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可遗传编码的荧光探针用于在体快速特异地检测去甲肾上腺素

中国生理学会张锡钧基金第十五届全国青年优秀生理学学术论文交流及评奖会议;中国生理学会第十三届全国青年生理学工作者学术会议

作者： Jiesi Feng julieta e.lischinsky Tongrui Qian Jingheng Zhou Guohong Cui Dayu Lin Yulong Li State Key Laboratory of Membrane Biology Peking University School of Life Sciences Neuroscience Institute New York University School of Medicine Neurobiology Laboratory National Institute of Environmental Health SciencesNational Institutes of HealthResearch Triangle Park

Norepinephrine (Ne) plays important roles in a wide range of physiological processes,including conducting sensory information,regulating the sleep-wake/arousal state,and mediating attentional function in the brain,as well as modulating heart function and blood pressure in the sympathetic nervous *** of the noradrenergic signaling is implicated in diseases such as stress,depression,ADHD,and ***,the precise dynamics and regulation remain poorly

关键词： New generation of GRAB sensors enable sensitive and specific monitoring of norepinephrine in vivo

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科学新闻 2020年第2期 89-89页

作者：李毓龙冯杰思 Changmei Zhang julieta e.lischinsky Miao Jing Jingheng Zhou Huan Wang Yajun Zhang Ao Dong Zhaofa Wu Hao Wu Weiyu Chen Peng Zhang Jing Zou S.Andrew Hires 朱骏崔国红林大宇杜久林北京大学生命科学学院北大—清华生命科学联合中心北京大学—IDG/麦戈文脑科学研究所李毓龙研究组南加州大学弗吉尼亚大学医学院美国国立卫生研究院纽约大学中国科学院神经科学研究所

文章简介在人的神经系统中有数十亿个神经元,这些细胞主要通过神经递质的释放和感知完成相互之间的通讯。去甲肾上腺素(Norepinephrine, Ne)是一种单胺类的神经递质,它作用于多种肾上腺素受体。在中枢神经系统和交感神经系统中都参与诸... 详细信息

文章简介在人的神经系统中有数十亿个神经元,这些细胞主要通过神经递质的释放和感知完成相互之间的通讯。去甲肾上腺素(Norepinephrine, Ne)是一种单胺类的神经递质,它作用于多种肾上腺素受体。在中枢神经系统和交感神经系统中都参与诸多必要的生理过程,如感觉信号的调节、注意力的调控、清醒与睡眠、学习与记忆等。去甲肾上腺素释放或信号传递的受损与一系列的精神疾病和神经退行

关键词：去甲肾上腺素

Mitochondrial dysfunction as a target in spinal cord injury:intimate correlation between pathological processes and therapeutic approaches

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Neural Regeneration Research 2023年第10期18卷 2161-2166页

作者： julieta Schmidt Héctor Ramiro Quintá Universidad de Buenos Aires CABAArgentina Laboratorio de Medicina experimental“Dr.J.Toblli” Hospital AlemánCABAArgentina Consejo Nacional de Investigaciones Científicas y Técnicas-CONICeT CABAArgentina Rehabilitation Medicine Department University of MinnesotaTwin CitiesMINUSA

Traumatic spinal cord injuries interrupt the connection of all axonal projections with their neuronal targets below and above the lesion site. This interruption results in either temporary or permanent alterations in the locomotor, sensory, and autonomic functions. Damage in the spinal tissue prevents the re-growth of severed axons across the lesion and their reconnection with neuronal targets. Therefore, the absence of spontaneous repair leads to sustained impairment in voluntary control of movement below the injury. For decades, axonal regeneration and reconnection have been considered the opitome of spinal cord injury repair with the goal being the repair of the damaged long motor and sensory tracts in a complex process that involves:(1) resealing injured axons;(2) reconstructing the cytoskeletal structure inside axons;(3) re-establishing healthy growth cones;and(4) assembling axonal cargos. These biological processes require an efficient production of adenosine triphosphate, which is affected by mitochondrial dysfunction after spinal cord injury. From a pathological standpoint, during the secondary stage of spinal cord injury, mitochondrial homeostasis is disrupted, mainly in the distal segments of severed axons. This result in a reduction of adenosine triphosphate levels and subsequent inactivation of adenosine triphosphate-dependent ion pumps required for the regulation of ion concentrations and reuptake of neurotransmitters, such as glutamate. The consequences are calcium overload, reactive oxygen species formation, and excitotoxicity. These events are intimately related to the activation of necrotic and apoptotic cell death programs, and further exacerbate the secondary stage of the injury, being a hallmark of spinal cord injury. This is why restoring mitochondrial function during the early stage of secondary injury could represent a potentially effective therapeutic intervention to overcome the motor and sensory failure produced by spinal cord injury. This

关键词： adenosine triphosphate axonal regeneration creatine mitochondria dysfunction mitochondria spinal cord injury

The technical and the social:challenges in the conservation of earthen vernacular architecture in a changing world(Jujuy,Argentina)

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Built Heritage 2021年第3期5卷 36-48页

作者： Jorge Tomasi julieta Barada CONICeT‑Laboratorio de Arquitecturas Andinas y Construcción con Tierra Instituto de Investigaciones sobre la Naturaleza y la Cultura“Rodolfo Kusch”Universidad Nacional de JujuyRivadavia 642TilcaraProvincia de JujuyArgentina

Vernacular earthen architecture presents a series of relevant conservation challenges that involve designing solutions for diferent kinds of alterations and *** challenges of a social nature simultaneously arise and are related,among other factors,to the participation of local communities and the actions of diferent institutional *** these phenomena has generally been approached from perspectives that take technical considera‑tions and social dynamics as separate *** current global context has resulted in an acceleration of changes in these dynamics,in terms of both techniques and management models,giving rise to the need to develop compre‑hensive conceptual and methodological approaches through which these challenges should be addressed jointly by recombining the technical and the *** paper will analyse the main problems afecting vernacular architectures in three communities in northern Argentina,where earthen techniques have been very *** will refect on various potentially useful theoretical frameworks,incorporating concepts from the anthropology of technology and methodological approaches from an ethnography of conservation as a way to work with multiple ontologies.

关键词： Heritage ethnography Vernacular architecture Anthropology of techniques

International Collaboration in Brazilian Higher education

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Frontiers of education in China 2015年第1期10卷 7-22页

作者： Creso SÁ julieta GRIeCO Ontario Institute for Studies in education University of TorontoTorontoOntario M5S 1V6Canada

This paper examines the approach Brazil has taken to promote the internationalization of higher education over the last *** key areas are identified:human resources development,institution building,and international *** analyses of initiatives in these areas demonstrate that Brazil does not follow global trends such as the creation of world-class universities or the pursuit of“excellence initiatives”to help universities reach higher positions in global ***,recent strategies for international collaboration in higher education follow variegated domestic goals that encompass the logics of foreign policy and the internal priorities of federal research and education *** nature and limitations of these strategies are discussed.

关键词： Brazilian higher education internationalization higher education policy international collaboration

Changes in leaflet shape and seeds per pod modify crop growth parameters, canopy light environment, and yield components in soybean

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The Crop Journal 2020年第2期8卷 351-364页

作者： julieta S.Bianchi Alvaro Quijano Carlos O.Gosparini Laboratorio de Fisiología Vegetal Facultad de Ciencias AgrariasUniversidad Nacional de Rosario(UNR)Campo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina Instituto de Investigaciones en Ciencias Agrarias de Rosario(IICAR) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)–UNRCampo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina Consejo de Investigaciones de la UNR(CIUNR) Campo Experimental J.VillarinoP.O.Box 142125 ZavallaSanta FeArgentina

Seed number(SN)is the component most strongly associated with yield in *** depends on pod number(PN)and seeds per pod(SPP).Whereas SPP is a relatively stable component,PN is strongly influenced by environmental and management ***,the environmental cues involved in PN regulation are not completely *** influence of increasing SPP on other yield components is *** trials were conducted in two growing seasons using two pairs of lanceolate(L)and ovate(O)nearisogenic lines,sown at low(LD)and high(HD)plant densities to evaluate the effect of leaflet shape on crop growth parameters,canopy red/far-red(R/FR)ratio,their relationships with pod initiation,PN,and yield;and the effect of increasing SPP on PN,SN,and yield.L canopies showed a higher number of pods initiated(PI)than O canopies owing to the increase of PI on *** association between PI and crop growth rate during the pod set period was *** was negatively associated with leaf area index(LAI)and light *** contrast,a positive association between PI and canopy R/FR ratio was *** latter association was sustained irrespective of whether the LAI was below or above its critical value,providing experimental evidence that R/FR ratio is positively associated with pod initiation in soybean *** increase in SPP produced a direct and steady increase in SN regardless of PN and plant density.A yield increase was observed for the L-LD treatment,which combined the increased SPP of L lines with the highest PN of L-LD *** results have implications for crop management and breeding strategies aimed at increasing the yield potential of soybean.

关键词： soybean breeding shape

Aspects of forest restoration and hydrology:the hydrological function of litter

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Journal of Forestry Research 2022年第2期33卷 543-552页

作者： Luara Castilho Pereira Leonardo Balbinot Marcelle Teodoro Lima julieta Bramorski Kelly Cristina Tonello Hydrology in Forest ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of São Carlos(UFSCar)SorocabaSão PauloBrazil Hydrology in Forest ecosystems Lab.(Hidrolef) Department of Environmental SciencesFederal University of Amapá(UNIFAP)MacapáAmapáBrazil

Although forests play important roles in the hydrological cycle,there is little information that relates the water retention capacity of litter in areas under passive restoration,especially in Cerrado *** study relates litter levels to water holding capacity and effective water retention among forest fragments under different passive restoration stages:46,11,and 8 years to better understand litter hydrological functions in the *** retention capacity and effective water retention capacity of litters(unstructured materials,branches and leaves)in the field were monitored on a monthly *** litter accumulation at 46 years was significantly higher than that of the other succession *** litter mass was significantly higher than that of leaves and *** 46-year stage had the highest water holding capacity in the leaf fraction,followed by unstructured material and *** the water holding capacity was lower in the oldest resto-ration,this site showed the highest efficiency under field *** process was quickly reestablished,as the 11-year restoration showed results closer to that for the 46-year stage in comparison to the area at 8 ***,passive restoration plays a key role in soil water mainte-nance due to the influence of litter in Cerrado *** and the imminent need of restoring degraded sites,highlight the need for further studies focused on bet-ter understanding of the process of forest restoration and its temporal effect on soil water recovery dynamics.

关键词： Forest hydrology Litter interception Stemflow Cerrado Águas Perenes Forest Water holding capacity

elemental Assessments in Paddy Soil for Geographical Traceability of Rice from Peninsular Malaysia

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Rice science 2023年第5期30卷 486-498页

作者： Nazaratul Ashifa Abdullah SALIM Norlida Mat DAUD julieta GRIBOFF Abdul Rahim HARUN Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Malaysian Nuclear Agency 43000 KajangSelangorMalaysia Innovation Centre for Confectionery Technology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia National Council for Scientific and Technical Research/Centre for Research in Clinical Biochemistry Immunology/Clinical Biochemistry Department Faculty of Chemical ScienceNational University of Córdoba/Ciudad UniversitariaMedina Allende esq.Haya de la Torre s/n5000 CórdobaArgentina

This investigation aimed to establish the geographical traceability of Malaysian rice by assessing the elemental composition in paddy ***-element determination in combination with a chemometric approach was applied to evaluate the elemental concentrations of paddy soil from granaries cultivated with the same rice variety and to assess the relationship between elements in the soil and rice(SAR) system.A total of 29 elements(aluminum,arsenic,barium,bromine,calcium,chlorine,cobalt,chromium,cesium,europium,iron,gallium,hafnium,potassium,lanthanum,lutetium,magnesium,manganese,sodium,rubidium,antimony,scandium,samarium,thorium,titanium,uranium,vanadium,ytterbium and zinc) were successfully determined in paddy soil from Kedah,Selangor and Langkawi by neutron activation analysis.A significant difference(P etween 18 elements in the soil samples was *** chemometric approaches of principal component and linear discriminant analyses demonstrated clear discrimination and highly corrected classification(100%) of the soil samples.A high classification(98.1%) was also achieved by assessing 10 elements(aluminum,arsenic,bromine,chlorine,potassium,magnesium,manganese,sodium,rubidium and zinc),which similarly applied to rice geographical origin *** elements in SAR were also observed for differences in the pattern of correlation and bioaccumulation factor between the ***,the generalized Procrustes analysis showed a 98% consensus between SAR and clear differences between the studied *** canonical correlation analysis demonstrated a significant correlation between the chemical profile of SAR(r~2 = 0.88,P erefore,the current work model provides a reliable assessment to establish rice provenance.

关键词： soil rice multi-element correlation geographical origin

High-throughput metabarcoding of SAR11 assemblages from the southwest Atlantic shelf and arid Patagonia:richness and associated rank abundance distributions

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Quantitative Biology 2023年第3期11卷 332-342页

作者： Leandro R.Jones julieta M.Manrique Laboratorio de Virología y Genética Molecular Universidad Nacional dela Patagonia San Juan BoscoTrelew CP 9100Argentina

Background:Massively parallel sequencing of environmental DNA allows microbiological studies to be performed in greater detail than was possible with first-generation *** example,it facilitates the use of approaches hitherto largely applied to flora and fauna,such as rank abundance distribution(RAD)***:Here,we set out to advance the knowledge on ***(SAR11)communities from southern South America using environmental sequences from the open ocean in the Argentine sea,the uncharted engaño Bay,as well as a river and an oligohaline shallow lake from the Patagonian Steppe *** structures of the SAR11 assemblages present in these ecosystems were dissected by direct and rarefaction-based estimates of species richness,and evaluations of the corresponding abundance distributions(ADs),which was addressed by RAD ***:Microbial community composition analyses revealed that the studied SAR11 assemblages coexist with 27 bacterial ***11 richness was in general very high,but ADs turned out to be highly *** results were compatible with prior knowledge,and similar to that derived from point estimates of ***,our comprehensive dissection allowed for more detailed quantitative comparisons to be made between the environments surveyed,and revealed differences regarding both richness and the underlying ***:Despite SAR11 assemblages being extremely rich,their ADs are very *** and ADs can vary,not only between fresh and salt water,but also between oceanic and coastal marine *** obtained results provide insights on general topics such as adaptation and the contrast between marine and freshwater radiations.

关键词： SAR11 richness species abundance distribution rank abundance distribution Patagonia Argentina