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Physico-chemical characterization of acid base disorders in patients with COVID-19:A cohort study

World Journal of Nephrology 2024年第2期13卷 16-23页

作者： Sergio Pinto de Souza juliana r caldas Marcelo Barreto Lopes Marcelo Augusto Duarte Silveira Fernanda Oliveira Coelho Igor Oliveira Queiroz Pedro Domingues Cury rogério da Hora Passos Department of Nephrology Hospital São RafaelSalvadorBA 41253190Brazil Department of Nephrology D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Faculty of Medicine Escola Bahiana de Medicina e Saúde Pública-EBMSPSalvadorBA 40290000Brazil Department of Intensive Care D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Hospital São rafael D’Or Institute for Research and Education(IDOR)SalvadorBA 41253190Brazil Department of Intensive Care Unit Hospital Israelita Albert EinsteinSao PauloSP 05652900Brazil

BACKGrOUND Acid-base imbalance has been poorly described in patients with coronavirus disease 2019(COVID-19).Study by the quantitative acid-base approach may be able to account for minor changes in ion distribution that may have been over-looked using traditional acid-base analysis *** a cohort of critically ill COVID-19 patients,we looked for an association between metabolic acidosis surrogates and worse clinical outcomes,such as mortality,renal dialysis,and length of hospital *** To describe the acid-base disorders of critically ill COVID-19 patients using Stewart’s approach,associating its variables with poor *** This study pertained to a retrospective cohort comprised of adult patients who experienced an intensive care unit stay exceeding 4 days and who were diagnosed with severe acute respiratory syndrome coronavirus 2 infection through a positive polymerase chain reaction analysis of a nasal swab and typical pulmonary involvement observed in chest computed tomography *** and clinical data were obtained from electronic *** variables were compared using Fisher’s exact *** data were presented as median and interquartile *** Mann-Whitney U test was used for *** In total,211 patients were *** mortality rate was 13.7%.Overall,149 patients(70.6%)presented with alkalosis,28 patients(13.3%)had acidosis,and the remaining 34 patients(16.2%)had a normal arterial pondus *** those presenting with acidosis,most had a low apparent strong ion difference(SID)(20 patients,9.5%).Within the group with alkalosis,128 patients(61.0%)had respiratory *** non-survivors were older,had more comorbidities,and had higher Charlson’s and simplified acute physiology score *** did not find severe acid-base imbalance in this *** analyzed Stewart’s variables(effective SID,apparent SID,and strong ion gap and the effect of albumin,lactate,phosphorus,and chloride)were not d

关键词： COVID-19 Physicochemical approach Acid-base status Critically ill patients Acute respiratory syndrome

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Cardiovascular risk burden and disability:findings from the International Mobility in Aging Study(IMIAS)

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Journal of Geriatric Cardiology 2024年第3期21卷 331-339页

作者： Juan-David Martinez-Aristizábal Carmen-Lucia Curcio juliana Fernandes Afshin Vafael Cristiano dos Santos Gomes Fernando Gomez Internal Medicine Critical Care DepartmentPablo Tobón Uribe HospitalMedellínColombia research Group in Geriatrics and Gerontology Faculty of Health SciencesUniversidad de CaldasManizalesColombia Laboratory of Physical Therapy and Collective Health Physical Therapy DepartmentFederal University of PernambucoJornalista Aníbal Fernandes Avenue RecifeBrazil Department of Public Health Sciences Queen’s UniversityKingstonONCanada Department of Physiotherapy University of PernambucoBR 203KmBrazil

BACKGrOUND The association of cardiovascular risk burden with disability is *** examined the association between trajectories of the Framingham general cardiovascular disease risk score(FGCrS)with the trajectories of limitations of physical function in older *** A total of 1219 participants with no disabilities from the International Mobility in Aging Study(IMIAS)study who had up to three repeated measures of FGCrS between 2012–2016 and without a history of stroke or coronary heart disease at baseline and follow-up were *** at baseline was assessed and categorized into *** function was evaluated with the Short Physical Performance Battery(SPPB).The data were analyzed using linear mixed-effects *** At baseline,FGCrS ranged between 3–94(mean score:24±15.8),participants were 32(2.6%),502(41.2%)and 685(56.2%)in lowest,middle,and highest tertiles,*** the trajectories of limitations of physical function,the lowest FGCrS had no differences,while the middle and highest had a decrease in physical performance between 2012–2014(P=0.0001).Age,being female,living in Andes Mountains,having middle and highest FGCrS,higher alcohol consumption,being obese,lack of exercise and cognitive impairment increase the probability of disability(Prnatively,living in more developed regions and having a higher educational level reduced the probability of disability during the follow-up time(Pr cardiovascular risk burden is associated with decreased physical performance,especially in *** suggest SPPB may provide a measure of cardiovascular health in older adults.

关键词： finding Battery burden

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Evolutionary fingerprint, phylogenetic and forest structure of tropical montane Atlantic cloud forests along an elevation gradient

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Journal of Mountain Science 2024年第4期21卷 1259-1271页

作者： ravi Fernandes MArIANO Vanessa Leite rEZENDE Cléber rodrigo de SOUZA Patrícia Vieira POMPEU rubens Manoel dos SANTOS Carolina Njaime MENDES Aloysio Souza de MOUrA Felipe Santana MACHADO Warley Augusto caldas CArVALHO Marco Aurélio Leite FONTES Department of Forest Sciences Federal University of LavrasLavras 37200-900Brazil 2Environmental Defence Association of Minas Gerais Belo Horizonte 30360-110Brazil Department of Ecology and Conservation Federal University of LavrasLavras 37200-900Brazil Department of Forest Sciences State University of Mato Grosso do SulAquidauana 79200-000Brazil Agência Zetta Federal University of LavrasLavras 37200-900Brazil. Department of Natural Sciences Federal University of São João del-ReiSão João del-Rei 36307-352Brazil.

Environmental conditions can change markedly over geographical distances along elevation gradients,making them natural laboratories to study the processes that structure *** work aimed to assess the influences of elevation on Tropical Montane Cloud Forest plant communities in the Brazilian Atlantic Forest,a historically neglected *** evaluated the phylogenetic structure,forest structure(tree basal area and tree density)and species richness along an elevation gradient,as well as the evolutionary fingerprints of elevation-success on phylogenetic lineages from the tree *** do so,we assessed nine communities along an elevation gradient from 1210 to 2310 m *** large elevation *** relationships between elevation and phylogenetic structure,forest structure and species richness were investigated through Linear *** occurrence of evolutionary fingerprint on phylogenetic lineages was investigated by quantifying the extent of phylogenetic signal of elevation-success using a genus-level molecular *** results showed decreased species richness at higher elevations and independence between forest structure,phylogenetic structure and *** also verified that there is a phylogenetic signal associated with elevation-success by *** concluded that the elevation is associated with species richness and the occurrence of phylogenetic lineages in the tree communities evaluated in Mantiqueira *** the other hand,elevation is not associated with forest structure or phylogenetic ***,closely related taxa tend to have their higher ecological success in similar ***,we highlight the fragility of the tropical montane cloud forests in the Mantiqueira range in face of environmental changes(*** warming)due to the occurrence of exclusive phylogenetic lineages evolutionarily adapted to environmental conditions(*** temperature)associated with each elevation range.

关键词： Atlantic Forest Cloud forest Conservation Community ecology Montane forests Phylogenetic diversity Phylogenetic signal

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Intracellular life of protozoan Toxoplasma gondii:Parasitophorous vacuole establishment and survival strategies

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BIOCELL 2023年第4期47卷 929-950页

作者： juliana A.POrTES rOSSIANE C.VOMMArO LUCIO AYrES caldas ErICA S.MArTINS-DUArTE Laboratório de Ultraestrutura Celular Hertha Meyer Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Núcleo Multidisciplinar de Pesquisa UFrJ–Xerém em Biologia Campus Duque de CaxiasUniversidade Federal do Rio de JaneiroDuque de CaxiasBrazil Laboratório de Quimioterapia de Protozoários Egler Chiari Departamento de ParasitologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil

Toxoplasma gondii is a protozoan of worldwide distribution and the agent of *** is estimated that 30%–50%of the world population could be infected with this *** the infection in immunocompetent individuals is mostly asymptomatic,the disease in immunosuppressed and pregnant is a risk *** a member of the phylum Apicomplexa,*** has an obligatory intracellular lifestyle;therefore,invading a host cell and establishing it inside a parasitophorous vacuole(PV)are mandatories for the survival of this *** construction of a perfect intracellular niche for *** requires the secretion of an arsenal of proteins from unique secretory *** proteins will remodel the vacuolar environment and the host cell organization and functions,allowing the parasite to access essential nutrients and stay“invisible”inside a host *** the present review,we will discuss the main steps involved in the PV formation and its differentiation to tissue cyst,focusing mainly on the strategies employed in the acquisition of nutrients and proteins involved in host cell modification.

关键词： Dense granule proteins rhoptry proteins Nutrient acquisition Intravacuolar network Immune evasion Tissue cyst

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Exotic and invasive species compromise the seed bank and seed rain dynamics in forests undergoing restoration at urban regions

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Journal of Forestry research 2017年第5期28卷 1019-1026页

作者： Vinícius Londe Hildeberto caldas de Sousa Alessandra r.Kozovits Graduate Program in Ecology of Tropical Biomes Department of BiodiversityEvolution and EnvironmentFederal University of Ouro Pretocampus Morro do Cruzeiro

The control of exotic and invasive species in areas undergoing recovery is a challenge for ecological restoration and this problem may be even greater in urbanized areas. This study evaluated the seed bank and seed rain of a 5-year-old riparian forest located at the metropolitan region of Belo Horizonte in southeast Brazil, and verified changes over time in the abundance and species richness and whether planted species already were providing propagules to the site. At the forest, fifteen parcels of 100 m2 were distributed randomly and soil samples were collected thrice (October 2011, March 2012 and July 2012) to evaluate the seed bank. Seed traps were installed in nine parcels to collect propagules over 1 year. Propagules were segregated and germinate at greenhouse. Species richness and abundance were estimated, and variance and similarity were quantified. In total, 86 species were recorded in the seed banks, 41.9% natives and 33.7% exotics, with the predominance of herbs (87.2%) and only 7% of trees. Species classified as weeds amounted to 52.3%. In the seed rain 642 seedlings germinated but they belonged to only 10 species, half of them were exotics. regarding life forms, half of the species were arboreal and dominated the samples, highlighting the exotic species Melia azedarach. The species richness of the seed bank did not differ by season, unlike the seed rain which varied significantly by month. Seed bank and seed rain species had a very low floristic similarity with the list of planted species, suggesting that few planted trees had dispersed or were stocking propagules. Many non-planted species were recorded, mostly exotics and/or invasive that were probably derived from the surrounding urban matrix. These might interrupt the successional dynamics of the restoration forest and compromise the restoration process in the medium and long-terms. Our results highlight: (1) the importance of monitoring areas undergoing restoration; (2) that restoration me

关键词： Exotic plants Monitoring indicators restoration ecology Urban forests

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Phenological study of congeneric Myrcia species and Clethra scabra in wetland and drained habitats in a Montane Forest

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Journal of Forestry research 2021年第4期32卷 1419-1427页

作者： Vinícius Londe Jaqueline Alves Pereira Hildeberto caldas de Sousa Lisbon Portugal Ecology of Tropical Biomes Graduate Course Federal University of Ouro PretoOuro PretoMinas Gerais 35400-000Brazil Department of Biodiversity Evolution and EnvironmentFederal University of Ouro PretoOuro PretoMinas Gerais 35400-000Brazil

Although important,phenological studies comparing congeneric species or the same species growing in different habitats are still scarce for the ***,we integrate phylogeny,ecology and biometeorology to verify whether the phenophases of congeneric species Myrcia laruotteana and Myrcia amazonica or Clethra scabra differ when their populations inhabit wetland and drained habitats and to determine what abiotic factors affect the vegetative and reproductive phenophases of these species in distinct habitat *** collected data on phenological events of 80 trees for 1 year in Itacolomi State Park,Brazil,and related them to abiotic local *** to our expectation,the phenophases of the congeneric species did not differ between habitats,but the reproductive phenophases of *** did and was greater in drained *** of *** were affected by the depth of the water table and maximum temperature in the wetland ***,precipitation,maximum temperature and relative humidity influenced Myrcia and Clethra in the drained *** differences between *** populations suggest that this species is phenotypically plastic and can present distinct phenophases depending on the habitat it *** the other hand,the congeneric Myrcia species may have similar phenophases in distinct habitats because of their shared similarities during their *** study provides a better understanding of the ecology of these species and their adaptations to different abiotic *** of this nature are important in a changing world and can inform strategies for adaptive management.

关键词： Abiotic factors Forest ecology Phenophases Soil types

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Co-expression network analysis predicts a key role of microrNAs in the adaptation of the porcine skeletal muscle to nutrient supply

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Journal of Animal Science and Biotechnology 2020年第2期11卷 327-347页

作者： Emilio Mármol-Sánchez Yuliaxis ramayo-caldas raquel Quintanilla TainãFigueiredo Cardoso rayner González-Prendes Joan Tibau Marcel Amills Centre for research in Agricultural Genomics(CrAG) CSIC-IRTA-UAB-UBUniversitat Autònoma de Barcelona08193 BellaterraSpain Animal Breeding and Genetics Program Institute for Research and Technology in Food and Agriculture(IRTA)Torre Marimon08140 Caldes de MontbuiSpain Present address:Embrapa Pecuária Sudeste Empresa Brasileira de Pesquisa Agropecuária(EMBRAPA)São CarlosSP 13560-970Brazil Department of Animal Science Universitat de Lleida-Agrotecnio Center25198 LleidaSpain Departament de Ciència Animal i dels Aliments Universitat Autònoma de Barcelona08193 BellaterraBarcelonaSpain

Background:The role of non-coding rNAs in the porcine muscle metabolism is poorly understood,with few studies investigating their expression patterns in response to nutrient ***,we aimed to investigate the changes in microrNAs(mirNAs),long intergenic non-coding rNAs(lincrNAs)and mrNAs muscle expression before and after food ***:We measured the mirNA,lincrNA and mrNA expression levels in the gluteus medius muscle of 12 gilts in a fasting condition(AL-T0)and 24 gilts fed ad libitum during either 5 h.(AL-T1,N=12)or 7 h.(AL-T2,N=12)prior to *** small rNA fraction was extracted from muscle samples retrieved from the 36 gilts and sequenced,whereas lincrNA and mrNA expression data were already *** terms of mean and variance,the expression profiles of mirNAs and lincrNAs in the porcine muscle were quite different than those of *** intake induced the differential expression of 149(AL-T0/AL-T1)and 435(AL-T0/AL-T2)mrNAs,6(AL-T0/AL-T1)and 28(AL-T0/AL-T2)mirNAs and none lincrNAs,while the number of differentially dispersed genes was much *** the set of differentially expressed mirNAs,we identified ssc-mir-148a-3p,ssc-mir-22-3p and ssc-mir-1,which play key roles in the regulation of glucose and lipid ***,co-expression network analyses revealed several mirNAs that putatively interact with mrNAs playing key metabolic roles and that also showed differential expression before and after *** case example was represented by seven mirNAs(ssc-mir-148a-3p,ssc-mir-151-3p,ssc-mir-30a-3p,ssc-mir-30e-3p,ssc-mir-421-5p,ssc-mir-493-5p and ssc-mir-503)which putatively interact with the PDK4 mrNA,one of the master regulators of glucose utilization and fatty acid ***:As a whole,our results evidence that microrNAs are likely to play an important role in the porcine skeletal muscle metabolic adaptation to nutrient availability.

关键词： Co-expression analysis lincrNAs microrNAs Pig regulatory impact factor Skeletal muscle

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release of Uranium by an Ore Treatment Unit at caldas,MG,Brazil

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Journal of Environmental Protection 2013年第6期4卷 570-574页

作者： Wagner de S.Pereira Alphonse Kelecom juliana r.de S.Pereira Delcy de A.Py Junior Multidisciplinary Group of radioprotection(GMr) Servico de RadioprotecaoUnidade de Tratamento de MinerioIndustrias Nu-cleares do BrasilCaldasBrazil Laboratory of radiobiology and radiometry Pedro Lopes dos Santos(LArArA-PLS) Group of Environmental Themes Assessment(GETA)Universidade Federal Fluminense(UFF)NiteroiBrazil Interdisciplinary under Graduation in Science and Technology Universidade Federal de AlfenasPocos de CaldasBrazil

This study aims to assess the behavior of the release of Unat (i.e. uranium isotopes in natural relative abundance) from the release of water treated by the Ore Treatment Unit (UTM) in caldas, state of Minas Gerais, Brazil, during the years 1999 to 2009. During this period, the unit showed no industrial activity, except between 2004 and 2005, when UTM operated 400 tons of monazite in a process to obtain rare earths. Unat was analyzed by spectrophotometry once per week in the effluent waters at sampling point 014. Two fractions were considered for analysis: the soluble one (that passes through a 0.45 μm filter) and the particulate one (retained on a 0.45 μm filter). Statistical analyses were performed: the “Z” test and Pearson’s r2 correlation index. The values for the soluble fraction were consistently lower than those of the particulate fraction and no statistically significant correlation was observed between the soluble and particulate fractions. However, the particulate and the total fractions (the sum of soluble and particulate) strongly correlated.

关键词： Uranium Ore Treatment Unit caldas radionuclide Monitoring

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Health Promotion and Life Course Dynamics: Transitions of Brazilian Elderly

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Health 2014年第7期6卷 616-624页

作者： Célia Pereira caldas Carina Berterö Department of Medical and Health Sciences Division of Nursing Science Faculty of Health Sciences Link&ouml ping University Link&ouml ping Sweden Nursing Faculty Rio de Janeiro State University Rio de Janeiro Brazil

Background: Understanding life transitions is important to help people to achieve their developmental needs. No studies have examined the patterns of responses to life transitions, eliciting the experiences of growing old of retired Brazilian older adults. Aim: To identify and describe the patterns of responses to life transitions of retired Brazilian older adults. Design: Using a theoretical perspective of transition as a guide, a qualitative, secondary narrative research design was incorporated to obtain data from 11 interviews. Method: Initial data collection took place during a broader study on the influence of people’s working life history. Eleven autonomous and independent persons, 64 - 82 years old, were interviewed at a geriatric outpatient unit in rio de Janeiro to obtain their perceptions of old age. The secondary, narrative holistic-content analysis focused on the patterns of responses to life transitions. results: The first turning point was a childhood event and the next was their first job. The third turning point was moving to another place/house or another city, the fourth starting a family, and retirement was the last turning point. Conclusions: While older people may feel environmentally disconnected throughout life, their patterns of response, together with the available resources and prevention/interventions influence the transition process. Health Promotion actions are needed at vulnerable points during the transition process, thereby facilitating the health outcomes.

关键词： Transitions Life Course Health Promotion Elderly Health Brazil

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Bacterial Vector-Borne Plant Diseases:Unanswered Questions and Future Directions

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Molecular Plant 2020年第10期13卷 1379-1393页

作者： Weijie Huang Paola reyes-caldas Marina Mann Shirin Seifbarghi Alexandra Kahn rodrigo P.P.Almeida Laure Béven Michelle Heck Saskia A.Hogenhout Gitta Coaker Department of Crop Genetics John Innes CentreNorwich Research ParkNorwich NR47UHUK Department of Plant Pathology University of CaliforniaDavisCA95616USA Department of Plant Pathology and Plant-Microbe Biology Cornell UniversityIthacaNY 14853USA Department of Environmental Science Policy and ManagementUniversity of CaliforniaBerkeleyCA 94720USA UMr 1332 Biologie du Fruit et Pathologie Univ.BordeauxINRAEVillenave d'Ornon 33882 France Boyce Thompson Institute IthacaNY 14853USA Emerging Pests and Pathogens research Unit Robert W.Holley CenterUSDA ARSIthacaNY 14853USA School of Environmental Sciences University of East AngliaNorwich Research ParkNorwich NR47T JUK

Vector-borne plant diseases have significant ecological and economic impacts,affecting farm profitability and forest composition throughout the *** vector-borne pathogens have evolved sophisticated strategies to interact with their hemipteran insect vectors and plant *** pathogens reside in plant vascular tissue,and their study represents an excellent opportunity to uncover novel biological mechanisms regulating intracellular pathogenesis and to contribute to the control of some of the world's most invasive emerging *** this perspective,we highlight recent advances and major unanswered questions in the realm of bacterial vector-borne disease,focusing on liberibacters,phytoplasmas,spiroplasmas,and Xylella fastidiosa.

关键词： liberibacter phytoplasma spiroplasma Xylella fastidiosa vector-borne disease effector plant immunity

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