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Leukemoid Reaction and Malignant Ascites in a Renal Carcinoma with Sarcomatoid Differentiation. Unusual Case Report and Literature Review

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Surgical Science 2019年第7期10卷 255-264页

作者： Alberto manuel González Chávez juan Antonio Matus Santos José de Jesús Curiel Valdés Mario Andrés González Chávez Ricardo Ray Huacuja Blanco Diego Abelardo álvarez Hernández Department of Surgery Hospital HMG Coyocán Mexico City México Department of Clinical Oncology Hospital HMG Coyocán Mexico City México Pathology Laboratory Grupo Diagnóstico Mexico City México Health Sciences Faculty Anahuac University North Campus Mexico City México

Renal cell carcinoma represents the 16th cause of death by cancer. It is one of the most frequent kidney tumors. This tumor could behave as a good mimicker, and is frequently associated with paraneoplastic syndromes. Metastases to peritoneum, mesentery or omentum are very rare. Sarcomatoid renal cell carcinoma is a high-grade undifferentiated component that can be found in any subtypes of renal cell carcinoma, and is associated with an aggressive behavior and a poor prognosis. We present the case of a 59-year-old male, diabetic patient, with nephron preserved left nephrectomy through lumbotomy seven years ago, upper pole renal carcinoma, admitted to the emergency department with indeterminate shock. He underwent a diagnostic laparoscopy and then open surgery due to findings where a greater omentum subtotal infarction. Omentum microscopic examination resulted in vaguely differentiated neoplasia, with sarcomatoid like cells, highly positive to CD10 inmunolabeling. Even though renal cell carcinomas have unusual clinical presentations, this case is unique because of the convergence of extremely rare manifestations such as the combination of malignant ascites, peritoneal carcinomatosis, and contralateral suprarenal gland metachronous metastases at the major omentum with paraneoplastic syndrome type leukemoid reaction;which have not been reported previously in literature.

关键词： Renal Cell Carcinoma Sarcomatoid Differentiation Paraneoplastic Syndrome Leukemoid Reaction Malignant Ascites

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SWAD： Secure Watermarking for Authentication of Scanned Documents

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通讯和计算机（中英文版） 2012年第11期9卷 1226-1230页

作者： Martin-Rodriguez Fernando Fernandez-Montenegro juan manuel Department of Signal Theory and Communications University of Vigo Vigo Spain

This paper is about an application that tries to help people in their relations with their local government. That is to say: in many bureaucratic processes, citizens are required to provide copies of paper documents such as diplomas, birth certificates etc.. Obviously, this kind of documents can not be provided online. Using this application, users are able to provide the required documents on the Internet and the administration can check document reliability to a level of security similar to that offered by an "in person" delivery.

关键词：安全级别文件身份验证水印扫描应用程序互联网可靠性

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Flexible distributed feedback lasers based on nanoimprinted cellulose diacetate with efficient multiple wavelength lasing

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npj Flexible Electronics 2019年第1期3卷 142-148页

作者： José R.Castro Smirnov Ahmad Sousaraei manuel R.Osorio Santiago Casado Jaime J.Hernández Longfei Wu Qi Zhang Ruidong Xia Daniel Granados Reinhold Wannemacher Isabel Rodriguez juan Cabanillas-Gonzalez Madrid Institute for Advanced Studies in Nanoscience IMDEA NanocienciaCalle Faraday 9Ciudad Universitaria de Cantoblanco28049 MadridSpain Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials National Jiangsu Synergistic Innovation Center for Advanced Materials(SICAM)Nanjing University of Posts and Telecommunications9 Wenyuan RoadNanjing 210046PR China

Here we present the assembly of novel transparent all-polymer distributed feedback(DFB)*** and highly transparent cellulose diacetate(CdA)was employed as substrate on which gratings with different periods were engraved by thermal nanoimprinting with high *** luminescent conjugated polymers(CP),poly(9,9-dioctylfluorene)(PFO),poly(9,9-dioctylfluorene-alt-benzothiadiazole)(F8BT),and a blend of F8BT and poly(3-hexylthiophene)-poly(9,9-dioctylfluorene-altbenzothiadiazole)(P3HT:F8BT)were deposited by spin coating onto the nanostructured plastic surfaces,giving rise to perpendicular single-mode lasing emission in the blue,green,and red wavelength ranges,*** lasers show linewidths below 1 nm and low thresholds(≈6μJcm^(−2) for blue and red lasing emission),comparable to other state-of-the-art lasers obtained from similar optical gain materials on rigid *** followed strategy is scalable and versatile,enabling the development of large area nanoimprinted DFB lasers(>1cm^(2))on plastic,which is highly relevant for applications in various markets.

关键词： lasers lasing transparent

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Role of Salmonella enterica exposure in Chilean Crohn's disease patients

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World Journal of Gastroenterology 2013年第35期19卷 5855-5862页

作者： manuel Alvarez-Lobos Daniela P Pizarro Christian E Palavecino Abner Espinoza Valentina P Sebastián juan C Alvarado Patricio Ibaez Carlos Quintana Orlando Díaz Alexis M Kalergis Susan M Bueno CAREI Group (Active Cohort Registry of Inflammatory Bowel Disease) Department of Gastroenterology Facultad de MedicinaPontificia Universidad Católica de Chile Departamento de Genética Molecular y Microbiología Facultad de Ciencias Biológicas Pontificia Universidad Católica de Chile School of Medicine Facultad de MedicinaPontificia Universidad Católica de Chile Department of Respiratory Diseases Facultad de Medicina Pontificia Universidad Católica de Chile

AIM:To study the association between exposure toSalmonella enterica(SE)and Crohn’s disease(CD)and its clinical implications in Chilean ***:Ninety-four unrelated Chilean CD patients from CAREI(Active Cohort Registry of Inflammatory Bowel Disease)presenting to a single inflammatory bowel disease(IBD)unit of a University Hospital were prospectively included in this study.A complete clinical evaluation,including smoking history,was performed at the initial visit,and all the important data of clinical evolution of CD were *** samples from these CD patients and 88 healthy sex-and agematched control subjects were analyzed for exposure to SE and for their NOD2/CARD15 gene status using the presence of anti-Salmonella lipopolysaccharide antibodies[immunoglobulin-G type(IgG)]and polymerase chain reaction(PCR),*** also evaluated exposure to SE in 90 sex-and age-matched patients without CD,but with known smoking status(30 smokers,30 non-smokers,and 30 former smokers).RESULTS:CD patients comprised 54 females and 40males,aged 35.5±15.2 years at diagnosis with a mean follow-up of 9.0±6.8 *** was inflammatory in 59 patients(62.7%),stricturing in 24(25.5%)and penetrating in 15(15.5%).Thirty cases(31.9%)had lesions in the ileum,29(30.8%)had ileocolonic lesions,32(34.0%)had colonic lesions and 23(24.4%)had perianal *** CD patients(17%)were exposed to SE compared to 15(17%)of 88 healthy control subjects(P=0.8).Thirty-one CD patients(32.9%)were smokers,and 7(7.4%)were former smokers at *** the group exposed to SE,10 of 16 patients(62.5%)were active smokers compared to 21 of 78 patients(26.9%)in the unexposed group(P=0.01).On the other hand,10 of 31 smoking patients(32%)were exposed to SE compared to 5 of 56 nonsmoking patients(9%),and one of the seven former smokers(14%)(P=0.01).In the group of 90 patients without CD,but whose smoking status was known,there was no differ-ence in exposure to SE[3 of 30 smokers(10%),5 of30 non-s

关键词： Crohn’s disease Salmonella Infection Tobacco Smoking Environmental factors

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Pharmacological Control of Estrus in Tropical Cattle,an Economical Assessment of Different Synchronization Protocols

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Open Journal of Veterinary Medicine 2012年第3期2卷 151-157页

作者： juan J.Molina Ivan Molina Alejandro Jimenez Carlos S.Galina juan J.Romero Asesor Laboratorios Intervet Schering Plough BogotaColombia Director Tecnico Agropecuaria Las Tinajas S.A. BogotaColombia Departamento de Reproduccion Facultad de Medicina Veterinaria y ZootecniaUniversidad Nacional Autonoma de MexicoMexico CityMexico Programa de Investigacion en Medicina Poblacional Escuela de Medicina VeterinariaUniversidad NacionalHerediaCosta Rica Campus Benjamín nunez HerediaCosta Rica

To compare the fertility results and to assess the cost-effectiveness of several synchronization protocols applied under the conditions of beef cattle enterprises in Colombia, 1658 multiparous zebu crossbred cows mostly Brahman and Nelore ranging between 2 - 6 parities were used. Five protocols of pharmacological treatments varying in hormones used, dosage and the time of application were tested. All cows were inseminated at 52 h by appointment. Pregnancy diagnosis was undertaken over 45 d after insemination by rectal palpation. The total cost per cow and the total cost per gestation, for each protocol, were calculated. Taking a herd of one-hundred cows as baseline for calculations, it was estimated the cost of the total amount of pregnancies possibly obtained in each protocol;then, the excess between the costs of a pregnant cow and the cost of a treated cow was estimated. Additionally, the costs due to cows empty after four services were calculated. A total of 874 pregnancies were registered (52.7%), with pregnancies per protocol varying between 46.9% and 66.2% (p < 005). The cost per treated cow, varied between $64.08 and $97.47 and the cost per gestation from $126.01 to $177.26, without association between the cost of the treatment and the pregnancy rate. Protocol A was the best cost-effective with the lowest additional costs, the lowest amount of open days (2107.7 to 2231.7 d) and IA straws (average = 134), with an additional costs of $6940.00. Synchronization of estrus using pharmacological products seems to have a place in the management of cattle;however, caution should be called upon a careful assessment both from the part of the farm and the professional in charge of the enterprise to avoid using the technique indiscriminatively thus propitiating the use of a method that might not be cost efficient.

关键词： Tropics Bos Indicus Cost-Benefit Estru Synchronization

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从“地方空间”到“流动空间”:隐私空间的代际演变与法律规制

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西北师大学报（社会科学版） 2016年第4期53卷 24-30页

作者：路鹃北京工商大学艺术与传媒学院北京100037

曼纽尔·卡斯特用二元空间理论揭示了网络社会的本质,"地方空间"向"流动空间"的演变意味着传统社会关系在网络中的转移和再造。传统隐私权理论对隐私空间的认知偏重于物理性,隐私空间在事实上的变化必然会导致法律规制上的变化。互联网... 详细信息

曼纽尔·卡斯特用二元空间理论揭示了网络社会的本质,"地方空间"向"流动空间"的演变意味着传统社会关系在网络中的转移和再造。传统隐私权理论对隐私空间的认知偏重于物理性,隐私空间在事实上的变化必然会导致法律规制上的变化。互联网的技术发展从历时性的角度分为web1.0、web2.0和web3.0时代,随着隐私空间物理属性的不断深化,法律规制的逻辑起点,应该转变网络空间只具有工具属性的认识,辨析合理的隐私期待,将其从"平面体系"塑造为"立体空间"。

关键词：地方空间流动空间隐私空间法律规制隐私期待

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Alcoholic liver disease:Utility of animal models

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World Journal of Gastroenterology 2018年第45期24卷 5063-5075页

作者： Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero Department of Immunology Ophthalmology and ORLComplutense University School of MedicineMadrid 28040Spain 12 de Octubre Health Research Institute(imas12) Madrid 28041Spain Institute for Bioengineering(IBioE) School of EngineeringFaraday BuildingThe University of EdinburghEdinburgh EH9 3 JLScotlandUnited Kingdom Department of Human Anatomy and Embryology Complutense University School of MedicineMadrid 28040Spain Instituto de Neurociencias Consejo Superior de Investigaciones CientíficasUniversidad Miguel HernándezSan Juan de Alicante 03550Spain Department of Cell Biology Complutense University School of MedicineMadrid 28040Spain Department of Genetics Physiology and MicrobiologyFaculty of BiologyUniversidad ComplutenseMadrid 28040Spain Department of Internal Medicine Ⅲ University Hospital RWTH AachenAachen 52062Germany

Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD.

关键词： Steatohepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Reactive oxygen species

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Role of capsule endoscopy in suspected celiac disease: A European multi-centre study

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World Journal of Gastroenterology 2017年第4期23卷 703-711页

作者： Marisol Luján-Sanchis Enrique Pérez-Cuadrado-Robles Javier Garcia-Lledo José-Francisco juanmartinena Fernandez Luca Elli Victoria-Alejandra Jiménez-García juan Egea-Valenzuela Julio Valle-Munoz Cristina Carretero-Ribón Ignacio Fernández-Urién-Sainz Antonio López-Higueras Noelia Alonso-Lazaro Mileidis Sanjuan-Acosta Francisco Sanchez-Ceballos Bruno Rosa Santiago González-Vázquez Federica Branchi Lucía Ruano-Díaz César Prieto-de-Frías Vicente Pons-Beltrán Pilar Borque-Barrera Begona González-Suárez Sofía Xavier Federico Argüelles-Arias juan-manuel Herrerías-Gutiérrez Enrique Pérez-Cuadrado-Martínez Javier Sempere-García-Argüelles Digestive Diseases Unit General University Hospital of Valencia Small Bowel Unit Hospital Morales Meseguer Digestive Diseases Unit General University Gregorio Maranón Unit of Gastroenterology and Endoscopy Complejo Hospitalario de Navarra Center for prevention and Diagnosis of Celiac Disease Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Unit of Gastroenterology and Endoscopy University Hospital Virgen Macarena Gastroenterology department Hospital Virgen de la Arrixaca Department of Gastroenterology Complejo Hospitalario de Toledo Department of Gastroenterology University of Navarra Clinic1 Endoscopy Digestive Unit Digestive Diseases AreaUniversitari i Politècnic La Fe Hospital1 Digestive Diseases Unit University Hospital Nuestra Senora de Candelaria1 Digestive Diseases Unit Clinical Hospital San Carlos1 Digestive Diseases Unit Hospital da Senhora da Oliveira-Guimaraes1 Endoscopy Digestive Unit Hospital Clinic de Barcelona

AIMTo analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE).METHODSThis is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group-I, n = 19), seropositive CD without atrophy (Group-II, n = 39), contraindication to gastroscopy (Group-III, n = 6), seronegative CD without atrophy, but with a compatible context (Group-IV, n = 99). DY, TI and the safety of CE were *** overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn’s). DY for groups I to IV was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated *** has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD.

关键词： Capsule endoscopy Celiac disease Anti-transglutaminase antibodies Gluten-free diet Non-celiac gluten sensitivity

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Caregiver Burden in the Management of Frail Elderly Patients with Diabetes in Internal Medicine

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Health 2018年第10期10卷 1383-1391页

作者： Jose Miguel Segui Ripoll Vicente Jesús Segui Llinares Miguel J.Reig Pérez Carles García Cervera juan manuel Núnez Cruz Pedro Esteve Atiénzar Sara Banón Escandell Alberto López Serrano María Dolores Jover Ríos juan Méndez Mora Carmen Segui Pérez María Josefa Navarro Navarro Pablo Roig Rico Department of Internal Medicine University Hospital of San JuanAlicanteSpain Department of Clinical Medicine Miguel Hernández UniversityElcheSpain Institute of Design and Manufacturing Polytechnic University of ValenciaCampus of AlcoyAlicanteSpain Department of Internal Medicine Hospital La Vega Baja of OrihuelaAlicanteSpain Secondary School Marist Brothers High SchoolAlicanteSpain Primary Medicine BenillobaSpain

Aim: Advanced age and fragility often lead to dependence, making caregiver assistance necessary for performing the activities of daily living. Patients with diabetes are characterized by an elevated presence of comorbidities and subsequent frailty—a relevant consideration when making decisions regarding treatment goals. Health professionals may overlook the caregiver experience when assessing the circumstances surrounding frail elderly patients with diabetes, but this factor can have a large impact on relevant caregiver and patient outcomes. Methods: An observational, retrospective study was carried out to assess the impact of improved management in diabetes on caregiver burden. We assessed patients’ performance of activities of daily living using the Barthel scale. Our primary outcome was caregiver burden, as assessed using the Zarit scale. Results: At baseline, 81.4% of the caregivers reported severe overburden (>55 points on the Zarit scale). At three months, the proportion of caregivers reporting this level of burden had dropped to 76.7% and remained stable at six months (77.1%). In contrast, 8.5% of the caregivers reported moderate overburden (47 to 55 points) at baseline, compared to 13.3% at three months and 12.5% at six. The proportion of caregivers reporting no overburden (Conclusions: Caregiver burden remained persistently high, decreasing only slightly after six months.

关键词： Elderly Diabetes Frail Patient Overload Caregiver

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Draft of Spanish Standard for the Use of Recycled Aggregate in the Production of Structural Concrete

Draft of Spanish Standard for the Use of Recycled Aggregate ...

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The 6th International Symposium on Cement & Concrete and Canmet/Aci International Symposium on Concrete Technology for Sustainable Development

作者： Pilar Alaejos Marta Sánchez de juan Marilda Barra manuel Burón Enrique Dapena Miren Etxebarría Gilbert Francisco Belén González Fonteboa Fernando Martínez Abella Isabel Martínez Lage José Luis Parray Alfaro juan Antonio Polanco Mariano Sanabria Enric Vázquez Task Force of Standing Committee of Concrete

In November 2002, the Spanish Standing committee of Concrete created a task force commissioned to draft a document to complement current regulations on structural concrete and to set out specific reco

关键词： Recycled concrete aggregate, Standardization, structural concrete.

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