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Development and validation of a nomogram model for predicting the risk of pre-hospital delay in patients with acute myocardial infarction

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World Journal of Cardiology 2024年第2期16卷 80-91页

作者： Jiao-Yu Cao Li-Xiang Zhang Xiao-juan zhou Department of Cardiology The First Affiliated Hospital of USTCDivision of Life Science and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

BACKGROUND Acute myocardial infarction(AMI)is a severe cardiovascular disease caused by the blockage of coronary arteries that leads to ischemic necrosis of the *** medical contact is critical for successful AMI treatment,and delays increase the risk of death for ***-hospital delay time(PDT)is a significant challenge for reducing treatment times,as identifying high-risk patients with AMI remains *** study aims to construct a risk prediction model to identify high-risk patients and develop targeted strategies for effective and prompt care,ultimately reducing PDT and improving treatment *** To construct a nomogram model for forecasting pre-hospital delay(PHD)likelihood in patients with AMI and to assess the precision of the nomogram model in predicting PHD *** A retrospective cohort design was employed to investigate predictive factors for PHD in patients with AMI diagnosed between January 2022 and September *** study included 252 patients,with 180 randomly assigned to the development group and the remaining 72 to the validation group in a 7:3 *** risk factors influencing PHD were identified in the development group,leading to the establishment of a nomogram model for predicting PHD in patients with *** model's predictive performance was evaluated using the receiver operating characteristic curve in both the development and validation *** Independent risk factors for PHD in patients with AMI included living alone,hyperlipidemia,age,diabetes mellitus,and digestive system diseases(P<0.05).A characteristic curve analysis indicated area under the receiver operating characteristic curve values of 0.787(95%confidence interval:0.716–0.858)and 0.770(95%confidence interval:0.660-0.879)in the development and validation groups,respectively,demonstrating the model's good discriminatory *** Hosmer–Lemeshow goodness-of-fit test revealed no statistically significant disparity between the an

关键词： Pre-hospital delay Acute myocardial infarction Risk prediction Nomogram

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A Study on the Path of Promoting External Dissemination of Regional Culture with Translation Technology under the Background of New Quality Productivity

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Journal of Contemporary Educational Research 2024年第8期8卷 26-31页

作者： juan zhou School of Foreign Languages Zaozhuang UniversityZaozhuang 277100Shandong ProvinceChina

With the introduction of the concept of new quality productivity characterized by high technology,efficiency,and quality,various industries in China have ignited a high spirit of innovation and *** this background,this article analyzes the significance and current situation of the external dissemination of regional culture and combines the application of translation technology empowered by new quality productivity to explore a path suitable for the wider,more effective,and higher-quality external dissemination of regional *** aim is to provide practical experience for promoting the effective dissemination of regional culture in China to the world and better build a cultural power.

关键词： New quality productivity Regional culture External dissemination Translation technology

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Virtual Reality-Based Mirror Therapy for Upper Extremity Function among Stroke Patients:A Meta-analysis and Systematic Review

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Medicinal Plant 2024年第5期15卷 44-49页

作者： juan zhou Department of Occupational Therapy Psychologyand Speech TherapyTaihe HospitalHubei University of MedicineShiyan 442000China

[Objectives]To investigate the evidence-based effect of virtual reality-based mirror therapy system(VR-MT)on upper extremity function among stroke patients.[Methods]A systematic electronic searching of the Medline,PubMed,Web of Science and CNKI was initially performed up to June 10,*** risk of bias of the included studies was evaluated using RevMan 5.4 software based on the Cochrane Handbook for Systematic *** random-effects model or fixed-effects models was employed to estimate the standardized mean difference(SMD).The subgroup analyses were conducted exploring theVR-MT type(immersive or non-immersive)and comparing with MT or control group.[Results]In total 8 studies with a total of 273 stroke patients were included in this *** pooled analysis of these trials showed a statistically significant enhancement inFMA-UE scores(6 studies,SMD=0.72,[95%CI 0.37 to 1.06];P<0.0001,I^(2)=31%)and Box and Block Test(BBT)(3 studies,SMD=0.49,[95%C/0.05 to 0.93];P=0.03,I^(2)=0%),rather than Manual Function Test(MFT)scores(3 studies,SMD=0.38,[95%CI-0.09 to 0.84];P=0.11,I^(2)=0%)following the application of reality-based mirror ***,the subgroup analysis results indicated that immersive VR-MT can significantly improve FMA-UE(5studies,SMD=0.73,[95%CI 0.24 to 1.23];P=0.004,I^(2)=43%).In contrast,the overall effect of non-immersive VR-MT was non-significant(2 studies,SMD=0.33,[95%CI-0.69 to 1.34];P=0.53,I^(2)=72%).[Conclusions]In this systematic review and meta-analysis,our findings indicate that immersiveVR-MT has the potential to improve upper extremity function among stroke patients.

关键词： Stroke Mirror therapy Virtual reality Upper extremity function Meta-analysis

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A Survey on the Current Situation of Prehospital First Aid about Knowledge, Belief and Behavior among University Students in Jingzhou

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Open Journal of Applied Sciences 2024年第5期14卷 1251-1261页

作者： Tianyue Zhang Hong zhou Chenyang Xu juan zhou Department of Medical Health Science Center Yangtze University Jingzhou China

Objective: To understand the current situation of prehospital first aid knowledge, attitude and behavior of university students in Jingzhou City. Methods: A prehospital first aid knowledge questionnaire and the convenience sampling method were used to survey 307 university students in Jingzhou City. Results: The mean score of prehospital first aid knowledge of university students in Jingzhou City was 12.85 ± 2.643, the mean score of attitude was 50.73 ± 4.114, and the mean score of behavior was 39.05 ± 8.898;There was a statistically significant difference in the scores of prehospital first aid knowledge, attitude, and behavior of university students depending on whether or not they had received prehospital first aid training (P P Conclusion: Jingzhou University students have a positive attitude toward pre-hospital first aid, but the knowledge level and behavior are low, which suggests that the government, society and the school should create good conditions to promote the improvement of pre-hospital first aid knowledge and ability.

关键词： Prehospital First Aid University Student Knowledge Attitude Behaviors

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LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： juan zhou Yiran Xu Luyao Wang Yu Cong Ke Huang Xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei Xu Xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child Health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

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The exploration of cell population data in clinical use: Beyond infectious diseases

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iLABMED 2024年第2期2卷 125-140页

作者： Shayuanzi Huang Yin Liu Liu Qian juan zhou Dong Wang Department of Laboratory Medicine the First Affiliated HospitalSun Yat-Sen UniversityGuangzhouGuangdongChina Department of Laboratory Medicine Guangxi Hospital Division of the First Affiliated HospitalSun Yat-Sen UniversityNanningGuangxiChina Department of Medical Affair Danaher Diagnostic PlatformShanghaiChina Department of Oncology General Hospital of the Southern Theatre CommandPLAGuangzhouGuangdongChina

Cell population data(CPD)is regarded as the fingerprint of a blood cell at a given *** parameters harbor information associated with cell morphology and can be automatically generated using modern hematological *** studies have revealed many unique clinical applications for CPD,especially for infectious diseases,such as *** example,one monocyte-related CPD parameter is the monocyte distribution width(MDW),which can be generated using a Beckman Coulter hematological *** has received FDA and CE approval for aiding in sepsis diagnosis in adult patients in the emergency ***,MDW can serve as a diagnostic biomarker in patients infected with *** has also been widely explored for possible clinical applications beyond infectious dis-eases,such as for predicting myelodysplastic syndromes,screening for he-matological malignancies,and detecting sterile *** parameter measurements are easily obtained and quite cost-effective,making them practical for clinical ***,there are some potential drawbacks of CPD *** pre-analytical conditions can affect CPD ***-more,CPD are specific to certain hematological analyzers and the result cannot be transferred between different *** practical usefulness of CPD reference intervals is also still *** this review,wesummarize the current studies related to CPD and its clinical *** well-designed clinical studies related to CPD are still expected.

关键词： cell population data Coulter principle hematology analyzer infectious diseases white blood cell

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基于STPA与模糊BN的新能源汽车安全性分析方法研究

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现代电子技术 2024年第8期47卷 18-24页

作者：张顺周娟中国计量大学质量与安全工程学院浙江杭州310018

随着新能源汽车自动化程度不断提高,各系统之间耦合造成的故障急剧增加,传统的安全分析方法已无法满足当前汽车复杂系统的危险性分析要求。针对新能源汽车突然失控事故存在的高危性、复杂多样的问题,提出一种基于STPA与模糊BN的新能源... 详细信息

随着新能源汽车自动化程度不断提高,各系统之间耦合造成的故障急剧增加,传统的安全分析方法已无法满足当前汽车复杂系统的危险性分析要求。针对新能源汽车突然失控事故存在的高危性、复杂多样的问题,提出一种基于STPA与模糊BN的新能源汽车安全性分析方法。首先,运用系统理论过程分析方法(STPA)分析新能源汽车突然失控事故,得出系统级事故及危险,构建控制反馈回路,并识别不安全控制行为;接着,根据STPA分析结果构建模糊BN,通过GeNIe软件训练数据,可视化模糊BN,得到基本事件的发生概率,并由试验仿真得出蓄电池及储能系统、电机电控和整车控制器的后验概率分别为0.70、0.17和0.16。结果表明,所提方法能有效识别系统潜在危险,发现系统薄弱环节,可为提高系统可靠性提供依据。

关键词：新能源汽车安全性分析系统理论过程分析方法模糊BN 系统级事故不安全控制行为

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基于随机森林的中医痰湿体质预测模型研究

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世界科学技术-中医药现代化 2024年第7期26卷 1906-1915页

作者：罗悦周娟成都中医药大学成都611137

目的基于随机森林算法建立一种可准确预测中医痰湿体质的模型,找出相关重要特征。方法数据预处理之后,共纳入2710名受试者,其中50%为痰湿体质者;利用RFECV方法进行特征选择,将筛选出来的特征子集用于构建基于随机森林的痰湿体质判定预... 详细信息

目的基于随机森林算法建立一种可准确预测中医痰湿体质的模型,找出相关重要特征。方法数据预处理之后,共纳入2710名受试者,其中50%为痰湿体质者;利用RFECV方法进行特征选择,将筛选出来的特征子集用于构建基于随机森林的痰湿体质判定预测模型,通过准确率、精确率、灵敏度、特异度、F1-score和AUC六个指标来对预测模型的性能进行评价,并与SVM和逻辑回归两种模型进行比较。结果通过RFECV特征选择方法,共有16个特征被用于痰湿体质预测模型的构建;在建模组和测试组中,随机森林模型预测准确率分别为0.907、0.814;精确率分别为0.936、0.827;灵敏度分别为0.885、0.806;特异度分别为0.932、0.822;F1-score分别为0.910、0.816;AUC值分别为0.970、、0.901,均大于其余两种预测模型。结论基于随机森林的中医痰湿体质预测模型具有较好的性能。本文的研究为中医体质类型预测的客观化模型构建提供了方法学参考。

关键词：随机森林痰湿体质预测模型特征选择

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运营公路边坡安全风险评价研究

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公路 2024年第5期69卷 96-100页

作者：周娟王琦贵州省交通规划勘察设计研究院股份有限公司贵阳市550081

贵州省已进入周期性的公路养护高峰期,山区运营公路边坡数量众多,随着公路服务时间增加,公路边坡安全风险愈发突出,风险管控难度大,对运营公路边坡开展风险评价尤为重要。基于贵州省运营公路边坡风险管控的需求与实际,在边坡风险评价体... 详细信息

贵州省已进入周期性的公路养护高峰期,山区运营公路边坡数量众多,随着公路服务时间增加,公路边坡安全风险愈发突出,风险管控难度大,对运营公路边坡开展风险评价尤为重要。基于贵州省运营公路边坡风险管控的需求与实际,在边坡风险评价体系、风险分级标准、风险处置原则等方面开展了研究,提出了适用于贵州省公路边坡风险评价的评价指标,并将研究成果应用于贵州某山区运营高速公路,验证了该评价体系的可操作性和评价结果的可靠性,可为其他地区类似工程提供参考。

关键词：公路边坡安全风险评价评价指标风险管控

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儿童嗜酸性粒细胞性胃肠炎的膳食管理

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中国实用儿科杂志 2024年第4期39卷 277-280页

作者：赵红梅周娟湖南省儿童医院消化营养科湖南长沙410007

儿童嗜酸性粒细胞性胃肠炎(eosinophilic gastroenteritis,EGE)是一种少见的胃肠道疾病,常见于5岁以下儿童。膳食管理是儿童EGE的有效治疗方法之一,旨在减少食物过敏原的暴露。膳食管理方法包含基于氨基酸的要素饮食、基于经验的排除饮... 详细信息

儿童嗜酸性粒细胞性胃肠炎(eosinophilic gastroenteritis,EGE)是一种少见的胃肠道疾病,常见于5岁以下儿童。膳食管理是儿童EGE的有效治疗方法之一,旨在减少食物过敏原的暴露。膳食管理方法包含基于氨基酸的要素饮食、基于经验的排除饮食以及基于食物过敏测试的靶向排除饮食。文章详细讨论了3种饮食疗法的优缺点,同时强调营养师评估EGE患儿营养摄入的重要性,为EGE患儿的膳食管理提供科学依据。

关键词：嗜酸性粒细胞性胃肠炎膳食营养

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