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VisuaLizations As Intermediate Representations (VLAIR): An approach for applying deep learning-based computer vision to non-image-based data

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Visual Informatics 2022年第3期6卷 35-50页

作者： Ai Jiang Miguel A.Nacenta juan ye School of Computer Science University of St AndrewsUK University of Victoria Canada

Deep learning algorithms increasingly support automated systems in areas such as human activity recognition and purchase *** identify a current trend in which data is transformed first into abstract visualizations and then processed by a computer vision deep learning *** call this VisuaLization As Intermediate Representation(VLAIR)and believe that it can be instrumental to support accurate recognition in a number of fields while also enhancing humans’ability to interpret deep learning models for debugging purposes or for personal *** this paper we describe the potential advantages of this approach and explore various visualization mappings and deep learning *** evaluate several VLAIR alternatives for a specific problem(human activity recognition in an apartment)and show that VLAIR attains classification accuracy above classical machine learning algorithms and several other non-image-based deep learning algorithms with several data representations.

关键词： Information visualization Convolutional neural networks Human activity recognition Smart homes Data representation Intermediate representations Interpretability Machine learning Deep learning

Artificial intelligence and deep learning in ophthalmology:Current status and future perspectives

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 47-53页

作者： Kai Jin juan ye Department of Ophthalmology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina

Background:The ophthalmology field was among the first to adopt artificial intelligence(AI)in *** availability of digitized ocular images and substantial data have made deep learning(DL)a popular *** text:At the moment,AI in ophthalmology is mostly used to improve disease diagnosis and assist decisionmaking aiming at ophthalmic diseases like diabetic retinopathy(DR),glaucoma,age-related macular degeneration(AMD),cataract and other anterior segment ***,most of the AI systems developed to date are still in the experimental stages,with only a few having achieved clinical *** are a number of reasons for this phenomenon,including security,privacy,poor pervasiveness,trust and explainability ***:This review summarizes AI applications in ophthalmology,highlighting significant clinical considerations for adopting AI techniques and discussing the potential challenges and future directions.

关键词： Artificial intelligence Deep learning Ophthalmology Diabetic retinopathy Glaucoma Age-related macular degeneration

Synthesis of(S) and(R)-tilisolol hydrochloride

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Chinese Chemical Letters 2009年第6期20卷 648-650页

作者： Shan Qian Xiao juan ye Fan Zheng Li Yang Yong Wu Key Laboratory of Drug Targeting West China School of Pharmacy Sichuan University Chengdu Sichuan 610041 China

Tilisolol hydrochloride 1, a non-selective β-adrenoceptor blocker, was developed as a drug for the treatment of hypertension and angina pectoris. The optical active forms of 1, la and lb were synthesized from inexpen... 详细信息

关键词： Tilisolol hydrochloride Optical Synthesis

Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions

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Neural Regeneration Research 2016年第9期11卷 1464-1470页

作者： Li-juan ye Hui Bian Yao-dong Fan Zheng-bo Wang Hua-lin Yu Yuan-ye Ma Feng Chen Department of Pathology Third Affiliated Hospital of Kunming Medical University Kunming Yunnan Province China Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan Province China Department of Physiology Kunming Medical University Kunming Yunnan Province China Second Department of Neurosurgery First Affiliated Hospital of Kunming Medical University Kunming Yunnan Province China Department of Radiology Hainan General Hospital Haikou Hainan Province China

Rhesus monkey neural stem cells are capable of differentiating into neurons and glial cells. Therefore, neural stem cell transplantation can be used to promote functional recovery of the nervous system. Rhesus monkey neural stem cells （1 ×10^5 cells/μL） were injected into bilateral hippocampi of rats with hippocampal lesions. Confocal laser scanning microscopy demonstrated that green fluorescent protein-la- beled transplanted cells survived and grew well. Transplanted cells were detected at the lesion site, but also in the nerve fiber-rich region of the cerebral cortex and corpus callosum. Some transplanted cells differentiated into neurons and glial cells clustering along the ventricular wall, and integrated into the recipient brain. Behavioral tests revealed that spatial learning and memory ability improved, indicating that rhesus monkey neural stem cells noticeably improve spatial learning and memory abilities in rats with hippocampal lesions.

关键词： nerve regeneration rhesus monkey neural stem cells hippocampal lesion cell transplantation spatial learning and memory abilities neural regeneration

Quantification and timing of porosity evolution in tight sand gas reservoirs:an example from the Middle Jurassic Shaximiao Formation,western Sichuan,China

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Petroleum Science 2015年第2期12卷 207-217页

作者： Zheng-Xiang Lü Su-juan ye Xiang Yang Rong Li Yuan-Hua Qing State Key Laboratory of Oil and Gas Reservoir Geology &Exploitation Chengdu University of Technology Exploration and Production Research Institute Sinopec Southwest Chengdu Institute of Geology and Mineral Resources PetroChina Tarim Oilfield Company

The diagenesis and porosity evolution of the Middle Jurassic Shaximiao sandstones were analyzed based on petrographic observations, X-ray diffractometry, scanning electron microscopy observations, carbon and oxygen stable isotope geochemistry, fluid inclusion mi- crothermometry, and thermal and burial history modeling results. The point count data show that secondary pores （av. 5.5 %） are more abundant than primary pores （av. 3.7 %） and are thus the dominant pore type in the Shaximiao sandstones. Analysis of porosity evolution indicates that alteration of sandstones mainly occurred during two paragenetic stages. Mechanical compaction and cementa- tion by early chlorite, calcite, and quartz typically decrease the depositional porosity （40.9 %） by an average of 37.2 %, leaving porosity of 3.7 % after stage I （〈85 ℃, 175-145 Ma）. The original intergranular porosity loss due to compaction is calculated to be 29.3 %, suggesting that mechanical compaction is the most significant diagenetic process in primary porosity destruction. Stage II can be further divided into two sub-stages （Stage IIa and Stage IIb）. Stage IIa （85-120 ℃, 145-125 Ma） is characterized by late dissolution, which enhanced porosity by 8.8 %, and the porosity increased from 3.7 % to 12.5 %. During stage IIb （〉120 ℃, 125-0 Ma）, the precipitation of late chlorite, calcite, quartz, and kaolinite destroyed 3.3 % porosity, leaving porosity of 9.2 % in the rock today.

关键词： Diagenesis Porosity evolution -Tight gas sandstones Jurassic Western Sichuan

A tarsus construct of a novel branched polyethylene with good elasticity for eyelid reconstruction in vivo

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Regenerative Biomaterials 2020年第3期7卷 259-269页

作者： Peifang Xu Xue Feng Honghao Zheng Zhongwei Feng Zhisheng Fu Changyou Gao juan ye Department of Ophthalmology The Second Affiliated Hospital of Zhejiang UniversityCollege of MedicineHangzhouZhejiang 310009China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Branched polyethylene(B-PE)elastomer was investigated for its potential medical application as a tarsus *** in vitro results showed that the B-PE and processed B-PE films or scaffolds did not exhibit noticeable cytotoxicity to the NIH3T3 fibroblasts and human vascular endothelial cells(ECs).The B-PE scaffolds with a pore size of 280–480 mm were prepared by using a gelatin porogen-leaching *** porous scaffolds implanted subcutaneously in rats exhibited mild inflammatory response,collagen deposition and fast fibrovascularization,suggesting their good *** real-time PCR analysis showed low expression of pro-inflammatory genes and up-regulated expressions of collagen deposition and vascularization-related genes,validating the results of historical evaluation in a molecular *** B-PE scaffolds and Medpor controls were transplanted in rabbits with eyelid *** B-PE scaffolds exhibited a similar elastic modulus and provided desirable repair effects with mild fibrous capsulation,less eyelid deformities,and were well integrated with the fibrovascular tissue compared with the Medpor controls.

关键词： branched polyethylene elasticity scaffolds fibrovascularization eyelid reconstruction

Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis

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Journal of Integrative Medicine 2022年第2期20卷 173-181页

作者： ye-juan Jia Tian-yu Li Peng Han Yu Chen Li-jia Pan Chun-sheng Jia School of Acupuncture Moxibustion and TuinaHebei University of Chinese MedicineShijiazhuang 050200Hebei ProvinceChina

Objective:This study was done to determine the effects of different courses of moxibustion on a rat knee osteoarthritis(KOA)model,and explore the dose–effect relationship of moxibustion on KOA from the perspectives of intestinal flora and inflammatory ***:Wistar rats were randomly divided into five groups:normal,model,moxibustion for 2 weeks,moxibustion for 4 weeks and moxibustion for 6 weeks groups(n=5 each group).A KOA rat model was induced by monosodium iodoacetate,and moxibustion intervention was performed at the acupoints“Dubi”(ST35)and“Zusanli”(ST36),once every other *** changes in the cartilage of rat knee joints were assessed after intervention,and fecal samples were subjected to 16 S r RNA high-throughput sequencing for microbial diversity ***:Damage to the knee articular cartilage was obvious in the model group,which also had increased levels of pro-inflammatory factors,decreased levels of anti-inflammatory factors,and intestinal flora disorders with decreased *** degree of cartilage damage in the 4 and 6 weeks of moxibustion groups was significantly improved compared with the model *** 4 and 6 weeks of moxibustion groups also demonstrated reduced levels of interleukin-1βand tumor necrosis factor-a and increased levels of interleukin-10(P<0.05).Both the abundance and diversity of the intestinal flora were increased,approaching those of the normal *** of probiotics Eubacterium coprostanoligenes group and Ruminococcaceae UCG-014 increased,while that of the pathogenic bacteria Lachnospiraceae NK4 A136 group decreased(P<0.05).Although the abundance of Lachnospiraceae NK4 A136 group decreased in the 2 weeks of moxibustion group compared with the model group(P<0.05),there was no statistically significant difference in serum inflammatory factors,flora species diversity or degree of pathological damage compared with the model ***:Moxibustion treatment led to significant improvements in t

关键词： Knee osteoarthritis Different courses Moxibustion treatment Intestinal flora Inflammatory cytokines

A description of ophthalmic management of late recovered facial paralysis with patient-tailored procedures:a case report

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 668-670页

作者： Hui-Na Zhang Jia-Jun Xie Qi Gao juan ye Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang UniversityZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhou 310003Zhejiang ProvinceChina

Dear Editor,We reported a case of a multidisciplinary therapy for late recovered facial paralysis 2y after the initial *** paralysis has an incidence of 20-30 people out of 100000 per year,and up to 1 in 60 people wil... 详细信息

关键词： has paralysis recovered

C176-loaded and phosphatidylserine-modified nanoparticles treat retinal neovascularization by promoting M2 macrophage polarization

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Bioactive Materials 2024年第9期39卷 392-405页

作者： An Shao Lulu Jin Yanni Ge Ziqiang ye Mingyu Xu Yifan Zhou Yingyu Li Linyan Wang Pinglong Xu Kai Jin Zhengwei Mao juan ye Eye Center The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou310009China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China MOE Key Laboratory of Biosystems Homeostasis&Protection and Zhejiang Provincial Key Laboratory of Cancer Molecular Cell Biology Life Sciences InstituteZhejiang UniversityHangzhou310030China

Retinal neovascularization(RNV),a typical pathological manifestation involved in most neovascular diseases,causes retinal detachment,vision loss,and ultimately irreversible *** intravitreal injections of anti-VEGF drugs were developed against RNV,with limitations of incomplete responses and adverse ***,a new treatment with a better curative effect and more prolonged dosage is ***,we induced macrophage polarization to anti-inflammatory M2 phenotype by inhibiting cGAS-STING signaling with an antagonist C176,appreciating the role of cGAS-STING signaling in the retina in pro-inflammatory M1 polarization.C176-loaded and phosphatidylserine-modified dendritic mesoporous silica nanoparticles were constructed and examined by a single intravitreal *** biosafe nanoparticles were phagocytosed by retinal macrophages through a phosphatidylserine-mediated“eat me”signal,which persistently release C176 to suppress STING signaling and thereby promote macrophage M2 polarization specifically.A single dosage can effectively alleviate pathological angiogenesis phenotypes in murine oxygen-induced retinopathy *** conclusion,these C176-loaded nanoparticles with enhanced cell uptake and long-lasting STING inhibition effects might serve as a promising way for treating RNV.

关键词： Retinal neovascularization Macrophage polarization cGAS-STING pathway Nanocarrier