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Dietary branched-chain amino acids modulate the dynamics of calcium absorption and reabsorption in proteinrestricted pigs

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Journal of Animal Science and Biotechnology 2022年第4期13卷 1083-1098页

作者： Mohammad Habibi Cedrick NShili julia sutton Parniyan Goodarzi Adel Pezeshki Department of Animal and Food Sciences Oklahoma State University206C Animal Science BuildingStillwaterOK 74078USA

Background:Very low-protein(VLP)diets negatively impact calcium(Ca)metabolism and *** objective of this study was to investigate the effect of supplemental branched-chain amino acids(BCAA)and limiting amino acids(LAA)on Ca digestibility,absorption and reabsorption in pigs fed with VLP ***-eight piglets were assigned to six treatments:positive control(PC),negative control(NC),and NC containing LAA 25%,LAA 50%,LAA+BCAA 25%(LB25)and LAA+BCAA 50%(LB50)more than ***:Relative to PC or NC,LB25 and LB50 had higher digestibility of Ca and plasma Ca and phosphorus(P),but lower plasma vitamin ***50 tended to increase vitamin D receptor transcript and protein in the gut,but decreased mRNA or protein abundance of parathyroid hormone 1 receptor(PTH1R),calbindin 1(CALB1),cytochrome P450 family 27 subfamily B member 1 and occludin in small ***50 increased the transcript of cytochrome P450 family 24 subfamily A member 1 and PTH1R but decreased the transcript of transient receptor potential cation channel subfamily V member 5,CALB1 and solute carrier family 17 member 4 in ***:Overall,BCAA increased Ca digestibility through regulating the transcellular and paracellular Ca absorption in the gut and reabsorption in kidney during protein restriction.

关键词： Branched-chain amino acids Calcium absorption and reabsorption Calcium digestibility Pig Very low protein diets

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Branched-chain amino acids partially recover the reduced growth of pigs fed with protein-restricted diets through both central and peripheral factors

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Animal Nutrition 2021年第3期7卷 868-882页

作者： Mohammad Habibi Cedrick Shili julia sutton Parniyan Goodarzi Excel Rio Maylem Leon Spicer Adel Pezeshki Department of Animal and Food Sciences Oklahoma State UniversityStillwaterOK74078USA

The objective of this study was to assess the growth efficiency of pigs fed with protein-restricted diets supplemented with branched-chain amino acids(BCAA)and limiting amino acids(LAA)above the rec-ommended *** 2 weeks of adaptation,48 young barrows were weight matched and randomly assigned to 6 treatments(8 pigs/treatment)for 4 weeks:positive control(PC)with standard protein,negative control(NC)with very low protein containing LAA(i.e.,Lys,Met,Thr and Trp)at rec-ommended levels,and NC containing LAA 25%(L25),LAA 50%(L50),LAA+BCAA(i.e.,Leu,Ile and Val)25%(LB25)and LAA+BCAA 50%(LB50)more than *** intake(FI)and body weight(BW)were measured daily and weekly,*** week 6,blood samples were collected,all pigs euthanized and tissue samples *** data were analyzed by univariate GLM or mixed procedure(SPSS)and the means were separated using paired Student's t-test followed by Benjamini-Hochberg *** to PC,NC had decreased FI,BW,unsupplemented plasma essential amino acids,serum insulin-like growth factor-I(IGF-I)and hypothalamic neuropeptide Y(NPY)(P<0.01).Compared to NC,L25 or L50,LB50 had increased BW and serum IGF-I and decreased plasma serotonin and both LB25 and LB50 had higher FI,plasma BCAA,hypothalamic 5-hydroxytryptamine-receptor 2A and NPY and jejunal 5-hydroxytryptamine-receptor 7(P<0.01).Overall,supplementation of protein-restricted diets with increased levels of dietary BCAA partially recovered the negative effects of these diets on growth through improved IGF-I concentration and FI,which was associated with changed expression of serotonin receptors,blood AA and hypothalamic NPY.

关键词： Branched-chain amino acid Very low protein diet NPY insulin-like growth factor-Ⅰ Serotonin Pig

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Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk

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World Journal of Gastroenterology 2012年第22期18卷 2805-2812页

作者： Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal julia Nathalie Charnaux Angela sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow INSERM U577(National Institute of Health and Medical Research) Inra Cnam University of Paris 13 (UREN) SMBH 74 rue Marcel Cachin F-93017 Bobigny France Department of Biochemistry Jean Verdier Hospital F-93140 Bondy France INSERM U698 University of Paris 13 F-93017 Bobigny France Department of Public Health Avicenne Hospital (AP-HP) University of Paris 13 F-93017 Bobigny France Department of Nutrition Ambroise Paré Hospital (AP-HP) University of Versailles Saint Quentin F-92100 Boulogne-Billancourt France

AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive ***: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies.

关键词：细胞粘附分子危险因素大肠癌脂联素可溶性诊断断水 Logistic回归模型

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