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Journal of Modern Power systems and Clean Energy 2023年第1期11卷 191-200页

作者： Pedro P.Vergara juan s.giraldo Mauricio salazar Nanda K.Panda Phuong H.Nguyen Intelligent Electrical Power Grids(IEPG)Group Delft University of TechnologyDelft 2628CDThe Netherlands Energy Transition studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Electrical Energy systems(EEs)Group Eindhoven University of TechnologyEindhovenThe Netherlands IEEE

A photovoltaic(PV)-rich low-voltage(LV)distribution network poses a limit on the export power of PVs due to the voltage magnitude *** defining a customer export limit,switching off the PV inverters can be avoided,and thus reducing power *** on this,this paper proposes a mixed-integer nonlinear programming(MINLP)model to define such optimal customer *** MINLP model aims to minimize the total PV power curtailment while considering the technical operation of the distribution ***,a nonlinear mathematical formulation is ***,a new set of linearizations approximating the Euclidean norm is introduced to turn the MINLP model into an MILP formulation that can be solved with reasonable computational *** extension to consider multiple stochastic scenarios is also *** proposed model has been tested in a real LV distribution network using smart meter measurements and irradiance profiles from a case study in the *** assess the quality of the solution provided by the proposed MILP model,Monte Carlo simulations are executed in OpenDss,while an error assessment between the original MINLP and the approximated MILP model has been conducted.

关键词： Low-voltage distribution network photovoltaic(PV)curtailment optimal power flow Monte Carlo simulations

Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC stochastic Optimal Power Flow

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Journal of Modern Power systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： juan s.giraldo Nataly Bañol Arias Pedro P.Vergara Maria Vlasiou Gerwin Hoogsteen Johann L.Hurink Energy Transition studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands Department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(sOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC sOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC sOPF is described where a distribution system operator(DsO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the DsO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(sOPF) risk awareness compensation mechanism

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Milking the Market

China Today 2025年第1期74卷 39-41页

作者： HOU juan China Economic Weekly

With climate change becoming direr and the WTO losing its teeth at 30,experts renew call for green collaboration among the world’s three largest *** competition intensifies in the global dairy product market,many foreign dairy companies are focusing on China."China is the best market to debut breakthrough products,"said Bruno Chevot,food and beverage multinational Danone China’s president for North Asia and Oceania.

关键词： companies Market China.

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia Jiménez-Díaz juan D.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which sal mediates dopaminergic neuronal death remains *** this study,we found that sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of sal on m~6A RNA methylation and suggest that sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

Predicting Natural and Chaotic Time series with a swarm-Optimized Neural Network

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Chinese Physics Letters 2011年第11期28卷 38-40页

作者： juan A Lazzús Departamento de Física Universidad de La SerenaCasilla 554La SerenaChile

Natural and chaotic time series are predicted using an artificial neural network(ANN)based on particle swarm optimization(PsO).Firstly,the hybrid ANN+PsO algorithm is applied on Mackey–Glass series in the short-term prediction𝑥(𝑡+6),using the current value𝑥(𝑡)and the past values:𝑥(𝑡−6),𝑥(𝑡−12),𝑥(𝑡−18).Then,this method is applied on solar radiation data using the values of the past years:𝑥(𝑡−1),...,𝑥(𝑡−4).The results show that the ANN+PsO method is a very powerful tool for making predictions of natural and chaotic time series.

关键词： series chaotic method

Nanoparticle-Mediated Genetic Engineering of Plants

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Molecular Plant 2019年第8期12卷 1037-1040页

作者： Jeffrey W.Wang Eduardo G.Grand io Gregory M.Newkirk Gozde s.Demirer salwan Butrus juan Pablo giraldo Markita P.Landry Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyCA 94720USA Department of Chemical Engineering University of MichiganAnn ArborMI 48103USA Department of Botany and Plant sciences University of CaliforniaRiversideCA 92521USA Institute of Integrative Genome Biology (IIGB) RiversideCA 92521USA Innovative Genomics Institute (IGI) BerkeleyCA 94720USA California Institute for Quantitative Biosciences QB3University of CaliforniaBerkeleyCA 94720USA Chan-Zuckerberg Biohub San FranciscoCA 94158USA

Genetic engineering of plants is at the core of sustainability efforts,natural product synthesis,and agricultural crop *** past several decades have brought remarkable progress in biotechnology with the improvement of genome editing and sequencing tools,which stand to advance plant synthetic biology and *** agriculture,genetic engineering can be employed to create crops that have in creased yields and nu tritio nal value,are resista nt to herbicides,in sects,diseases,and abiotic stresses,in cludi ng drought and heat .In pharmaceuticals and therapeutics,genetically engineered plants can be used to synthesize valuable small-molecule drugs and recombinant proteins.

关键词： Nanoparticle-Mediated Genetic Engineering Plants biotechnology

Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** sUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,syn and p53,but positive for GFAP,vimentin and s-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification supratentorial ZFTA:RELA fusion Case report

Novel Activated Carbon Monoliths for Methane Adsorption Obtained from Coffee Husks

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Materials sciences and Applications 2011年第5期2卷 331-339页

作者： Liliana giraldo juan Carlos Moreno-Piraján 不详

Methane adsorption by different forms of activated carbon obtained from coffee husks, including monolith honeycomb and disc types, was studied by activation with zinc salts and potassium hydroxide at 298.15 K and 303.15 K and pressures up to 30.00 atm in a volumetric adsorption apparatus. We observed increased methane adsorption capacity on a mass basis in the different activated carbon monoliths with increasing surface area, total pore volume and micropore volume, with the honeycomb type displaying the highest methane absorption capacity. The maximum volumetric methane uptake by the synthesised carbon monoliths was observed to be 130 V/V at 298.15 K and 30.00 atm for honeycomb monoliths synthesised with zinc chloride (ZnCl2) and Polyvinyl alcohol (PVA) as the binder. Adsorption calorimetry results were used to describe the interaction between guest molecules and the adsorbent at low surface coverage and the energetic heterogeneous surface nature of the adsorbent.

关键词： Coffee Husk Activated Carbon Isotherm Adsorption Carbon Monolith Methane Adsorption Isosteric Heat of Adsorption sEM

New partners for old friends: Plant sWI/sNF complexes

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Molecular Plant 2021年第6期14卷 870-872页

作者： juan s.Ramirez-Prado Moussa Benhamed Centre of Microbial and Plant Genetics KU Leuven3001 LeuvenBelgium Institute of Plant sciences Paris-saclay(IPs2) UniversitéParis-SaclayCNRSINRAEUniv EvryOrsay 91405France Institute of Plant sciences Paris saclay Universitéde ParisCNRSINRAEOrsay(IPS2)91405France Institut Universitaire de France(IUF) France

The physical accessibility of specific genomic regions is a chromatin property that regulates gene expression and allows the establishment of an appropriate transcriptional landscape in response to environmental and developmental *** eukaryotes,ATP-dependent chromatin remodeling complexes use the energy produced via ATP hydrolysis by an ATPase subunit to perform DNA *** complexes are classified into four subfamilies,based on the domain organization of their catalytic ATPases(Clapier et al.,2017).

关键词： complexes hydrolysis property