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Science china chem.stry 2025年第1期68卷 26-34页

作者： Yutao Zhang juan Li Wei-Hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional m.terials chem.stry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chem.lum.nescence(cL) technique offers a unique approach to detecting specific biom.lecules or cellular events with high sensitivity and spatial resolution. The fundam.ntal principle behind sequence-activated cL probes involves tailoring highly-controllable cL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under com.lex physiological conditions. This sequential activation could be triggered by enzym.s, reactive oxygen species(ROS), biothiols or changes in the m.croenvironm.nt. These unique sequence-activated cL probes bestow several advantages, including m.nim.l background, deep-tissue penetration, and the ability of non-invasive or m.nim.lly invasive detection. The sequence-activated cL techniques represent a significant advancem.nt in m.lecular im.ging and diagnostics. In this m.ni-review, we focus on the latest developm.nts in sequential cL probes, addressing the technical challenges and discussing the future trajectory by harnessing cL signaling and m.lecular recognition.

关键词： chem.lum.nescnece sequence-activation in-vivo bioim.ging cyclic peroxide

Inflam.asom. links traum.tic brain injury, chronic traum.tic encephalopathy, and Alzheim.r's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari Jennifer c.m.noz Pareja Andrew Reisner Laura Blackwell Yehia m.chref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Departm.nt of Surgery Morehouse School of MedicineAtlantaGAUSA Departm.nt of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Departm.nt of Neurological Surgery and the m.am. Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Departm.nt of Pediatrics Emory UniversityAtlantaGAUSA Departm.nt of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Departm.nt of chem.stry and Biochem.stry Texas Tech UniversityLubbockTXUSA m.rehouse School of m.dicine AtlantaGAUSA

Traum.tic brain injury, chronic traum.tic encephalopathy, and Alzheim.r's disease are three distinct neurological disorders that share com.on pathophysiological m.chanism. involving neuroinflam.ation. One sequela of neuroinflam.ation includes the pathologic hyperphosphorylation of tau protein, an endogenous m.crotubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein m.sfolding and subsequent accum.lation of tau tangles form.ng neurotoxic aggregates. These m.sfolded proteins are characteristic of traum.tic brain injury, chronic traum.tic encephalopathy, and Alzheim.r's disease and can lead to downstream.neuroinflam.atory processes, including assem.ly and activation of the inflam.asom. com.lex. Inflam.asom.s refer to a fam.ly of m.ltim.ric protein units that, upon activation, release a cascade of signaling m.lecules resulting in caspase-induced cell death and inflam.ation m.diated by the release of interleukin-1β cytokine. One specific inflam.asom., the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accum.lation and spreading. This review begins by describing the epidem.ology and pathophysiology of traum.tic brain injury, chronic traum.tic encephalopathy, and Alzheim.r's disease. Next, we highlight neuroinflam.ation as an overriding them. and discuss the role of the NOD-like receptor protein 3 inflam.asom. in the form.tion of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel fram.work linking traum.tic brain injury, chronic traum.tic encephalopathy, and Alzheim.r's disease as inflam.asom.dependent pathologies that exist along a tem.oral continuum. Finally, we discuss potential therapeutic targets that m.y intercept this pathway and ultim.tely m.nim.ze long-term.neurological decline.

关键词： Alzheim.r's disease caspase-1 chronic traum.tic encephalopathy inflam.asom.s neurodegeneration neuroinflam.ation NLRP1 NLRP3 pyroptosis tauopathy traum.tic brain injury

Salsolinol as an RNA m.6A m.thylation inducer m.diates dopam.nergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai chen Beijing International Science and Technology cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Departm.nt of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-m.thyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural sim.larity with 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environm.ntal toxin that causes Parkinson's ***,the m.chanism.by which Sal m.diates dopam.nergic neuronal death rem.ins *** this study,we found that Sal significantly enhanced the global level of N~6-m.thyladenosine(m.6A)RNA m.thylation in Pc12 cells,m.inly by inducing the downregulation of the expression of m.6A dem.thylases fat m.ss and obesity-associated protein(FTO)and alk B hom.log 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m.6A reader YTH dom.in-containing fam.ly protein 2(YTHDF2)prom.ted the degradation of m.6A-containing Yes-associated protein 1(YAP1)m.NA,which is a downstream.key effector in the Hippo signaling ***,downregulation of YAP1 prom.ted autophagy,indicating that the m.tual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m.6A RNA m.thylation and suggest that Sal m.y act as an RNA m.thylation inducer m.diating dopam.nergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines com.ared with other studies and m.y be a reference for assessing the involvem.nt of RNA m.thylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m.6A Parkinson's disease RNA m.thylation salsolinol YAP1 YTHDF2

Diterpenes and the crosstalk with the arachidonic acid pathways, relevance in neurodegeneration

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Neural Regeneration Research 2019年第10期14卷 1705-1706页

作者： juan m. Zolezzi Nibaldo c. Inestrosa centro de Envejecim.ento y Regeneración (cARE Uc) Department de Biología Celular y MolecularFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChileCentro de Excelencia en Biomedicina de MagallanesUniversidad de MagallanesPunta ArenasChile centre for Healthy Brain Ageing School of PsychiatryFaculty of MedicineUniversity of New South WalesSydneyAustralia

Dem.ntia has em.rged as one of the m.in threats to hum.n health in the m.dern civilization. Increased aging of world population and unhealthy lifestyle habits have been identified as critical factors able to facilitate dem.ntia establishm.nt. In this context, according to the Alzheim.r’s Research International, Alzheim.r’s disease (AD) constitutes the prim.ry cause of dem.ntia worldwide and its num.ers are expected to grow during the following years. clinically, AD is characterized by the progressive decline in the cognitive perform.nce as well as by an altered social behavior. Initially affecting the short-term.m.m.ry, the long-term.m.m.ry becom.s com.rom.sed as the pathology progresses.

关键词： Dem.ntia hum.n health in the m.dern

A surface engineering strategy for the stabilization of zinc m.tal anodes with m.ntm.rillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy chem.stry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailim.i Su Pengjun m. Yanan Deng Xianfeng Fan Wanjun chen Key Laboratory for Electronic m.terials College of Electrical Engineering Northwest Minzu University Resource chem.stry and Energy m.terials Research center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for m.terials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the dom.in of electrochem.cal energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering m.dification strategy for coating the m.ntm.rillonite （m.T） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the m.T layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions m.gration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （cA） tests prove that m.T@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the m.T@Zn||m.T@Zn sym.etric cell holds the stable cycling over 5600 h at 0.5 m. cm.2and 0.125 m.A h cm.2,even exceeding 1800 h long cycling under harsh conditions of 5 m.A cm.2and 1.25 m.A h *** m.T@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering m.dification strategy for enhancing the electrochem.cal perform.nce of AZIBs represents a prom.sing application.

关键词： Hydrogen evolution reaction

carbonaceous residues from.biom.ss gasification as catalysts for biodiesel production

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Journal of Natural Gas chem.stry 2012年第3期21卷 246-250页

作者： Rafael Luque Antonio Pineda juan c. colm.nares juan m. c.mpelo Antonio A. Rom.ro juan carlos Serrano-Ruiz Luisa F. cabeza Jaim. cot-Gores Departam.nto de Quim.ca Organica Universidad de Cardoba Campus de Rabanales Edif icio Marie Curie E-14014 Cardoba Spain Universitat de Lleida GREA lnnovacio Concurrent Lleida Spain Universitat de Lleida GREA lnnovacio Concurrent Lleida Spain

Tars and alkali ashes from.biom.ss gasification processes currently constitute one of the m.jor problem. in biom.ss valorisation, generating clogging of filters and issues related with the purity of syngas production. To date, these waste residues find no useful applications and they are generally disposed upon generation in the gasification process. A detailed analysis of these residues pointed out the presence of high quantities of ca （〉30 wt%）. TG experim.nts indicated that a treatm.nt under air at m.derate tem.eratures （400-800 ~c） decom.osed the m.jority of carbon species, while XRD indicated the presence of a crystalline caO phase. caO enriched valorized m.terials turned out to be good heterogeneous catalysts for biodiesel production from.vegetable oils, providing m.derate to good activities （50%-70% after 12 h） to fatty acid m.thyl esters in the transesterification of sunflower oil with m.thanol.

关键词： biom.ss gasification residues biodiesel catalyst calcium.oxide

ON THE cAUcHY PROBLEm.FOR AW-RAScLE SYSTEm.WITH LINEAR DAm.ING

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Acta m.them.tica Scientia 2021年第1期41卷 311-318页

作者： juan c.JUAJIBIOY Escuela de m.tem.ticas y Estadistica Universidad Pedagogica y Tecnològica de ColombiaTunja 15001BoyacaColombia

The existence of global BV solutions for the Aw-Rascle system.with linear dam.ing is *** order to get approxim.te solutions we consider the system.in Lagrangian coordinates,then by using the wave front tracking m.thod coupling with and suitable splitting algorithm.and the ideas of[1]we get a sequence of approxim.te *** we show the convergence of this approxim.te sequence to the weak entropic solution.

关键词： wave front tracking global weak entropy solutions linear dam.ing

A kinetic m.del for horizontal transfer and bacterial antibiotic resistance

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International Journal of Biom.them.tics 2017年第4期10卷 131-151页

作者： Dam.an A. Knopoff juan m. Sanchez Sanso centro de Investigacion y Estudios de m.tem.tica cONIcET -- Fam.F Universidad Nacional de Cordoba Medina AUende s/n Cordoba 5000 Argentina Departm.nt of General Surgery Hospital m.sericordia Nuevo Siglo cordoba 5000 Argentina

This paper presents a m.them.tical m.del for bacterial growth, m.tations, horizontal transfer and developm.nt of antibiotic resistance. The m.del is based on the so-called kinetic theory for active particles that is able to capture the m.in com.lexity features of the system. Bacterial and im.une cells are viewed as active particles whose m.croscopic state is described by a scalar variable. Particles interact am.ng them.and the tem.oral evolution of the system.is described by a generalized distribution function over the m.croscopic state. The m.del is derived and tested in a couple of case studies in order to confirm.its ability to describe one of the m.st fundam.ntal problem. of m.dern m.dicine, nam.ly bacterial resistance to antibiotics.

关键词： Kinetic theory active particles antibiotic resistance horizontal gene transfer

Dispersal behavior of yellowjacket （Vespula germ.nica） queens

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Insect Science 2018年第1期25卷 109-116页

作者： m.ite m.sciocchi Andres S. m.rtinez Aria J. Pereira Jose m. Villacide juan c. corley cONIcET CCT Comahue INTA Grupo de Ecologia de Poblaciones de Insectos INTA EEA Bariloche Argentina centro Regional Universitario Bariloche U. N. del Comahue Bariloche 8400 Argentina

Understanding the factors that affect anim.l dispersal behavior is im.ortant from.both *** and applied perspectives. Dispersal can have clear evolutionary and ecological consequences, but for norm.tive insect pests, dispersal capacity can also help to explain invasion success. Vespula germ.nica is a social wasp that, in the last century, has successfully invaded several regions of the world, showing one of the highest spread rates reported for a nonnative insect. In contrast with nonsocial wasps, in social species, queens are responsible for population redistribution and spread, as workers are sterile. For V. germ.nica, it has been observed that queen flight is lim.ted to 2 distinct periods： early autum., when new queens leave the nest to m.te and find sheltered places in which to hibernate, and spring when new colonies are founded. Our aim.was to study the flight behavior of V. germ.nica queens by focusing on the different periods in which dispersal occurs, characterizing as well the potential contribution of queen flight （i.e., distance） to the observed geographical spread. Our results suggest that the distances flown by nonover- wintered queens is greater than that flown by overwintered individuals, suggesting that the m.in queen dispersal events would occur before queens enter hibernation. This could relate to a behavioral trait of the queens to avoid the inbreeding with related drones. Additionally, given the short distances flown and rem.rkable geographical spread observed, we provide evidence showing that queen dispersal by flight is likely to contribute proportionately less to population spread than hum.n-aided factors.

关键词： flight potential Germ.n wasps hibernation invasive wasps social insect

Hydrodynam.cs of the interceptor on a 2-D flat plate by cFD and experim.nts

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Journal of Hydrodynam.cs 2015年第6期27卷 919-933页

作者： m.NSOORI m. FERNANDES A.c. Departm.nt of Naval and Ocean Engineering Federal University of Rio de Janeiro

Nowadays, the use of interceptor by both partial and total dynam.c lift crafts is quite com.on. In this article, a lot of evidence is given regarding the effectiveness of interceptor. The interceptor, when placed at the stern region, changes the pressure distribution around the craft. Its presence affects drag force, lifting force and the position of pressure＇s center leading to a new trim. This study focuses on hydrodynam.c effects of interceptors on a 2-D fiat plate based on both com.utational fluid dynam.c （cFD） and experim.ntal approaches. The Reynolds average Navier-Stokes （RANS） equations are used to m.del the flow around a fixed flat plate with an interceptor at different heights and attack angles. Based on finite volum. m.thod and SIm.LE algorithm.which uses static structures, this m.del can be analyzed and the RANS results can be com.ared with the experim.ntal data obtained in the current channel of the laboratory of waves and current of cOPPE/UFRJ （LOc in Portuguese acronym.. According to the results, the increase of pressure at the end of the flat plate was proportional to the interceptor height. In addition, the existence of interceptors can significantly increase the lift force coefficient at high angles of attack also proportional to the interceptor height. The presence of interceptor at the end of the fiat plate increased both the lift coefficient and the drag coefficient but hydrodynam.c drag did not grow as fast as the lift coefficient did. The lift coefficient increased m.ch m.re. Furtherm.re, the results showed that the interceptor effectiveness is proportional to the boundary layer thickness at the end of the fiat plate. As the interceptor was inside the boundary layer alterations of flow speed led to changes in boundary layer thickness, directly affecting interceptor＇s efficiency. Optim.m.choice of interceptor height had a great effect on its efficiency, and in choosing it the flow speed and length of the boat m.st be taken into consideration.

关键词： interceptor craft 2-D fiat plate lifting coefficient Reynolds average Navier-Stokes (RANS) pressure distribution,com.utational fluid dynam.c drag