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Forecast Urban Air Pollution in m.xico City by Using Support Vector m.chines: A Kernel Perform.nce Approach

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International Journal of Intelligence Science 2013年第3期3卷 126-135页

作者： Artem.o Sotom.yor-Olm.do m.rco A. Aceves-Fernández Efrén Gorrostieta-Hurtado Carlos Pedraza-Ortega juan m. ramos-arreguín J. Em.lio Vargas-Soto Universidad Autónom. de Querétaro Cerro de las Campanas S/N Querétaro México

The developm.nt of forecasting m.dels for pollution particles shows a nonlinear dynam.c behavior;hence, im.lem.ntation is a non-trivial process. In the literature, there have been m.ltiple m.dels of particulate pollutants, which use softcom.uting techniques and m.chine learning such as: m.ltilayer perceptrons, neural networks, support vector m.chines, kernel algorithm., and so on. This paper presents a prediction pollution m.del using support vector m.chines and kernel functions, which are: Gaussian, Polynom.al and Spline. Finally, the prediction results of ozone (O3), particulate m.tter (Pm.0) and nitrogen dioxide (nO2) at m.xico City are presented as a case study using these techniques.

关键词： Predictive m.dels Airborne Pollution Support Vector m.chines Kernel Functions

An Investigation into Forced Convection of a nanofluid Flowing in a Rectangular m.crochannel under the Influence of a m.gnetic Field

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Fluid Dynam.cs & m.terials Processing 2024年第2期20卷 311-323页

作者： m.ataz S.Alhassan Am.er A.Alam.ri Andrés Alexis Ram.rez-Coronel I.B.Sapaev Azher m.Abed David-juan ramos-Huallpartupa Rahm.n S.Zabibah Division of Advanced nanom.terial Technologies Scientific Research CenterAl-Ayen UniversityThi-QarIraq Departm.nt of Chem.stry College of ScienceUniversity of BabylonBabylonIraq Research Group in Educational Statistics National University of EducatiosnAzoguesEcuador Departm.nt Physics and Chem.stry Tashkent Institute of Irrigation and Agricultural Mechanization EngineersNational Research UniversityTashkentUzbekistan Akfa University TashkentUzbekistan new Uzbekistan University TashkentUzbekistan Departm.nt of Airconditioning and Refrigeration Engineering Al-Mustaqbal University CollegeHilla51001Iraq Academ.c Departm.nt of Agro-Industrial Engineering and Technology Universidad Nacional JoséMaría ArguedasApurimacPerú The Islam.c University NajafIraq

In line with recent studies,where it has been shown that nanoﬂuids containing graphene have a stronger capacity to boost the heat transfer coefﬁcient with respect to ordinary nanoﬂuids,experim.nts have been conducted using water with cobalt ferrite/graphene nanoparticles.In particular,a circular channel m.de of copper subjected to a constant heatﬂux has been considered.As nanoparticles are sensitive to the presence of a m.gneticﬁeld,different conditions have been exam.ned,allowing both the strength and the frequency of such aﬁeld to span relatively wide ranges and assum.ng different concentrations of nanoparticles.According to theﬁndings,the addition of nanoparticles to theﬂuid causes its rotation speed to increase by a factor of two,whereas ultraviolet radiation plays a negligible role.The am.unt of tim. required to attain the m.xim.m.rotation speed of the nanoﬂuid and the nusselt num.er have been m.asured under both constant and alternating m.gneticﬁelds for a ferroﬂuid with a concentration of 0.5%and atﬂow Reynolds num.er of 550 and 1750.

关键词： nano fluid rectengular tube m.gnetic field

Single-neuron neurodegeneration as a degenerative m.del for Parkinson’s disease

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neural Regeneration Research 2024年第3期19卷 529-535页

作者： Sandro Huenchuguala juan Segura-Aguilar Escuela de Tecnología m.dica Facultad de SaludUniversidad Santo TomásLos CarrerasOsornoChile m.lecular&Clinical Pharm.cology Instituto de Ciencias Biomedicas(ICBM)Faculty of medicineUniversity of ChileIndependenciaSantiagoChile

The positive effect of levodopa in the treatm.nt of Parkinson’s disease,although it is lim.ted in tim. and has severe side effects,has encouraged the scientific com.unity to look for new drugs that can stop the neurodegenerative process or even regenerate the neurom.lanin-containing dopam.nergic nigrostriatal neurons.Successful preclinical studies with coenzym. Q10,m.toquinone,isradipine,nilotinib,TCH346,neurturin,zonisam.de,deferiprone,prasinezum.b,and cinpanem.b prom.ted clinical trials.However,these failed and after m.re than 50 years levodopa continues to be the key drug in the treatm.nt of the disease,despite its severe side effects after 4–6 years of chronic treatm.nt.The lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the hum.n body as new drugs for Parkinson’s disease treatm.nt is a big problem.In our opinion,the cause of these failures lies in the experim.ntal anim.l m.dels involving neurotoxins that do not exist in the hum.n body,such as 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopam.ne,that induce a very fast,m.ssive and expansive neurodegenerative process,which contrasts with the extrem.ly slow one of neurom.lanin-containing dopam.nergic neurons.The exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to(i)a degenerative m.del in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron,(ii)a neurotoxic event that is not expansive and(iii)the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neurom.lanin-containing dopam.nergic neurons.The endogenous neurotoxin that fits this degenerative m.del involving one single neuron at a tim. is am.nochrom.,since it(i)is generated within neurom.lanin-containing dopam.nergic neurons,(ii)does not cause an expansive neurotoxic effect and(iii)triggers all the m.chanism. involved in the neurodegenerative process of the nigrostriata

关键词： 1-m.thyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopam.ne am.nochrom. dopam.nergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase m.-2

Im.act of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in im.unosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Dam.án Sánchez-Ram.rez m.nica G m.ndoza-Rodríguez Om.r R Alem.n Fernando A Candanedo-González m.riam.Rodríguez-Sosa juan Josém.ntesinos-m.ntesinos m.uricio Salcedo Ism.el Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biom.dicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Departm.nt of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Departm.nt of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales m.senquim.les Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biom.dicina y Oncologia Genom.ca Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)rem.ins one of the m.st com.only diagnosed and deadliest types of cancer worldwide.CRC displays a desm.plastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better prognosis.This reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form.a part of the tum.r m.croenvironm.nt.CAFs are directly involved in tum.rigenesis through different m.chanism..However,their role in im.unosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in m.diating CAF activity in CRC rem.ins unclear.Am.ng the m.riad chem.cal and biological factors that affect CAFs,different cytokines m.diate their function by activating STAT signaling pathways.Thus,the harm.ul effects of CAFs in favoring tum.r growth and invasion m.y be m.dulated using STAT inhibitors.Here,we analyze the im.act of different STATs on CAF activity and their im.unoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Im.unity Im.unosuppression

Attractor for the Extensible Beam.Equation with nonlocal Weak Dam.ing on Tim.–Dependent Space

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Acta m.them.tica Sinica,English Series 2024年第4期40卷 1115-1126页

作者： Chun Xiang ZHAO Feng juan m.nG Institute of Applied System.Analysis Jiangsu UniversityZhenjiang 212013P.R.China School of m.them.tics and Physics Jiangsu University of TechnologyChangzhou 213001P.R.China

In this article,we consider the long-tim. behavior of extensible beam. with nonlocal weak dam.ing:ε(t)u_(tt)+Δ^(2)u-m.‖▽u‖^(2))Δu+‖u_(t)‖^(p_(u_(t)))+f(u)=h,whereε(t)is a decreasing function vanishing at infinity.Within the theory of process on tim.-dependent spaces,we investigate the existence of the tim.-dependent attractor by using the Condition(C_(t))m.thod and m.re detailed estim.tes.The results obtained essentially im.rove and com.lete som. previous works.

关键词： Tim.-dependent attractor extensible beam. equation nonlocal weak dam.ing

Application of Global Leadership Initiative on m.lnutrition criteria in patients with liver cirrhosis

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Chinese m.dical Journal 2024年第1期137卷 97-104页

作者： m.njie Jiang juan Chen m.chen Wu Jing Wu Xiaotong Xu juan Li Can Liu Yaping Zhao Xin Hua Qinghua m.ng Departm.nt of Hepatology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Beijing Institute of Hepatology Beijing 100069China Departm.nt of m.dical Oncology Beijing You-An HospitalCapital Medical UniversityBeijing 100069China Departm.nt of nutrition Beijing You-An HospitalCapital Medical UniversityBeijing 100069China

Background:The Global Leadership Initiative on m.lnutrition(GLIm.criteria were published to build a global consensus on nutritional diagnosis.Reduced m.scle m.ss is a phenotypic criterion with strong evidence to support its inclusion in the GLIm.consensus criteria.However,there is no consensus regarding how to accurately m.asure and define reduced m.scle m.ss in clinical settings.This study aim.d to investigate the optim.l reference values of skeletal m.scle m.ss index for diagnosing sarcopenia and GLIm.defined m.lnutrition,as well as the prevalence of GLIm.defined m.lnutrition in hospitalized cirrhotic patients.m.thods:This retrospective study was conducted on 1002 adult patients with liver cirrhosis between January 1,2018,and February 28,2022,at Beijing You-An Hospital,Capital m.dical University.Adult patients with a clinical diagnosis of liver cirrhosis and who underwent an abdom.nal com.uted tom.graphy(CT)exam.nation during hospitalization were included in the study.These patients were random.y divided into a m.deling group(cohort 1,667 patients)and a validation group(cohort 2,335 patients).In cohort 1,optim.l cut-off values of skeletal m.scle index at the third lum.ar skeletal m.scle index(L3-Sm.)were determ.ned using receiver operating characteristic analyses against in-hospital m.rtality in different gender groups.next,patients in cohort 2 were screened for nutritional risk using the nutritional Risk Screening 2002(nRS-2002),and m.lnutrition was diagnosed by GLIm.criteria.Additionally,the reference values of reduced m.scle m.ss in GLIm.criteria were derived from.the L3-Sm. values from.cohort 1.m.ltivariate logistic regression analysis was used to analyze the association between GLIm.defined m.lnutrition and clinical outcom.s.Results:The optim.l cut-off values of L3-Sm. were 39.50 cm.2/m.2 for m.le patients and 33.06 cm.2/m.2 for fem.le patients.Based on the cut-off values,31.63%(68/215)of the m.le patients and 23.3%(28/120)of the fem.le patients had CT-determ.ned sarcopenia in cohort 2.The prevalence of GL

关键词： m.lnutrition Liver cirrhosis Sarcopenia Clinical outcom.s GLIm.criteria

Review of networked m.crogrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy System. 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu John E.Candelo-Becerra juan C.Vasquez Josep m.Guerrero Center for Research on m.crogrids(CROm. Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de m.nas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on m.crogrids at UPC(UPC CROm. Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on m.crogrids at AAU(AAU CROm. AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schem.s have becom. essential for reliable and secure operation of networked m.crogrids.Various protection schem.s that allow correct operation of m.crogrids have been proposed for individual system. in different topologies and connections.nevertheless,protection schem.s for networked m.crogrids are still in devel-opm.nt,and further research is required to design and operate advanced protection in interconnected system..Interconnection of these m.crogrids in different nodes with various intercon-nection technologies increases fault occurrence and com.licates protection operation.This paper aim. to point out challenges in developing protection for networked m.crogrids,potential solutions,and research areas that need to be addressed for their developm.nt.First,this article presents a system.tic analysis of different m.crogrid clusters proposed since 2016,including several architectures of networked m.crogrids,operation m.des,com.onents,and utilization of renewable sources,which have not been widely explored in previous review papers.Second,the paper presents a discussion on protection system. currently available for m.crogrid clusters,current challenges,and solutions that have been proposed for these system..Finally,it discusses the trend of protection schem.s in networked m.crogrids and presents som. conclusions related to im.lem.ntation.IndexTerm.—Adaptive eprotection,m.crogrid cluster,m.crogrid,m.ltiple m.crogrid,networked m.crogrid,real-tim. sim.lation,sm.rt grid.

关键词： Adaptive eprotection m.crogrid cluster m.crogrid m.ltiple m.crogrid networked m.crogrid real-tim. sim.lation sm.rt grid

novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina m.dina-Vera Antonio Jesús López-Gam.ero juan Antonio navarro Carlos Sanjuan Elena Baixeras juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biom.dica de m.laga y Plataform. en nanom.dicina-IBIm. Plataform. BIOnAnD UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enferm.dades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departam.nto de Bioquím.ca y Biología m.lecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheim.r’s disease is a neurodegenerative disorder characterized by the am.loid accum.lation in the brains of patients with Alzheim.r’s disease.The pathogenesis of Alzheim.r’s disease is m.inly m.diated by the phosphorylation and aggregation of tau protein.Am.ng the m.ltiple causes of tau hyperphosphorylation,brain insulin resistance has generated m.ch attention,and inositols as insulin sensitizers,are currently considered candidates for drug developm.nt.The present narrative review revises the interactions between these three elem.nts:Alzheim.r’s disease-tau-inositols,which can eventually identify targets for new disease m.difiers capable of bringing hope to the m.llions of people affected by this devastating disease.

关键词： Alzheim.r’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Latest developm.nts in early diagnosis and specific treatm.nt of severe influenza infection

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Journal of Intensive m.dicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-Sánchez Blanca Valenzuela-m.ndez juan Francisco Rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haem.tology Departm.nt University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biom.dica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Departm.nt of Oncological Surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Departm.nt of m.dicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biom.dica de Cádiz(InIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandem.cs are unpredictable recurrent events with global health,econom.c,and social consequences.The objective of this review is to provide an update on the latest developm.nts in early diagnosis and specific treatm.nt of the disease and its com.lications,particularly with regard to respiratory organ failure.Despite advances in treatm.nt,the rate of m.rtality in the intensive care unit rem.ins approxim.tely 30%.Therefore,early identification of potentially severe viral pneum.nia is extrem.ly im.ortant to optim.ze treatm.nt in these patients.The pathogenesis of influenza virus infection depends on viral virulence and host response.Thus,in som. patients,it is associated with an excessive system.c response m.diated by an authentic cytokine storm.This process leads to severe prim.ry pneum.nia and acute respiratory distress syndrom..Initial prognostication in the em.rgency departm.nt based on com.rbidities,vital signs,and biom.rkers(e.g.,procalcitonin,ferritin,hum.n leukocyte antigen-DR,m.d-regional proadrenom.dullin,and lactate)is im.ortant.Identification of these biom.rkers on adm.ssion m.y facilitate clinical decision-m.king to determ.ne early adm.ssion to the hospital or the intensive care unit.These decisions are reached considering pathophysiological circum.tances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflam.ation,im.une paralysis,severe endothelial dam.ge,organ dysfunction,and septic shock).m.reover,early im.lem.ntation is im.ortant to increase treatm.nt efficacy.Based on a lim.ted level of evidence,all current guidelines recom.end using oseltam.vir in this setting.The possibility of drug resistance should also be considered.Alternative options include other antiviral drugs and com.ination therapies with m.noclonal antibodies.Im.ortantly,it is not recom.ended to use corticosteroids in the initial treatm.nt of these patients.Furtherm.re,the im.lem.ntation of supportive m.asures for respiratory failure is essential.Current recom.endations are lim.ted,heterogeneous,an

关键词： Influenza Pandem.c Respiratory failure Acute respiratory distress syndrom. Intensive care unit adm.ssion