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Sequential treatment with doxorubicin and zoledronic acid has no additive effects in an aggressive model of established bone metastases

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Journal of Cancer Metastasis and Treatment 2019年第2期4卷 87-99页

作者： Mari I.Suominen Rami Käkönen jukka P.Rissanen Jussi M.HaIIeen Pirkko Härkönen Sanna-Maria Käkönen Pharmatest Services Ltd. Turku FI-20520Finland Aurexel Life Sciences Ltd. Askainen FI-21240Finland PreclinApps Ltd. Raisio FI-21200Finland Institute of Biomedicine University of TurkuTurku 20520Finland

Aim: Bisphosphonates are used as an adjuvant treatment in breast cancer bone metastasis patients, often simultaneously with chemotherapeutic agents. Interestingly, their sequential combination has been reported to have synergistic anti-tumor effects on bone metastases in preclinical models. We studied the effects of doxorubicin (DOX) and zoledronic acid (ZOL) and their combination on established bone metastases in the MDA-MB-231(SA) GFP bone metastasis model. Methods: Tumor burden and osteolytic bone lesions were quantitated by fluorescence imaging and radiography, respectively. The mice were randomized in four groups receiving vehicle, DOX, ZOL or both DOX and ZOL in a sequential combination on day 14. Serum marker of osteoclast number was followed weekly, and blood ionized calcium was measured at sacrifice. Bone and tumor area, apoptosis and proliferation of tumor cells were analyzed from histological sections. Results: ZOL prevented hypercalcemia and osteolytic lesion progression, whereas DOX induced apoptosis in the MDA-MB-231(SA)GFP cells. However, neither of the treatments alone nor in sequential combination were able to reduce tumor burden in bone. Furthermore, no additive effects on tumor cell apoptosis were observed in the ;combination group. Conclusion: No additive effects in combination of DOX and ZOL were observed in this aggressive model of breast cancer bone metastasis.

关键词： Combination treatment breast cancer bone metastasis MDA-MB-231(SA) doxorubicin zoledronic acid

Changes of Surface Composition and Morphology after Incorporation of Ions into Biomimetic Apatite Coating

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Journal of Biomaterials and Nanobiotechnology 2010年第1期1卷 7-16页

作者： Wei Xia Carl Lindahl Cecilia Persson Peter Thomsen jukka Lausmaa Håkan Engqvist Materials in Medicine Applied Materials SciencetheÅngstrom LaboratoryUppsala UniversityUppsalaSweden Biomatcell VINN Excellence Center of Biomaterials and Cell TherapyGothenburgSweden Institute for Clinical Sciences Sahlgrenska Academy at University of GothenburgGothenburgSweden Department of Chemistry and Materials Technology SP Technical Research Institute of SwedenBoråsSweden

Fabrication of trace elements incorporated apatite coating could combine the ions’ pharmaceutical effect into the materials. In this study, strontium, silicon, and fluoride ions have been incorporated into apatite coatings through a biomineralization method, which mimics an in vitro mineralization process. The surface composition is tested with X-ray diffraction and X-ray photoelectron spectroscopy, and the surface morphology is characterized with scanning electron microscopy. Compared with pure hydroxyapatite coating, the strontium, silicon, and fluoride substituted apatite coatings show different morphology as spherical, needle-like, and nano-flake-like, individually. The crystal size of these biomimetic hydroxyapatite coatings decreased after ion substitution. The results of the analysis of surface composition present the ion substitutions are increased with the increasing of ion concentrations in the soaking solution. That means the ion incorporation into the apatite structure based on the biomineralization method could not only vary the ion content in but also change the morphology of the apatite coatings. Herein, the role of ion substitution is considered from the point of view of materials science at the micro structural and surface chemistry levels.

关键词： Biomineralization Hydroxyapatite Coating Substitution Biomimetic

Do the Right Patients use the Ambulance Service in South-Eastern Finland?-A Prospective Descriptive Study of Ambulance Dispatching in Relation to the Ambulance Staff’s Assessment of Patients’Needs in a Subset in the South East of Finland

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International Journal of Clinical Medicine 2011年第5期2卷 544-549页

作者： Bjorn-Ove Suserud Lena Beillon Ingvar Karlberg jukka Pappinen Maaret Castren Johan Herlitz University of Boras BorasSweden Nordic School of Public Health GoteborgSweden Center for Health System Analysis GothenburgSweden Tampere University TampereFinland Karolinska Institutet StockholmSweden

Background: Several Emergency Medical Systems use a criteria-based prioritization system for ambulance response. The emergency medical priority dispatching of ambulances was introduced in the 1980s. In a system of this kind, the operators at the medical emergency dispatch centers have to assess the patients’ symptoms and the need for ambulance response. The prioritization of the ambulance response is based on the seriousness of the patient’s symptoms, his/her current condition and, in the case of trauma, the trauma mechanism. The priority system is supposed to optimize the use of the ambulance service and to match and meet the patients’ needs with an adequate response from the ambulances. The aim of this study was to describe the dispatching and utilization of the ambulance service in a part of Finland. Results: There was a substantial divergence between the initial priority assigned and the patients’ medical status at the scene. The ambulance staff confirmed the need for ambulance transport for 65% of all the patients who were assigned an ambulance by the dispatch center. Conclusions: Using a criteria-based dispatch protocol, the dispatch operator works with a wider safety margin in the priority assessments for ambulance response than was actually confirmed by the ambulance personnel at the scene. In this sample, there may be some overuse of the ambulance service. According to the assessments made by the ambulance staff, 35% of the patients did not require ambulance transport. The emergency system has to accept and work with safety margins. At the same time, there must be a balance between a safety margin and a waste of limited resources.

关键词： Ambulance Dispatching Emergency Medical Services Prioritizing

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POM技术:清洁、快速和稳定的流送系统

中华纸业 2016年第1期37卷 48-51页

作者： jukka Helin 嘉兴埃富得机械有限公司(AFT)

纸机流送系统中的空气给正常的生产带来了很多问题。如：干扰网部脱水;在纸面上形成针孔和斑点;因为空气的存在使系统需要更大的体积,降低了系统的灵活性,从而增大了能耗;增大了化学药品的消耗量;产生不稳定和波动;产生絮集、胶黏物,从... 详细信息

纸机流送系统中的空气给正常的生产带来了很多问题。如：干扰网部脱水;在纸面上形成针孔和斑点;因为空气的存在使系统需要更大的体积,降低了系统的灵活性,从而增大了能耗;增大了化学药品的消耗量;产生不稳定和波动;产生絮集、胶黏物,从而形成进一步的污染;易于断纸等问题。而这些问题的产生最终难免导致生产成本的增大,降低了产量和成纸的质量。

关键词： POM 断纸网部胶黏物纸张强度纸种除气器技术设计生产成本压力筛

兼顾效率与可用性——光伏系统专用的全新ABB组串逆变器

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电气时代 2012年第7期 48-50页

作者： jukka Nurmi

全球变暖以及油气价格狂飙上涨意味着必须提高可再生能源的利用以满足不断增长的全球能源需求。地球一直拥有丰富的可再生能源——太阳光。光伏电池是最简单的太阳能利用方法。这些电池可产生直流电,而直流电转换为交流电这一转化由逆... 详细信息

全球变暖以及油气价格狂飙上涨意味着必须提高可再生能源的利用以满足不断增长的全球能源需求。地球一直拥有丰富的可再生能源——太阳光。光伏电池是最简单的太阳能利用方法。这些电池可产生直流电,而直流电转换为交流电这一转化由逆变器实现。ABB组串逆变器正是为该类住宅和中小型商业建筑光伏系统专门设计的。新逆变器系列带有内置保护功能,可大大减少对造价昂贵且耗费空间的外部保护装置以及大型机箱的需求。

关键词：光伏系统逆变器 ABB 可用性光伏发电系统功率变流器成本效益功率范围

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夏季轮胎测试报告

轿车情报 2015年第4期 236-243页

作者： jukka Antila Lasse Allard

我们是怎样测试的 HOW WE TESTED Braking tests 制动测试制动测试是在启用ABS并全部踩下制动的情况下进行的，初始速度分别是湿地时80km/h和干地时100km/h。 Driving grip on wet 湿地抓地力湿地抓着力主要是记录汽车在包括各种拐弯... 详细信息

我们是怎样测试的 HOW WE TESTED Braking tests 制动测试制动测试是在启用ABS并全部踩下制动的情况下进行的，初始速度分别是湿地时80km/h和干地时100km/h。 Driving grip on wet 湿地抓地力湿地抓着力主要是记录汽车在包括各种拐弯、加速、制动和不同高度的赛道上的绕圈时间，这样就可以比较容易地看出来不同的动态驾驶条件下轮胎的潜力。

关键词：测试报告夏季轮胎初始速度 grip 驾驶条件制动 ABS 湿地

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探索全球标签印刷发展趋势

今日印刷 2014年第1期 12-14页

作者： jukka-Pekka Haapanen 芬欧蓝泰标签亚太区

全球经济形势对整体业务的影响目前,有4个方面的问题影响着标签行业的发展。全球经济日趋衰势的挑战尚未解决,但是相比以前经济环境稍显乐观;西方国家老龄化问题将改变消费者的消费及其模式;新兴市场发展迅猛,新兴国家的标签业发展潜力... 详细信息

全球经济形势对整体业务的影响目前,有4个方面的问题影响着标签行业的发展。全球经济日趋衰势的挑战尚未解决,但是相比以前经济环境稍显乐观;西方国家老龄化问题将改变消费者的消费及其模式;新兴市场发展迅猛,新兴国家的标签业发展潜力巨大;全球经济影响力的转移仍在加速进行。201 2-2020年,大部分经济增长将出现在新兴市场。至2020年,各区域GDP增长预测情况为：美国＆加拿大为2.7%;欧洲发达国家为1.4%;欧洲新兴国家为3.6%：中国为7.1%;南亚6.7%;东南亚5.0%;日本、韩国为1.7%;澳大利亚、新西兰为1.8%：非洲5.3%;拉丁美洲为3.8%。

关键词：标签印刷发展趋势全球经济市场发展经济形势经济环境西方国家发展潜力

Periodontal bacteria in different sampling sites of pericoronitis patients

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Open Journal of Stomatology 2012年第2期2卷 98-102页

作者： Ari Rajasuo Virpi Laine Kirsti Kari Anna Pyhäjärvi jukka H.Meurman Department of Oral and Maxillofacial Diseases Mikkeli Central HospitalMikkeliFinland Mikkeli Region Health Centre MikkeliFinland Institute of Dentistry University of HelsinkiHelsinkiFinland Department of Oral and Maxillofacial Surgery Helsinki University Central HospitalHelsinkiFinland

The study investigated bacteria sampled from the mandibular third molar pericoronitis with the hypothesis that the same species also can be detected in several sites of the oral cavity. Subgingival plaque samples were taken from 41 patients (mean age 23.2 ± 4.2 years), from the third molar pericoronal pocket and from 3 adjacent gingival pockets, from the tongue and saliva. Aggregatibacter actinomycetemcomitans (A.a.), Porphyromonas gingivalis (P.g.), Tan- ne-rella forsythia (T.f.), Prevotella intermedia (P.i.), Pre-votella nigrescens (P.n.), and Treponema denticola (T.d.) were analyzed by qualitative PCR method. All the species analyzed were found in the pericoronitis samples in the following frequency: T.f. 73%, T.d. 68%, P.i. + P.n. 35%, A.a. 5%, and P.g. 5%. Saliva and tongue samples were also highly positive with T.f. (both 76%) and T.d. (saliva 57%, tongue 76%) and better sources for A.a. (saliva 8%, tongue 14%), and P.g. (saliva 14%, tongue 8%) than the pericoronitis pocket. The gingival pocket samples were less frequently positive the further the site in question was from the pericoronitis site. Contrary to earlier observations T.f. was frequently defected in pericoronitis sites. The results emphasize the importance of pericoronitis as a focus of infection.

关键词： Molar Third Pericoronitis Periodontitis Bacteria Saliva

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卫生纸机的质量管理系统

国际造纸 2009年第4期28卷 16-22页

作者： jukka Sorsa 黄景霞（译）美卓自动化不详

卫生纸的抄造过程中有很多方面可以改进,如在开机和断纸后更快地达到质量要求,提高纸种更换效率和减少损纸产生量,纸机稳定运转以达到更好的运行性能。这些改进可使卫生纸的生产更具成本效益——这是每个卫生纸生产商共同的目标。如果... 详细信息

卫生纸的抄造过程中有很多方面可以改进,如在开机和断纸后更快地达到质量要求,提高纸种更换效率和减少损纸产生量,纸机稳定运转以达到更好的运行性能。这些改进可使卫生纸的生产更具成本效益——这是每个卫生纸生产商共同的目标。如果能够节省昂贵的能源费用或实现产能的增加,利润就会更高。

关键词：质量管理系统卫生纸机卫生纸生产商抄造过程运行性能稳定运转成本效益能源费用