec

关键词： Liver transplantation Hepatopulmonary syndrome Refractory hypoxemia Treatment Extracorporeal membrane oxygenation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Scientometric Approach to Analyze Scientific Development on Renewable Energy Sources

引用

Journal of Data and Information Science 2021年第1期6卷 87-119页

作者： Jones Luís Schaefer julio Cezar Mairesse Siluk Ismael Cristofer Baierle Elpidio Oscar Benitez Nara Universidade Federal de Santa Maria Avenida Roraima1000Santa Maria 97105-900Brazil Universidade de Santa Cruz do Sul Avenida Independencia2293Santa CruzRS 96815-900Brazil

Purpose: This paper aims to point out the scientific development and research density of renewable energy sources such as photovoltaic, wind, and biomass, using a mix of computational tools. Based on this, it was possible to verify the existence of new research trends and opportunities in a macro view regarding management, performance evaluation, and decision-making in renewable energy generation systems and ***/methodology/approach: A scientometric approach was used based on a research protocol to retrieve papers from the Scopus database, and through four scientometric questions, to analyze each area. Software such as the Science Mapping Analysis Software Tool(Sci MAT) and Sci2 Tool were used to map the science development and ***: The scientific development of renewable energy areas is highlighted, pointing out research opportunities regarding management, studies on costs and investments, systemic diagnosis, and performance evaluation for decision-making in businesses in these *** limitations: This paper was limited to the articles indexed in the Scopus database and by the questions used to analyze the scientific development of renewable energy *** implications: The results show the need for a managerial perspective in businesses related to renewable energy sources at the managerial, technical, and operational levels, including performance evaluation, assertive decision making, and adequate use of technical and financial ***/value: This paper shows that there is a research field to be explored, with gaps to fill and further research to be carried out in this area. Besides, this paper can serve as a basis for other studies and research in other areas and domains.

关键词： Solar energy Photovoltaic energy Wind energy Biomass energy Scientometrics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：