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Pleistocene history of Iberomys,an endangered endemic rodent from southwestern Europe

Integrative Zoology 2014年第4期9卷 481-497页

作者： Gloria CUENCA-BESCÓS juan manuel lópez-GARCÍA María Angeles GAlINDO-PEllICENA Rosa GARCÍA-PEREA Julio GISBERT juan ROFES Jacint VENTURA Research Group Aragosaurus-IUCA PaleontologyEarth Sciences DepartmentUniversity of ZaragozaZaragozaSpain Research Group of Paleobiology and Prehistory Human Studies DepartmentUniversity of FerraraFerraraItaly Research Institute of Evolution and Human Behavior UCM-ISCIIIMadridSpain GAlEMIA Conservation and Study of Forgotten VertebratesMadridSpain Department of Stratigraphy and Paleontology Faculty of Sciences and TechnologyUniversity of the Basque CountryGipuzkoaGuipúzcoaSpain Department of Animal Biology Plant Biology and EcologyFaculty of BiosciencesUniversity Autonoma de BarcelonaBarcelonaSpain

The extant Cabrera’s vole,Microtus cabrerae,differs in morphology and evolutionary history from the other species of *** arvicoline has unique derived features in the cranium,mandible and ***bly its most conspicuous features are its large size,the high skull in lateral view,the long and distally broad nasals,and the triangle shape of the anteroconid complex,with a marked labio-lingual asymmetry of the occlusal surface of the first lower *** this study,we propose a phylogenetic lineage that includes Cabrera’s vole in what until now has been the Microtus subgenus *** information and several life history traits support the elevation of Iberomys to the rank of *** Iberomys comprises species that have appeared in succession during the Quaternary:in the Early Pleistocene,the extinct *** in the Middle Pleistocene,the extinct *** and in the late Pleistocene,the extant ***,the extant species shows several biological singularities,such as multiple polymorphic copies of the SRY male-specific gene in both males and females,and the lowest basal metabolic rate in relation to weight among arvicoline ***,its habitat requirement is unique among the Iberian ***,the biological and paleontological data that we present in this work support the elevation of its taxonomic rank to that of ge*** study also suggests a modification of nomenclature:Microtus(Iberomys)brecciensis is replaced with *** and the common name of the extant M.(I.)cabrerae changed from‘topillo’to‘iberon’to improve conservation and protection actions.

关键词： Cabrera’s vole conservation Iberoccitanian endemism Iberomys origin

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Enantioselective Synthesis,(Chir)optical Properties,and Postsynthetic Functionalization of Furan-Containing Oxa[5]-,Oxa[6]-,and Dioxa[6]helicenes

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CCS Chemistry 2024年第10期6卷 2439-2451页

作者： Wei Fu Valentina Pelliccioli Raquel Casares-lópez juan M.Cuerva Martin Simon Christopher Golz manuel Alcarazo Institut für Organische und Biomolekulare Chemie Georg-August-Universität Göttingen37077 Göttingen Departamento de Química Orgánica Universidad de GranadaUnidad de Excelencia Química Aplicada a Biomedicina y MedioambienteE-18071 Granada

An expedient synthesis of a series of configurationally stable oxa[5]helicenes,oxa[6]helicenes,and dioxa[6]helicenes has been developed using an intramolecular,highly enantioselective,Au-catalyzed,alkyne hydroarylation *** absolute configuration of the newly prepared structures has been established by crystallography,their inversion barriers have been determined theoretically and experimentally,and their chiroptical properties have been *** of these data with those reported for thia-or carbohelicenes sharing an otherwise identical helical framework enables the establishment of comprehensive correlations between the nature of the embedded(hetero)atom(s)and the magnitude of these *** studies on the postsynthetic functionalization of the oxahelicenes obtained are also ***,siteselective bromination at the 15-position in oxa[5]helicene 5d allows its subsequent manipulation into pyridine-containing aza-oxa[7]helicene 13d;while the two termini of oxa[6]helicene 7d have been intramolecularly cyclised into the pleiadeno[1,12,11-bcde]benzofuran derivative 15d by acidic *** transformations take place without erosion of the enantiopurity.

关键词： Au-catalysis enantioselective synthesis oxa[n]helicenes racemization dynamics postsynthetic functionalization

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Taxonomic Distinctness of the Intertidal Fish Community on the Pacific Coast of Baja California Sur, México

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Open Journal of Marine Science 2019年第2期9卷 86-97页

作者： Emelio Barjau-González José Ange Armenta-Quintana juan manuel lópez-Viva Eleonora Romero-Vadillo Departamento Académico de Ciencia Animal y Conservación del Hábitat Universidad Autónoma de Baja California Sur La Paz México Departamento Académico de Ciencias Marinas y Costeras Universidad Autónoma de Baja California Sur La Paz México Departamento Académico de Ciencia Animal y Conservación del Hábitat Universidad Autónoma de Baja California Sur La Paz México

The intertidal zone is a complex coastal area exposed to a wide variety of environmental factors. During low tide, rocky pools are exposed to air for several hours throughout the day, and environmental conditions such as temperature and salinity are highly variable. Fish communities that inhabit these tide pools are also exposed to environmental variability;therefore it is important to look at fish community structure in relation to important environmental factors such as temperature, salinity and dissolved oxygen on tide pools during spring tides, time of greater exposure to air. Therefore, the aim of the present study was to analyze the variation of the taxonomic distinctness of intertidal fish communities considering temperature, salinity and dissolved oxygen of the water that remains trapped in the tide pools during low tide. Visual census surveys were carried out monthly, from January to December 2015, in the intertidal zone of El Faro during spring tides on full moon days, when fluctuations of environmental variables are significant. Total extension of the census surveys was 156 × 5 m (780 m2). A total of 145 tide pools were sampled and divided in three groups (small, medium and large) according to size and depths that ranged from 20 to 45 cm. Temperature, salinity and dissolved oxygen fluctuate throughout the year of study. Thermal difference between open ocean and tide pools ranged from 3.5°C to 4.5°C. A total of 3757 organisms from 22 species, 12 families, four orders and one class were recorded. When comparing taxonomic distinctness and average taxonomic distinctness between months and tide pools of different sizes, values fell within the confidence intervals in the tunnel and were located close to the mean.

关键词： Taxonomic Distinctness Exposed Coast Climate Change

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Promotion of structural plasticity in area V2 of visual cortex prevents against object recognition memory deficits in aging and Alzheimer's disease rodents

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Neural Regeneration Research 2024年第8期19卷 1835-1841页

作者： Irene Navarro-lobato Mariam Masmudi-Martín manuel F.lópez-Aranda juan F.lópez-Téllez Gloria Delgado Pablo Granados-Durán Celia Gaona-Romero Marta Carretero-Rey Sinforiano Posadas María E.Quiros-Ortega Zafar U.Khan laboratory of Neurobiology Centro de Investigaciones Médico Sanitarias(CIMES)University of MalagaMalagaSpain Department of Medicine Faculty of MedicineUniversity of MalagaMalagaSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) Institute of Health Carlos IIIMadridSpain the Donders Institute for Brain Cognition and Behaviour Radboud UniversityNijmegenThe Netherlands the Brain Metastasis Group National Cancer Research Centre(CNIO)MadridSpain the Department of Neurobiology University of California-Los AngelesLos AngelesCAUSA

Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for *** till now,all potential drug candidates have failed to produce satisfa ctory ***,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of *** this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s ***,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM *** findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s ***,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.

关键词： behavioral performance brain-derived neurotrophic factor cognitive dysfunction episodic memory memory circuit activation memory deficits memory enhancement object recognition memory prevention of memory loss regulator of G protein signaling

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Improved organs at risk segmentation based on modified U‐Net with self‐attention and consistency regularisation

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 850-865页

作者： Maksym Manko Anton Popov juan manuel Gorriz Javier Ramirez Electronic Engineering Department Igor Sikorsky Kyiv Polytechnic InstituteKyivUkraine Department of Signal Theory Telematics and CommunicationsUniversity of GranadaGranadaSpain

Cancer is one of the leading causes of death in the world,with radiotherapy as one of the treatment *** planning starts with delineating the affected area from healthy organs,called organs at risk(OAR).A new approach to automatic OAR seg-mentation in the chest cavity in Computed Tomography(CT)images is *** proposed approach is based on the modified U‐Net architecture with the ResNet‐34 encoder,which is the baseline adopted in this *** new two‐branch CS‐SA U‐Net architecture is proposed,which consists of two parallel U‐Net models in which self‐attention blocks with cosine similarity as query‐key similarity function(CS‐SA)blocks are inserted between the encoder and decoder,which enabled the use of con-sistency *** proposed solution demonstrates state‐of‐the‐art performance for the problem of OAR segmentation in CT images on the publicly available SegTHOR benchmark dataset in terms of a Dice coefficient(oesophagus-0.8714,heart-0.9516,trachea-0.9286,aorta-0.9510)and Hausdorff distance(oesophagus-0.2541,heart-0.1514,trachea-0.1722,aorta-0.1114)and significantly outperforms the *** current approach is demonstrated to be viable for improving the quality of OAR segmentation for radiotherapy planning.

关键词： 3‐D computer vision deep learning deep neural networks image segmentation medical image processing object segmentation

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Guest Editorial:Knowledge‐based deep learning system in bio‐medicine

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 787-789页

作者： Yu‐Dong Zhang juan manuel Górriz University of leicester LeicesterUK University of Granada GranadaSpain

Numerous healthcare procedures can be viewed as medical sector *** the modern era,computers have become indispensable in the realm of medical decision‐***-ever,the common view of computers in the medical field typically extends only to applications that support doctors in diagnosing *** more tightly intertwine computers with the biomedical sciences,professionals are now more frequently utilising knowledge‐driven deep learning systems(KDlS)and their foundational technologies,especially in the domain of neuroimaging(NI).

关键词： learning computer doctor

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Rehabilitation of Semi-Arid Grasslands through the Perennialization of lots by Implementing Perennial Forage Exotic Grass

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Phyton-International Journal of Experimental Botany 2024年第8期93卷 2115-2125页

作者： Delfina Arancio Sidoti juan manuel Zeberio Guadalupe Peter Universidad Nacional de Río Negro Sede AtlánticaCEANPaViedma8500Argentina Consejo Nacional de Investigaciones Científicas y Técnicas CONICETCABABuenos Aires1425Argentina Chacra Experimental Patagones Ministerio de Desarrollo Agrario de la Provincia de Buenos AiresCarmen de Patagones8504Argentina

Argentina is the country with the highest proportion of arid and semi-arid ecosystems in latin *** the rangelands of Southwestern Buenos Aires(Patagones Department),there is a clear advancement of the agricultural frontier to the detriment of the native forest in this *** to rainfall variation and seed acquisition,Thinopyrum ponticum is cultivated as a forage perennial crop in this *** objective was to evaluate the performance of *** as a facilitating crop for the medium-term rehabilitation of natural grasslands in semi-arid *** working hypotheses were that:1)native perennial grass cover increases over the years and 2)diversity and specific richness of the vegetation are enhanced by the duration of Tall Wheatgrass *** were collected from commercial plots where *** was shown:recent implantation(5–8 years,RI);medium implantation(13–15 years,MI);and old implantation(20–22 years,OI).Thirty-four species were identified and classified into seven functional groups:Annual grasses,annual herbs,perennial herbs,exotic perennial herbs,perennial forage grasses,exotic perennial forage grasses,perennial forage exotic grasses,and nonforage perennial *** ponticum’s total cover was between RI and *** cover,species richness,and Shannon-Weaver diversity index showed no differences among *** forage grasses exhibited higher cover values in sites with greater implantation age and annual grasses showed the opposite *** results indicated that *** does not invade the sampled plots and enhances the colonization of the planted plots by perennial forage native ***,even though the herbaceous cover had been recovered,the woody layer which could provide environmental services and specific values for conservation was not.

关键词： Wheatgrass clearing vegetation monte Thinopyrum ponticum

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GAN‐MD:A myocarditis detection using multi‐channel convolutional neural networks and generative adversarial network‐based data augmentation

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 866-878页

作者： Hengame Ahmadi Golilarz Alireza Azadbar Roohallah Alizadehsani juan manuel Gorriz Department of Medical Radiation Engineering Faculty of EngineeringLahijan BranchIslamic Azad UniversityLahijanIran Department of Medical Radiation Engineering Lahijan BranchIslamic Azad UniversityLahijanIran Institute for Intelligent Systems Research and Innovation(IISRI) Deakin UniversityWaurn PondsVictoriaAustralia Data Science and Computational Intelligence Institute University of GranadaGranadaSpain

Myocarditis is a significant public health concern because of its potential to cause heart failure and sudden *** standard invasive diagnostic method,endomyocardial bi-opsy,is typically reserved for cases with severe complications,limiting its widespread ***,non‐invasive cardiac magnetic resonance(CMR)imaging presents a promising alternative for detecting and monitoring myocarditis,because of its high signal contrast that reveals myocardial *** assist medical professionals via artificial intelligence,the authors introduce generative adversarial networks‐multi discriminator(GAN‐MD),a deep learning model that uses binary classification to diagnose myocarditis from CMR *** approach employs a series of convolutional neural networks(CNNs)that extract and combine feature vectors for accurate *** authors suggest a novel technique for improving the classification precision of *** generative adversarial networks(GANs)to create synthetic images for data augmentation,the authors address challenges such as mode collapse and unstable *** a reconstruction loss into the GAN loss function requires the generator to produce images reflecting the discriminator features,thus enhancing the generated images'quality to more accurately replicate authentic data ***,combining this loss function with other reg-ularisation methods,such as gradient penalty,has proven to further improve the perfor-mance of diverse GAN models.A significant challenge in myocarditis diagnosis is the imbalance of classification,where one class dominates over the *** mitigate this,the authors introduce a focal loss‐based training method that effectively trains the model on the minority class *** GAN‐MD approach,evaluated on the Z‐Alizadeh Sani myocarditis dataset,achieves superior results(F‐measure 86.2%;geometric mean 91.0%)compared with other deep learning models and traditional machine learning methods.

关键词： 2‐D 3‐D

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Brent *** Texas Intermediate in the US petro derivatives price formation

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Petroleum Science 2024年第1期21卷 729-739页

作者： Alejandro Almeida Antonio A.Golpe juan manuel Martín-Alvarez Jose Carlos Vides Universidad Internacional de la Rioja Department of Quantitative Methods for Economics and BusinessLa RiojaSpain University of Huelva Department of Economics and Centro de Estudios Avanzados en FisicaMatematicas y Computacion and ICEIHuelvaSpain Complutense University of Madrid Department of Applied and Structural Economics and History and ICEIMadridSpain

In this paper,we apply the spatial panel model to explore the relationship between the dynamic of two types of crude oil prices(WTI and Brent crude oil)and their refined products over *** the turbulent months of 2011,when Cushing Oklahoma had reached capacity and the crude oil export ban removal in 2015 as breakpoints,we apply this method both in the full sample and the three resultant ***,results suggest our results show that both WTI and Brent display very similar behaviour with the refined ***,when attending to each regime,results derived from the first and third regimes are quite similar to the full sample ***,during the second regime,Brent crude oil became the benchmark in the petrol market,and it influenced the distillate ***,our model can let us determine the price-setters and price-followers in the price formation mechanism through refined *** results possess important considerations to policymakers and the market participants and the price formation.

关键词： Crude oil prices Spatial panel model Refined products Price formation

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Quality evaluation of Nothofagus pumilio seeds linked to forest management and climatic events

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Ecological Processes 2024年第1期13卷 98-107页

作者： Julian Rodríguez-Souilla Jimena E.Chaves María Vanessa lencinas juan manuel Cellini Fidel A.Roig Pablo l.Peri Guillermo Martinez Pastur laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) laboratorio de Investigaciones en Maderas (lIMAD) Universidad Nacional de la Plata (UNLP) Instituto Argentino de Nivología Glaciología y Ciencias Ambientales (IAN-IGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Nacional de Tecnología Agropecuaria (INTA) Universidad Nacional de la Patagonia Austral (UNPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background Forest ecosystems undergo significant transformations due to harvesting and climate fluctuations, emphasizing the critical role of seeding in natural regeneration and long-term structural preservation. Climate change further amplifies these dynamics, affecting phenology across species and regions. In Tierra del Fuego(Argentina), Nothofagus pumilio(lenga) forests represent the most important timber resource, and it is managed through different silvicultural strategies. This species demonstrates notable post-disturbance regeneration, yet seed fall exhibits signifi-cant variability, leading to variations in seed quality(e.g., viability). This study aims to assess fluctuations in N. pumilio seed quality, determine how it varies concerning forest management strategies, annual productivity, and the co-occurrence of climatic phenomena including El Ni?o-Southern Oscillation(ENSO) and the Southern Annular Mode(SAM).Results Viable seeds represented 18.4% of the total, notably higher in unharvested than in managed areas. Con-versely, empty seeds were more prevalent in harvested areas(> 75%). Seed quality exhibited significant differences across silvicultural treatments, except for insect-predated seeds, which had similar proportions across all areas, though dispersed retention showed higher predation. When considering years with varying production levels, high-production years favoured full and viable seeds, particularly in unharvested forests and aggregated retention, while low-production years saw reduced viability across all treatments. Quadratic models revealed that viability increased with seed production, where unharvested forests achieved the highest values. Climate variability influenced seed proportions, where ENSO+/SAM+ promoting more full and viable seeds, while ENSO–/SAM+ favoured non-predated seeds, especially in unharvested *** Seed quality varies among treatments and years with different levels of seeding. Variations in seed qual-ity, l

关键词： Forest management Seeding Climate change Extreme event Patagonia

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