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环境与职业医学 2015年第1期32卷 90-95页

作者： Martine Vrijheid rémy Slama Oliver robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent juan r.gonzalez Berit Granum regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas rosemary r.C.McEachan Helle Margrete Meltzer Eduard Sabidó PerE.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for research in Environmental Epidemiology(CrEAL) Universitat Pompeu Fabra(UPF) CIBEr Epidemiología y Salud Pública(CIBErESP) Institut National de la Santé et de la recherche Médicale(INSErM) Institut Albert Bonniot(U823) University of Crete(UOC) Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT) Sensing & Control Systems S.L(.S&C) Institut National de l’Environnement Industriel et des risques(INErIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.r.L(.HYLO) Centre for Genomic regulation(CrG) IMIM Hospital del Mar research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de Compostela Center of Excellence in Genomic Medicine research King Abdulaziz University Vytauto Didziojo Universitetas(VDU)

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项... 详细信息

[背景]人类在生命早期的发育期间可能特别容易受到环境暴露的影响。有关这一主题的人体研究一般集中在单一暴露与健康效应之间的关系。而"暴露组"的概念涵盖了从受孕开始的的全部暴露,完善了基因组。[目的]人类生命早期暴露组(HELIX)项目是一个新的合作研究项目,目的是为了采用新的暴露评估和生物标志分析方法来描述生命早期多种环境因素的暴露,并将这些与生物标志组学和儿童健康结局相关联,从而刻画"生命早期暴露组"。本文描述了该项目的总体设计。[方法]HELIX将利用欧洲现有的6个出生队列研究来估计产前、产后暴露的一系列化学和物理暴露。建立全部队列中总共32 000对母亲和儿童的暴露模型,并在一个包含1 200对母亲和儿童的子队列中测量生物标志。嵌套重复采样的定组研究(n=150)将收集生物标志的变化数据,利用智能手机来评估流动性和体力活动,并监测个体暴露。采用组学技术确定与暴露相关的分子学特征(代谢组、蛋白质组、转录组和表观基因组)。对于多次暴露,采用统计方法估计胎儿和儿童的成长、肥胖、神经发育和呼吸系统结局中的暴露-效应关系。项目还将进行一项健康效应评估测试,以评价组合暴露的风险和收益。[结论]HELIX是描述欧洲人群生命早期暴露组并解开它与组学标志物和儿童健康之间关联的首次尝试之一。作为对暴露组学这一概念的验证,该项目向生命过程中暴露组迈出了重要的第一步。

关键词：人类生命早期暴露设计出生队列研究儿童健康生物标志效应评估生命早期

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人类生命早期暴露组(HELIX)：项目理念与设计(续完)

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环境与职业医学 2015年第2期32卷 186-190页

作者： Martine Vrijheid rémy Slama Oliver robinson Leda Chatzi Muireann Coen Peter van den Hazel Cathrine Thomsen John Wright Toby J.Athersuch Narcis Avellana Xavier Basagana Celine Brochot Luca Bucchini Mariona Bustamante Angel Carracedo Maribel Casas Xavier Estivill Lesley Fairley Diana van Gent juan r.gonzalez Berit Granum regina Grazuleviiene Kristine B.Gutzkow Jordi Julvez Hector C.Keun Manolis Kogevinas rosemary r.C.McEachan Helle Margrete Meltzer Eduard Sabidó Per E.Schwarze Valérie Siroux Jordi Sunyer Elizabeth J.Want Florence Zeman Mark J.Nieuwenhuijsen 何蓉操仪汪源金泰廙 Centre for research in Environmental Epidemiology(CrEAL) Universitat Pompeu Fabra(UPF) CIBEr Epidemiologíay Salud Pública(CIBErESP) Institut National de la Santé et de la recherche Médicale(INSErM) Institut Albert Bonniot(U823) University of Crete(UOC) HeraklionCreteGreece Imperial College London(ICL) Veiligheids-en Gezondheidsregio Gelderland Midden(VGGM) Norwegian Institute of Public Health(NIPH) Bradford Institute for Health research Sensing & Control Systems S.L.(S&C) Institut National de l’Environnement Industriel et des risques(INErIS) Unit of Models for Ecotoxicology and Toxicology Hylobates Consulting S.r.L.(HYLO) RomeItaly Centre for Genomic regulation(CrG) IMIM Hospital del Mar research Insititute Grupo de Medicina Xenomica Fundación Pública Galega de Medicina Xeómica(SERGAS)CIBERERCEGENUniversidade de Santiago de CompostelaSantiago de CompostelaSpain Center of Excellence in Genomic Medicine research King Abdulaziz UniversityJeddahKingdom of Saudi Arabia Vytauto Didziojo Universitetas(VDU) KaunusLithuania Bradford Institute for Health research Bradford Teaching Hospitals NHS Foundation Trust(BTHFT)

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的... 详细信息

3．2研究2：室外暴露传统h基于居住区评估的暴露，如室外空气污染、噪声、建筑环境，可以通过收集时间一空间活动以及（就空气污染而言）个人吸入空气量的信息，改善暴露评估和减小测量误差。例如，可替代吸入率（Kawahara等，2011）的体力活动方面的信息与个人空气污染测量结合来评估吸入剂量。基于暴露评估的新一代地理信息系统（GIS）（Beelen等，2013;Eeflens等，2012）、遥感（Dadvand等，2012）和智能手机技术（deNazelle等，2013）使评估室外暴露和整合个人活动范围及体力活动数据变得更容易。

关键词：早期暴露人类生命地理信息系统设计空气污染测量误差体力活动建筑环境

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Management of oligometastatic disease in soft tissue sarcomas

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 258-273页

作者： Marcos r.gonzalez Maria L.Inchaustegui Kim ruiz-Arellanos Felipe F.de Souza Ty K.Subhawong juan Pretell-Mazzini Facultad de Medicina Alberto Hurtado Universidad Peruana Cayetano HerediaLima 15102Peru Division of Orthopaedic Oncology Department of Orthopaedic SurgeryMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of radiology Division of Musculoskeletal RadiologyUniversity of Miami Miller School of MedicineMiamiFL 33136USA Miami Cancer Institute Division of Orthopedic OncologyBaptist Health System South FloridaPlantationFL 33176USA

Oligometastatic soft tissue sarcoma represents an intermediate state between localized and disseminated *** A combination of surgery,radiotherapy and systemic treatment significantly improves prognosis,with a 5-year overall survival as high as 50%.Due to the high prevalence of lung metastases,most of the surgical evidence is centered around lung *** decision to perform surgical metastasectomy remains dependent on optimal patient *** post-surgical lung function,absence of extrapulmonary metastases,control of the primary tumor,and feasibility of achieving negative margins are major criteria for patients to undergo successful *** margins,longer disease-free interval,unilateral,limited number(≤2),metachronous and small(ry metastasis are some factors associated with improved ***,especially SBrT,is an effective treatment for disease control,and its use as(neo)-adjuvant therapy has shown promising ***,studies comparing radiotherapy against surgery are missing and the efficacy of radiotherapy independent of surgery is not yet *** radiology techniques such as percutaneous thermal ablation(PTA)or arterial embolization have also been described as potential treatment alternatives in candidates deemed not fit for *** treatment has traditionally consisted of an anthracycline(doxorubicin)-based regimen with the addition of ifosfamide in certain *** advances in systemic treatment include the use of targeted therapy and immunotherapy in(oligo)-metastatic ***,except for certain histologies,most STS subtypes are chemoresistant,and the response to systemic treatment is poor.

关键词： Soft tissue sarcoma oligometastasis surgery treatment

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rectal cancer treatment: improving the picture

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World Journal of Gastroenterology 2007年第44期13卷 5805-5812页

作者： juan A Diaz-gonzalez Leire Arbea Javier Aristu Department of Oncology Clinica Universitaria Universtity of Navarra Pamplona 31080 Spain

Multidisciplinary approach for rectal cancer treatment is currently well defined. Nevertheless, new and promising advances are enriching the portrait. Since the US NIH Consensus in the early 90's some new characters have been added. A bird's-eye view along the last decade shows the main milestones in the development of rectal cancer treatment protocols. New drugs, in combination with radiotherapy are being tested to increase response and tumor control outcomes. However, therapeutic intensity is often associated with toxicity. Thus, innovative strategies are needed to create a better-balanced therapeutic ratio. Molecular targeted therapies and improved technology for delivering radiotherapy respond to the need for accuracy and precision in rectal cancer treatment.

关键词： rectal cancer Chemoradiotherapy Intensitymodulated radiation therapy Molecular targeted therapy

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Three-dimensional acoustic propagation model for shallow waters based on an indirect boundary element method

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Chinese Physics B 2023年第5期32卷 485-495页

作者： Edmundo F.Lavia juan D.gonzalez Silvia Blanc Acoustic Propagation Department Argentinian Navy Research Office(DIIV)Buenos Aires 1638Argentina UNIDEF(National Council of Scientific and Technical research/Ministry of Defense) Buenos AiresArgentina

This work has a two-fold *** the one hand,the theoretical formulation of a three-dimensional(3D)acoustic propagation model for shallow waters with a constant sound speed is presented,based on the boundary element method(BEM),which uses a half-space Green function instead of the more conventional free-space Green *** the other hand,a numerical implementation is illustrated to explore the formulation in simple idealized cases,controlled by a few parameters,which provides necessary tests for the accuracy and performance of the *** half-space Green's function,which has been previously used in scattering and diffraction,adds terms to the usual expressions of the integral operators without altering their continuity *** against the wavenumber integration solution of the Pekeris waveguide suggest that the model allows an adequate prediction for the acoustic ***,numerical experiments in relation to the necessary mesh size for the description of the water-marine sediment interface lead to the conclusion that a transmission loss prediction with acceptable accuracy can be obtained with the use of a limited mesh around the desired evaluation region.

关键词： three-dimensional acoustic propagation boundary element method half-space Green function

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review of 500 single incision laparoscopic colorectalsurgery cases-Lessons learned

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World Journal of Gastroenterology 2016年第2期22卷 659-667页

作者： Deborah S Keller juan r Flores-gonzalez Sergio Ibarra Eric M Haas Colorectal Surgical Associates HoustonTX 77054United States Division of Colon and rectal Surgery Houston Methodist HospitalThe University of Texas Medical School at HoustonHoustonTX 77054United States Division of Minimally Invasive Surgery Department of SurgeryThe University of Texas Medical School at HoustonHoustonTX 77054United States

Single incision laparoscopic surgery(SILS) is a minimally invasive platform with specific benefits over traditional multiport laparoscopic surgery. The safety and feasibility of SILS has been proven, and the applications continue to grow with experience. After 500 cases at a high-volume, single-institution, we were able to standardize instrumentation and operative steps, as well as develop adaptations in technique to help overcome technical and ergonomic challenges. These technical adaptations have allowed the successful application of SILS to technically difficult patient populations, such as pelvic cases, inflammatory bowel disease cases, and high body mass index patients. This review is a frame of reference for the application and wider integration of the single incision laparoscopic platform in colorectal surgery.

关键词： Laparoscopic colectomy Minimally invasivecolorectal surgery Single-incision laparoscopic surgery

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Temporal stability and directional change in a color cline of a marine snail from NW Spain

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Current Zoology 2024年第2期70卷 163-173页

作者： juan Gefaell ramon Vigo A.Honorato gonzalez-Vazquez juan Galindo Emilio rolan-Alvarez Centro de Investigacion Marina Universidade de VigoDepartamento de BioquimicaGenetica e Inmunologia36310 VigoSpain

The evolution and maintenance of color clines is a classic topic of research in evolutionary ***,studies analyzing the temporal dynamics of such clines are much less frequent,due to the difficulty of obtaining reliable data about past color distributions along environmen-tal *** this article,we describe a case of decades-long temporal stability and directional change in a color cline of the marine snail Littorina saxatilis along the coastal inlet of the ria de Vigo(NW Spain).*** from this area shows a clear color cline with 3 distinct areas from the innermost to the more wave-exposed localities of the ria:the inner,protected localities show an abundance of fawn-like individuals;the intermediate localities show a high diversity of colors;and the outer,wave-exposed localities show populations with a high frequency of a black and lineated *** compare data from the 1970s and 2022 in the same localities,showing that the cline has kept relatively stable for at least over half a century,except for some directional change and local variability in the frequency of certain *** regression analyses and biodiversity measures are presented to provide clues into the selective pressures that might be involved in the maintenance of this color *** research avenues to properly test the explanatory power of these selective agents as well as the possible origins of the cline are discussed.

关键词： clinal variation color polymorphism ecological gradient Littorina saxatilis natural selection wave exposure.

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Assessing a novel modelling approach with high resolution UAV imagery for monitoring health status in priority riparian forests

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Forest Ecosystems 2021年第4期8卷 810-830页

作者： juan Guerra-Hernandez ramon A.Diaz-Varela juan Gabriel Avarez-gonzalez Patricia Maria rodriguez-gonzalez edata Centro de iniciativas empresariaisFundacion CEL.O Palomar s/n27004 LugoSpain Forest research Centre School of AgricultureUniversity of LisbonInstituto Superior de Agronomia(ISA)Tapada da Ajuda1349-017 LisbonPortugal Biodiversity and Applied Botany Unit(GI BIOAPLIC 1809) Department of BotanyEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus Universitario27002 LugoSpain Sustainable Forest Management Unit(UXFS) Department of Agroforestry EngineeringEscuela Politecnica SuperiorR/Benigno LedoUniversity of Santiago de CompostelaCampus UniversitarioE-27002 LugoSpain

Background:Black alder(Alnus glutinosa)forests are in severe decline across their area of distribution due to a disease caused by the soil-borne pathogenic Phytophthora alni species complex(class Oomycetes),“alder Phytopththora”.Mapping of the different types of damages caused by the disease is challenging in high density ecosystems in which spectral variability is high due to canopy *** obtained by unmanned aerial vehicles(UAVs)may be particularly useful for such tasks due to the high resolution,flexibility of acquisition and cost efficiency of this type of *** this study,*** decline was assessed by considering four categories of tree health status in the field:asymptomatic,dead and defoliation above and below a 50% threshold.A combination of multispectral Parrot Sequoia and UAV unmanned aerial vehicles-red green blue(rGB)data were analysed using classical random forest(rF)and a simple and robust three-step logistic modelling approaches to identify the most important forest health indicators while adhering to the principle of parsimony.A total of 34 remote sensing variables were considered,including a set of vegetation indices,texture features from the normalized difference vegetation index(NDVI)and a digital surface model(DSM),topographic and digital aerial photogrammetry-derived structural data from the DSM at crown ***:The four categories identified by the rF yielded an overall accuracy of 67%,while aggregation of the legend to three classes(asymptomatic,defoliated,dead)and to two classes(alive,dead)improved the overall accuracy to 72% and 91% *** the other hand,the confusion matrix,computed from the three logistic models by using the leave-out cross-validation method yielded overall accuracies of 75%,80% and 94% for four-,three-and two-level classifications,***:The study findings provide forest managers with an alternative robust classification method for the rapid,effective assessment of area

关键词： Alder rPAS Multi-spectral Defoliation Texture variables 3D point cloud Tree health monitoring

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Flexible mating tactics and associated reproductive effort during the rutting season in male reindeer （rangifer tarandus, L. 1758）

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Current Zoology 2015年第5期61卷 802-810页

作者： Eliana PINTUS Stefania UCCHEDDU Knut H. rФED Javier Perez gonzalez juan CArrANZA Mauri NIEMINEN Фystein HOLAND Department of Veterinary Sciences Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Kamycka 129 165 21 Prague 6 - Suchdol Czech Republic Ungulate research Unit Game and Fish Research Center University of Cordoba 14071 Cordoba Spain Department of Basic Sciences and Aquatic Medicine Norwegian University of Life Sciences EO. Box 8146 Dep. N-0033 Oslo Norway Guarderia rural Mancomunidad de Municipios Centro (MIMC) 06810 Calamonte Spain Finnish Game and Fisheries research Institute Reindeer Research Station 99910 Kaamanen Finland Department of Animal and Aquacultural Sciences Norwegian University of Life Sciences RO. Box 5003 N-1432 As Norway

Polygynous males can change their mating tactics across their lifetime, but information is scarce on the flexibility of this trait within a given season and the relative costs and benefits of using different tactics. Here, we monitored individually marked male reindeer rangifer tarandus and classified their mating tactics as harem-defense, sneaking, or mixed. The costs of the male reproductive effort were assessed using both direct （i.e. percentage of body mass lost） and indirect measures （i.e. activity patterns such as feeding, standing, and walking）, while mating group size and reproductive success were recorded as mating ef- fort benefits. Our results show that reindeer males may switch between the harem-defense and sneaking tactics throughout the same breeding season, providing further support to the notion that reproductive tactics are flexible in ungulates. The costs and benefits of male mating effort vary according to the mating tactic, reaching the highest values in harem-holders and the lowest values in sneaking males. Moreover, males who switched between the sneaking tactic and the harem-defence tactic tended to achieve higher mating success than males who consistently used the least costly tactic. Indeed, all harem-holders successfully sired offspring, whereas only two out of three mixed-tactic males sired one calf, and sneaking males did not sire any calves. In conclusion, our results show that reindeer males can modulate their mating efforts during the same breeding season by switching between the most costly harem-defense tactic and the least costly sneaking tactic, suggesting individual solutions to the balance between reproductive effort and mating opportunities [Current Zoology 61 （5）： 802-810, 2015].

关键词： Alternative mating tactics Intraspecific variation Phenotypic flexibility Polygynous ungulate Sexual behaviour

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Alliance Free and Alliance Cover Sets

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Acta Mathematica Sinica,English Series 2011年第3期27卷 497-504页

作者： juan Alberto rODrIGUEZ-VELAZQUEZ Jose Maria SIGArrETA Ismael gonzalez YErO Sergio BErMUDO Departament d'Enginyeria Informdtica i Matematiques Universitat Rovira i Virgili Av. Paisos Catalans 26 43007 Tarragona Spain Faculty of Mathematics Autonomous University of Guerrero Carlos E. Adame 5 Col. La Garita Acapuleo Guerrero Mexico Departament d'Enginyeria Informatica i Matematiques Universitat Rovira i Virgili Av. Pai'sos Catalans 26 43007 Tarragona Spain Department of Economy Quantitative Methods and Economic History Pablo de Olavide University Carretera de Utrera Kin. 1 41013 Sevilla Spain

A defensive （offensive） k-alliance in F = （V, E） is a set S C V such that every v in S （in the boundary of S） has at least k more neighbors in S than it has in V ／ S. A set X C_ V is defensive （offensive） k-alliance free, if for all defensive （offensive） k-alliance S, S／ X ≠ 0, i.e., X does not contain any defensive （offensive） k-alliance as a subset. A set Y C V is a defensive （offensive） k-alliance cover, if for all defensive （offensive） k-alliance S, S ∩ Y ≠ 0, i.e., Y contains at least one vertex from each defensive （offensive） k-alliance of F. In this paper we show several mathematical properties of defensive （offensive） k-alliance free sets and defensive （offensive） k-alliance cover sets, including tight bounds on their cardinality.

关键词： Defensive alliance offensive alliance alliance free set alliance cover set

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