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Rotational Dynamics: An Exciting Challenge

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World Journal of Mechanics 2017年第3期7卷 68-84页

作者： julio cano Advanced Dynamics C.B. Madrid Spain

This paper presents the reference criteria of rotational dynamics of accelerated systems in the field of Rational Mechanics, exposing the differentiation between inertial and non-inertial dynamic systems, and describes the unique research project developed by Advanced Dynamics CB up to proposing the Theory of Dynamic Interactions. This paper aims to deliver a commentary on developments in the field of rotational dynamics. Professor Barceló proposes that in today’s physics, a change of mindset is necessary that allows us to accept the true behavior of mobile objects subject to non-coaxial speed variations. The proposed dynamic allows us understand certain effects of rotating bodies. The application of these dynamic hypotheses to other fields of physics and technology will possibly allow new and suggestive advances in research, especially to bodies and systems with rotation in astrophysics and astronautics, allowing new dynamic working hypotheses.

关键词： Rotational Motion Dynamic Interactions Rotational Inertia Accelerated Systems Angular Displacement

The Pendulum of Dynamic Interactions

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Journal of Applied Mathematics and Physics 2015年第9期3卷 1186-1198页

作者： julio cano Lacunza Advanced Dynamics CB Madrid Spain

In this paper, we present evidence to show that the dynamics of rigid solid bodies is not a closed discipline, particularly in the field of rotational dynamics. From the observation of bodies with intrinsic rotation in our universe, our research group proposes new dynamic hypotheses that explain the behaviour observed when these bodies are subject to new simultaneous non-coaxial rotations. A new gyroscopic conical pendulum was designed for this purpose. Experimental tests initially conducted with this new gyroscopic conical pendulum were repeated for their recording on video, which accompanied this paper for better understanding thereof. These experimental tests positively confirm the new Theory of Dynamic Interactions, and its dynamic laws, which help us to understand the behaviour of this pendulum and, in general, that of the baryonic mass when it is subject to non-coaxial simultaneous rotations. It thus provides a better understanding of the nature and the dynamic behaviour of our universe.

关键词： Theory of Dynamic Interactions Rotating Bodies Non-Coaxial Spins Dynamic Interactions

Inconsistencies in four-dimensional Einstein-Gauss-Bonnet gravity

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Chinese Physics C 2021年第1期45卷 89-96页

作者： julio Arrechea Adria Delhom Alejandro Jimenez-cano Instituto de Astrofisica de Andalucia(IAA-CSIC) Glorieta de la AstronomiaGranadaSpain Departamento de Fisica Teorica and IFIC Centro Mixto Universidad de Valencia-CSIC.Universidad de ValenciaBuijassot-46100ValenciaSpain Departamento de Fisica Teorica y del Cosmos and CAFPE Universidad de Granada18071 GranadaSpain

We attempt to clarify several aspects concemi ng the recently presented four-dimensional Ein stein-Gauss-Bonnet *** argue that the limiting procedure outlined in[***.124,081301(2020)]generally involves ill-defined terms in the four dimensional field *** ways to circumvent this issue are discussed,alongside remarks regarding specific solutions of the *** prove that,although linear perturbations are well behaved around maximally symmetric backgrounds,the equations for second-order perturbations are illdefined even around a Minkowskia n *** on ally,we perform a detailed analysis of the spherically symmetric solutions and find that the central curvature singularity can be reached within a finite proper time.

关键词： alternative theories of gravity singularities Einstein・Gauss-Bonnet

Matrix metalloproteases and their tissue inhibitors in non-alcoholic liver fibrosis of human immunodeficiency virus-infected patients

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World Journal of Virology 2017年第2期6卷 36-45页

作者： julio Collazos Eulalia Valle-Garay Tomás Suárez-Zarracina Angel-Hugo Montes José A Cartón Víctor Asensi Infectious Diseases Hospital de Galdácano Biochemistry and Molecular Biology Hospital Universitario Central de AsturiasOviedo University School of Medicine Infectious Diseases Hospital Universitario Central de AsturiasOviedo University School of Medicine

AIM To investigate the relationships among diverse metalloproteases(MMPs) and their tissue inhibitors(TIMPs) and non-alcoholic liver fibrosis in human immunodeficiency virus(HIV)-infected *** Single nucleotide polymorphisms(SNPs) in MMPs, TNF-α and CCR5 genes, and serum levels of MMPs and TIMPs were determined in HIV-infected individuals with/out hepatitis C virus(HCV) coinfection. A total of 158 patients were included, 57 of whom were HCVcoinfected. All patients drank < 50 g ethanol/day. Diverse SNPs(MMP-1-1607 1G/2G, MMP-8-799C/T, MMP-9-1562 C/T, MMP-13-77A/G, TNF-α-308 G/A,CCR5-?32), and serum levels of MMPs(2, 3, 8, 9 and 10) and TIMPs(1, 2 and 4) were assessed. Liver fibrosis was determined by transient elastometry, although other non-invasive markers of fibrosis were also considered. Significant liver fibrosis(F ≥ 2) was defined by a transient elastometry value ≥ 7.1 kP *** A total of 34 patients(21.5%) had liver fibrosis ≥ F2. MMP-2 and TIMP-2 serum levels were higher in patients with liver fibrosis ≥ F2(P = 0.02 and P = 0.03, respectively) and correlated positively with transient elastometry values(P = 0.02 and P = 0.0009, respectively), whereas MMP-9 values were negatively correlated with transient elastometry measurements(P = 0.01). Multivariate analyses showed that high levels of MMP-2(OR = 2.397; 95%CI: 1.191-4.827, P = 0.014) were independently associated with liver fibrosis ≥ F2 in the patients as a whole. MMP-2(OR = 7.179; 95%CI: 1.210-42.581, P = 0.03) and male gender(OR = 10.040; 95%CI: 1.621-62.11, P = 0.013) were also independent predictors of fibrosis ≥ F2 in the HCV-infected subgroup. Likewise, MMP-2, TIMP-2 and MMP-9 were independently associated with transient elastometry values and other non-invasive markers of liver fibrosis. None of the six SNPs evaluated had any significant association with liver fibrosis ≥ *** Certain MMPs and TIMPs, particularly MMP-2, seems to be associated with non-alcoholic liver fibrosis

关键词： Human immunodeficiency virus Hepatitis C virus Liver fibrosis Transient elastometry Noninvasive fibrosis markers Metalloproteases Their tissue inhibitors Genetic polymorphisms

Can antiretroviral therapy be tailored to each human immunodeficiency virus-infected individual? Role of pharmacogenomics

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World Journal of Virology 2015年第3期4卷 169-177页

作者： Victor Asensi julio Collazos Eulalia Valle-Garay Infectious Diseases-HIV Unit Hospital Universitario Central de AsturiasOviedo University School of Medicine Infectious Diseases Unit Hospital de Galdácano Biochemistry and Molecular Biology Department Oviedo University School of Medicine

Pharmacogenetics refers to the effect of single nucleotide polymorphisms(SNPs) within human genes on drug therapy outcome. Its study might help clinicians to increase the efficacy of antiretroviral drugs by improving their pharmacokinetics and pharmacodynamics and by decreasing their side effects. HLAB*5701 genotyping to avoid the abacavir-associated hypersensitivity reaction(HSR) is a cost-effective diagnostic tool, with a 100% of negative predictive value, and, therefore, it has been included in the guidelines for treatment of human immunodeficiency virus(HIV) infection. HALDRB*0101 associates with nevirapine-induced HSR. CYP2B6 SNPs modify efavirenz plasma levels and their genotyping help decreasing its central nervous system, hepatic and HSR toxicities. Cytokines SNPs might influence the development of drug-associated lipodystrophy. APOA5, APOB, APOC3 and APOE SNPs modify lipids plasma levels and might influence the coronary artery disease risk of HIV-infected individuals receiving antiretroviral therapy. UGT1A1*28 and ABCB1(MDR1) 3435 C > T SNPs modify atazanavir plasma levels and enhance hyperbilirubinemia. Much more effort needs to be still devoted to complete large prospective studies with multiple SNPs genotyping in order to reveal more clues about the role played by host genetics in antiretroviral drug efficacy and toxicity.

关键词： Pharmacogenomics Pharmacokinetics Antiretroviral drugs Adverse effects Human immunodeficiency virus infection Single nucleotide polymorphisms