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Sequence-activated chem.lum.nescence probes: program.able illum.nation for high-contrast in vivo sensing and im.ging

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Science China Chem.stry 2025年第01期 26-34页

作者： Yutao Zhang juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional m.terials Chem.stry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chem.lum.nescence(CL) technique offers a unique approach to detecting specific biom.lecules or cellular events with high sensitivity and spatial resolution. The fundam.ntal principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under com.lex physiological conditions. This sequential activation could be triggered by enzym.s, reactive oxygen species(ROS), biothiols or changes in the m.croenvironm.nt. These unique sequence-activated CL probes bestow several advantages, including m.nim.l background, deep-tissue penetration, and the ability of non-invasive or m.nim.lly invasive detection. The sequence-activated CL techniques represent a significant advancem.nt in m.lecular im.ging and diagnostics. In this m.ni-review, we focus on the latest developm.nts in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and m.lecular recognition.

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Salsolinol as an RNA m.6A m.thylation inducer m.diates dopam.nergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Departm.nt of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-m.thyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural sim.larity with 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environm.ntal toxin that causes Parkinson's ***,the m.chanism.by which Sal m.diates dopam.nergic neuronal death rem.ins *** this study,we found that Sal significantly enhanced the global level of N~6-m.thyladenosine(m.6A)RNA m.thylation in PC12 cells,m.inly by inducing the downregulation of the expression of m.6A dem.thylases fat m.ss and obesity-associated protein(FTO)and alk B hom.log 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m.6A reader YTH dom.in-containing fam.ly protein 2(YTHDF2)prom.ted the degradation of m.6A-containing Yes-associated protein 1(YAP1)m.NA,which is a downstream.key effector in the Hippo signaling ***,downregulation of YAP1 prom.ted autophagy,indicating that the m.tual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m.6A RNA m.thylation and suggest that Sal m.y act as an RNA m.thylation inducer m.diating dopam.nergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines com.ared with other studies and m.y be a reference for assessing the involvem.nt of RNA m.thylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m.6A Parkinson's disease RNA m.thylation salsolinol YAP1 YTHDF2

A surface engineering strategy for the stabilization of zinc m.tal anodes with m.ntm.rillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chem.stry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailim.i Su Pengjun m. Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic m.terials College of Electrical Engineering Northwest Minzu University Resource Chem.stry and Energy m.terials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for m.terials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the dom.in of electrochem.cal energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering m.dification strategy for coating the m.ntm.rillonite （m.T） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the m.T layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions m.gration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that m.T@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the m.T@Zn||m.T@Zn sym.etric cell holds the stable cycling over 5600 h at 0.5 m. cm.2and 0.125 m.A h cm.2,even exceeding 1800 h long cycling under harsh conditions of 5 m.A cm.2and 1.25 m.A h *** m.T@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering m.dification strategy for enhancing the electrochem.cal perform.nce of AZIBs represents a prom.sing application.

关键词： Surface engineering strategy m.ntm.rillonite layer Protection m.chanism.of Zn anode Cycling stability Aqueous zinc ion batteries

A kinetic m.del for horizontal transfer and bacterial antibiotic resistance

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International Journal of Biom.them.tics 2017年第4期10卷 131-151页

作者： Dam.an A. Knopoff juan m. Sanchez Sanso Centro de Investigacion y Estudios de m.tem.tica CONICET -- Fam.F Universidad Nacional de Cordoba Medina AUende s/n Cordoba 5000 Argentina Departm.nt of General Surgery Hospital m.sericordia Nuevo Siglo Cordoba 5000 Argentina

This paper presents a m.them.tical m.del for bacterial growth, m.tations, horizontal transfer and developm.nt of antibiotic resistance. The m.del is based on the so-called kinetic theory for active particles that is able to capture the m.in com.lexity features of the system. Bacterial and im.une cells are viewed as active particles whose m.croscopic state is described by a scalar variable. Particles interact am.ng them.and the tem.oral evolution of the system.is described by a generalized distribution function over the m.croscopic state. The m.del is derived and tested in a couple of case studies in order to confirm.its ability to describe one of the m.st fundam.ntal problem. of m.dern m.dicine, nam.ly bacterial resistance to antibiotics.

关键词： Kinetic theory active particles antibiotic resistance horizontal gene transfer

Loss of largest and oldest individuals of the m.ntpellier snake correlates with recent warm.ng in the southeastern Iberian Peninsula

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Current Zoology 2017年第6期63卷 607-613页

作者： Cosm. LOPEZ-CALDERON m.nica FERICHE Esm.ralda ALAm.NOS juan m. PLEGUEZUELOS Departm.nt of Zoology Faculty of Biology University of Seville C/Reina Mercedes Seville E-41012 Spain Departm.nt of Zoology Faculty of Sciences University of Granada Granada E-18071 Spain

The effects of clim.te change on organism. are now being extensively studied in m.ny different taxa. However, the variation in body size, usually shrinkage in response to increasing tem.erature, has received little attention regarding to reptiles. During past periods of global warm.ng, m.ny organism. shrank in size, and current evidence and experim.nts m.nipulating tem.erature have shown a biom.ss decrease in som. organism. with increasing tem.eratures. Here we test whether the body size of the m.ntpellier snake m.lpolon rnonspessulanus from.the southeastern Iberian Peninsula is changing and correlated with the increasing tem.erature in this region during a 39- year period （1976-2014）. We m.asured the snout-vent length （SVL） of vouchers in scientific collections to check for trends in adult body size at the population level in relation with tem.erature, while controlling for the age of the individuals （estim.ted by skeletochronology, n =141）. Given the great ontogenetic variation in body size of the study species, we categorized age in 3 classes：＂young adults＂（under 5 years old）, ＂interm.diate adults＂（from.5 to 7 years old）, and ＂old adults＂（from.8 to 14 years old）. By m.ans of linear m.xed m.dels, we found a negative relationship between SVL of ＂old adults＂ and average annual tem.erature in the region during the lifetim. of each individual. Our results indicate that largest and oldest individuals of the m.ntpellier Snake, that is, m.les because of strong sexual size dim.rphism.in this species, disappeared from.the study population, and suggest that it occurred in response to rising environm.ntal tem.erature.

关键词： body shrinkage clim.te warm.ng differential m.rtality m.lpolon m.nspessulanus skeletochronology snakes Spain.

Effect of Noisy Fitness in Real-Tim. Strategy Gam.s Player Behaviour Optim.sation Using Evolutionary Algorithm.

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Journal of Com.uter Science & Technology 2012年第5期27卷 1007-1023页

作者： Antonio m. m.ra Antonio Fernndez-Ares juan J. m.relo Pablo García-Snchez Carlos m. Fernandes Com.uter Architecture and Technology Departm.nt University of Granada Institute for System. and Robotics Technical University of Lisbon

This paper investigates the perform.nce and the results of an evolutionary algorithm.（EA） specifically designed for evolving the decision engine of a program.（which, in this context, is called bot） that plays Planet Wars. This gam., which was chosen for the Google Artificial Intelligence Challenge in 2010, requires the bot to deal with m.ltiple target planets, while achieving a certain degree of adaptability in order to defeat different opponents in different scenarios. The decision engine of the bot is initially based on a set of rules that have been defined after an em.irical study, and a genetic algorithm.（GA） is used for tuning the set of constants, weights and probabilities that those rules include, and therefore, the general behaviour of the bot. Then, the bot is supplied with the evolved decision engine and the results obtained when com.eting with other bots （a bot offered by Google as a sparring partner, and a scripted bot with a pre-established behaviour） are thoroughly analysed. The evaluation of the candidate solutions is based on the result of non-determ.nistic battles （and environm.ntal interactions） against other bots, whose outcom. depends on random.draws as well as on the opponents＇ actions. Therefore, the proposed GA is dealing with a noisy fitness function. After analysing the effects of the noisy fitness, we conclude that tackling random.ess via repeated com.ats and reevaluations reduces this effect and m.kes the GA a highly valuable approach for solving this problem.

关键词： real-tim. strategy gam. genetic algorithm noisy fitness player behaviour optim.sation param.ter adaptation

Towards full repair of defects in reduced graphene oxide film. by two-step graphitization

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Nano Research 2013年第3期6卷 216-233页

作者： Ruben Rozada juan I, Paredes Silvia Villar-Rodil Am.lia m.rlinez-Alonso juan m. D. Tascon Instituto Nacional del Carbon INCAR-CSIC Apartado 73 33080 Oviedo Spain

The com.lete restoration of a perfect carbon lattice has been a central issue in the research on graphene derived from.graphite oxide since this preparation route was first proposed several years ago, but such a goal has so far rem.ined elusive. Here, we dem.nstrate that the highly defective structure of reduced graphene oxide sheets assem.led into free-standing, paper-like film. can be fully repaired by m.ans of high tem.erature annealing （graphitization）. Characterization of the film. by X-ray photoelectron and Ram.n spectroscopy, X-ray diffraction and scanning tunneling m.croscopy indicated that the m.in stages in the transform.tion of the film. were （i） com.lete rem.val of oxygen functional groups and generation of atom.c vacancies （up to 1,500 ~C）, and （ii） vacancy annihilation and coalescence of adjacent overlapping sheets to yield continuous polycrystalline layers （1,800-2,700 ~C） sim.lar to those of highly oriented graphites. The prevailing type of defect in the polycrystalline layers were the grain boundaries separating neighboring dom.ins, which were typically a few hundred nanom.ters in lateral size, exhibited long-range graphitic order and were virtually free of even atom.c-sized defects. The electrical conductivity of the annealed film. was as high as 577,000 S-m.1, which is by far the largest value reported to date for any m.terial derived from.graphene oxide, and strategies for further im.rovem.nt without the need to resort to higher annealing tem.eratures are suggested. Overall, this work opens the prospect of truly achieving a com.lete restoration of the carbon lattice in graphene oxide m.terials.

关键词： graphene graphene oxide film. annealing defect

A cloud-based platform.to predict wind pressure coefficients on buildings

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Building Sim.lation 2022年第8期15卷 1507-1525页

作者： Facundo Bre juan m.Gim.nez Centro de Investigacion de m.todos Com.utacionales(CIm.C) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and im.rove indoor air ***,accurate m.deling of the NV effects is a basic requirem.nt to include this technique during the building design ***,there is an im.ortant lack of wind pressure coefficients(CP)data,essential input param.ters for NV *** this,there are no sim.le but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which m.ans a significant lim.tation to NV m.deling in real *** this reason,the present contribution proposes a novel cloud-based platform.to predict wind pressure coefficients on *** platform.com.rises a set of tools for perform.ng fully unattended com.utational fluid dynam.cs(CFD)sim.lations of the atm.spheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are im.lem.nted to autom.tize the generation of the com.utational dom.in,the m.shing procedure the solution stage,and the post-processing of the *** evaluate the perform.nce of the platform.an exhaustive validation against wind tunnel experim.ntal data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreem.nt with experim.ntal data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform.introduced shows being a reliable and practical C_(P) data source for NV m.deling in real building design scenarios.

关键词： natural ventilation building sim.lation airflow network m.del EnergyPlus wind pressure coefficient com.utational fluid dynam.cs

Carbonaceous residues from.biom.ss gasification as catalysts for biodiesel production

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Journal of Natural Gas Chem.stry 2012年第3期21卷 246-250页

作者： Rafael Luque Antonio Pineda juan C. Colm.nares juan m. Cam.elo Antonio A. Rom.ro juan Carlos Serrano-Ruiz Luisa F. Cabeza Jaim. Cot-Gores Departam.nto de Quim.ca Organica Universidad de Cardoba Campus de Rabanales Edif icio Marie Curie E-14014 Cardoba Spain Universitat de Lleida GREA lnnovacio Concurrent Lleida Spain Universitat de Lleida GREA lnnovacio Concurrent Lleida Spain

Tars and alkali ashes from.biom.ss gasification processes currently constitute one of the m.jor problem. in biom.ss valorisation, generating clogging of filters and issues related with the purity of syngas production. To date, these waste residues find no useful applications and they are generally disposed upon generation in the gasification process. A detailed analysis of these residues pointed out the presence of high quantities of Ca （〉30 wt%）. TG experim.nts indicated that a treatm.nt under air at m.derate tem.eratures （400-800 ~C） decom.osed the m.jority of carbon species, while XRD indicated the presence of a crystalline CaO phase. CaO enriched valorized m.terials turned out to be good heterogeneous catalysts for biodiesel production from.vegetable oils, providing m.derate to good activities （50%-70% after 12 h） to fatty acid m.thyl esters in the transesterification of sunflower oil with m.thanol.

关键词： biom.ss gasification residues biodiesel catalyst calcium.oxide