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Diagnostic Approach of Thrombocytopenia in Pregnancy: A Review

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Open Journal of Obstetrics and Gynecology 2022年第8期12卷 784-792页

作者： John Alexander Yela Cono Sandra Ximena Olaya david Ricardo Murillo-Garcia Brahyan Osorio juan david hernández Susana Lopez de Valencia Hospital Popayán Colombia Institución Universitaria Visión de las Américas Pereira Colombia The Jewish Hospital Cincinnati USA Universidad Tecnológica de Pereira Pereira Colombia

Thrombocytopenia (defined as platelet count 9/L) is present in 7% - 12% of pregnant women at delivery. Although there are mild etiologies of this condition that are often diagnosed incidentally, there are more severe causes that can be life threating. Thrombocytopenia also has a great implication in surgical risk and regional anesthesia. A structured evaluation of thrombocytopenia is necessary to allow an adequate diagnostic approach. Here we summarized the current knowledge of thrombocytopenia in pregnancy.

关键词： Pregnancy Thrombocytopenia Gestational Thrombocytopenia Preeclampsia HELLP Syndrome Immune Thrombocytopenia Thrombotic Microangiopathy Heparin-Induced Thrombocytopenia Disseminated Intravascular Coagulation

Metabolic profiling of four synthetic stimulants,including the novel indanyl-cathinone 5-PPDi,after human hepatocyte incubation

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Journal of Pharmaceutical Analysis 2020年第2期10卷 147-156页

作者： david Fabregat-Safont Marie Mardal juan V.Sancho Félix hernández Kristian Linnet María Ibánez Research Institute for Pesticides and Water University Jaume IAvda.Sos Baynat s/n12071CastellónSpain Department of Forensic Medicine Section of Forensic ChemistryFaculty of Health and Medicinal SciencesUniversity of CopenhagenFrederik V's vej 112100KФbenhavnФDenmark Department of Occupational and Environmental Medicine University Hospital of Northern NorwaySykehusvegenTromsoeNorway

Synthetic cathinones are new psychoactive substances that represent a health risk *** most of the 130 reported compounds,information about toxicology and/or metabolism is not available,which hampers their detection(and subsequent medical treatment)in intoxication *** principles of forensic analytical chemistry and the use of powerful analytical techniques are indispensable for stab-lishing the most appropriate biomarkers for these *** metabolic fate of synthetic cathinones can be assessed by the analysis of urine and blood obtained from authentic consumers;however,this type of samples is limited and difficult to *** this work,the metabolic behaviour of three synthetic cathinones(4-CEC,4-CPrC and 5-PPDi)and one amphetamine(3-FEA)has been evalu-ated by incubation with pooled human hepatocytes and metabolite identification has been performed by high-resolution mass *** in vitro approach has previously shown its feasibility for obtaining excretory human metabolites.4-CEC and 3-FEA were not metabolised,and for 4-CPrC only two minor metabolites were *** the contrary,for the recently reported 5-PPDi,twelve phase I metabolites were *** to our knowledge,this is the first metabolic study of an *** reported in this paper will allow the detection of these synthetic stimulants in intoxi-cation cases,and will facilitate future research on the metabolic behaviour of other indanyl-based cathinones.

关键词： Synthetic cathinones 5-PPDi Metabolite identification In vitro metabolism Hepatocyte incubation High resolution mass spectrometry

On the unsteady motion and stability of a heaving airfoil in ground effect

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Acta Mechanica Sinica 2011年第2期27卷 164-178页

作者： juan Molina david Angland School of Engineering Sciences University of Southampton Southampton SO17 1BJ UK

This study explores the fluid mechanics and force generation capabilities of an inverted heaving airfoil placed close to a moving ground using a URANS solver with the Spalart-Allmaras turbulence model. By varying the mean ground clearance and motion frequency of the airfoil, it was possible to construct a frequency-height diagram of the various forces acting on the airfoil. The ground was found to enhance the downforce and reduce the drag with respect to freestream. The unsteady motion induces hysteresis in the forces’ behaviour. At moderate ground clearance, the hysteresis increases with frequency and the airfoil loses energy to the flow, resulting in a stabilizing motion. By analogy with a pitching motion, the airfoil stalls in close proximity to the ground. At low frequencies, the motion is unstable and could lead to stall flutter. A stall flutter analysis was undertaken. At higher frequencies, inviscid effects overcome the large separation and the motion becomes stable. Forced trailing edge vortex shedding appears at high frequencies. The shedding mechanism seems to be independent of ground proximity. However, the wake is altered at low heights as a result of an interaction between the vortices and the ground.

关键词： Oscillating airfoil · Flutter · Wing in ground effect · Vortex shedding

Yearly variation in the structure and diversity of a non-breeding passerine bird community in a Mediterranean wetland

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Avian Research 2020年第3期11卷 238-245页

作者： juan Arizaga Daniel Alonso ArinCrespo Xabier Esparza Efrén Fernández Iógo López david Martín Antonio Vilches Department of Ornithology Aranzadi Sciences Society S. Sebastián Spain

Background:The dynamics and structure of many bird communities are changing due to the global warming and changes in the land use and *** Ebro Valley constitutes one of the chief wintering areas for several passerine species in Iberia,and the reed beds spread across this Valley concentrate huge numbers of birds that use them to roost,while the surrounding agricultural areas serve as main foraging *** aims of this work are(1)to quantify how variable a non-breeding passerine bird community associated to a reed bed area in the Ebro Valley is,and,(2)to test for the effect of weather on possible annual fluctuations in species’proportions at a regional/local ***:We used for that ringing data collected at Badina de Escudera lagoon(Navarra)over a 12-year ***:Though,overall,the assemblage did not vary strongly among years(most similarity values were>0.8),we still found a significant linear effect of year on the proportion of captures of Reed Buntings(Emberiza schoeniclus),i.e.,the dominant species detected in our passerine *** increasing loss of weight of Reed Buntings in the community was due to a progressive decrease in its ***:The structure and diversity of passerine community in Badina Escudera was not influenced by meteorological conditions at a local scale,suggesting that local weather would not have an impact on numbers of Reed Buntings in winter.

关键词： Navarra Emberiza schoeniclus Ringing Long-term monitoring

Dendritic nanoarchitecture imparts ZSM-5 zeolite with enhanced adsorption and catalytic performance in energy applications

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Journal of Energy Chemistry 2023年第5期80卷 77-88,I0003页

作者： María del Mar Alonso-Doncel Cristina Ochoa-hernández Gema Gómez-Pozuelo Adriana Oliveira JoséGonzález-Aguilar ángel Peral Raúl Sanz david P.Serrano Thermochemical Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Heterogeneous Catalysis Max-Planck-Institut für KohlenforschungKaiser-Wilhem-Platz14540Muheim an der RuhGermay Department of Chemical and Environmental Technology Rey Juan Carlos UniversityC/Tulipan s/nE28933MostolesMadridSpain High Temperature Processes Unit IMDEA Energy InstituteAvda.Ramon de la Sagra3E28935MostolesMadridSpain Department of Chemical Energy and Mechanical TechnologyRey Juan Carlos UniversityC/Tulipan s/n28933MostolesMadridSpain

The development of zeolites possessing dendritic features represents a great opportunity for the design of novel materials with applications in a large variety of fields and,in particular,in the energy sector to afford its transition towards a low carbon *** the current work,ZSM-5 zeolite showing a dendritic3D nanoarchitecture has been synthesized by the functionalization of protozeolitic nanounits with an amphiphilic organosilane,which provokes the branched aggregative growth of zeolite *** ZSM-5 exhibits outstanding accessibility arising from a highly interconnected network of radially-oriented mesopores(3-10 nm)and large cavities(20-80 nm),which add to the zeolitic micropores,thus showing a well-defined trimodal pore size *** singular features provide dendritic ZSM-5 with sharply enhanced performance in comparison with nano-and hierarchical reference materials when tested in a number of energy related applications,such as VOCs(toluene)adsorption(improved capacity),plastics(low-density polyethylene)catalytic cracking(boosted activity)and hydrogen production by methane catalytic decomposition(higher activity and deactivation resistance).

关键词： Dendritic ZSM-5 VOCs adsorption Plastics cracking Methane decomposition Hydrogen production

A novel simple procedure to consider seismic soil structure interaction effects in 2D models

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Earthquake Engineering and Engineering Vibration 2014年第3期13卷 535-543页

作者： juan Diego Jaramillo juan david Gómez Doriam Restrepo Santiago Rivera Universidad EAFIT Medellín Colombia INTEGRAL S.A Medellín Colombia

A method is proposed to estimate the seismic soil-structure-interaction （SSI） effects for use in engineering practice. It is applicable to 2D structures subjected to vertically incident shear waves supported by homogenous half-spaces. The method is attractive since it keeps the simplicity of the spectral approach, overcomes some of the difficulties and inaccuracies of existing classical techniques and yet it considers a physically consistent excitation. This level of simplicity is achieved through a response spectra modification factor that can be applied to the free-field 5%-damped response spectra to yield design spectral ordinates that take into account the scattered motions introduced by the interaction effects. The modification factor is representative of the Transfer Function （TF） between the structural relative displacements and the free- field motion, which is described in terms of its maximum amplitude and associated frequency. Expressions to compute the modification factor by practicing engineers are proposed based upon a parametric study using 576 cases representative of actual structures. The method is tested in 10 cases spanning a wide range of common fundamental vibration periods.

关键词： seismic soil structure interaction simplified procedures modified response spectra

GenoDrawing:An Autoencoder Framework for Image Prediction from SNP Markers

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Plant Phenomics 2023年第4期5卷 816-824页

作者： Federico Jurado-Ruiz david Rousseau juan A.Botía Maria José Aranzana Center for Research in Agricultural Genomics(CRAG) 08193 BarcelonaCerdanyolaSpain Universitéd'Angers LARISINRAe UMR IRHS49000 AngersFrance Department of Information and Communication Engineering University of Murcia30071 MurciaSpain IRTA(Institut de Recerca i Tecnologia Agroalimentàries) BarcelonaSpain

Advancements in genome sequencing have facilitated whole-genome characterization of numerous plant species,providing an abundance of genotypic data for genomic *** selection and neural networks(NNs),particularly deep learning,have been developed to predict complex traits from dense genotypic ***,an NN model to extract features from images in an unsupervised manner,has proven to be useful for plant *** study introduces an autoencoder framework,GenoDrawing,for predicting and retrieving apple images from a low-depth single-nucleotide polymorphism(SNP)array,potentially useful in predicting traits that are difficult to *** demonstrates proficiency in its task using a small dataset of shape-related *** indicate that the use of SNPs associated with visual traits has substantial impact on the generated images,consistent with biological *** using substantial SNPs is crucial,incorporating additional,unrelated SNPs results in performance degradation for simple NN architectures that cannot easily identify the most important *** proposed GenoDrawing method is a practical framework for exploring genomic prediction in fruit tree phenotyping,particularly beneficial for small to medium breeding companies to predict economically substantial heritable *** GenoDrawing has limitations,it sets the groundwork for future research in image prediction from genomic *** studies should focus on using stronger models for image reproduction,SNP information extraction,and dataset balance in terms of phenotypes for more precise outcomes.

关键词： Auto Drawing prediction

High-precision chaotic radial basis function neural network model:Data forecasting for the Earth electromagnetic signal before a strong earthquake

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Geoscience Frontiers 2022年第1期13卷 364-373页

作者： Guocheng Hao juan Guo Wei Zhang Yunliang Chen david AYuen School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China School of Computer Science China University of GeosciencesWuhan 430074China Department of Mathematics Duke UniversityDurhamNC 27708USA Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA

The Earth’s natural pulse electromagnetic field data consists typically of an underlying variation tendency of intensity and *** change tendency may be related to the occurrence of earthquake *** of the underlying intensity trend plays an important role in the analysis of data and disaster *** chaos theory and the radial basis function neural network,this paper proposes a forecasting model of the chaotic radial basis function neural network to conduct underlying intensity trend forecasting by the Earth’s natural pulse electromagnetic field *** main strategy of this forecasting model is to obtain parameters as the basis for optimizing the radial basis function neural network and to forecast the reconstructed Earth’s natural pulse electromagnetic field *** verification experiments,we employ the 3 and 6 days’data of two channels as training samples to forecast the 14 and 21-day Earth’s natural pulse electromagnetic field data *** to the forecasting results and absolute error results,the chaotic radial basis function forecasting model can fit the fluctuation trend of the actual signal strength,effectively reduce the forecasting error compared with the traditional radial basis function ***,this network may be useful for studying the characteristics of the Earth’s natural pulse electromagnetic field signal before a strong earthquake and we hope it can contribute to the electromagnetic anomaly monitoring before the earthquake.

关键词： Earth’s natural pulse electromagnetic field Chaos theory Radial Basis Function neural network Forecasting model

A neural network to predict reactor core behaviors

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Nuclear Science and Techniques 2014年第1期25卷 75-80页

作者： juan Jose Ortiz-Servin david A.Pelta Jose Alejro Castillo Instituto Nacional de Investigaciones Nucleares Carretera Mexico Toluca S/NLa Marquesa OcoyoacacEstado de Mexico ETS Ingenieria Informatica y Telecomunicaciones Universidad de GranadaC/Daniel Saucedo Aranda

The global fuel management problem in BWRs(Boiling Water Reactors) can be understood as a very complex optimization problem,where the variables represent design decisions and the quality assessment of each solution is done through a complex and computational expensive *** last aspect is the major impediment to perform an extensive exploration of the design space,mainly due to the time lost evaluating non promising *** this work,we show how we can train a Multi-Layer Perceptron(MLP) to predict the reactor behavior for a given *** trained MLP is able to evaluate the configurations immediately,thus allowing performing an exhaustive evaluation of the possible configurations derived from a stock of fuel lattices,fuel reload patterns and control rods *** our particular problem,the number of configurations is approximately 7.7×10^(10);the evaluation with the core simulator would need above 200 years,while only 100hours were required with our approach to discern between bad and good *** later were then evaluated by the simulator and we confirm the MLP *** good core configurations reached the energy requirements,satisfied the safety parameter constrains and they could reduce uranium enrichment costs.

关键词：神经网络预测行为质量评估堆芯沸水反应堆多层感知器 MLP 优化问题