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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong juan tian Jin Deng Lei Wei Hua Wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

Dietary supplementation with succinic acid improves growth performance and flesh quality of adult Nile tilapia(Oreochromis niloticus)fed a high-carbohydrate diet

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Animal Nutrition 2024年第3期18卷 390-407页

作者： Manxia Cao Ningning Xie Jianmin Zhang Ming Jiang Feng Huang Lixue Dong Xing Lu Hua Wen juan tian Key Laboratory of Freshwater Biodiversity Conservation Ministry of AgricultureYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Key Laboratory for Animal Nutrition and Feed Science of Hubei Province Wuhan Polytechnic UniversityWuhan 430023China

To evaluate the effects of dietary supplementation with succinic acid on growth performance,flesh quality,glucose,and lipid metabolism of Nile tilapia(Oreochromis niloticus)fed a high-carbohydrate diet(HCD),five iso-nitrogenous and iso-lipidic diets were prepared as follows:HCD(control group)consisting of 55%corn starch and HCD supplemented with 0.5%,1.0%,2.0%,and 4.0%succinic acid,*** with an initial body weight of 204.90±1.23 g randomly assigned to 15 tanks with 3 replicates per group and 10 fish per tank fed for 8 *** dietary succinic acid supplementation resulted in significant second-order polynomial relationship in the weight gain rate(WGR),specific growth rate(SGR),feed conversion ratio(FCR),protein efficiency rate(PER),viscerosomatic index,condition factor,and contents of muscular crude lipid and glycogen(P<0.05).The hepatosomatic index,mesenteric fat index,liver glycogen content and crude lipid contents of the whole-body and liver demonstrated significantly linear and second-order polynomial relationship(P<0.05).Quadratic curve model analysis based on WGR,SGR,PER,and FCR demonstrated that optimal supplementation with succinic acid in the HCD of Nile tilapia ranged from 1.83%to 2.43%.Fish fed with 1.0%succinic acid had higher muscular hardness,increased the contents of alkali-soluble hydroxyproline in collagen,docosahexaenoic acid(DHA)and n-3 polyunsaturated fatty acid(n-3PUFA)in muscle,and lower total fatty acid content in muscle(P<0.05)compared with the control *** to the control group,dietary supplementation with 1.0%succinic acid significantly increased the contents of total bounding amino acid(arginine,histidine,isoleucine,lysine,methionine,alanine,proline),total flavor amino acid(free aspartic acid),the catalase(CAT)activity and total antioxidant capacity,and the mRNA relative expression levels of CAT,superoxide dismutase(SOD),and nuclearfactor erythroidderived 2-like 2(Nrf2)in muscle(P<0.05).Furthermore,succini

关键词： Oreochromis niloticus High-carbohydrate diet Succinic acid Antioxidant capacity Muscular nutritional value Muscle growth

Synthesis,Structure and Chemical Bonding of Polyantimony Clusters Containing Coinage Metals[M_(2)Sb_(14)]^(4-)(M=Cu,Ag)

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Chinese Journal of Chemistry 2024年第6期42卷 617-622页

作者： Wei-Xing Chen Yu-He Xu Cui-Cui Wang Lei Qiao Zi-Yan Guo Wen-juan tian Zhong-Ming Sun State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin300350 China Institute of Molecular Science Shanxi UniversityTaiyuanShanxi030006 China

Binary polyantimony clusters,namely[Cu_(2)Sb_(14)]^(4–) and [Ag_(2)Sb_(14)]^(4–),containing coinage metals,were successfully synthesized and characterized,in which two homoatomic Sb73–subunits are bridged by two coinage metals in η^(4):η^(1) and η^(1):η^(1) coordination modes,***[M_(2)Sb_(14)]^(4-),two bridging Cu ions and two Sb atoms form a planar rhombic unit,which was revealed to have antiaromatic properties by theoretical *** electron structure and bonding analysis confirmed the presence of delocalized bonds in the rhombic unit and the metallophilic interaction between two formal M^(+) ions.

关键词： Polyantimony cluster Copper Silver Antiaromaticity Metallophilic interaction Quantum chemical calculations

Enhancing growth, liver health, and bile acid metabolism of tilapia(Oreochromis niloticus) through combined cholesterol and bile acid supplementation in plant-based diets

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Animal Nutrition 2024年第2期17卷 335-346页

作者： Jiayuan Jiang Xing Lu Lixue Dong juan tian Jianmin Zhang Zhongbao Guo Yongju Luo Zongbin Cui Hua Wen Ming Jiang College of Fisheries and Life Science Shanghai Ocean University Yangtze River Fisheries Research Institute Chinese Academy of Fishery Sciences Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application State Key Laboratory of Applied Microbiology Southern ChinaInstitute of MicrobiologyGuangdong Academy of Sciences Guangxi Institute of Fisheries

The present study aimed to compare the nutritional effects of cholesterol, bile acids, and combination of cholesterol with bile acids in plant-based diets on juvenile genetically improved farmed tilapia(GIFT;Oreochromis niloticus). The isonitrogenous(321 g/kg crude protein) and isolipidic(76 g/kg crude fat) diets(Con diet) were based on plant protein sources, which included corn gluten meal, soybean meal, cottonseed meal and rapeseed meal. The Con diet was supplemented with 12 g/kg cholesterol(CHO diet), 0.2 g/kg bile acids(BAs diet), a combination of 12 g/kg cholesterol and 0.2 g/kg bile acids(CHO-BAs diet),respectively. Each diet was fed to three tanks in an indoor recirculating aquaculture system for 9 *** showed that compared to the Con group, fish had a higher weight gain rate, hepatosomatic index,and a lower feed conversion ratio in the CHO-BAs group. The highest levels of whole-fish fat and ash were found in the Con group. Serum parameters, including activities of alanine aminotransferase(ALT) and aspartate transaminase(AST), along with levels of glucose(GLU) and triglyceride(TG) except for total cholesterol(TCHO), were lower in the CHO, BAs, and CHO-BAs groups than those in the Con group(P <0.001). Histological examination revealed that fish in the Con group exhibited severe hepatocyte vacuolization and diminished hepatocyte proliferation. Gene expression analysis indicated that the transcriptional levels of bile acid metabolism-related genes(including fxr, fgf19, bsep) were up-regulated in the CHO-BAs group(P < 0.05), whereas cholesterol metabolism-related genes(acly and hmgcr) were downregulated in both CHO and CHO-BAs groups(P < 0.001). Moreover, UPLC-MS/MS analysis revealed that the higher taurine-conjugated bile acids(T-BAs), followed by free bile acids(Free-BAs) and glycine(G-BAs)were determined in tilapia bile. Among these, taurochenodeoxycholic bile acid was the predominant bile acid. Dietary bile acids supplementation also increased the pr

关键词： Bile acid metabolism Tilapia Plant-based feed Cholesterol Liver health

Metal-metal bonds in Zintl clusters:Synthesis,structure and bonding in[Fe_(2)Sn_(4)Bi_(8)]^(3-)and[Cr_(2)Sb_(12)]^(3-)

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Chinese Chemical Letters 2024年第8期35卷 558-566页

作者： Ya-Nan Yang Zi-Sheng Li Sourav Mondal Lei Qiao Cui-Cui Wang Wen-juan tian Zhong-Ming Sun John E.McGrady State Key Laboratory of Element-Organic Chemistry Tianjin Key Lab for Rare Earth Materials and ApplicationsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China Department of Chemistry University of OxfordInorganic Chemistry LaboratoryOxfordOX13QRUnited Kingdom

We report here the synthesis and characterization of two new members of the M2 E 12 family of endohe-dral Zintl clusters,[Fe_(2)Sn_(4)Bi_(8)]^(3-)and[Cr_(2)Sb_(12)]^(3-),both of which contain open-shell metal dimers encap-sulated inside a triple-decker cluster of main-group *** 75-electron[Fe_(2)Sn_(4)Bi_(8)]^(3-)cluster has a D4h-symmetric structure,while[Cr_(2)Sb_(12)]^(3-),despite having the same 75-electron count,is strongly dis-torted to a geometry that resembles a CrSb_(8)crown capped by a CrSb_(4)*** structural differences between the two are driven by the increasing availability of 3d electron density in the earlier transi-tion metal,which leads,ultimately,to different electronic configurations in the two *** trends precisely mirror those observed in the ME_(10)and ME_(12)families containing a single transition metal ion.

关键词： Zintl anions Endohedral clusters Metal-metal bond Second-order Jahn-Teller effect DFT calculation

Structural insights, synthesis, and electrocatalysis of high entropy nanoparticles for fuel cell, metal-air battery, and water-splitting applications

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Progress in Natural Science:Materials International 2024年第03期34卷 512-523页

作者： Xin Tong Hao Ye Yunrou Wu Xinxing Zhan Manqi Gu Shixia Luo Jiangning Gong juan tiana Yadian Xie School of Chemistry and Material Science Guizhou Normal University Center for the Physics of Low-Dimensional Materials School of Physics and Electronics School of Future Technology Henan University Key Laboratory of Low-Dimensional Materials and Big Data Guizhou Minzu University

High-entropy alloy nanoparticles(HEA-NPs) have recently sparked great interest in materials science. Their solidsolution states, derived from distinct HEA configurations, make them promising candidates for catalysts with exceptional activity, stability, and tunable performance. However, a comprehensive understanding of the underlying mechanisms governing their electrocatalytic behavior is still lacking, hindering the rational design of HEA electrocatalysts. This review summarizes the fundamental knowledge of HEA-NPs, including the structureactivity correlations of HEA-NPs, diverse synthesis strategies, and applications in electrochemical catalysis. The design strategies for guiding improvements in tunable performance were highlighted. The article concludes with insights, perspectives, and future directions, encapsulating the state-of-the-art knowledge and paving the way for further exploration in this dynamic field.

关键词： High-entropy alloy nanoparticles Structure-activity correlations Synthesis strategies Electrochemical catalysis

加氢中质油-减压渣油共焦化提高液收技术研究

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石油化工应用 2024年第6期43卷 112-116页

作者：田娟湖南长炼新材料科技股份公司湖南岳阳414012

延迟焦化是炼油厂重油轻质化的重要手段,该工艺成熟,投资低,产品柴汽比高,具有较好的经济效益。针对延迟焦化装置存在的焦炭产率高、液体产品收率低的问题,开展了加氢中质油作供氢剂,与减压渣油共焦化降低焦炭产率、提高炼油厂液收的研... 详细信息

延迟焦化是炼油厂重油轻质化的重要手段,该工艺成熟,投资低,产品柴汽比高,具有较好的经济效益。针对延迟焦化装置存在的焦炭产率高、液体产品收率低的问题,开展了加氢中质油作供氢剂,与减压渣油共焦化降低焦炭产率、提高炼油厂液收的研究。实验结果表明,加氢中质油与减压渣油共焦化能明显提高焦化反应的产品液收,改善液体产品品质,降低焦炭产率。在常压、反应温度500℃和反应时间120 min条件下,掺炼5%的加氢中质油(氢耗1.82%),焦炭产率降低2.78%,液收增加3.69%,其中,产物中干气和汽油收率分别降低1.37%和1.82%,柴油和蜡油收率分别增加0.13%和5.39%。

关键词：延迟焦化石油焦液收加氢中质油

Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

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World Journal of Clinical Oncology 2024年第3期15卷 434-446页

作者： Hua Li Yi-Po Ma Hai-Long Wang Cai-juan tian Yi-Xian Guo Hong-Bo Zhang Xiao-Min Liu Peng-Fei Liu Department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin 300060China Department of Critical Care Medicine Dingzhou City People’s HospitalDingzhou 073000Hebei ProvinceChina Department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China tianjin Marvel Medical Laboratory Tianjin Marvelbio Technology Co.LtdTianjin 300180China Department of Intelligent Technology Tianjin Yunquan Intelligent Technology Co.LtdTianjin 300381China Department of Oncology Tianjin Huanhu HospitalTianjin 300350China

BACKGROUND The ubiquitin-proteasome pathway(UPP)has been proven to play important roles in *** To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these *** In this study,UPP-related E1,E2,E3,deubiquitylating enzyme,and proteasome gene sets were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,aiming to screen the prognostic genes using univariate and multivariate regression analysis and develop a prognosis predictive model based RESULTS Five genes(including autophagy related 10,proteasome 20S subunit alpha 8,proteasome 20S subunit beta 2,ubiquitin specific peptidase 17 like family member 2,and ubiquitin specific peptidase 8)were proven significantly correlated with prognosis and used to develop a prognosis predictive model for liver *** training,validation,and Gene Expression Omnibus sets,the overall survival differed significantly between the high-risk and low-risk *** expression of the five genes was significantly associated with immunocyte infiltration,tumor stage,and postoperative recurrence.A total of 111 differentially expressed genes(DEGs)were identified between the high-risk and low-risk groups and they were enriched in 20 and 5 gene ontology and KEGG *** division cycle 20,Kelch repeat and BTB domain containing 11,and DDB1 and CUL4 associated factor 4 like 2 were the DEGs in the E3 gene set that correlated with *** We have constructed a prognosis predictive model in patients with liver cancer,which contains five genes that associate with immunocyte infiltration,tumor stage,and postoperative recurrence.

关键词： Liver cancer Ubiquitin-proteasome pathway Prognosis prediction Gene expression Immune infiltration

基于TRIZ理论的财经类专业课程教学改革探索

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河北工程大学学报（社会科学版） 2024年第1期41卷 102-107页

作者：田娟岳志春河北经贸大学工商管理学院河北石家庄050061 河北工程大学管理工程与商学院河北邯郸056038

新财经的教育改革要求培养财经技能和职业素养相结合的复合型人才,需要多路径深化财经类专业课程教学改革。TRIZ理论作为创新方法为教师打破原有教学思维模式提供了全新的思路。该研究结合TRIZ理论的创新思维方式,探索了动态创新教学模... 详细信息

新财经的教育改革要求培养财经技能和职业素养相结合的复合型人才,需要多路径深化财经类专业课程教学改革。TRIZ理论作为创新方法为教师打破原有教学思维模式提供了全新的思路。该研究结合TRIZ理论的创新思维方式,探索了动态创新教学模式下的教学理念,基于最终理想解(IFR)的理论,优化教学目标;基于物-场模型理论,营造教学环境;结合39个工程参数及阿奇舒勒矛盾矩阵理论,创新教学方法。根据研究结果提出了采用基于TRIZ理论的动态教学创新理念,重构课程知识体系;基于理想解(IFR)的模式来设定精细化的教学目标;通过物-场分析法来构建教学环境;利用阿奇舒勒矛盾矩阵研发多种教学方法等财经类专业课程教学改革的对策。

关键词： TRIZ理论财经教学改革创新思维能力

双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响

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系统医学 2024年第5期9卷 17-20页

作者：徐蕾田娟陈娟江苏省启东市妇幼保健院新生儿科江苏启东226200

目的探究双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响。方法采用横断面法,选取2020年10月—2023年6月江苏省启东市妇幼保健院接收的86例黄疸患儿为研究对象,利用统计学方法对其进行随机编号并分为对照组(43例)及观察组(43例)。对... 详细信息

目的探究双歧杆菌联合光疗对黄疸患儿血清胆红素水平的影响。方法采用横断面法,选取2020年10月—2023年6月江苏省启东市妇幼保健院接收的86例黄疸患儿为研究对象,利用统计学方法对其进行随机编号并分为对照组(43例)及观察组(43例)。对照组单纯使用蓝光治疗法,观察组予以双歧杆菌联合蓝光照射治疗。对比两组患儿血清胆红素水平、免疫功能及心功能。结果观察组总胆红素(123.12±26.47)μmol/L、间接胆红素(112.36±22.49)μmol/L、直接胆红素(8.56±2.17)μmol/L水平均低于对照组,差异有统计学意义(t=2.437、2.514、3.380,P均<0.05)。观察组T淋巴细胞(TLymphocytes,CD3+)、辅助T细胞(HelperTCells,CD4+)、CD4+/细胞毒性T细胞(Cytotoxic T Cells,CD8+)均高于对照组,且CD8+低于对照组,差异有统计学意义(P均<0.05)。观察组肌酸激酶、肌酸激酶同工酶MB型、乳酸脱氢酶、天冬氨酸氨基转移酶水平均低于对照组,差异有统计学意义(P均<0.05)。结论针对黄疸患儿采取蓝光照射治疗联合双歧杆菌治疗,有助于降低血清胆红素水平,并改善细胞免疫功能及心功能。

关键词：双歧杆菌蓝光照射黄疸血清胆红素免疫功能心功能