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规模化养殖园区土壤中抗生素污染特征和生态风险评价

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环境科学 2024年第7期45卷 4302-4311页

作者：陈进王亚娟陶红张锐宁夏大学地理科学与规划学院银川750021 宁夏(中阿)旱区资源评价与环境调控重点实验室银川750021 宁夏大学经济管理学院银川750021

采集规模化养殖园区不同土地利用类型的土壤,采用高效液相色谱仪检测土壤中抗生素的含量,分析抗生素与土壤理化性质之间的关系,并利用风险商值法对养殖场园区土壤中的抗生素进行生态风险评价.结果表明,养殖场周边土壤受到不同程度的抗... 详细信息

采集规模化养殖园区不同土地利用类型的土壤,采用高效液相色谱仪检测土壤中抗生素的含量,分析抗生素与土壤理化性质之间的关系,并利用风险商值法对养殖场园区土壤中的抗生素进行生态风险评价.结果表明,养殖场周边土壤受到不同程度的抗生素污染,其中检出率和含量平均值最高的是四环素(TC);不同土地利用类型的土壤中,ω(抗生素)平均值大小排序为:玉米地(1.48μg·kg^(-1))>养殖场围栏外0.5 m处(1.27μg·kg^(-1))>山药地(1.03μg·kg^(-1))>牧草地(0.69μg·kg^(-1))>林地(0.18μg·kg^(-1));冗余分析结果显示,全氮、全磷和纤维素酶对土壤样品中抗生素的含量影响较大.根据生态风险评价结果可知,土霉素(OTC)、金霉素(CTC)、强力霉素(DOC)、环丙沙星(CIP)和四环素(TC)属于低风险等级,磺胺嘧啶(SD)和磺胺二甲嘧啶(Sm2)为中高风险,应当重视对养殖场周边土壤抗生素污染管控,加强兽用抗生素的管理.

关键词：抗生素污染特征冗余分析风险评价养殖场

The Iberian Roma Population Variant Server(IRPVS)

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Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola mavillard Javier Perez-Florido Francisco m.Ortuño Amador Valladares miren L.Álvarez-Villegas Gema Roldán Rosario Carmona manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana maría Nuñez-Negrillo Alejandra Carvajal Yolanda morgado Daniel Arteaga Rosa Ufano Pablo mir juan F.Gamella Joaquín Dopazo Carmen Paradas macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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高出水标准含氟工业废水深度处理工程实例

中国给水排水 2024年第2期40卷 126-130页

作者：李娟杨大卫绵阳市水务<集团>有限公司四川绵阳621000 世源科技工程有限公司北京100000

绵阳市某工业园需配套建设园区污水处理厂,对面板生产企业排放的含氟有机废水进行深度处理。设计采用一、二级反应沉淀+强化水解+改良AO生化处理+mBR+活性炭滤池+紫外消毒组合工艺。该工程是目前四川省内规模最大的含氟废水处理工程,总... 详细信息

绵阳市某工业园需配套建设园区污水处理厂,对面板生产企业排放的含氟有机废水进行深度处理。设计采用一、二级反应沉淀+强化水解+改良AO生化处理+mBR+活性炭滤池+紫外消毒组合工艺。该工程是目前四川省内规模最大的含氟废水处理工程,总投资约4.5亿元,直接处理成本约3.7~4.7元/m^(3)。实际运行效果表明,出水水质稳定达标且优于《城镇污水处理厂污染物排放标准》(GB 18918—2002)的一级A标准。

关键词：面板生产废水含氟废水深度处理改良AO mBR工艺活性炭滤池

茯苓酸对具核梭杆菌诱导的肠上皮细胞炎性反应的抑制作用及机制的研究

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中国临床药理学杂志 2024年第4期40卷 544-548页

作者：陈桂美毛娟川北医学院临床医学院四川南充637007

目的研究茯苓酸(PA)对具核梭杆菌(Fn)感染的肠上皮细胞HIEC-6炎性反应的影响及其可能的作用机制。方法将HIEC-6细胞分为对照组、模型组(1×10^(8) CFU·mL^(-1) Fn感染)、低剂量实验组(1×10^(8) CFU·mL^(-1) Fn+2μmol·L^(-1) PA)... 详细信息

目的研究茯苓酸(PA)对具核梭杆菌(Fn)感染的肠上皮细胞HIEC-6炎性反应的影响及其可能的作用机制。方法将HIEC-6细胞分为对照组、模型组(1×10^(8) CFU·mL^(-1) Fn感染)、低剂量实验组(1×10^(8) CFU·mL^(-1) Fn+2μmol·L^(-1) PA)、中剂量实验组(1×10^(8) CFU·mL^(-1) Fn+4μmol·L^(-1)的PA)、高剂量实验组(1×10^(8) CFU·mL^(-1) Fn+8μmol·L^(-1)的PA)、pcDNA-TLR4组(1×10^(8) CFU·mL^(-1) Fn+8μmol·L^(-1)的PA+转染pcDNA-TLR4质粒)。处理12 h后分别用细胞计数试剂盒8(CCK-8)实验、Edu实验检测细胞增殖情况;分别用酶联免疫吸附测定(ELISA)实验和实时荧光定量聚合酶链反应(RT-qPCR)实验检测炎性细胞因子表达情况;用流式细胞术检测细胞凋亡情况;用蛋白质印迹法检测细胞相关蛋白表达水平。结果对照组、模型组、低剂量实验组、中剂量实验组、高剂量实验组、pcDNA-TLR4组细胞凋亡率分别为(3.51±0.31)%、(23.38±1.85)%、(16.74±0.54)%、(12.10±1.44)%、(8.89±0.63)%和(14.87±0.88)%;白细胞介素-8(IL-8)含量分别为(23.25±1.41)、(79.69±4.37)、(68.94±2.63)、(51.46±2.56)、(34.18±2.63)和(71.09±5.08)pg·mL^(-1);白细胞介素-1β(IL-1β)含量分别为(8.81±0.49)、(51.65±2.13)、(35.98±3.47)、(24.83±2.47)、(14.79±1.25)和(43.89±1.59)pg·mL^(-1)。模型组与对照组比较,低、中、高剂量实验量组与模型组比较,pcDNA-TLR4组与高剂量实验组比较,在统计学上差异均有统计学意义(均P<0.05)。结论茯苓酸可能通过抑制TLR4/NF-κB通路,抑制炎性反应改善Fn感染的肠上皮细胞凋亡。

关键词：茯苓酸具核梭杆菌肠上皮细胞炎性反应 Toll-样受体4/核因子-κB通路

Study on Detection of Antibiotic Contents in Water around Landfill Sites

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Agricultural Biotechnology 2024年第2期13卷 33-37页

作者： Sha FENG Dandan LIU juan LUO Qing LI Tao mO Zheng LIU Xiaonan ZOU Guangzhou GRG metrology&Test(Hunan)Co. Ltd.Changsha 410007China Anhua Administration for market Regulation Yiyang 413500China Guizhou Engineering Vocational College Tongren 565200China

[Objectives] An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-mS/mS) method was established for simultaneous determination of 26 antibiotics in the water around landfills. [methods] After an HLB solid-phase extraction column was activated, and a water sample, which was adjusted with phosphoric acid to a pH of (2±0.5) and added with 500 mg of disodium EDTA, was loaded, and 5 ml of water and 20% methanol water was added for washing. Next, 10 ml of elution solution was added for elution, and the collected eluate was evaporated under reduced pressure at 40 ℃ to near dryness, and 1 ml of reconstitution solution was added to a constant volume. An ACQUITY UPLC BEH C18 (100 mm×2.1 mm, 2.6 μm) chromatographic column was adopted for LC separation by gradient elution with 0.1% formic acid aqueous solution-acetonitrile as the mobile phase. For mS detection, the mRm mode was adopted for collection, and the positive and negative ion modes were switched for simultaneous determination, and the internal standard method was used for quantification. [Results] The correlation coefficient R2 was greater than 0.99 in the linear range of each target substance. The limits of detection ranged from 0.15 to 3.00 ng/L, and the limits of quantitation were between 0.80 and 10.00 ng/L, and the recoveries ranged from 77.9% to 104.85%. [Conclusions] The method has high sensitivity, good accuracy and strong practical value.

关键词： Landfill Antibiotics Ultra high performance liquid chromatography-tandem mass spectrometry

Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily P.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana maría Ruiz-León Rosa Casas Ramón Estruch Patricia Bodega mercedes de miguel Amaya de Cos-Gandoy Jesús martínez-Gómez Gloria Santos-Beneit juan m.Fernández-Alvira Rodrigo Fernández-Jiménez Rosa m.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and michael A.Wiener Cardiovascular Institute， Icahn School of medicine at mount Sinai Department de Nutrició， Ciències de l'Alimentació I Gastronomia， XIA， Facultat de Farmàcia i Ciències de l'alimentació， Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB)， Universitat de Barcelona Department of Internal medicine， Hospital Clínic， Institutd'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS)， University of Barcelona Consorcio CIBER， m.P.Fisiopatología de la Obesidad y Nutrición (CIBERObn)， Instituto de Salud Carlos III (ISCIII) mediterranean Diet Foundation 5. Foundation for Science， Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! Program for Secondary Schools trial (NCT03504059). (Poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the Phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (BP) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， P-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， P-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， P-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， P-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， P-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， P-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， P-for trend mpared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through mYC degradation

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3519-3532页

作者： Alvaro Quintanal-Villalonga Kenta Kawasaki Esther Redin Fathema Uddin Swanand Rakhade Vidushi Durani Amin Sabet moniquetta Shafer Wouter R.Karthaus Samir Zaidi Yingqian A.Zhan Parvathy manoj Harsha Sridhar Dennis Kinyua Hong Zhong Barbara P.mello metamia Ciampricotti Umesh K.Bhanot Irina Linkov juan Qiu Radhika A.Patel Colm morrsey Sanjoy mehta Jesse Barnes michael C.Haffner Nichlas D.Socci Richard P.Koche Elisa de Stanchina Sonia molina-Pinelo Sohrab Salehi Helena A.Yu Joseph m.Chan Charles m.Rudin Department of medicine Thoracic Oncology ServiceMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Cancer Biology and Genetics Program Sloan Kettering InstituteMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Vagelos College of Physicians and Surgeons Columbia UniversityNew YorkNYUSA Weill Cornell Graduate School of medical Sciences Weill Cornell MedicineNew YorkNYUA Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Center for Epigenetics Research Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Pathology Core Facilty Department of Pathology and Laboratory MedicineMSKCCNew YorkNYUSA Antitumor Assessment Core Memorial Sloan Kettering Cancer CenterNew YorkNYUSA Divisionsof Human Biology and Clinical Research Fred Hutchinon Cancer CenterSeattleWAUSA Deparmentof Urology University of WashingtonSeattleWAUSA Gene Editing&Screening Core Facility memorial Sloan Kettering Cancer Center New YorkNYUSA Department of Laboratory medicine and Pathology University of WashingtonSeattleWAUSA Bioinfomatics CoreFacility Memorial Soan Kettering Cancer CenterNew YorkNYUSA Institute of Biomedicine of Seille(Bis) HURCSCUniversidad de SevillaSevilleSpain Computational Oncology Department of Epidemiology and BiostatisticsMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Well Cornell medical College New York NYUSA Present address:Swiss Institute for Experimental Cancer Research(ISREC) School of Life SciencesEPFLLausanneSwitzerland

Neuroendocrine(NE)transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor *** to date,even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53(TP53)and Retinoblastoma Transcriptional Corepressor 1(RB1)mutations in their tumors,no therapeutic strategies are available to prevent or delay histological *** of the cell cycle kinase Cell Division Cycle 7(CDC7)occurred in tumors during the initial steps of NE transformation,already after TP53/RB1 co-inactivation,leading to induced sensitivity to the CDC7 inhibitor ***7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the mYC Proto-Oncogen(mYC),implicated in stemness and histological *** overexpression of a degradation-resistant mYC isoform reestablished the NE transformation phenotype observed on targeted therapy,even in the presence of ***7 inhibition also markedly extended response to standard cytotoxics(cisplatin,irinotecan)in lung and prostate small cell carcinoma *** results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity,as well as to effectively treat NE tumors de novo or after *** simurosertib clinical efficacy trials are ongoing,this concept could be readily translated for patients at risk oftransformation.

关键词： tumors markedly transformation

水氮调控对宁夏中部旱区马铃薯产量与土壤质量的影响

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农业机械学报 2024年第9期55卷 358-370,458页

作者：杨莹攀尹娟朱银浩李升宁夏大学土木与水利工程学院银川750021 旱区现代农业水资源高效利用教育部工程中心银川750021

针对宁夏中部干旱区马铃薯产量不高和土壤质量较低等问题,本研究探讨和评价宁夏中部旱区马铃薯农田土壤质量状况,马铃薯产量与农田环境因子的相互关系,以提高马铃薯产量和农田土壤质量。以马铃薯农田为研究对象,2年试验采用三因素完全... 详细信息

针对宁夏中部干旱区马铃薯产量不高和土壤质量较低等问题,本研究探讨和评价宁夏中部旱区马铃薯农田土壤质量状况,马铃薯产量与农田环境因子的相互关系,以提高马铃薯产量和农田土壤质量。以马铃薯农田为研究对象,2年试验采用三因素完全随机设计,灌溉处理设置灌溉定额(2250 m^(3)/hm^(2),W3)、节水20%(1800 m^(3)/hm^(2),W2)、节水40%(1350 m^(3)/hm^(2),W1);施氮处理设置施氮量(195 kg/hm^(2),N3)、减氮20%(156 kg/hm^(2),N2)、减氮40%(117 kg/hm^(2),N1),以当地不施氮肥和不灌水为CK处理,测定土壤养分含量、酶活性、微生物量碳氮磷含量及产量,并将其纳入土壤质量指数(SQI),与马铃薯产量进行拟合分析。结果表明:水氮调控对土壤速效钾、有效磷、硝态氮、铵态氮、全氮、全磷、全钾、有机质含量均有显著影响,不同水氮调控下0~20 cm土层过氧化氢酶活性(SP)、蔗糖酶活性(SS)、土壤脲酶活性(SU)、土壤碱性磷酸酶活性(SAP)W2N2处理最大,较CK处理增加23.66%、86.28%、58.66%、56.92%,并随土壤深度增加呈逐渐降低趋势。马铃薯产量、土壤微生物量碳氮磷含量及化学计量在W2N2(1800 m^(3)/hm^(2)、156 kg/hm^(2))处理最大。通过SQI得出中水中氮(W2N2)土壤质量等级最高,通过拟合发现W2N2处理能够协同提升土壤综合质量与马铃薯产量,该研究结果可为中国北方干旱地区马铃薯可持续生产和土壤质量提升提供理论依据。

关键词：马铃薯产量土壤化学性质灌溉定额施氮量土壤质量指数

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高质量发展背景下地方高校办学特色研究

菏泽学院学报 2024年第3期46卷 93-98页

作者：程娟娟菏泽学院人文与新闻传播学院山东菏泽274015

办学特色是高校服务国家重大战略和地方经济发展的坚实基础,是高等教育实现内涵式高质量发展的重要抓手,也是新一轮审核评估中高校分类管理考核的关键指标。地方高校办学特色可以分为聚焦特色科研、凝练特色学科、厚植地方文化等不同类... 详细信息

办学特色是高校服务国家重大战略和地方经济发展的坚实基础,是高等教育实现内涵式高质量发展的重要抓手,也是新一轮审核评估中高校分类管理考核的关键指标。地方高校办学特色可以分为聚焦特色科研、凝练特色学科、厚植地方文化等不同类型。通过明确办学定位和办学理念、打造一流特色学科、深化育人模式改革、发挥本土文化优势等措施,地方高校可以增强办学特色的内驱动力,在建设教育强国的生动实践中展现高等教育的使命担当。

关键词：应用型地方高校办学特色办学定位