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Rheological and stability analysis of cement pastes incorporating silica-based wastes

Particuology 2024年第6期89卷 144-152页

作者： julia da Rosa Martins Janaíde Cavalcante Rocha Dachamir Hotza Luciano Senff Graduate Program in Materials Science and engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil engineering(PPGeC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical engineering(POSeNQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study investigates the influence of waste characteristics,especially zeta potential,on the properties of cement pastes and *** focus is to evaluate the impact of the zeta potential of cement particles and waste materials on the sedimentation speed,rheology,and hardening time of stabilized cement *** Cement II F 40,retarder additive,silica,and fly ash were used in the *** pastes were prepared,and during the stabilization period,their rheological properties and pH were *** zeta potential and sedimentation speed of the cement and waste particles were measured at the pH that the pastes presented during the entire stabilization *** the stabilization period,the pastes were subjected to the hardening time *** zeta potential analyses revealed diverse values for the different powder types,with the cement particles exhibiting a zeta potential of−3.0 mV,the silica particles exhibiting−10.5 mV,and the fly ash particles exhibiting−20.3 *** influence of the high zeta potential modulus was observed on the sedimentation speed,with the solution containing fly ash exhibiting a speed of 40.01μm/s,whereas the solution containing only cement exhibited a speed of 99.38μm/*** the pastes,the results indicate that the presence of fly ash particles with a significantly negative zeta potential led to a 16%reduction in hardening time compared to particles with a lower modulus of zeta *** tests showed that the inclusion of fly ash particles prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was found to have no effect on yield stress or viscosity.

关键词： Wastes Zeta potential Setting time Rheometry

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Barosinusitis due to routine weather changes:A cross-sectional analysis of public websites

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 18-23页

作者： James C.Campbell julia e.cani.k Philip G.Chen Ralph Abi Hachem David W.Jang Department of Head and Neck Surgery&Communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Duke University School of Medicine DurhamNorth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery University of Texas Health Science Center San AntonioSan AntonioTexasUSA

Background:Sinusitis is a common diagnosis that can be erroneously associated with routine weather‐related barometric pressure *** actuality,these pressure changes likely exacerbate migraine headaches,which can cause facial pain and pressure rather than true sinus ***:The present study sought to characterize the representation of both sinusitis and migraine in association with barometric pressure changes across websites on the ***:An Internet search for relevant terms was conducted,and content of the resulting pages was assessed for associations between weather‐related pressure changes and either sinusitis or *** in reported results across different subtypes of Internet sources were *** primary outcomes measured were(1)whether a given media source associated barometric weather changes with sinusitis,(2)whether that source associated barometric weather changes with migraine,and(3)treatment options offered by that ***:Of the 116 included webpages,36(31.03%)associated sinusitis and routine barometric pressure *** these,10(27.77%)were otolaryngology practice ***‐seven webpages(57.76%)associated migraine and routine barometric pressure *** these,nonotolaryngology webpages were more likely to report this ***:Otolaryngology practice sites were observed to be the most frequent professional medical resource reporting the unsubstantiated claim that routine barometric pressure changes are associated with *** sources were more likely to link weather‐related pressure changes to *** results suggest that opportunities exist for otolaryngology practice sites to educate patients about nonrhinogenic headache etiologies.

关键词： acute rhinosinusitis balloon sinus dilation headache migraine sinusitis

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Otolaryngology residency program factors associated with female resident representation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 7-11页

作者： julia e.cani.k James C.Campbell Charles R.Woodard Lars J.Grimm Alissa M.Collins Duke University School of Medicine DurhamNorth CarolinaUSA Department of Head and Neck Surgery&Communication Sciences Duke University School of MedicineDurhamNorth CarolinaUSA Department of Radiology Duke University School of MedicineDurhamNorth CarolinaUSA

Objective:Female representation in the field of otolaryngology is *** is the first point at which medical school graduates specialize in a chosen field and thus represents an opportunity to recruit and train more female *** study sought to identify program factors associated with greater female representation among resident ***:Departmental websites of all 124 otolaryngology residency programs in the United States and Puerto Rico were examined for a list of *** programs with a resident roster available,the genders of residents,faculty,program directors,and chairpersons were *** and city population for each program was also recorded,as was female resident *** were compared using Pearson Chi‐squared univariate ***:1,632 residents and 2,605 faculty were included in the analysis of 109 *** median female resident representation was 40%.Programs with larger faculty sizes,more female faculty,and urban location were associated with an above‐median female resident *** with a larger residency cohort approached significance regarding above‐median female resident *** female faculty representation,program director gender,chairperson gender,and US region were not associated with variation in female resident ***:Greater female otolaryngology residency representation was associated with programs having an urban location and greater numbers of female and total *** was also likely that a larger resident cohort size may affect female resident *** proportions of female faculty,program director,and chairperson gender,as well as the US region,were not associated with variation in female resident gender representation.

关键词： gender program director recruitment residency training

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eZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

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Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： keith Al-Hasani Safiya Naina Marikar Harikrishnan kaipananickal Scott Maxwell Jun Okabe Ishant khurana Thomas karagiannis julia J.Liang Lina Mariana Thomas Loudovaris Thomas kay Assam el-Osta epigenetics in Human Health and Disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia epigenetics in Human Health and Disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong kong Institute of Diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1D),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1D owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the eZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1D donors to the FDAapproved eZH2 inhibitors GSk126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3k27me3 and H3k4me3 chromatin *** eZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： eZH2 struction inhibitors

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Ca^(2+) binding to the C_(2)e domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose kathrin kusch Carolin Wichmann Nicola Strenzke Barbara Vona julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerearLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DeRDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of excellence(MBexC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Broadband mechanoresponsive liquid metal sensors

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npj Flexible electronics 2022年第1期6卷 718-725页

作者： Md Saifur Rahman julia e.Huddy Andrew B.Hamlin William J.Scheideler Thayer School of engineering Dartmouth CollegeHanoverNH 03755USA

Stretchable electronics have the fundamental advantage of matching the complex geometries of the human body,providing opportunities for real-time biomechanical *** report a method for high-frequency AC-enhanced resistive sensing that leverages deformable liquid metals to improve low-power detection of mechanical stimuli in wearable *** fundamental mechanism of this enhancement is geometrical modulation of the skin effect,which induces current crowding at the surface of a liquid metal *** combination with DC sensing,this method quantitatively pinpoints mechanical modes of deformation such as stretching in-plane and compression out-of-plane that are traditionally impossible to *** we explore this method by finite element simulations then employ it in a glove to detect hand gestures and tactile forces as well as a respiratory sensor to measure ***,this AC sensor uses lower power(100X)than DC sensors,enabling a new generation of energy-efficient wearables for haptics and biomedical sensing.

关键词： wear deformation liquid

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Achieving exceptional wear resistance in a crack-free high-carbon tool steel fabricated by laser powder bed fusion without pre-heating

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Journal of Materials Science & Technology 2023年第25期156卷 1-19页

作者： konrad kosiba Daniel Wolf Matthias Bönisch kai Neufeld Ruben Hühne Tobias Gustmann Jozef Bednarčík Hongyu Chen Xiaoliang Han Volker Hoffmann Lukas Beyer Uta kühn Sergio Scudino Lars Giebeler julia k.Hufenbach Leibniz Institute for Solid State and Materials Research (IFW) Dresden e.V. Helmholtzstr. 20Dresden 01069Germany Department of Materials engineering KU LeuvenKasteelpark Arenberg 44bus 2450Leuven 3001Belgium Department of Condensed Matter Physics Institute of PhysicsP.J. Safarik University in KosicePark Angelinum 9Kosice 04154Slovakia Institute of experimental Physics Slovak Academy of ScienceWatsonova 47Kosice 040 01Slovakia key Laboratory of Impact and Safety engineering of Ministry of education of China Ningbo UniversityNingbo 315211China TU Bergakademie Freiberg Institute of Materials ScienceGustav-Zeuner-Str. 5Freiberg 09599Germany

Laser powder bed fusion(LPBF)for the fabrication of dense components used for tooling applications,is highly *** stresses,which evolve in the additively manufactured part,are inherent to LPBF *** additional stress contribution in high-carbon steels arises from the austenite-to-martensite phase transformation,which may eventually lead to cracking or even *** an alternative to pre-heating the base plate,which is not striven by industry,lowering the martensite content which forms in the part,is essential for the fabrication of dense parts by LPBF of high-carbon tool steels which are then adapted to *** this study,a successful strategy demonstrates the processing of the Fe85Cr4Mo1V1W8C1(wt%)high-carbon steel by LPBF into dense parts(99.8%).The hierarchical microstructure consists of austenitic and martensitic grains separated by elemental segregations in which nanoscopic carbide particles form a network.A high density of microsegregation was observed at the molten pool boundary ultimately forming a *** LPBF-fabricated steel shows a yield strength,ultimate compressive stress,and total strain of 1210 MPa,3556 MPa,and 27.4%,*** mechanical and wear performance is rated against the industrially employed and highly wear-resistant 1.2379 tool steel taken as the *** its lower macro-hardness,the LPBF steel(58.6 HRC,0.0061 mm^(3) Nm^(-1))shows a higher wear resistance than the reference steel(62.6 HRC,0.0078 mm^(3) Nm^(-1)).This behavior results from the wear-induced formation of martensite in a microscale thick layer directly at the worn surface,as it was proven via high-energy X-ray diffraction mapping.

关键词： Additive manufacturing Laser powder bed fusion Steel Wear TRIP

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Phylogenomic analyses shed light on the relationships of chiton superfamilies and shell‑eye evolution

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Marine Life Science & Technology 2023年第4期5卷 525-537页

作者： Xu Liu julia D.Sigwart Jin Sun key Laboratory of evolution&Marine Biodiversity(Ministry of education)and Institute of evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China Department of Marine Zoology Senckenberg Research Institute and Natural History Museum Frankfurt60325 Frankfurt Am MainGermany

Mollusca is the second-largest animal phylum with over 100,000 extant species representing eight *** 1000 extant species in the class Polyplacophora,chitons have a relatively constrained morphology but with some notable *** genera possess“shell eyes”,i.e.,true eyes with a lens and retina that are embedded within the dorsal *** phylogeny of the major chiton clades is mostly well established,in a set of superfamily-level and higher level taxa supported by various approaches,including morphological studies,multiple gene markers,mitogenome-phylogeny,and phylotranscriptomic ***,one critical lineage has remained unclear,namely Schizochiton which was controversially suggested as being the potential independent origin of chiton shell ***,with the draft genome sequencing of Schizochiton incisus(superfamily Schizochitonoidea)plus assemblies of transcriptome data from other polyplacophorans,we present phylogenetic reconstructions using both mitochondrial genomes and phylogenomic approaches with multiple *** found that phylogenetic trees from mitogenomic data are inconsistent,reﬂecting larger scale confounding factors in molluscan ***,a consistent and robust topology was generated with protein-coding genes using diﬀerent models and *** results support Schizochitonoidea as the sister group to other Chitonoidea in Chitonina,in agreement with the established classiﬁ*** with evidence from fossils,our phylogenetic results suggest that the earliest origin of shell eyes is in Schizochitonoidea,and that these structures were also gained secondarily in other genera in *** results have generated a holistic review of the internal relationship within Polyplacophora,and a better understanding of the evolution of Polyplacophora.

关键词： Chiton Mollusca Phylogenomics Polyplacophora Shell eyes

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Organochlorine pesticide and heavy metal residues in some edible biota collected from Quanzhou Bay and Xinghua Bay,Southeast China

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Journal of environmental Sciences 2010年第2期22卷 314-320页

作者： Mangala Yatawara Odhiambo Joshua Owago julia e Burnet key Laboratory of Biogeology and environmental Geology of Ministry of education

In order to assess the contamination of edible marine organisms in Quanzhou and Xinghua Bays, Fujian Province, China, concentrations of organochlorine pesticides （hexachlorocyclohexane isomers or HCHs and dichlorodiphenyltrichloroethane isomers/derivatives or DDTs） and heavy metals （Cu, Pb, Zn, As, Cr, Cd, Ni and Hg） in 13 species collected from different sites in the hays were analyzed by GC-eCD and ICP-MS. The concentration of the sum of DDTs exceeded that the sum of HCHs in the samples. Most of the organisms showed higher levels of DDTs than the first level criterion （10 ng/g） for marine biological quality in China （GB 18421-2001） but conformed to the first level criterion （20 ng/g） for HCHs. The estimated mean daily uptake of pesticides was below the level for minimal risk to the consumers. The levels of Cd, As and Pb in most organisms from both bays were markedly elevated and above the recommended legal limits for human consumption. Our results showed the need for routine monitoring of marine species contamination to ensure public and environmental health.

关键词： organochlorine pesticides residue levels technical HCH heavy metals Fujian Province

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A design framework for a kinetic shading device system for building envelopes

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Frontiers of Architectural Research 2023年第5期12卷 837-854页

作者： Felipe Tavares da Silva julia Cruz Gaspari Veras Architecture and Urbanism Department Universidade Federal da ParaibaJoão PessoaPBBrazil Architecture Faculty Universidade Federal da BahiaSalvadorBABrazil

This paper presents a design framework of a shading device applied on a building envelope,with a scheduled automatic activation logic,based on a sun path *** proposal aims to balance the direct sun indoor exposure by evaluating the envelope area exposed to direct sun rays and the hourly activation rate of shading *** procedures are over the parametric modeling and simulation platform using raytracing,structural finite element analysis,and Computer Numerical Control(CNC)*** design process of building envelopes equipped with kinetic devices can use all these design *** kinetic device’s activation logic relies on the feed-forward paradigm,scheduling the activation from the parametric modeling and the sun path diagram,using an angle threshold between the device post and the sun vector as a *** design framework showed the preliminary path to develop shading devices considering the building envelope shape with a feedforward activation logic based on local sun path characteristics.

关键词： kineticarchitecture Shading device kinetic design environmental control

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