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Electrochemical biosensors for point-of-care testing

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Bio-Design and Manufacturing 2024年第4期7卷 548-565页

作者： Jinsol Kim juho Jeong Seung Hwan Ko Department of Mechanical Engineering Seoul National UniversitySeoul 08826Republic of Korea Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National UniversitySeoul 08826Republic of Korea

Point-of-care testing(POCT)is the practice of diagnosing and monitoring diseases where the patient is located,as opposed to traditional treatment conducted solely in a medical laboratory or other clinical *** has been less common in the recent past due to a lack of portable medical devices capable of facilitating effective medical ***,recent growth has occurred in this field due to advances in diagnostic technologies,device miniaturization,and progress in wearable *** these developments,electrochemical sensors have attracted interest in the POCT field due to their high sensitivity,compact size,and *** are used in various applications,from disease diagnosis to health status *** this paper we explore recent advancements in electrochemical sensors,the methods of fabricating them,and the various types of sensing mechanisms that can be ***,we delve into methods for immobilizing specific biorecognition elements,including enzymes,antibodies,and aptamers,onto electrode surfaces and how these sensors are used in real-world POCT settings.

关键词： Point-of-care testing(POCT) Electrochemical sensor Enzyme Antibody Health care

Clustering Structure Analysis in Time-Series Data With Density-Based Clusterability Measure

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1332-1343页

作者： juho Jokinen Tomi Raty Timo Lintonen VTT Technical Research Centre of Finland Vuorimiehentie 3 P.O.Box 100002044 EspooFinland

Clustering is used to gain an intuition of the struc tures in the *** of the current clustering algorithms pro duce a clustering structure even on data that do not possess such *** these cases,the algorithms force a structure in the data instead of discovering *** avoid false structures in the relations of data,a novel clusterability assessment method called density-based clusterability measure is proposed in this paper.I measures the prominence of clustering structure in the data to evaluate whether a cluster analysis could produce a meaningfu insight to the relationships in the *** is especially useful in time-series data since visualizing the structure in time-series data is *** performance of the clusterability measure is evalu ated against several synthetic data sets and time-series data sets which illustrate that the density-based clusterability measure can successfully indicate clustering structure of time-series data.

关键词： Clustering exploratory data analysis time-series unsupervised learning

Gate-versus defect-induced voltage drop and negative differential resistance in vertical graphene heterostructures

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npj Computational Materials 2022年第1期8卷 480-488页

作者： Tae Hyung Kim juho Lee Ryong-Gyu Lee Yong-Hoon Kim School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-roYuseong-guDaejeon34141Korea

To enable the computer-aided design of vertically stacked two-dimensional(2D)van der Waals(vdW)heterostructure devices,we here introduce a non-equilibrium first-principles simulation method based on the multi-space constrained-search density functional *** it to graphene/few-layer hBN/graphene field-effect transistors,we show that the negative differential resistance(NDR)characteristics can be produced not only from the gating-induced mismatch between two graphene Dirac cones in energy-momentum space but from the bias-dependent energetic shift of defect ***,for a carbon atom substituted for a nitrogen atom(C_(N))within inner hBN layers,the increase of bias voltage is found to induce a self-consistent electron filling of in-gap C_(N)states,which in turn changes voltage drop profiles and produces symmetric NDR *** the CN placed on outer hBN layers,however,the pinning of C_(N)states to nearby graphene significantly modifies device characteristics,demonstrating the critical impact of atomic details for 2D vdW devices.

关键词： defect resistance details

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萨塔玛活动中心芬兰科特卡

世界建筑导报 2024年第2期39卷 77-81页

作者： juho Grönholm Antti Nousjoki Samuli Woolston Sampo Honkala Chris Morris Ricardo Cruz Recalde Mirja Sillanpää Niklas Mahlberg Thomas Miyauchi Stephanie Polochowitz Tuomas Uusheimo(摄影) ALA建筑师事务所不详

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于... 详细信息

新开业的萨塔玛活动中心位于科特卡市最古老的港口坎塔萨塔玛,距离著名的维拉莫海事中心(已在港口区立足15年)只有几步之遥。该活动中心与目前正在建设的芬兰东南应用科技大学新校区大楼和未来酒店位于同一地块。这三座新建筑将有助于加强港口与城市中心之间的视觉和功能联系。该活动中心是举办各种文化、体育和商务活动的理想场所。ALA建筑师事务所的设计工作侧重于将极具吸引力的建筑与功能性和环境目标相结合。其建筑特征来源于环境和项目目标。

关键词：活动中心建筑师事务所大学新校区港口区科特萨塔功能性芬兰

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芬兰驻新德里大使馆翻新印度新德里

世界建筑导报 2024年第2期39卷 96-99页

作者： juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Simo Nuojua Harri Ahokas Anders Jönsson Lotta Kindberg Mirja Sillanpää Sari Vesanen Tuomas Uusheimo(摄影) ALA建筑师事务所不详

皮耶蒂莱夫妇(Reima and Raili Pietilä)赢得了1963年的芬兰大使馆设计竞赛,该大使馆位于新德里查卡雅布里的外交飞地,参赛作品美而有力,名为“雪在山上说”。经过长时间的拖延,该项目于1980年被正式委托,并在原有概念的基础上重新进行... 详细信息

皮耶蒂莱夫妇(Reima and Raili Pietilä)赢得了1963年的芬兰大使馆设计竞赛,该大使馆位于新德里查卡雅布里的外交飞地,参赛作品美而有力,名为“雪在山上说”。经过长时间的拖延,该项目于1980年被正式委托,并在原有概念的基础上重新进行了设计。大使馆最终于1986年开放,1960年设计的巨大单体屋顶被分成六个独立建筑,围绕在一个中心花园周围。雕塑般的屋顶,这是大使馆最显著的建筑特征,类似于芬兰北部库萨莫附近的雪湖Kitkajärvi。

关键词：中心花园设计竞赛印度新德里芬兰

Particle size distribution in CPFD modeling of gas-solid flows in a CFB riser

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Particuology 2015年第4期13卷 107-117页

作者： Qinggong Wang Timo Niemi juho Peltola Sirpa Kallio Hairui Yang Junfu Lu Lubin Weic Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Thermal Engineering.Tsinghua University VTT Technical Research Centre of Finland School of Chemical and Environmental Engineering China University of Mining and Technology

A computational particle fluid dynamics （CPFD） numerical method to model gas-solid flows in a circulating fluidized bed （CFB） riser was used to assess the effects of particle size distribution （PSD） on solids distribution and flow. We investigated a binary PSD and a polydisperse PSD case. Our simulations were compared with measured solids concentrations and velocity profiles from experiments, as well as with a published Eulerian-Eulerian simulation. Overall flow patterns were similar for both simulation cases, as confirmed by experimental measurements. However, our fine-mesh CPFD simulations failed to predict a dense bottom region in the riser, as seen in other numerical studies. Above this bottom region, distri- butions of particle volume fraction and particle vertical velocity were consistent with our experiments, and the simulated average particle diameter decreased as a power function with riser height. Interactions between particles and wails also were successfully modeled, with accurate predictions for the lateral profiles of particle vertical velocity. It was easy to implement PSD into the CPFD numerical model, and it required fewer computational resources compared with other models, especially when particles with a polydisperse PSD were present in the heterogeneous flow.

关键词： Circulating fluidized bed riser Particle size distribution CPFD Numerical simulation

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拉彭兰塔城市剧院芬兰拉彭兰塔

世界建筑导报 2024年第2期39卷 114-116页

作者： juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Harri Ahokas Tiina Liisa Juuti Julius Kekoni Auvo Lindroos Niklas Mahlberg Marlène Oberli-Räihä Pekka Sivula Tuomas Uusheimo(摄影) ALA建筑师事务所不详

拉彭兰塔城市剧院的概念与众不同:剧院建在一个购物中心的顶层。然而,这个概念很古老,这也是剧院回归本源、回归市场、回归公众的原因。购物中心每年有数百万客流,这些人可以欣赏各种戏剧,然后在餐厅用餐休息或下榻酒店。门厅采用平静... 详细信息

拉彭兰塔城市剧院的概念与众不同:剧院建在一个购物中心的顶层。然而,这个概念很古老,这也是剧院回归本源、回归市场、回归公众的原因。购物中心每年有数百万客流,这些人可以欣赏各种戏剧,然后在餐厅用餐休息或下榻酒店。门厅采用平静的单色氛围,与购物中心繁忙的明亮色彩形成对比。一块几乎透明的波浪形金属丝网帘将门厅与下方的购物中心分隔开来。楼梯从拱廊通向剧院门厅,观众穿过巨大的白色楼梯后抵达剧院。

关键词：购物中心金属丝网波浪形塔城市楼梯剧院回归

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校园城市村落芬兰埃斯波

世界建筑导报 2024年第2期39卷 104-105页

作者： juho Grönholm Antti Nousjoki Janne Teräsvirta Samuli Woolston Willem Barendregt Vladimir Ilic Julius Kekoni Auvo Lindroos Aleksi Niemeläinen Pekka Sivula Pekka Tainio Jussi Vuori Haley Zhou ErikaÖsterlund ALA建筑师事务所

ALA建筑师事务所在阿尔托大学的2015校园国际设计竞赛中提出了“大型联合建筑群——活动孵化器”的理念。他们的目标是连接现有的结构和项目,创建一个新的区域热点,一个充满街道生活气息的城市集中区,促进创造力的展示。

关键词：建筑师事务所国际设计竞赛孵化器创造力生活气息阿尔托大学校园集中区

Successful Strategic Management for Growth-Oriented Timber Haulage Entrepreneurs

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Journal of Modern Accounting and Auditing 2011年第4期7卷 397-407页

作者： juho Soirinsuo University of Helsinki Finland

The aim of this study was to investigate the growth of a timber haulage company and the entrepreneur behind the growth. The purpose of the study was to find out what kind of impact strategic management has on the growth of profitability. Entrepreneurs＇ financial and strategic objectives were studied, as well as growth strategies and their implications. Studied companies were all located in Finland. The research material was collected by personal interviews in 2008 from 23 entrepreneurs. Their financial statements from 2001 to 2007 were also taken into account. The study found that the role of management seems to be crucial in profitable growth and much more meaningful than, for example, the financial situation. Strategic objectives and chosen growth strategy seem especially to be key elements for successful growth. Particularly in low profit sectors, management should not focus growth purely on current conditions, but also on seeking other ways to exploit the company＇s resources.

关键词： Finland growth long-term objectives low profit sectors strategic management timber haulageentrepreneurs