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上海精神医学 2016年第5期28卷 293-300页

作者： GE L TU JX ZHANG H WANG H HE H GUNZLER d department of Biostatistics and Computational Biology University of RochesterRochesterNYUSA. SUNY Upstate Medical University SyracuseNYUSA. department of Biostatistics St.Jude Children’s Research HospitalMemphisTNUSA. department of Epidemiology Tulane UniversityNew OrleansLAUSA Case Western Reserve University at Metro Health Medical Center ClevelandOHUSA.

纵向研究可用于精神卫生及其服务领域的科研中。纵向数据分析的主要方法是广义线性混合效应模型(GLMM)和加权广义估计方程(WGEE)。虽然这两个模型已被广泛应用,也有大量文献发表,但是人们并没有清晰地描述这些方法间的差别以及方法本身... 详细信息

纵向研究可用于精神卫生及其服务领域的科研中。纵向数据分析的主要方法是广义线性混合效应模型(GLMM)和加权广义估计方程(WGEE)。虽然这两个模型已被广泛应用,也有大量文献发表,但是人们并没有清晰地描述这些方法间的差别以及方法本身的局限性,缺少相关的文献记录。遗憾的是,有些差别和局限性会明显影响对研究结果的报告、比较和解释。本文回顾了纵向数据分析的两种主要方法,强调两者的相似之处和主要差别。我们使用真实数据和模拟数据着重比较这两类模型的假设、对参数的解释、适用性和局限性,并讨论了将这两种不同的方法用于真实数据研究时的注意事项,提出了相关的警示。

关键词：二分类变量相关结果广义线性混合效应模型加权广义估计方程潜变量模型 R SAS

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Comparison of nutritional intake in US adolescent swimmers and non-athletes

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Health 2012年第10期4卷 873-880页

作者： Andy C. Collins Kenneth d. Ward Bridget Mirza deborah L. Slawson Barbara S. McClanahan Christopher Vukadinovich College of Public Health East Tennessee State University Johnson City USA department of Epidemiology & Cancer Control St Jude Children’s Research Hospital Memphis USA department of Health and Sport Sciences The University of Memphis Memphis USA division of Social and Behavioral Sciences School of Public Health The University of Memphis Memphis USA Memphis USA

Swimming is a very popular sport among adolescents in the US. Little is known about the diet of competitive adolescent swimmers in the US but data from other countries indicate several inadequacies, including excessive intake of fat and lower than recommended intake of carbohydrate and several micronutrients that may affect athletic performance and bone accrual. We assessed usual diet, using a food frequency questionnaire and calcium checklist, among 191 adolescent males and females [91 swimmers (mean 13.7, s = 2.5 years) and 100 non-athletes (mean 14.4, s = 2.8 years)]. For both males and females, swimmers and non-athletes generally had similar average intakes of macro- and micro-nutrients, including higher than recommended amounts of total fat (36%) and saturated fat (12%), and inadequate amounts of calcium, vitamin d, and daily servings of fruits, vegetables, grains, and dairy products. This first study of nutritional intake among adolescent swimmers in the US suggests that dietary habits of adolescents who swim competitively may jeopardize optimal athletic performance and place them at risk for future chronic diseases, including osteoporosis.

关键词： Nutrition dietary Intake Swimming Bone Health

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NOTUM inhibition increases endocortical bone formation and bone strength

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Bone Research 2019年第1期7卷 54-65页

作者： Robert Brommage Jeff Liu Peter Voge Faika Mseeh Andrea Y.Thompson david G.Potter Melanie K.Shadoan Gwenn M.Hansen Sabrina Jeter-Jones Jie Cui dawn Bright Jennifer P.Bardenhagen deon d.doree Sofia Moverare-Skrtic Karin H.Nilsson Petra Henning Ulf H.Lerner Claes Ohlsson Arthur T.Sands James E.Tarver david R.Powell Brian Zambrowicz Qingyun Liu Lexicon Pharmaceuticals The WoodlandsTXUSA Wntrix HoustonTXUSA PRA Health Sciences RaleighNCUSA University of Pennsylvania PhiladelphiaPAUSA Regeneron Pharmaceuticals TarrytownNYUSA University of Texas HoustonTXUSA Centre for Bone and Arthritis Research Institute of MedicineThe Sahlgrenska Academy at University of GothenburgGothenburgSweden Centre for Bone and Arthritis Research University of GothenburgGothenburgSweden Biogen CambridgeMAUSA St.jude Children’s Research Hospital MemphisTNUSA Md Anderson Cancer Center HoustonTXUSA Bethyl Laboratories MontgomeryTXUSA Merck RahwayNJUSA Nurix San FranciscoCAUSA

The disability,mortality and costs caused by non-vertebral osteoporotic fractures are *** osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral *** bone is a major determinant of non-vertebral bone *** identify novel osteoporosis drug targets,we phenotyped cortical bone of 3 366 viable mouse strains with global knockouts of druggable *** bone thickness was substantially elevated in Notum?/?*** is a secreted WNT lipase and we observed high NOTUM expression in cortical bone and osteoblasts but not *** orally active small molecules and a neutralizing antibody inhibiting NOTUM lipase activity were *** increased cortical bone thickness and strength at multiple skeletal sites in both gonadal intact and ovariectomized rodents by stimulating endocortical bone ***,inhibition of NOTUM activity is a potential novel anabolic therapy for strengthening cortical bone and preventing non-vertebral fractures.

关键词： disability osteoporosis fractures

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Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

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中国神经肿瘤杂志 2006年第1期4卷 18-18页

作者： Thompson MC Fuller C Hogg TL dalton J Finkelstein d Lau CC Chintagumpala M Adesina A Ashley dM KeUie SJ Taylor Md Curran T Gajjar A Gilbertson RJ St jude Children＇s Research Hospital Memphis TN Texas Children＇ s Hospital Houston TX Royal Chil-dren＇s Hospital Melbourne The Children＇ s Hospital at Westmead and University of Sydney Sydney Australia and Hospital for Sick Children Toronto Ontario Canada.

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Nature：研究鉴定出侵袭性胰腺癌细胞及其弱点

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现代生物医学进展 2017年第14期17卷 I0002-I0003页

作者： Genovese, Giannicola Carugo, Alessandro Tepper, James Robinson, Frederick Scott Li, Liren Svelto, Maria Nezi, Luigi Corti, denise Minelli, Rosalba Pettazzoni, Piergiorgio Gutschner, Tony Wu, Chia-Chin Seth, Sahil Akdemir, Kadir Caner Leo, Elisabetta Amin, Samirkumar dal Molin, Marco Ying, Haoqiang Kwong, Lawrence N. Colla, Simona Takahashi, Koichi Ghosh, Papia Giuliani, Virginia Muller, Florian dey, Prasenjit Jiang, Shan Garvey, Jill Liu, Chang-Gong Zhang, Jianhua Heffernan, Timothy P. Toniatti, Carlo Fleming, Jason B. Goggins, Michael G. Wood, Laura d. Sgambato, Alessandro Agaimy, Abbas Maitra, Anirban Roberts, Charles W. M. Wang, Huamin Viale, Andrea dePinho, Ronald A. draetta, Giulio F. Chin, Lynda Univ Texas Md Anderson Canc Ctr Dept Genom Med Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Inst Appl Canc Sci Houston TX 77030 USA European Inst Oncol I-20141 Milan Italy Sun Yat Sen Univ Ctr Canc State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Univ Cattolica Sacro Cuore Ist Patol Gen I-00168 Rome Italy Baylor Coll Med Grad Program Struct & Computat Biol & Mol Biophys Houston TX 77030 USA Johns Hopkins Univ Sol Goldman Pancreat Canc Res Ctr Dept Pathol Baltimore MD 21287 USA Univ Texas Md Anderson Canc Ctr Dept Mol & Cellular Oncol Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Translat Mol Pathol Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Leukemia Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Off Technol Commercializat Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Canc Syst Imaging Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Canc Biol Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Expt Therapeut Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr ORBIT Platform Houston TX 77030 USA Univ Texas Md Anderson Canc Ctr Dept Surg Oncol Houston TX 77030 USA Friedrich Alexander Univ Erlangen Nuremberg Univ Hosp Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Dept Pathol D-91054 Erlangen Germany Friedrich Alexander Univ Erlangen Nuremberg Sheikh Ahmed Bin Zayed Nahyan Ctr Pancreat Canc R D-91054 Erlangen Germany St jude Childrens Res Hosp Ctr Comprehens Canc Memphis TN 77027 USA St jude Childrens Res Hosp Dept Oncol Memphis TN 77027 USA C4 Therapeut Cambridge MA 02142 USA Univ Texas Syst Inst Hlth Transformat Austin TX 78701 USA

在一项新的研究中，来自美国德州大学Md安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,Pdx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为... 详细信息

在一项新的研究中，来自美国德州大学Md安德森癌症中心的研究人员利用患者源性肿瘤异种移植（patient—derived tumorxenograft,Pdx）和模式小鼠开展一系列临床前实验，鉴定出一种门卫蛋白（gatekee Perprotein）阻止胰腺癌细胞转化为一种极具侵袭性的细胞类型，并且也发现剔除这种门卫蛋白的疗法能够阻止这些癌细胞。这些发现有助为携带这种进展迅速的治疗抵抗性的胰腺癌细胞亚群的患者开发出潜在的疗法。

关键词：胰腺癌癌细胞侵袭性鉴定异种移植研究人员细胞类型细胞转化

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