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Single-center study comparing computed tomography colonography with conventional colonoscopy

World Journal of Gastroenterology 2008年第3期14卷 469-473页

作者： Ian c Roberts-Thomson Graeme R Tucker Peter J Hewett Peter cheung Ruben A Sebben EE Win Khoo julie D Marker Wayne K clapton Department of Gastroenterology The Queen Elizabeth Hospital South Australia Australia Department of Health South Australia Australia Department of colorectal Surgery The Queen Elizabeth Hospital South Australia Australia Department of Radiology The Queen Elizabeth Hospital South Australia Australia

AIM:To compare the results from computed tomography (cT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. cT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. colonoscopists were initially blinded to the results of cT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of cT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at cT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either cT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and cT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by cT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of cT colonography was 50% (95% cI, 39%-61%) but this increased to 71% (95% cI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% cI, 39%-58%) increasing to 67% (95% cI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured cT colonography. cONcLUSION: Although cT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients.

关键词： colorectal polyps colorectal cancer computed tomography colonography colonoscopy

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Biological Parts for Plant Biodesign to Enhance Land-Based carbon Dioxide Removal

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BioDesign Research 2021年第1期2021卷 17-38页

作者： Xiaohan yang Degao Liu Haiwei Lu David J.Weston Jin-Gui chen Wellington Muchero Stanton Martin yang Liu Md Mahmudul Hassan Guoliang yuan Udaya c.Kalluri Timothy J.Tschaplinski julie c.Mitchell Stan D.Wullschleger Gerald A.Tuskan Biosciences Division Oak Ridge National LaboratoryOak RidgeTN 37831USA The center for Bioenergy Innovation Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Genetics Cell Biology and DevelopmentCenter for Precision Plant Genomicsand Center for Genome EngineeringUniversity of MinnesotaSaint PaulMN 55108USA Department of Academic Education Central Community College-HastingsHastingsNE 68902USA Environmental Sciences Division and climate change Science Institute Oak Ridge National LaboratoryOak RidgeTN 37831USA

A grand challenge facing society is climate change caused mainly by rising cO_(2) concentration in Earth’s *** plants are linchpins in global carbon cycling,with a unique capability of capturing cO_(2) via photosynthesis and translocating captured carbon to stems,roots,and soils for long-term ***,many researchers postulate that existing land plants cannot meet the ambitious requirement for cO_(2) removal to mitigate climate change in the future due to low photosynthetic efficiency,limited carbon allocation for long-term storage,and low suitability for the *** address these limitations,there is an urgent need for genetic improvement of existing plants or construction of novel plant systems through biosystems design(or biodesign).Here,we summarize validated biological parts(e.g.,protein-encoding genes and noncoding RNAs)for biological engineering of carbon dioxide removal(cDR)traits in terrestrial plants to accelerate land-based decarbonization in bioenergy plantations and agricultural settings and promote a vibrant ***,we first summarize the framework of plant-based cDR(e.g.,cO_(2) capture,translocation,storage,and conversion to value-added products).Then,we highlight some representative biological parts,with experimental evidence,in this ***,we discuss challenges and strategies for the identification and curation of biological parts for cDR engineering in plants.

关键词： dioxide roots locating

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The newly identified augmin complex is required in the assembly of the acentrosomal microtubule assay in higher plants

The newly identified augmin complex is required in the assem...

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从植物科学到农业发展——2012全国植物生物学大会

作者： yuh-Ru julie Lee Department of Plant Biology University of CaliforniaDavisCalifornia

In higher plant cells,microtubules(MTs) are nucleated and organized in a centrosome-independent *** is unclear whether augmin-dependent mechanisms underlie spindle MT organization in plant cells as they do in animal *** AUGMIN subunit3(AUG3),which encodes a homolog of animal dimy-tubulin 3/human augmin-like complex,subunit 3,was disrupted in Arabidopsis thaliana,gametogenesis frequently failed due to defects in cell *** with the controlmicrospores,which formed bipolar spindles at the cell periphery,the mutant cells often formed peripheral half spindlesthat only attached to condensed chromosomes or formed elongated spindles with unfocused interior *** addition,defective cells exhibited disorganized phragmoplast MT arrays,which caused aborted *** resulting pollengrains were either shrunken or contained two nuclei in an undivided ***3 was localized along MTs in thespindle and phragmoplast,and its signal was pronounced in anaphase spindle *** AUG3-green fluorescent proteinfusion exhibited a dynamic distribution pattern, similar to that of the y-tubulin complex *** usingrobustimmunoprecipitation and mass spectrometry,we further identified the entire plant augmin complex that contains eight *** them,AUG1 to AUG6 share low sequencesimilarity with their animal counterparts,but AUG7 and AUG8 share homology only with proteins of plant *** conclude that assembly ofMT arrays during plant mitosis depends on the augmin complex,which includes two plant-specific subunits.

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Predictive Study of Velocimetry in the coronary Artery after Iodinated contrast Agent Injection

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International Journal of Medical Physics, clinical Engineering and Radiation Oncology 2017年第1期6卷 93-104页

作者： Nora Hocine julie colnot Helene Masset Didier Franck Institut de Radioprotection et de Surete Nucleaire(IRSN) Fontenay-aux-RosesFrance centre Hospitalier Universitaire Henri Mondor CreteilFrance

This study aims to determine the retention time of iodinated contrast agents (IcA) in the coronary artery. The mechanical aspect of IcA displacement was studied in order to better understand the effect of these products on the inner wall of the artery of patients with coronary artery stenosis, undergoing repeated imaging examinations with iodinated contrast agents. IcA flow, IcA and blood flow in the artery were modelled. The fluid was regarded to be viscous, incompressible and Newtonian. Blood flow was presumed to be unidirectional, laminar and unstationary. Iodine flow velocity and retention time were calculated using the Runge-Kutta 4th order method programmed in c++ and MatLab R2013a language. The results showed that for coronary artery cT-scans, IcA retention time is 1 minute 40 seconds and for coronary arteriography it is between 2.41 and 3.61 seconds. The values calculated were compared to theoretical values and to clinical observations. The results enabled us to validate our model.

关键词： coronary Artery Iodinated contrast Agent Blood Flow

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Effects of Fructooligofructoses chain Length on the Bifidobacteria of the Human colon: A Pilot Study

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Food and Nutrition Sciences 2012年第12期3卷 1615-1618页

作者： Krista Mendlik julie A. Albrecht Marilynn Schnepf Department of Nutrition and Health Sciences University of Nebraska—Lincoln Lincoln USA

Human gastrointestinal health may be improved by the consumption of prebiotic food ingredients such as fructooligo-fructoses. A study was initiated to determine the effect of fructooligofructoses of different chain lengths on gastrointes-tinal parameters. Nineteen healthy subjects aged 20 - 57 y took part in a 10-week cross-over designed study. Subjects consumed either inulin or oligofructose for 3 weeks followed by a 2-week washout period between treatments. Stool samples were collected five times (baseline, 2 treatments, 2 washout) and analyzed for bifidobacteria. Daily records were kept for stool frequency, stool consistency and flatulence frequency. Bifidobacteria counts (cfu/ml) were higher (trending toward significance) during inulin and oligofructose intakes (1.2 × 107 ± 4.8 × 107 and 2.0 × 108 ± 4.7 × 108) and washout periods (2.9 × 106 ± 6.5 × 106 and 1.1 × 107 ± 1.6 × 107) than baseline counts (2.2 × 105 ± 5.1 × 105 and 2.9 × 106 ± 6.5 × 106), respectively. Inulin and oligofructose treatment periods had a significant effect on stool consistency (watery/very hard) and flatulence frequency, but not stool frequency, when compared to baseline (P ch is needed to confirm these results due to small sample size and the need for a longer washout period between treatments.

关键词： Prebiotics Fructooligofructoses Inulin Oligofructose Bifidobacteria

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Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

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cancer communications 2022年第11期42卷 1212-1216页

作者： Nicolas Alejandro Fraunhoffer Analía Meilerman Abuelafia Brice chanez Martin Bigonnet Odile Gayet julie Roques Eduardo chuluyan Nelson Dusetti Juan Iovanna cancer Research center of Marseille InsermPaoli-Calmettes InstitutAix-Marseille UniversityScientific and Technological Park of LuminyMarseille 13288France Buenos Aires University Center for Pharmacological and Botanical StudiesFaculty of MedicineNational Council for Scientific and Technical ResearchBuenos AiresC1121ABGArgentina Buenos Aires University Faculty of MedicineDepartment of MicrobiologyParasitology and ImmunologyBuenos Aires C1121ABGArgentina Predicting Med Scientific and Technological Park of LuminyMarseille 13288France

Dear Editor,Pancreatic ductal adenocarcinoma(PDAc)treatment is focused on two *** polychemotherapy,FOLFIRINOX(folinic acid,fluorouracil,irinotecan,oxali-platin),is used in patients with good health conditions[1],while gemcitabine,as monotherapy,in patients with poor health conditions[2–4].Gemcitabine resistance-associated pathways have been targeted to sensitize cancer cells,but the results were *** a transcrip-tomic bioinformatics analysis combined with biological validation,we showed that glucuronidation was associ-ated with the gemcitabine resistance in PDAc,and its inhibition could switch tumors from resistant to sensitive.

关键词： gemcitabine cancer chemotherapy

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Gradient Temperature Raman Spectroscopy of Fatty Acids with One to Six Double Bonds Identifies Specific carbons and Provides Systematic Three Dimensional Structures

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Journal of Biophysical chemistry 2018年第1期9卷 1-14页

作者： c. Leigh Broadhurst Walter F. Schmidt julie K. Nguyen Jianwei Qin Kuanglin chao Moon S. Kim Environmental Microbiology and Food Safety Laboratory US Department of Agriculture Agricultural Research Service Beltsville MD USA Department of Mechanical Engineering University of Maryland Baltimore County Baltimore MD USA

Specialized pro-resolving mediators provide promising targets for new drugs and natural products. Much work has been accomplished on the structure/ function of the lipoxygenase and cyclooxygenase enzymes but not on the substrates. A better visualization of three-dimensional lipid structures will allow increased refinement of the interactions that produce the pro-resolving mediators, and lead to improvements in synthetic pathways. We present systematic analysis of oleic (18:1n-9), linoleic (18:2n-6), alpha-linolenic (18:3n-3), arachidonic (20:4n-6), docosapentaenoic (22:5n-3), and docosahexaenoic (22:6n-3) acids. continuous gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry to Raman spectroscopy. GTRS can identify and differentiate specific carbon chain sites, finally allowing Raman analysis to explain why the long-chain polyunsaturated fatty acids (Lc-PUFA) exhibit such extreme functional differences despite minimal changes in chemical structure. Detailed vibrational analysis of the important frequency ranges 1450 - 1200 cm-1 (includes cH2 bending and twisting) and 1750 - 1425 cm-1 (includes c=c stretching and c-c stretching plus H-c in-plane rocking) shows for the first time that each molecule has its own characteristic set of modes with only some redundancy/commonality. The number and frequency of modes correlates with three-dimensional molecular structure, not the degree of unsaturation. The high degree of specificity of lipoxygenase and cyclooxygenase enzymes should be reconsidered in light of the fact that individual sites on the polyunsaturated fatty acid chain are nonequivalent, and each Lc-PUFA molecule has an individual, specific three dimensional structure incorporating torsion.

关键词： Gradient Temperature Raman Spectroscopy Raman Spectroscopy Arachidonic Acid Docosapentaenoic Acid Docosahexaenoic Acid Alpha-Linolenic Acid N-3DPA DHA GTRS

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澳大利亚全科医学近几十年的变化

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中国全科医学 2016年第33期19卷 4025-4027页

作者： Helena Britt Graeme c Miller Lisa Valenti Joan Henderson clare Bayram julie Gordon 本刊编辑部悉尼大学悉尼医学院公共卫生学院中国全科医学杂志社编辑部

全科医学一直是澳大利亚医疗体系的基石,几乎所有的澳大利亚人每年至少看1次全科医生。本文试图概述1990—2015年澳大利亚全科医生队伍、全科医生接诊的患者以及患者疾病的复杂性所发生的主要变化,发现在过去的25年里,全科医生群体、接... 详细信息

全科医学一直是澳大利亚医疗体系的基石,几乎所有的澳大利亚人每年至少看1次全科医生。本文试图概述1990—2015年澳大利亚全科医生队伍、全科医生接诊的患者以及患者疾病的复杂性所发生的主要变化,发现在过去的25年里,全科医生群体、接诊的患者情况和就诊内容均发生了变化,全科医生的临床工作重点更倾向于老年人保健、慢性病管理、临床和治疗程序、转诊和检查。

关键词：全科医学澳大利亚全科医生

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Beta-adrenergic receptor polymorphisms: A basis for pharmacogenetics

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World Journal of cardiovascular Diseases 2013年第6期3卷 406-411页

作者： Efstratios K. Theofilogiannakos Konstantinos Dean Boudoulas Brian E. Gawronski Taimour y. Langaee Timotheos G. Kelpis Antonios A. Pitsis julie A. Johnson Harisios Boudoulas Agios Lukas Hospital Thessaloniki Greece The Ohio State University Division of Cardiovascular Medicine Columbus Ohio USA The Ohio State University Division of Cardiovascular Medicine Columbus Ohio USA Aristotelian University of Thessaloniki Thessaloniki Greece University of Florida Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics Gainesville Florida USA

Aims: Polymorphisms of the β-adrenergic receptor, the frequency of which may differ in ethnic groups, alters β-receptor function. The aim of this study was to elucidate the frequency of β1 and β2-adrenergic receptor polymorphisms in healthy Greeks and to compare with those of caucasian European (Euro) and African American (AA) origin. Methods: Ninety-nine individuals with a median age of 63 without clinical evidence of any disease were studied. Blood samples were obtained and common β1 and β2-adrenergic receptor polymorphisms that change the en-coded amino acid were determined by pyrosequencing. Results: The most common β1-adrenergic receptor polymorphism in Greeks is nucleotide substitution cytosine for guanine at position 1165 (1165 c/G) resulting in amino acid substitution arginine for glycine at position 389 (389 Arg/Gly) with a minor allele frequency of 28% (Euro 27%, AA 42%);this polymorphism increases the sensitivity of the β1-receptor. The most common β2-adrenergic receptor polymorphism in Greeks is the nucleotide substitution guanine for adenine at position 46 (46 G/A) resulting in amino acid substitution glycine for arginine at position 16 (16 Gly/Arg) with a minor allele frequency of 38% (Euro 41%, AA 50%);this polymerphism facilitates receptor down-regulation during chronic adrenergic stimulation. conclusion: The most common β1 and β2-adrenergic receptor polymorphisms in the Greek population are similar to those of other European ancestry, and less common than in those of African origin indicating variability in ethnic groups. This information provides insight into common polymorphisms that may assist in optimizing β-antagonist and agonist therapy.

关键词： β1 and β2-Adrenergic Receptor Polymorphism Ethnic Variability

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Genetic identification and reiterated captures suggest that the Astyanax mexicanus El Pachón cavefish population is closed and declining

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Zoological Research 2023年第4期44卷 701-711页

作者： Laurent Legendre julie Rode Isabelle Germon Marie Pavie carla Quiviger Maxime Policarpo julien Leclercq Stéphane Père julien Fumey carole Hyacinthe Patricia Ornelas-García Luis Espinasa Sylvie Rétaux Didier casane UniversitéParis-Saclay CNRSIRDUMRÉvolutionGénomesComportement etÉcologieGif-sur-Yvette 91190France Objectif Sciences International NGO OSI-Panthera ProgramGeneva 99140Switzerland Institut de Neuroscience Paris-Saclay UniversitéParis-Saclay and CNRSSaclay 91400France Institut Pasteur UniversitéParis CitéCNRS UMR 2000Microbial Paleogenomics UnitParis 75015France Institut Pasteur UniversitéParis CitéBioinformatics and Biostatistics HubParis 75015France Department of Genetics Harvard Medical SchoolBlavatnik InstituteBoston MA 02115USA colección Nacional de Peces Departamento de ZoologíaInstituto de BiologíaUniversidad Nacional Autónoma de MéxicoMéxico DF CP 04510México School of Science Marist CollegePoughkeepsieNew York 12601USA UniversitéParis cité UFR Sciences du VivantParis 75013France Zoological Institute Department of Environmental SciencesUniversity of BaselBaselSwitzerland

The sizes of Astyanax mexicanus blind cavefish populations of North-East Mexico are demographic parameters of great importance for investigating a variety of ecological,evolutionary,and conservation ***,few estimates have been *** these mobile animals living in an environment difficult to explore as a whole,methods based on capture-mark-recapture are appropriate,but their feasibility and interpretation of results depend on several assumptions that must be carefully ***,we provide evidence that minimally invasive genetic identification from captures at different time intervals(three days and three years)can give insights into cavefish population size dynamics as well as other important demographic parameters of *** also provide tools to calibrate sampling and genotyping efforts necessary to reach a given level of *** results suggest that the El Pachón cave population is currently very small,of an order of magnitude of a few hundreds of individuals,and is distributed in a relatively isolated *** probable decline in population size in the El Pachón cave since the last census in 1971 raises serious conservation issues.

关键词： cavefish Population size conservation Swabbing Genetic identification

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