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自身免疫起源的迟发性癫痫流行率和临床结局:一项前瞻性观察性人群队列研究

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癫痫杂志 2018年第3期4卷 242-248页

作者： felix von Podewils Marie Suesse julia Geithner 张颖颖童馨慕洁 Gaida b Wang ZI Lange J Dressel A Grothe M Kessler C Langner S Runge U bien CG

众所周知,随着年龄增长新发癫痫的发病率增加。通常,这些患者的病因难以明确。研究调查了有非诱导性迟发性癫痫发作且不合并肿瘤(可能患有副肿瘤性脑炎)患者的潜在自身免疫反应情况。在4.75年内前瞻性连续纳入了66例患者(至少有一次癫... 详细信息

众所周知,随着年龄增长新发癫痫的发病率增加。通常,这些患者的病因难以明确。研究调查了有非诱导性迟发性癫痫发作且不合并肿瘤(可能患有副肿瘤性脑炎)患者的潜在自身免疫反应情况。在4.75年内前瞻性连续纳入了66例患者(至少有一次癫痫或癫痫发作,病程≤6个月,36例女性,年龄≥55岁)。检测所有患者的血清、脑脊液抗体和神经细胞表面、细胞内抗原。45例患者(68%)进行了核磁共振(MRI)检查。对于抗体阳性的患者随访时间至少6个月。2例患者血清、脑脊液中抗接触蛋白相关性蛋白样-2(Contactin associated protein-like 2,CASPR2)抗体滴度高,符合明确边缘性脑炎的诊断标准。另外2例患者MRI显示双侧脑颞区炎性异常,尽管血清、脑脊液抗体阴性,也符合明确边缘性脑炎的诊断标准。这4例患者年龄55~70岁之间,均接受了抗免疫治疗和(或)抗癫痫治疗之后变成癫痫再无发作。该研究发现提示自身免疫应该被认为是迟发型癫痫患者的一个重要病因。对于这些患者,神经元抗体检测和大脑MRI可能是有价值的检查手段。

关键词：自身免疫性病因迟发型癫痫神经元抗体

Influence of Photoperiod over Morphometric and Hematological Parameters of Juvenile Piracanjubas （brycon orbygnianus）

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Journal of Agricultural Science and Technology(b) 2016年第5期6卷 350-359页

作者： Monica Rodrigues ferreira Machado] Eliane Aparecida de Andrade Estefania de Souza Andrade Daniella Aparecida de Jesus Paula julia Alvarenga Oliveira Adriano Carvalho Costa Ana Paula Peconick Luis David Solis Murgas Department of biological Science Federal University of Goias (UFG) Campus Cidade Universitaria CEP 75801-615 JataiGoias Brazil Department of Veterinary Medicine Cdmpus Universitario Federal University of Lavras (UFLA) Lavras Minas Gerais CEP3 7200-000 Brazil Department of Animal Science Federal Institute of Rio Verde (IFR V) Rio Verde Goias CEP 75901-970 Brazil

The aim of this study was to evaluate morphometric and hematological parameters of juveniles Piracanjubas treated with two distinct photoperiod. Twenty nine fish with 100 g, in a factorial design were performed in 18 h light：6 h dark （18L：6D） and 6L：lSD two different photoperiod, and morphometric and hematological parameters were evaluated at 45 d and 90 d after photoperiod treatment. benzocaine 1% was used for euthanasia. Fish were weighed and measured, so as visceral fat, liver and gonads. Hematocrit, total count of white cells, lymphocytes and neutrophils were counted. Results showed that there was no significant relationship between bodyweight and standard length. Significant interaction （P = 0.00018） had been found between the fat index （FI） and gonado-somatic index （GSI） and the photoperiod and time. At 90 d, the fish kept in 18L：6D had a lower rate of fat than the fish kept in 6L：18D （P 〈 0.05）. The GSI was higher in the group 6L.＇18D compared with the 18L：6D （P 〈 0.005）. There was no interaction between photoperiod and period of treatment for total leukocyte count, however with 90 d, the total leukocyte count was decreased （P 〈 0.05）. Moreover, decrease of the hematocrit from 58.1% to 46.9% and an increase of lymphocytes from 31.5% to 43.5% had been found in fish kept in 18L：6D after 90 d （P 〈 0.05）. Fish kept in 6L：ISD presented an increase in segmented neutrophils and lymphocytes （P 〈 0.05）. It is concluded that photoperiod maintained at 6L： 18D for Piracanjubas permits a greater gonadal development and an amount of immune cells over the photoperiod maintained in 18L： 6D.

关键词： Circadian rhythm fish maturity cellular immune response photoperiod.

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浮云

疯狂英语（初中天地） 2002年第23期 1-1页

作者： julia b.Straus 曾爱民江西省遂川县堆前中学

起先我看见一个篮子——篮子里面放着一盏灯。接着又看见一个身材魁梧的人, 模样像是山姆大叔。

关键词：浮云

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor biology RWTH Aachen UniversityAachenGermany Institute of Medical biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MbD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MbD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(bAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin

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W大阪酒店

现代装饰 2021年第3期 128-135页

作者： Rob Wagemans bart de beer julia Hundermark Sofie Ruytenberg Cathelijne Vreugdenhil femke Zumbrink Marlou Spierts ylvie Meuffels Rene Kroondijk Erik van Dillen Valentina Venturi Petra Moerbeek Minouk balster t.b.d.(摄影) 舒禹(编译) 不详

W酒店的每家酒店都针对其特定的地理位置而设计,邀请外国设计师,提供作为局外人的新鲜视角。W在日本的第一家酒店邀请了阿姆斯特丹的Concrete Architectural Associates在世界另一端的古老港口城市中寻找灵感。大阪曾经是日本的帝国首... 详细信息

W酒店的每家酒店都针对其特定的地理位置而设计,邀请外国设计师,提供作为局外人的新鲜视角。W在日本的第一家酒店邀请了阿姆斯特丹的Concrete Architectural Associates在世界另一端的古老港口城市中寻找灵感。大阪曾经是日本的帝国首都与经济中心。设计师探索了大阪的过去,现在和未来,研究其城市和自然景观,以及迷人的文化。日本的极简主义美学,与色彩饱和的都市之间的对比,给他们留下了深刻的印象。大阪闪烁的霓虹灯,大自然的简单之美都令人叹为观止。

关键词：港口城市极简主义外国设计师酒店阿姆斯特丹霓虹灯自然景观大阪

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中国文学的跃进——评《围城》企鹅版英译本

外国语文研究 2022年第1期8卷 59-62页

作者：蓝诗玲余承法(译) 伦敦大学伯克贝克学院湖南师范大学外国语学院

由于“冷战”、中西文化差异、翻译质量和编辑水平等因素,中国文学作品的英译一直没有引起英国读者的重视,但钱锺书的《围城》首次登上“企鹅现代经典”的榜单,标志中国小说开始跃进式地进入英语读者的视野。这部小说取材于中国抗日战... 详细信息

由于“冷战”、中西文化差异、翻译质量和编辑水平等因素,中国文学作品的英译一直没有引起英国读者的重视,但钱锺书的《围城》首次登上“企鹅现代经典”的榜单,标志中国小说开始跃进式地进入英语读者的视野。这部小说取材于中国抗日战争时期的一段悲惨境遇,字里行间流露出接受西化教育的青年知识分子对传统桎梏的反叛。作品对人物心理的细腻刻画、对时空变幻的强烈感悟、对人类现状的哲学洞察,都具有文学普适意义,但书中的大量双关语和典故对译者构成了巨大挑战。

关键词：钱锺书《围城》英译本中国文学跃进

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啤酒中真菌毒素的调查研究

中外酒业 2016年第15期 61-65页

作者：张振国陆健 julia I. bauer Madeleine Gross Christoph Gottschalk Ewald Usieber 江南大学生物工程学院

应用酶免疫测定方法研究了44种德国市售啤酒中的一些真菌毒素,包括麦角生物碱、交链孢酚(AOH)、脱氧雪腐镰刀菌烯醇(DON)和玉米烯酮(ZEA)。啤酒中DON、ZEA、麦角生物碱、AOH的检测限分别为2.1、0.14、0.06和0.18μg/L.。从75%的啤酒样... 详细信息

应用酶免疫测定方法研究了44种德国市售啤酒中的一些真菌毒素,包括麦角生物碱、交链孢酚(AOH)、脱氧雪腐镰刀菌烯醇(DON)和玉米烯酮(ZEA)。啤酒中DON、ZEA、麦角生物碱、AOH的检测限分别为2.1、0.14、0.06和0.18μg/L.。从75%的啤酒样品中检测到DON(2.2-20μg/L,中位数为3.7μg/L),所有样品表现为ZEA阳性(0.35-2.0μg/L,中位数为0.88μg/L)和AOH阳性(0.23-1.6μg/L,中位数为0.45μg/L),93%的样品表现为麦角生物碱阳性(0.07-0.47μg/L,中位数为0.15μg/L)。欧盟关于DON、ZEA和麦角生物碱规定的每日耐受摄入量(TDI)分别为1、0.25和0.6μg/kg b.w.,鉴于此,啤酒并不是这些毒素的主要摄入来源,虽然没有关于AOH每日耐受摄入量的数据,但是考虑到其他食物中的相关毒素水平,啤酒应该不是这一毒素的主要摄入来源。然而,麦角生物碱和AOH的频繁出现促使我们需进一步研究啤酒用原料中的这两种真菌毒素。

关键词：真菌毒素麦角生物碱交链孢酚脱氧雪腐镰刀菌烯醇啤酒

减少足月妊娠初产妇第一产程延长行剖宫产术的最佳处理策略

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英国医学杂志中文版 2018年第3期21卷 168-172页

作者： Sara Kenyon julia Sanders Lee Middkton Tracev Johnston 罗美朱磊 Institute of Applied Health Research University of Birmingham Birmingham B 15 2TT UK Healthcare Sciences Cardiff University Cardiff CF24 0AB UK birmingham Clinical Trials Unit School of Cancer Sciences Robert Aitken Institute University of Birmingham Birmingham birmingham Women's and Children's NHS Foundation Trust Birmingham 首都医科大学附属北京朝阳医院妇产科

分娩过程常分为3个产程。第一产程和第二产程的时间取决于产妇的分娩次数。图1是英国国家健康与临床优选研究所（NICE）定义的产程阶段和预期持续时间。初产妇的产程往往比经产妇更长。产程延长可由子宫收缩乏力引起，或由胎儿的大小、... 详细信息

分娩过程常分为3个产程。第一产程和第二产程的时间取决于产妇的分娩次数。图1是英国国家健康与临床优选研究所（NICE）定义的产程阶段和预期持续时间。初产妇的产程往往比经产妇更长。产程延长可由子宫收缩乏力引起，或由胎儿的大小、先露部和胎方位与阻碍阴道分娩的母体骨盆的关系等因素引起。子宫收缩功能障碍影响11％～30％初产妇的产程，也是本文关注的重点。

关键词：女人生育术语舞台劳动

Co-contaminants of microplastics in two seabird species from the Canadian Arctic

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Environmental Science and Ecotechnology 2022年第4期12卷 87-96页

作者： Roxana Sühring julia E.baak Robert J.Letcher birgit M.braune Amila de Silva Cody Dey Kim fernie Zhe Lu Mark L.Mallory Stephanie Avery-Gomm Jennifer F.Provencher Department of Chemistry and biology Toronto Metropolitan University(formerly known as Ryerson University)350 Victoria StTorontoONM5B 2K3Canada Department of Natural Resource Science McGill UniversitySainte Anne de BellevueQuebecH9X 3V9Canada Environment and Climate Change Canada National Wildlife Research CentreCarleton UniversityRaven RoadOttawaOntarioK1A 0H3Canada Aquatic Contaminants Research Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Ecotoxicology&Wildlife Health Division Environment and Climate Change CanadaBurlingtonOntarioL7S 1A1Canada Institut des Sciences de la Mer de Rimouski Université du Québec à RimouskiRimouskiQuébecG5L 3A1Canada Department of biology Acadia UniversityWolfvilleNova ScotiaB4P 2R6Canada

Through ingestion and subsequent egestion,Arctic seabirds can bioaccumulate microplastics at and around their colony breeding *** microplastics in Arctic seabirds have been well documented,it is not yet understood to what extent these particles can act as transport vehicles for plastic-associated contaminants,including legacy persistent organic pollutants(POPs),trace metals,and organic *** investigated the occurrence and pattern of organic and inorganic co-contaminants of microplastics in two seabird species from the Canadian Arctic-northern fulmar(Fulmarus glacialis)and black-legged kittiwake(Rissa tridactyla).We found that fulmars had higher levels of plastic contamination and emerging organic compounds(known to be plastic additives)than kittiwakes,whereas higher concentrations of legacy POPs were found in kittiwakes than the ***,fulmars,the species with the much larger foraging range(~200 km),had higher plastic pollution and overall contaminant burdens,indicating that birds may be acting as long-range transport vectors for plasticassociated *** results suggest a potential connection between plastic additive contamination and plastic pollution burdens in the bird stomachs,highlighting the importance of treating plastic particles and plastic-associated organic additives as co-contaminants rather than separate pollution issues.

关键词： Plastic contaminants Contaminants of emerging arctic concern Arctic Seabirds PFAS OPEs PbDEs Trace metals