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a.peruloside Promotes a.optosis of Cervica. Ca.cer Cells through Endopla.mic Reticulum Stress-Mitochondria. Pa.hwa.

Chinese Journa. of Integra.ive Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min Wa.G Xia.LIU Xia.ZHa. juan Medica. Exa.ina.ion Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Depa.tment of Gyna.cology a.d Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimenta. Center for Tea.hing Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investiga.e the effects of a.peruloside on cervica. ca.cer ba.ed on endopla.mic reticulum(ER) stress a.d mitochondria. pa.hwa.. Methods: Different doses(12.5–800 μg/mL) of a.peruloside were used to trea. cervica. ca.cer cell lines Hela.a.d Ca.ki to ca.cula.e the ha.f ma.ima. inhibitory concentra.ion(IC_(50)) of a.peruloside. The cell prolifera.ion wa. a.a.yzed by clone forma.ion a.sa.. Cell a.optosis, intra.ellula. rea.tive oxygen species(ROS) a.d mitochondria. membra.e potentia. were determined by flow cytometry. The protein expressions of clea.ed-ca.pa.e-3, Bcl-2, Ba., Cyt-c, clea.ed-ca.pa.e-4 a.d glucose-regula.ed protein 78(GRP78) were a.a.yzed by Western blot. a.d the inhibitor of ER stress, 4-phenyl butyric a.id(4-PBa. wa. used to trea. cervica. ca.cer cells to further verify the role of ER stress in the a.optosis of cervica. ca.cer cells induced by a.peruloside. Results: a.peruloside of 325, 650, a.d 1300 μg/mL significa.tly inhibited the prolifera.ion a.d promoted a.optosis of Hela.a.d Ca.ki cells(Pa.l doses of a.peruloside significa.tly increa.ed intra.ellula. ROS levels, reduced mitochondria. membra.e potentia., significa.tly reduced Bcl-2 protein expression level, a.d increa.ed Ba., Cyt-c, GRP78 a.d clea.ed-ca.pa.e-4 expressions(Pa.dition, 10 mmol/L 4-PBa.trea.ment significa.tly promoted cell prolifera.ion a.d reduced a.optosis(Pa.d 650 μg/mL a.peruloside could reverse 4-PBa.induced increa.ed cell prolifera.ion, decrea.ed a.optosis a.d clea.ed-ca.pa.e-3,-4 a.d GRP78 protein expressions(Pa.ed the role of a.peruloside in cervica. ca.cer, suggesting tha. a.peruloside promotes a.optosis of cervica. ca.cer cells through ER stress-mitochondria. pa.hwa..

关键词： a.peruloside Chinese medicine cervica. ca.cer endopla.mic reticulum stress mitochondria. da.a.e a.optosis

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Impa.t of comorbid subthreshold depressive symptoms on ca.cerrela.ed fa.igue a.d complica.ions in a.ults with leukemia

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World Journa. of Psychia.ry 2024年第7期14卷 1009-1016页

作者： Yue-Xia. Liu juan Wa.g Depa.tment of Hema.ology Central Hospital Affiliated to Shandong First Medical UniversityJinan 250013Shandong ProvinceChina

Ba.KGROUND Pa.ients not only experience symptoms ca.sed by ca.cer but a.so suffer from the a.compa.ying psychologica. ***,these pa.ients do not ha.e high qua.ity of *** to the World Hea.th Orga.iza.ion,the incidence of leukemia.in China.in 2020 wa. 5.1/100000,the morta.ity ra.e wa. 3.3/100000,a.d the preva.ence ra.e wa. 16.7/***,it is importa.t to exa.ine the influence of comorbid subthreshold depressive symptoms on leukemia.*** To determine the impa.t of comorbid subthreshold depressive symptoms on ca.cer-rela.ed fa.igue a.d complica.ions in leukemia.pa.ients,thereby providing a.ba.is for ea.ly dia.nosis a.d trea.ment in clinica. *** a.questionna.re survey wa. conducted a.ong leukemia.pa.ients a.mitted to a.tertia.y hospita. in Xi'a.,Sha.nxi Province,China.from a.gust 2022 to December *** with a.score>16 on the Chinese Cla.sifica.ion of Menta. Disorders(CCMD-3)a.d a.Ha.ilton Depression Ra.ing Sca.e score of 8-17 were cla.sified a. the subthreshold depressive group(n=95),while 100 leukemia.pa.ients a.mitted during the sa.e period were cla.sified a. the control *** were collected using Epida.a.3.1 softwa.e,a.d compa.isons were ma.e between the two groups rega.ding genera. clinica. da.a.the Piper Fa.igue Sca.e(PFS),the Pittsburgh Sleep Qua.ity Index(PSQI),the Numeric Ra.ing Sca.e for pa.n a.sessment,la.ora.ory indica.ors,a.d the occurrence of *** In this survey,120 leukemia.pa.ients with depression were prelimina.ily screened,95 pa.ients with subthreshold depression were ultima.ely selected a. the subthreshold depression group,a.d 100 leukemia.pa.ients a.mitted during the sa.e period were enrolled a. the norma. *** of ba.ic clinica. da.a.between the two groups revea.ed no significa.t differences in a.e,sex,body ma.s index,cognitive function,or comorbidity with other chronic ***,there were sta.istica.ly significa.t differences in the use of ra.iothera.y

关键词： Subthreshold depression Leukemia Ca.cer-rela.ed fa.igue Complica.ions Minor depression

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Pra.tica. effect of different tea.hing modes in tea.hing ga.trointestina. surgery nursing

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World Journa. of Ga.trointestina. Surgery 2024年第1期16卷 166-172页

作者： Xia.-juan Rong Zhen Ning Depa.tment of Nursing Medical College in Jiangxi University of TechnologyNanchang 330098Jiangxi ProvinceChina

Ba.KGROUND With the continuous development a.d progress of medica. technology,the position of surgica. nursing in the field of clinica. medicine is becoming in-crea.ingly *** a. importa.t bra.ch of the surgica. field,the nursing requirements a.d difficulty of ga.trointestina. surgery a.e a.so *** order to improve the tea.hing qua.ity of nursing ca.e in ga.trointestina. surgery,ma.y educa.ors a.d resea.chers a.e a.tively exploring new tea.hing *** them,the tea.hing method ca.e-ba.ed lea.ning(CBL),scene-simula.ed lea.ning(SSL),ta.k-ba.ed lea.ning(TBL),combining self-eva.ua.ion a.d tra.ning mode is considered a. a. effective *** method a.ms to help students to better ma.ter knowledge a.d skills a.d improve their comprehensive qua.ity by cultiva.ing their self-eva.ua.ion *** To explore the pra.tica. effect of CBL-SSL-TBL combined with tra.ning mode a.d student self-a.sessment in nursing tea.hing of ga.trointestina. *** Seventy-one nursing interns in our hospita. from December 2020 to December 2021 were *** to different tea.hing modes,they were divided into observa.ion group CBL-SSL-TBL combined with tra.ning mode combined with student self-a.sessment a.d control group(conventiona. tea.hing mode),of which 36 were in observa.ion group a.d 35 were in control *** results of opera.iona. skills,theoretica. knowledge,nursing students'sa.isfa.tion,lea.ning effectiveness questionna.re a.d tea.hing effect were compa.ed between the two *** Compa.ed between the two groups,the opera.iona. skills a.d theoretica. knowledge scores of the observa.ion group were higher tha. those of the control group,a.d the difference wa. sta.istica.ly significa.t(Pa.ed between the two groups,the tota. sa.isfa.tion ra.io of the observa.ion group wa. higher tha. tha. of the control group,the difference wa. sta.istica.ly significa.t(Pa.ed between the two groups,the observa.ion group wa. lower tha

关键词： Ga.trointestina. surgery Nursing tea.hing Tea.hing model Pra.tica. effect Lea.ning a.ility

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Effect of rela.ive humidity on the desulfuriza.ion performa.ce of ca.cium-ba.ed desulfurizer

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Journa. of Environmenta. Sciences 2024年第4期138卷 179-188页

作者： juan Lǖ Yu Fu Ha.ya. Yu Hua.Wa.g Zhe Wa.g Ha.ya. Chen School of Environment a.d Resource Southwest University of Science and TechnologyMianyang 621010China Gua.gyua. Emergency Ma.a.ement burea. Guangyuan 628000China

Low desulfuriza.ion efficiency impedes the wide a.plica.ion of dry desulfuriza.ion technology,which is a.low-cost a.d simple process,a.d one significa.t solution is the development a.d ma.ufa.ture of high-performa.ce *** this study,firstly,a.stea. jet mill wa. used to digest quicklime;then,we utilized numerica. simula.ion to study the flow field distribution a.d a.a.yze the driving fa.tors of quicklime digestion;a.d la.tly,the desulfuriza.ion performa.ce of the desulfurizer wa. eva.ua.ed under different rela.ive *** results show tha. the desulfurizer prepa.ed via.the stea. jet mill ha. better a.pa.ent a.tivity tha. tra.itiona. ***,the entire jet flow field of the stea. jet mill is in a.supersonic a.d highly turbulent flow sta.e,with high crushing intensity a.d good pa.ticle a.celera.ion *** conta.t with the na.cent surfa.e ma.imizes the forma.ion of sla.ed *** experiments demonstra.ed tha. the opera.ing time with 100%desulfuriza.ion efficiency a.d the“brea.-through”time for the desulfurizer prepa.ed via.the stea. jet mill is longer tha. tha. of tra.itiona. desulfurizers,a.d ha. significa.t a.va.ta.es,especia.ly a. low flue ga. rela.ive *** with tra.itiona. desulfurizers,the desulfurizer prepa.ed via.stea. jet mill expa.ds the ra.ge of a.cepta.le flue ga. tempera.ure,a.d the fa.lure tempera.ure is 1.625 times tha. of tra.itiona. *** work brea.s through the technica. bottleneck of low dry desulfuriza.ion efficiency,which is a. importa.t step in pushing forwa.d the a.plica.ion of dry desulfuriza.ion.

关键词： Dry desulfuriza.ion Rela.ive humidity Desulfuriza.ion efficiency High-efficiency desulfurizer Quicklime digestion

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One-dimensiona. molecula. co-crysta. a.loys ca.a.le of full-color emission for low-loss optica. wa.eguide a.d optica. logic ga.e

Aggregate

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a.grega.e 2024年第1期5卷 299-308页

作者： Zhenhong Qi Yu-juan Ma.Dongpeng Ya. Beijing Key La.ora.ory of Energy Conversion a.d Stora.e Ma.eria.s College of ChemistryKey Laboratory of Radio-pharmaceuticals Ministry of EducationBeijing Normal UniversityBeijingChina

The luminescence color of molecule-ba.ed photoa.tive ma.eria.s is the key to the a.plica.ions in lighting a.d optica. *** continuous regula.ion of emission color in molecula. systems is highly desira.le but still rema.ns a.cha.lenge due to the individua. emission ba.d of purely orga.ic ***,a.novel a.loy stra.egy ba.ed on molecula. co-crysta.s is *** a.justing the mola. ra.io of pyrene(Py)a.d fluora.hene(Flu),three types of molecula. co-crysta. a.loys(MCa.)a.semblies a.e prepa.ed involving Py-Flu-OFN-x%,Py-Flu-TFP-x%,Py-Flu-TCNB-x%.Multiple energy level structure a.d Förster resona.ce energy tra.sfer(FRET)process endow ma.eria.s with tuna.le full-spectra.emission color in visible ***,these MCa. a.d co-crysta.s ca. be successfully a.plied to low optica. loss wa.eguide a.d optica. logic ga.e by virtue of a.l-color luminescence from blue a.ross green to red,together with smooth surfa.e of onedimensiona. microrods,which show promising a.plica.ions a. continuous light emitters for a.va.ce photonics a.plica.ions.

关键词： full-color emission microrods molecula. co-crysta. optica. wa.eguide orga.ic a.loys

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Improved orga.s a. risk segmenta.ion ba.ed on modified U‐Net with self‐a.tention a.d consistency regula.isa.ion

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Ca.I Tra.sa.tions on Intelligence Technology 2024年第4期9卷 850-865页

作者： Ma.sym Ma.ko a.ton Popov juan Ma.uel Gorriz Ja.ier Ra.irez Electronic Engineering Depa.tment Igor Sikorsky Kyiv Polytechnic InstituteKyivUkraine Depa.tment of Signa. Theory Telematics and CommunicationsUniversity of GranadaGranadaSpain

Ca.cer is one of the lea.ing ca.ses of dea.h in the world,with ra.iothera.y a. one of the trea.ment *** pla.ning sta.ts with delinea.ing the a.fected a.ea.from hea.thy orga.s,ca.led orga.s a. risk(Oa.).a.new a.proa.h to a.toma.ic Oa. seg-menta.ion in the chest ca.ity in Computed Tomogra.hy(CT)ima.es is *** proposed a.proa.h is ba.ed on the modified U‐Net a.chitecture with the ResNet‐34 encoder,which is the ba.eline a.opted in this *** new two‐bra.ch CS‐Sa.U‐Net a.chitecture is proposed,which consists of two pa.a.lel U‐Net models in which self‐a.tention blocks with cosine simila.ity a. query‐key simila.ity function(CS‐Sa.blocks a.e inserted between the encoder a.d decoder,which ena.led the use of con-sistency *** proposed solution demonstra.es sta.e‐of‐the‐a.t performa.ce for the problem of Oa. segmenta.ion in CT ima.es on the publicly a.a.la.le SegTHOR benchma.k da.a.et in terms of a.Dice coefficient(oesopha.us-0.8714,hea.t-0.9516,tra.hea.0.9286,a.rta.0.9510)a.d Ha.sdorff dista.ce(oesopha.us-0.2541,hea.t-0.1514,tra.hea.0.1722,a.rta.0.1114)a.d significa.tly outperforms the *** current a.proa.h is demonstra.ed to be via.le for improving the qua.ity of Oa. segmenta.ion for ra.iothera.y pla.ning.

关键词： 3‐D computer vision deep lea.ning deep neura. networks ima.e segmenta.ion medica. ima.e processing object segmenta.ion

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Fa.t prediction of ra.n erosion in wind turbine bla.es using a.da.a.ba.ed computa.iona. tool

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Journa. of Hydrodyna.ics 2024年第3期36卷 504-518页

作者： juan M.Gimenez Sergio R.Idelsohn Eugenio Oña.e Centre Interna.iona. de Mètodes Numèrics en Enginyeria.CIMNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)fa.e a.high risk of fa.lure due to environmenta. fa.tors like erosion,pa.ticula.ly in high-precipita.ion a.ea. a.d offshore *** this pa.er we introduce a.novel computa.iona. tool for the fa.t prediction of ra.n erosion da.a.e on WT bla.es tha. is useful in opera.ion a.d ma.ntena.ce decision ma.ing *** a.proa.h is a. follows:Pseudo-Direct Numerica. Simula.ion(P-DNS)simula.ions of the droplet-la.en flow a.ound the bla.e section profile a.e employed to build a.high-fidelity da.a.set of impa.t sta.istics for potentia. opera.ing *** this da.a.a.e a. tra.ning da.a.a.ma.hine lea.ning-ba.ed surroga.e model provides the fea.ure of the impa.t pa.tern over the 2-D section for given wind a.d ra.n *** this informa.ion,a.fa.igue-ba.ed model estima.es the rema.ning lifetime a.d erosion da.a.e for both homogeneous a.d coa.ing-substra.e bla.e *** prediction is done by qua.tifying the a.cumula.ed droplet impa.t energy a.d eva.ua.ing opera.ive conditions over time periods for which the wea.her a. the insta.la.ion site is *** this work,we describe the modules tha. compose the prediction method,na.ely the da.a.a.e crea.ion,the tra.ning of the surroga.e model a.d their coupling to build the prediction ***,the method is a.plied to predict the rema.ning lifetime a.d erosion da.a.e to the bla.e sections of a.reference *** eva.ua.e the relia.ility of the tool,severa. site loca.ions(offshore,coa.ta.,a.d inla.d),the coa.ing ma.eria. a.d the coa.ing thickness of the bla.e a.e *** few minutes we a.e a.le to estima.e erosion a.ter ma.y yea.s of *** results a.e in good a.reement with field observa.ions,showing the promise of the new ra.n erosion prediction a.proa.h.

关键词： Wind turbine bla.es lea.ing edge erosion fa.igue Pseudo-Direct Numerica. Simula.ion(P-DNS) ma.hine lea.ning ebla.er

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Sudden openings a.d gra.ua. closures in ca.opy cover modula.e a.clima.ion,surviva.,a.d growth of a.sha.e-tolera.t ra.nforest tree species

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Journa. of Forestry Resea.ch 2024年第5期35卷 78-90页

作者： a.a.Pa.la.Moretti Fla.ia.Yesica.Olguin juan Ma.celo Ga.na.Corina.Gra.ia.o INFIVE(CONICET-Universida. Na.iona. de La.Pla.a. Diagonal 113 N°4951900 La PlataProvincia de Buenos AiresArgentina CONICET Godoy Cruz 2290C1425FQB Buenos AiresArgentina Fa.ulta. de Ciencia. a.ra.ia.y Foresta.es Universidad Nacional de La PlataCalle 60y 1181900 La PlataProvincia de Buenos AiresArgentina Fa.ulta. de Ciencia. Foresta.es Universidad Nacional de MisionesBertoni 124 km 33380 EldoradoProvincia de MisionesArgentina

Forest disturba.ces a. ga. levels a.e one of the most importa.t events for the regenera.ion a.d esta.lishment of intermedia.e tree *** ca.opy openings expose pla.ts to high light intensity a.d high eva.ora.ive dema.ds tha. stress sha.e-a.clima.ed ***,the slow closure of ga.s reduces light a.a.la.ility to pla.ts esta.lished when the incident irra.ia.ion wa. *** work eva.ua.ed the morphologica. a.d physiologica. a.clima.ion of Ca.ra.ea.ca.jera.a.Vell)*** to sudden a.d to gra.ua. cha.ges in ca.opy cover.a.pot experiment wa. ca.ried out with pla.ts exposed to a.sudden opening.a.few da.s a.ter the light shock,pla.ts ra.idly increa.ed photosynthetic ra.es a.d decrea.ed lea. wa.er *** two months,pla.ts a.tiva.ed physiologica. responses a. lea. a.d whole pla.t levels to high light a.d wa.er stresses,e.g.,increa.ed stoma.ta. conducta.ce,stoma.a. index a.d reduction of lea.:fine roots ra.io a.d *** seven months,hydra.lic conductivity of petioles a.d the whole lea. increa.ed,a.d growth wa. much higher tha. pla.ts tha. rema.ned under the *** a.field experiment in ga.s in the ra.nforest,pla.ts a.clima.ed to a.l ca.opy *** yea.s a.ter pla.ting,growth wa. ma.imum in open environments within the ga.s,even if the ca.opy closed during the first 20 months a.ter *** conclusion,if this species is pla.ted to enrich the ra.nforest,positions within ga.s with lower ca.opy cover should be chosen a.d ga. closure will not a.fect *** ma.a.e *** na.ura. regenera.ion,the opening of ga.s a.d remova. of understory will increa.e surviva. a.d growth without the risk tha. the stress ca.sed by these sudden openings could lea. to the dea.h of ***-bining pot a.d field experiments helps to understa.d the a.tecology of trees with pa.ticula. ecologica. interest,a.d to build sound restora.ion pra.tices.

关键词： Ca.ra.ea.ca.jera.a a.la.tic forest a.iotic stress Regenera.ion Seedling

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Oligodendroctyes:the forgotten pla.ers of dia.etes pa.hophysiology

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Neura. Regenera.ion Resea.ch 2024年第11期19卷 2349-2350页

作者： juan a.tonio López-Villodres Bea.riz Ga.cía.Día. Depa.ta.ento Fisiología.Huma.a Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investiga.ión Biomédica.de Mála.a.y Pla.a.orma.en Na.omedicina.IBIMa.Pla.a.orma.Biona.d) MálagaSpain

Oligodendrocytes(OLs),glia. cells tha. provide myelin shea.hs to a.ons in the centra. nervous system(CNS),ha.e a.dua. ***,this myelin fa.ty cover a.ound the a.ons protects the nerves a.d is crucia. for the sa.ta.ory propa.a.ion of a.tion *** a.d not less importa.t,OLs provide trophic support to neurons a.d ***,OL meta.olism is importa.t for OL well-being a.d the proper a.complishment of their functions,a.d OL meta.olism energetics directly a.fect the energy meta.olism of neighboring neurons.

关键词： meta.olism nerves myelin

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Triphenylphosphine-a.sisted Exsolution Engineering on Ruddlesden-Popper Perovskites for Promoting Oxygen Evolution

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Energy & Environmenta. Ma.eria.s 2024年第4期7卷 433-441页

作者： juan Ba. Jing Sha.g Jun Mei Dongchen Qi Ting Lia. Ziqi Sun School of Chemistry a.d Physics Queensland University of Technology Centre for Ma.eria.s Science Queensland University of Technology School of Ma.eria.s Science a.d Engineering Shaanxi University of Science and Technology School of Mecha.ica. Medica. a.d Process Engineering Queensland University of Technology

Meta. exsolution engineering ha. been rega.ded a. a.promising stra.egy for a.tiva.ing intrinsica.ly inert perovskite oxide ca.a.ysts towa.d efficient oxygen evolution *** meta. exsolution processes on perovskites a.e often a.hieved by using the reducing hydrogen ga.; however,this is not effective for the rela.ively sta.le pha.e,such a. Ruddlesden-Popper perovskite oxides.

关键词： exsolution oxygen evolution perovskite reconstruction Ruddlesden–Popper

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