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IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity

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Cellular & Molecular Immunology 2017年第11期14卷 875-877页

作者： julia D Boehme Dunja Bruder Infection Immunology Group Institute of Medical Microbiology and Hospital HygieneOtto-von-Guericke UniversityMagdeburgGermany Immune Regulation Group Department of Immune ControlHelmholtz Centre for Infection ResearchBraunschweigGermany

Influenza A virus(IAV)is the causative agent of mostly mild to moderate seasonal respiratory infections and several pandemic outbreaks,the most recent of which was reported in *** IAV pandemics were associated with an enormous death toll;for example,the 1918 H1N1 pandemic affected hundreds of millions of people globally and resulted in~50 million deaths.1 Microbiologic analyses of patient samples revealed a strong incidence of bacterial pathogens in fatal complications of viral infection.2 To date,many pieces of epidemiologic and experimental evidence reveal pronounced susceptibility to detrimental bacterial superinfection in IAVinfected individuals.

关键词： immunity respiratory hundreds

Subcutaneous sarcoidosis of the upper and lower extremities: A case report and review of the literature

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World Journal of Clinical Cases 2019年第17期7卷 2505-2512页

作者： Raman Mehrzad julia Festa Reena Bhatt Department of Plastic and Reconstructive Surgery Rhode Island Hospital the Warren Alpert Medical School of Brown University

BACKGROUND Sarcoidosis is a granulomatous disease of unknown etiology that most often impacts the *** manifestations of sarcoidosis are seen among 9%- 37% of *** sarcoidosis is a rare presentation of cutaneous sarcoidosis with estimates of frequency ranging from 1.4%-16%.To date,very few articles and case reports have been written about this *** this paper,we describe a case of subcutaneous sarcoidosis and perform a review of the literature to determine if there are commonalities among patients who present with subcutaneous *** SUMMARY A 38-year-old female,with a past medical history of arthritis and recurrent nephrolithiasis,presents with an 8-mo history of 4 firm,asymptomatic,skincolored nodules on her left and right upper extremities and *** biopsy and post-excisional pathology report both revealed well-formed,dense,noncaseating granulomas localized to the subcutaneous *** computed tomography revealed mild mediastinal lymphadenopathy.A diagnosis of subcutaneous sarcoidosis was made,and the lesions were surgically *** Commonalities among patients presenting with subcutaneous sarcoidosis include: middle-aged female,lesions localizing to the upper or lower limbs,lymphadenopathy or pulmonary infiltration on chest imaging,elevated serum angiotensin-converting enzyme.

关键词： Subcutaneous sarcoidosis Upper extremity Granulomatous disease Case report

Strikha家具系列设计,传统文化与现代美学的融合

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工业设计 2024年第2期 16-16页

作者： julia Kononenko 不详

Strikha系列家具的设计灵感来源于古老的乌克兰小木屋,类似茅草屋顶的造型营造了一种轻盈和自然的感觉。每件作品都由工匠们手工制作,让家具呈现出独特性。这一系列家具融合了传统与现代,将古老的设计元素转化为现代、时尚的室内家具作品。

关键词：室内家具现代美学手工制作小木屋系列设计设计灵感乌克兰融合

维普期刊数据库博看期刊

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The Journal of Biomedical Research 2014年第2期28卷 75-77页

作者： julia Munsch Department of Pharmacy UC Davis Medical Center

INTRODUCTION After much anticipation, approval of the first U.S. biosimilar medications may be around the corner. Biosimilars hold the promise of reducing healthcare spending by offering lower-cost alternatives to hi... 详细信息

关键词： Biosimilars

Sox9 in the developing central nervous system:a jack of all trades?

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Neural Regeneration Research 2021年第4期16卷 676-677页

作者： julia K.Vogel Michael Wegner Institut für Biochemie Emil-Fischer-ZentrumFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Sox9–gliogenesis and beyond:Neurons and glial cells are the major neuroectodermal cell types of the vertebrate central nervous system(CNS).Their generation from common progenitor cells takes place mostly during embryonic and early postnatal *** closure of the neural tube,neural epithelial progenitor cells(NEPs)establish the ventricular zone(VZ).By asymmetrical cell division,NEPs first give rise to neuronal precursor cells(NPs)that then differentiate into various types of ***,NEPs predominantly produce glial precursor cells that become either astroglia or oligodendroglia.

关键词： development. mostly closure

Characterizing drug-metabolizing enzymes and transporters that are bona fide CAR-target genes in mouse intestine

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Acta Pharmaceutica Sinica B 2016年第5期6卷 475-491页

作者： Shinhee Park Sunny Lihua Cheng julia Yue Cui Department of Environmental and Occupational Health Sciences University of Washington

Intestine is responsible for the biotransformation of many orally-exposed *** constitutive androstane receptor(CAR/Nr1i3) is known to up-regulate many genes encoding drugmetabolizing enzymes and transporters(drug-processing genes/DPGs) in liver,but less is known regarding its effect in ***-day-old wild-type and Car / mice were administered the CARligand TCPOBOP or vehicle once daily for 4 *** wild-type mice,Car m RNA was down-regulated by TCPOBOP in liver and *** / mice had altered basal intestinal expression of many DPGs in a section-specific *** with the liver data(Aleksunes and Klaassen,2012),TCPOBOP upregulated many DPGs(Cyp2b10,Cyp3a11,Aldh1a1,Aldh1a7,Gsta1,Gsta4,Gstm1-m4,Gstt1,Ugt1a1,Ugt2b34,Ugt2b36,and Mrp2–4) in specific sections of small intestine in a CAR-dependent ***,the m RNAs of Nqo1 and Papss2 were previously known to be up-regulated by TCPOBOP in liver but were not altered in ***,many known CAR-target genes were highest expressed in colon where CAR is minimally expressed,suggesting that additional regulators are involved in regulating their *** conclusion,CAR regulates the basal expression of many DPGs in intestine,and although many hepatic CAR-targeted DPGs were bona fide CAR-targets in intestine,pharmacological activation of CAR in liver and intestine are not identical.

关键词： Drug-processing genes Intestine Mice CAR Drug-metabolizing enzymes Transporters

Phylogenomic analyses shed light on the relationships of chiton superfamilies and shell‑eye evolution

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Marine Life Science & Technology 2023年第4期5卷 525-537页

作者： Xu Liu julia D.Sigwart Jin Sun Key Laboratory of Evolution&Marine Biodiversity(Ministry of Education)and Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China Department of Marine Zoology Senckenberg Research Institute and Natural History Museum Frankfurt60325 Frankfurt Am MainGermany

Mollusca is the second-largest animal phylum with over 100,000 extant species representing eight *** 1000 extant species in the class Polyplacophora,chitons have a relatively constrained morphology but with some notable *** genera possess“shell eyes”,i.e.,true eyes with a lens and retina that are embedded within the dorsal *** phylogeny of the major chiton clades is mostly well established,in a set of superfamily-level and higher level taxa supported by various approaches,including morphological studies,multiple gene markers,mitogenome-phylogeny,and phylotranscriptomic ***,one critical lineage has remained unclear,namely Schizochiton which was controversially suggested as being the potential independent origin of chiton shell ***,with the draft genome sequencing of Schizochiton incisus(superfamily Schizochitonoidea)plus assemblies of transcriptome data from other polyplacophorans,we present phylogenetic reconstructions using both mitochondrial genomes and phylogenomic approaches with multiple *** found that phylogenetic trees from mitogenomic data are inconsistent,reﬂecting larger scale confounding factors in molluscan ***,a consistent and robust topology was generated with protein-coding genes using diﬀerent models and *** results support Schizochitonoidea as the sister group to other Chitonoidea in Chitonina,in agreement with the established classiﬁ*** with evidence from fossils,our phylogenetic results suggest that the earliest origin of shell eyes is in Schizochitonoidea,and that these structures were also gained secondarily in other genera in *** results have generated a holistic review of the internal relationship within Polyplacophora,and a better understanding of the evolution of Polyplacophora.

关键词： Chiton Mollusca Phylogenomics Polyplacophora Shell eyes

The Secret Life of Chloroplast Precursor Proteins in the Cytosol

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Molecular Plant 2020年第8期13卷 1111-1113页

作者： Athina Hristou julia Grimmer Sacha Baginsky Biochemistry of Plants Faculty of Biochemistry and BiotechnologyRuhr University BochumUniversit(a)tsstrasse 15044801 BochumGermany Institute of Biochemistry and Biotechnology Martin-Luther-University Halle-WittenbergCharles Tanford ProteinzentrumKurt-Mothes-Str.3a06120 Halle(Saale)Germany

Eukaryotic cells contain semi-autonomous organelles that have lost most of their coding capacity for essential proteins to the ***,their functioning depends on the cytosolic translation products of nuclear-encoded genes that must be imported by a specialized protein import *** import between 2500 and 3500 proteins for their functioning,demonstrating that the bulk of the chloroplast proteome is shuttied through the cytosol as precursor *** proteins usually contain an N-terminal transit peptide that is cleaved off by a signa/processing peptidase(SPP)and degraded by the chloroplast protease network upon *** the cytosol,precursors can be co-and post-translationally modified,interact with a set of chaperones,co-chaperones,14-3-3 proteins,and/or E3 ligases before they are either imported or degraded by the cytosolic proteasome *** is now clear that precursors are not only a transient transport form of functional proteins but that their cytosolic transition is of regulatory importance.

关键词： specialized autonomous imported

Towards Societies Living with COVID-19

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China CDC weekly 2021年第7期3卷 144-145页

作者： Peter Piot julia Spencer London School of Hygiene&Tropical Medicine LondonUK

The coronavirus disease 2019(COVID-19)pandemic is undoubtedly the greatest challenge in peacetime facing the world for more than 100 *** country is untouched with more than 100 million confirmed cases and over 2 million deaths as of January 28,2021(1),and the actual number of infections is probably closer to one billion as few countries had sufficient testing capacity to identify all cases,particularly throughout early 2020.

关键词： doubt closer peace