检索结果-南通市图书馆

fine-mapping of a candidate gene for web blotch resistance in Arachis hypogaea L.

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Journal of Integrative Agriculture 2024年第5期23卷 1494-1506页

作者： Xiaohui Wu Mengyuan Zhang Zheng Zheng Ziqi Sun feiyan Qi Hua Liu juan Wang Mengmeng Wang Ruifang Zhao Yue Wu Xiao Wang Hongfei Liu Wenzhao Dong Xinyou Zhang College of Agronomy Henan Agricultural UniversityZhengzhou 450046China Henan Academy of Agricultural Sciences/Henan Academy of Crop Molecular Breeding/Key Laboratory of Oil Crops in Huang-Huai-Hai Plain Ministry of Agriculture and Rural Affairs/Henan Provincial Key Laboratory for Oil Crop ImprovementZhengzhou 450002China The Shennong Laboratory Zhengzhou 450002China Shangqiu Academy of Agricultural and forestry Sciences Shangqiu 476000China

Peanut(Arachis hypogaea L.)is a globally important oil *** blotch is one of the most important foliar diseases affecting peanut,which results in serious yield losses *** web blotch-resistant peanut varieties is the most effective and economically viable method for minimizing yield losses due to web *** the current study,a bulked segregant analysis with next-generation sequencing was used to analyze an f2:3 segregating population and identify candidate loci related to web blotch *** on the fine-mapping of the candidate genomic interval using kompetitive allele-specific PCR(KASP)markers,we identified a novel web blotch resistance-related locus spanning approximately 169 kb on chromosome *** region included four annotated genes,of which only Arahy.35VVQ3 had a non-synonymous single nucleotide polymorphism in the coding region between the two *** markers(Chr.16.12872635 and Chr.16.12966357)linked to this gene were shown to be co-segregated with the resistance of peanut web blotch by 72 randomly selected recombinant inbred lines(RIL),which could be used in marker-assisted breeding of resistant peanut varieties.

关键词： peanut web blotch bulked segregant analysis KAsP markers resistant gene

Sema3A secreted by sensory nerve induces bone formation under mechanical loads

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International Journal of Oral Science 2024年第1期16卷 62-72页

作者： Hongxiang Mei Zhengzheng Li Qinyi Lv Xingjian Li Yumeng Wu Qingchen feng Zhishen Jiang Yimei Zhou Yule Zheng Ziqi Gao Jiawei Zhou Chen Jiang Shishu Huang juan Li State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduChina

Bone formation and deposition are initiated by sensory nerve infiltration in adaptive bone remodeling. Here, we focused on the role of Semaphorin 3A(Sema3A), expressed by sensory nerves, in mechanical loads-induced bone formation and nerve withdrawal using orthodontic tooth movement(OTM) model. firstly, bone formation was activated after the 3rd day of OTM,coinciding with a decrease in sensory nerves and an increase in pain threshold. Sema3A, rather than nerve growth factor(NGf),highly expressed in both trigeminal ganglion and the axons of periodontal ligament following the 3rd day of OTM. Moreover, in vitro mechanical loads upregulated Sema3A in neurons instead of in human periodontal ligament cells(hPDLCs) within 24 ***, exogenous Sema3A restored the suppressed alveolar bone formation and the osteogenic differentiation of hPDLCs induced by mechanical overload. Mechanistically, Sema3A prevented overstretching of f-actin induced by mechanical overload through ROCK2 pathway, maintaining mitochondrial dynamics as mitochondrial fusion. Therefore, Sema3A exhibits dual therapeutic effects in mechanical loads-induced bone formation, both as a pain-sensitive analgesic and a positive regulator for bone formation.

关键词： Sema3A formation overload

An allelic variation in the promoter of the LRR-RLK gene,qSS6.1,is associated with melon seed size

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Journal of Integrative Agriculture 2024年第10期23卷 3522-3536页

作者： Xiaoxue Liang Jiyu Wang Lei Cao Xuanyu Du Junhao Qiang Wenlong Li Panqiao Wang juan Hou Xiang Li Wenwen Mao Huayu Zhu Luming Yang Qiong Li Jianbin Hu College of Horticulture Henan Agricultural UniversityZhengzhou 450002China Henan Engineering Research Center for Cucurbit Germplasm Enhancement and Utilization Zhengzhou 450002China International Joint Laboratory of Henan Horticultural Crop Biology Zhengzhou 450002China

Seed size is an important agronomic trait in melons that directly affects seed germination and subsequent seedling ***,the genetic mechanism underlying seed size in melon remains *** the present study,we employed Bulked-Segregant Analysis sequencing(BSA-seq)to identify a candidate region(~1.35 Mb)on chromosome 6 that corresponds to seed *** interval was confirmed by QTL mapping of three seed size-related traits from an f2 population across three *** mapping region represented nine QTLs that shared an overlapping region on chromosome 6,collectively referred to as *** InDel markers were developed in the qSS6.1 region,narrowing it down to a 68.35 kb interval that contains eight annotated *** variation analysis of the eight genes identified a SNP with a C to T transition mutation in the promoter region of MELO3C014002,a leucine-rich repeat receptor-like kinase(LRR-RLK)*** mutation affected the promoter activity of the MELO3C014002 gene and was successfully used to differentiate the large-seeded accessions(C-allele)from the small-seeded accessions(T-allele).qRT-PCR revealed differential expression of MELO3C014002 between the two parental *** predicted protein has typical LRR-RLK family domains,and phylogenetic analyses reveled its similarity with the homologs in several plant ***,these findings suggest MELO3C014002 as the most likely candidate gene involved in melon seed size *** results will be helpful for better understanding the genetic mechanism regulating seed size in melons and for genetically improving this important trait through molecular breeding pathways.

关键词： melon QTL mapping seed size candidate gene allelic variation

SOSNet:一种非对称编码器-解码器结构的非小细胞肺癌CT图像分割模型

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电子学报 2024年第3期52卷 824-837页

作者：谢娟英张凯云陕西师范大学计算机科学学院陕西西安710119

非小细胞肺癌严重损害人类健康,早期非小细胞肺癌CT(Computed Tomography)图像中的肿瘤结节体积小,不易发现,极易造成漏诊和误诊.为了精确分割非小细胞肺癌CT图像中的小体积肿瘤结节,本文提出SOSNet(Small Object Segmentation Networks... 详细信息

非小细胞肺癌严重损害人类健康,早期非小细胞肺癌CT(Computed Tomography)图像中的肿瘤结节体积小,不易发现,极易造成漏诊和误诊.为了精确分割非小细胞肺癌CT图像中的小体积肿瘤结节,本文提出SOSNet(Small Object Segmentation Networks)自动分割模型,利用ResNet(Residual Network)基础层和空洞卷积构造非对称编码器-解码器结构作为分割主网络,利用轴向取反注意力模块ARA(Axial Reverse Attention)逐步擦除背景中对分割有影响的结构,再使用结构细化模块SR(Structure Refinement)对主网络输出的粗略特征图进行结构细化,从而实现非小细胞肺癌肿瘤结节分割.在非小细胞肺癌公开数据集的实验测试表明,本文提出的小目标自动分割模型SOSNet可以有效分割出非小细胞肺癌CT图像中的小体积肿瘤结节,其mDice(mean-Dice)、mIoU(mean Intersection over Union)、Sensitivity、f1、Specificity、平均绝对误差MAE(Mean Absolute Error)均优于当前最先进的小目标分割模型CaraNet(Context Axial Reverse Attention Network).

关键词：小目标分割非小细胞肺癌非对称编码器-解码器结构细化轴向取反注意力 CT图像深度学习卷积

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基于深度学习的隧道衬砌多病害检测算法

浙江大学学报（工学版） 2024年第6期58卷 1161-1173页

作者：宋娟贺龙喜龙会平邵阳学院土木与建筑工程学院湖南邵阳422000

针对已有目标检测算法在隧道衬砌病害检测中全局信息提取不充分、检测精度低的问题,提出隧道衬砌表观病害检测算法TDD-YOLO.该算法以YOLOv7框架为基础,采用MobileViT作为主干特征提取网络,提高网络全局信息和局部信息提取能力;在特征金... 详细信息

针对已有目标检测算法在隧道衬砌病害检测中全局信息提取不充分、检测精度低的问题,提出隧道衬砌表观病害检测算法TDD-YOLO.该算法以YOLOv7框架为基础,采用MobileViT作为主干特征提取网络,提高网络全局信息和局部信息提取能力;在特征金字塔网络的上采样和下采样后增加Coordinate attention (CA)注意力模块,突出病害的特征信息,去除背景信息的干扰;提出卷积模块TP Block,在计算量较小的情况下进一步提高网络的特征提取能力.为了验证所提出算法的有效性,选用SSD、 faster-RCNN、 EfficientDet、 YOLOv5、 YOLOv7这5种算法进行对比分析.实验结果表明,TDD-YOLO算法的f1为77.43%,相对5种对比算法,分别提高了15.58%、17.36%、 12.19%、 6.32%、 6.14%;mAP为77.52%,相对5种对比算法,分别提高了15.20%、 14.24%、 9.44%、 7.44%、6.39%. TDD-YOLO算法病害识别精度最高,综合性能最优,适用于实际隧道工程的病害检测任务.

关键词：隧道病害深度学习病害识别目标检测神经网络

玉米杂交群体产量性状及其特殊配合力全基因组关联分析

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作物学报 2024年第2期50卷 363-372页

作者：马娟曹言勇河南省农业科学院粮食作物研究所河南郑州450002

提高产量是玉米育种的长期目标,解析产量相关性状及其配合力的遗传基础对选育高产玉米新品种具有重要意义。本研究选用123份玉米自交系和8份测验种作为亲本,根据NCⅡ(North Carolina design Ⅱ)获得540份杂交种为材料,在新乡和周口试验... 详细信息

提高产量是玉米育种的长期目标,解析产量相关性状及其配合力的遗传基础对选育高产玉米新品种具有重要意义。本研究选用123份玉米自交系和8份测验种作为亲本,根据NCⅡ(North Carolina design Ⅱ)获得540份杂交种为材料,在新乡和周口试验田调查f1杂交种的单穗粒重、单穗重、百粒重、行粒数等8个产量及构成性状,利用玉米5.5K液相育种芯片检测亲本基因型,推断f1杂交种的基因型,利用BLINK(Bayesian information and linkage-disequilibrium iteratively nested keyway)加性和显性模型开展f1杂交种表型与其特殊配合力(special combining ability, SCA)的全基因组关联分析。结果表明,利用加性和显性模型对f1杂交种分别检测到10个和31个显著关联位点。利用显性模型检测到8个SNPs(single nucleotide polymorphisms)与SCA显著关联。不同性状和模型间共定位位点有7个,其中1个为单穗重与其SCA同时关联位点。通过对主效和共定位SNPs的扫描,共鉴定到26个候选基因,其中转录因子MYBR85、NLP9、PHD3、生长素上调小RNA(SAUR11和SAUR12)、fCS-like锌指蛋白基因fLZ16等可能是控制f1杂交种产量性状与其SCA的重要候选基因。

关键词：玉米杂交种特殊配合力全基因组关联分析

Hydrocephalus Secondary to Intraventricular Myxopapillary Ependymoma: Case Report

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World Journal of Neuroscience 2024年第3期14卷 85-91页

作者： juan Carlos Ayala-Alvarez Onyekachi Emmanuel Anyagwa fátima Gabriela Macías-Ortiz Oluwatoyin Adalia Dairo Courtney Storm Truebody Reza Badrnejad Aishwarya Bhuta Shashwat Sandeep Phade Srushti Kishor Jamdar Mostafa Yassin Vismaja Vijayan Neurology Department Hospital Civil Fray Antonio Alcalde Guadalajara Jalisco Mxico School of Medicine New Vision University Tbilisi Georgia

Ependymomas are a somewhat diverse category of glial tumors that often develop from the lining of the brain’s ventricles, or the spinal cord’s central canal. They make up 5% of all neuroepithelial tumors, 10% of paediatric brain tumors, and up to 33% of brain tumors in children under the age of three. Hydrocephalus is one of the complications, and it can be identified as progressive macrocephaly or increasing head circumference crossing percentiles, nausea, vomiting, poor appetite, irritability, and regression of developmental milestones.

关键词： Hydrocephalus Myxopapillary Ependymoma (MPE) Paediatrics Neurosurgery Glioma Intracranial Hypertension

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基于随机森林的中医痰湿体质预测模型研究

世界科学技术-中医药现代化 2024年第7期26卷 1906-1915页

作者：罗悦周娟成都中医药大学成都611137

目的基于随机森林算法建立一种可准确预测中医痰湿体质的模型,找出相关重要特征。方法数据预处理之后,共纳入2710名受试者,其中50%为痰湿体质者;利用RfECV方法进行特征选择,将筛选出来的特征子集用于构建基于随机森林的痰湿体质判定预... 详细信息

目的基于随机森林算法建立一种可准确预测中医痰湿体质的模型,找出相关重要特征。方法数据预处理之后,共纳入2710名受试者,其中50%为痰湿体质者;利用RfECV方法进行特征选择,将筛选出来的特征子集用于构建基于随机森林的痰湿体质判定预测模型,通过准确率、精确率、灵敏度、特异度、f1-score和AUC六个指标来对预测模型的性能进行评价,并与SVM和逻辑回归两种模型进行比较。结果通过RfECV特征选择方法,共有16个特征被用于痰湿体质预测模型的构建;在建模组和测试组中,随机森林模型预测准确率分别为0.907、0.814;精确率分别为0.936、0.827;灵敏度分别为0.885、0.806;特异度分别为0.932、0.822;f1-score分别为0.910、0.816;AUC值分别为0.970、、0.901,均大于其余两种预测模型。结论基于随机森林的中医痰湿体质预测模型具有较好的性能。本文的研究为中医体质类型预测的客观化模型构建提供了方法学参考。

关键词：随机森林痰湿体质预测模型特征选择

Covering corneal stromal lenticule for macular hole in pathological myopia

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1675-1680页

作者： Zi-Yan Tang Gang Qiao Xiao-juan Zhang Li-Jun Xie Qiang-Xing Zou Chun-Mei He Long Zhao Hua-Qing Yang Yu Quan Kui Cao Hui Jiang Yu-Kun He Wanjiang Eye Hospital of Mianyang Mianyang 621000Sichuan ProvinceChina

AIM:To evaluate the clinical effect of a new surgery technique(covering corneal stromal lenticule,CSL)for macular hole(MH)in pathological ***:This was a prospective non-randomized series case *** eyes of 14 patients whose axial length were more than 29 mm and suffered from MH and macular hole retinal detachment(MHRD)were included in this *** cases were treated with 25-gauge pars plana vitrectomy(PPV)with internal limiting membrane(ILM)peeling,covering CSL and C_(3)f_(8) gas *** cases were followed for 6mo,and the best-corrected visual acuity(BCVA),healing status of MH,the reattached rate of retinal detachment(RD),and reoperation rate were ***:All cases were successfully performed the surgery and the postoperative follow-up was *** surgery,MHs were healed in all 14 eyes(100%,14/14)after assessed by optical coherence *** reattachment of retina was achieved in all 6 eyes(100%,6/6)with *** was improved in 12 eyes(85.71%,12/14),and had no significant change in 2 eyes(14.29%,2/14).The overall mean BCVA was improved from 1.80±0.77 to 0.82±0.46 logMAR(f=10.46,Pf RD and high healing rate of MH in pathological myopia in the preliminary *** it can effectively improve the visual function of *** new technique offers meaningful new ideas for treating refractory MH in pathological myopia.

关键词： corneal stromal lenticule macular hole pathological myopia