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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-Navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández julio virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International Collaborative Donor Project ('Proyecto Colaborativo Internacional Donante' 30007 Casillas Murcia Spain Department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant Centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital Clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain Department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain Department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de Navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de Cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de Cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain Departamento de Cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (Complejo Hospitalario Universitario de Canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain Departamento de Ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PCID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).CONCLUSION: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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Karyotype analysis and polyploidy in Palaua and a comparison with its sister group Fuertesimalva(Malvaceae)

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Journal of Systematics and Evolution 2010年第3期48卷 175-182页

作者： julio V SCHNEIDER Marilú L HUERTAS Systematic Botany Biologie IUniversity of Leipzig Botany and Molecular Evolution Research Institute and Natural History Museum Senckenberg and Johann Wolfgang Goethe-Universitt

Palaua(Malveae,Malvaceae)comprises 15 species endemic to the hyperarid coastal desert of Chile and *** far,chromosome counts have been known for two diploid species(2n=2x=10)*** we report new chromosome numbers for 12 species of Palaua and four of its sister group *** including 4,6-diamidino-2-phenylindole dihydrochloride(DAPI)/chromomycin(CMA3)fluorescent banding are presented for selected species representative of each of the main clades of *** important finding is the discovery of polyploids in one exclusively tetraploid species(***)and four species with mixed diploid and tetraploid cytotypes(***,***,***,and ***).The diploid and tetraploid karyotypes are all unimodal,symmetrical and show one or two pairs of satellite chromosomes with their associated CMA+/DAPI- band depending on the *** some of the tetraploids an autopolyploid origin is suggested.

关键词： autopolyploidy chromosome base number desert fluorochrome staining lomas Malveae Urocarpidium.

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Genome Organization and Function： A View from Yeast and Arabidopsis

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Molecular Plant 2010年第4期3卷 678-690页

作者： julio Saez-Vasquez Olivier Gadal LGDP-UMR 5096 CNRS-IRD-Universite de Perpignan via Dornitia 58 Av. Paul Alduy 66860 Perpignan France Laboratoire de Biologie Moleculaire Eucaryote Universite de Toulouse Toulouse France LBME CNRS Toulouse France

Recent progress in understanding higher-order chromatin organization in the nucleus has been considerable. From single gene to chromosome territory, realistic biophysical models can now accurately predict some of the structural feature of cell nuclei. Despite growing evidence of a deterministic nuclear organization, the physiological consequence of spatial genome organization is still unclear. In the simple eukaryotic model, Saccharomyces cerevisiae, clear correlation between gene position and transcription has been established. In this review, we will focus on higher-order chromatin organization in yeast with respect to the nuclear envelope and nucleolus. In Arabidopsis thaliana, a model plant for which we have a complete genome sequence, chromosome territory （CT） arrangement and somatic homologous pairing in interphase nuclei seem to occur randomly. Since chromosomes containing nucleolar organizer regions associate more frequently to form a single nucleolar structure, as in yeast, the nucleolus seems to play a major role in organizing nuclear space. Recent findings have begun to elucidate how plant regulatory factors, such as chromatin remodeling or histone chaperones, affect the chromatin state of ribosomal DNA genes located in two distinct CTarrangements in the nucleus. The functional outcome of yeast nuclear organization allowed us to propose how nuclear organization might contribute to a novel type of epigenetic regulation： the spatial regulation of transcription.

关键词： Nuclear structure chromatin organization nuclear body nucleolus.

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Prefoldins 3 and 5 Play an Essential Role in Arabidopsis Tolerance to Salt Stress

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Molecular Plant 2009年第3期2卷 526-534页

作者： Miguel A. Rodriguez-Milla julio Salinas Departamento de Biologfa de Plantas Centro de Investigaciones Biologicas-CSIC Ramiro de Maeztu 9 28040 Madrid Spain

During the last years, our understanding of the mechanisms that control plant response to salt stress has been steadily progressing. Pharmacological studies have allowed the suggestion that the cytoskeleton may be involved in regulating such a response. Nevertheless, genetic evidence establishing that the cytoskeleton has a role in plant tolerance to salt stress has not been reported yet. Here, we have characterized Arabidopsis T-DNA mutants for genes encoding proteins orthologous to prefoldin （PFD） subunits 3 and 5 from yeast and mammals. In these organisms, PFD subunits, also known as Genes Involved in Microtubule biogenesis （GIM）, form a heterohexameric PFD complex implicated in tubulin and actin folding. We show that, indeed, PFD3 and PFD5 can substitute for the loss of their yeast orthologs, as they are able to complement yeast gim2Δ and gim5Δ mutants, respectively. Our results indicate that pfd3 and pfd5 mutants have reduced levels of α- and β-tubulin compared to the wild-type plants when growing under both control and salt-stress conditions. In addition, pfd3 and pfd5 mutants display alterations in their developmental patterns and microtubule organization, and, more importantly, are hypersensitive to high concentrations of NaCl but not of LiCl or mannitol. These results demonstrate that the cytoskeleton plays an essential role in plant tolerance to salt stress.

关键词： Prefoldins cytoskeleton tubulin actin microtubule salt tolerance Arabidopsis

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Inconsistencies in four-dimensional Einstein-Gauss-Bonnet gravity

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Chinese Physics C 2021年第1期45卷 89-96页

作者： julio Arrechea Adria Delhom Alejandro Jimenez-Cano Instituto de Astrofisica de Andalucia(IAA-CSIC) Glorieta de la AstronomiaGranadaSpain Departamento de Fisica Teorica and IFIC Centro Mixto Universidad de Valencia-CSIC.Universidad de ValenciaBuijassot-46100ValenciaSpain Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada18071 GranadaSpain

We attempt to clarify several aspects concemi ng the recently presented four-dimensional Ein stein-Gauss-Bonnet *** argue that the limiting procedure outlined in[***.124,081301(2020)]generally involves ill-defined terms in the four dimensional field *** ways to circumvent this issue are discussed,alongside remarks regarding specific solutions of the *** prove that,although linear perturbations are well behaved around maximally symmetric backgrounds,the equations for second-order perturbations are illdefined even around a Minkowskia n *** on ally,we perform a detailed analysis of the spherically symmetric solutions and find that the central curvature singularity can be reached within a finite proper time.

关键词： alternative theories of gravity singularities Einstein・Gauss-Bonnet

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Linear OPF-based Robust Dynamic Operating Envelopes with Uncertainties in Unbalanced Distribution Networks

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1320-1326页

作者： Bin Liu julio H.Braslavsky Nariman Mahdavi Energy Centre Commonwealth Scientific and Industrial Research Organisation(CSIRO)Newcastle 2300Australia the Network Planning Division TransgridSydney 2000Australia the Energy Systems Program Energy CentreCommonwealth Scientific and Industrial Research Organisation(CSIRO)Newcastle 2300Australia

Dynamic operating envelopes(DOEs),as key enablers to facilitate distributed energy resource(DER)integration,have attracted increasing attention in the past ***,uncertainties,which may come from load forecasting errors or inaccurate network parameters,have been rarely discussed in DOE calculation,leading to compromised quality of the hosting capacity allocation *** letter studies how to calculate DOEs that are immune to such uncertainties based on a linearised unbalanced three-phase optimal power flow(UTOPF)*** uncertain parameters constrained by norm balls,formulations for calculating robust DOEs(RDOEs)are presented along with discussions on their *** cases,including a 2-bus illustrative network and a representative Australian network,are tested to demonstrate the effectiveness and efficiency of the proposed approach.

关键词： Distributed energy resource(DER) dynamic operating envelope(DOE) feasible region robust optimisation uncertainty modelling unbalanced optimal power flow

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SIMPLE COMPUTING OF THE CUSTOMER LIFETIME VALUE:A FIXED LOCAL-OPTIMAL POLICY APPROACH

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Journal of Systems Science and Systems Engineering 2014年第4期23卷 439-459页

作者： julio B.Clempner Alexander S.Poznyak Center for Economics Management and Social Research Department of Control Automatics Center for Research and Advanced Studies

In this paper,we present a new method for finding a fixed local-optimal policy for computing the customer lifetime *** method is developed for a class of ergodic controllable finite Markov *** propose an approach based on a non-converging state-value function that fluctuates（increases and decreases） between states of the dynamic *** prove that it is possible to represent that function in a recursive format using a one-step-ahead fixed-optimal ***,we provide an analytical formula for the numerical realization of the fixed local-optimal *** also present a second approach based on linear programming,to solve the same problem,that implement the c-variable method for making the problem computationally *** the end,we show that these two approaches are related：after a finite number of iterations our proposed approach converges to same result as the linear programming *** also present a non-traditional approach for ergodicity *** validity of the proposed methods is successfully demonstrated theoretically and,by simulated credit-card marketing experiments computing the customer lifetime value for both an optimization and a game theory approach.

关键词： Customer lifetime value optimization optimal policy method linear programming ergodic controllable Markov chains asynchronous games

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Encroachment drives facilitation at alpine shrublines

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Forest Ecosystems 2024年第1期11卷 62-72页

作者： Yafeng Wang Eryuan Liang J.julio Camarero College of Ecology and Environment Nanjing Forestry UniversityNanjing210037China State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing100101China Instituto Pirenaico de Ecología(IPE-CSIC) Zaragoza50080Spain

Ongoing encroachment is driving recent alpine shrubline dynamics globally,but the role of shrub-shrub interactions in shaping shrublines and their relationships with stem density changes remain poorly ***,the size and age of shrubs from 26 Salix shrubline populations along a 900-km latitudinal gradient(30°-38°N)were measured and mapped across the eastern Tibetan *** pattern analyses were used to quantify the spatial distribution patterns of juveniles and adults,and to assess spatial associations between *** intensity of univariate and bivariate spatial patterns was related to biotic and abiotic *** mark correlation functions with a quantitative mark(shrub height,basal stem diameter,crown width)were also employed to investigate the spatial relationships between shrub traits of juveniles and *** equation models were used to explore the relationships among conspecific interactions,patterns,shrub traits and recruitment dynamics under climate *** shrublines showed clustered patterns,suggesting the existence of conspecific *** patterns of juveniles and conspecific interactions(potentially facilitation)tended to intensify with increasing soil moisture *** warming before 2010 triggered positive effects on population interactions and spatial patterns via increased shrub ***,summer warming after2010 triggered negative effects on interactions through reduced shrub ***,shrub recruitment shifts under rapid climate change could impact spatial patterns,alter conspecific interactions and modify the direction and degree of shrublines responses to *** changes would have profound implications for the stability of alpine woody ecosystems.

关键词： Alpine shrubline Positive interactions Facilitation Spatial clustering Point pattern analyses

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Interpenetrating polymers supported on microporous polypropylene membranes for the transport of chromium ions

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Chinese Journal of Chemical Engineering 2017年第7期25卷 938-946页

作者： Yesid Tapiero julio Sánchez BernabéL.Rivas Polymer Department Faculty of ChemistryUniversity of ConcepdonCasilla 160-C ConcepcionChile

Modifying polypropylene membranes with interpenetrating polymer networks(IPNs) through the incorporation of poly(glycidyl methacrylate-N-methyl-D-glucamine)(P(GMA-NMG)) was performed by in situ synthesis via radical polymerization. The surface of the polypropylene membrane was activated by hydrophilic grafted polyelectrolyte, and then, pressure injection was used for the impregnation of the reactive solution in the *** types of pore-filled membranes were synthesized, chelating interpenetrating homopolymer networks of P(GMA-NMG), and chelating-ion exchange interpenetrating polymer networks(e.g., P(GMA-NMG)/P(AA),P(GMA-NMG)/P(AMPSA), and P(GMA-NMG)/P(Cl VBTA)). After their synthesis, the modified polypropylene membranes were characterized using techniques such as the electrokinetic potential, SEM, FT-IR, and Donnan dialysis to corroborate the chromium ion transport. The P(GMA-NMG) and complex network membranes exhibited a hydrophilic character with a water-uptake capacity between 20% and 35% and a percentage of modification between 4.0% and 7.0% in comparison with the behavior of the unmodified polypropylene *** chromium ions were efficiently transported from the food chamber at p H 9.0 when the 65.2%MTA1 P(Cl VBTA) homopolymer IPN membrane and 48.5% MTAG P(GMA-NMG)/P(Cl VBTA) IPN membrane were used. Similarly, hexavalent chromium ions were removed from the food chamber at pH 3.0 when MTAG(63.30%) and MTA1(35.68%) were used in 1 mol·L^(-1)Na Cl solution as the extraction reagent.

关键词： Polypropylene N-methyI-D-glucamine Ion exchange Donnan dialysis Interpenetrating polymer networks Chromium

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Clinical heterogeneity in autoimmune acute liver failure

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World Journal of Gastroenterology 2007年第12期13卷 1824-1827页

作者： Norberto C Chavez-Tapia julio Martinez-Salgado julio Granados Misael Uribe Felix I Tellez-Avila Department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City MexicoJulio Granados Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City Mexico

AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids.

关键词： Autoimmune hepatitis Acute liver failure Corticosteroids

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