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Synthesis and Anti-inflammatory Action of (η-C_5H_5)_2Ti(Sal)_2 and (η-C_5H_5)_2Ti(Clo)_2

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Chemical Research in Chinese Universities 2006年第1期22卷 6-10页

作者： LI Xiu-juan ZENG Zheng-zhi College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China

Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NmR, ^13C NmR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.

关键词： Salicylate acid N-(m-Chlorophenyl) anthranilic acid Cyclopentadienyltitanium complexes Anti-in-flammatory

Symptomatic accommodative and binocular dysfunctions from the use of flat-panel displays

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 501-505页

作者： Esteban Porcar juan Carlos montalt Alvaro m. Pons Enrique Espana-Gregor Department of Optics Optometry and Vision Sciences Physics College University of Valencia Burjassot (Valencia) 46100 Spain Department of Surgery Ophthalmology Unit Faculty of Medicine and Odontology la Fe University and Polytechnic Hospital Valencia 46026 Spain

AIm： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （***） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. mETHODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use. Then, a thorough eye examination excluded those subjects with a significant uncorrected refractive error or other problem, such as ocular motility disorders, vertical deviation, strabismus and eye diseases. Finally, the remaining participants underwent an exhaustive assessment of their accommodative and binocular vision status. RESULTS： Eighty-nine VDU users （46 females and 43 males） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented *** （22.5%）. Convergence excess was the most frequent non-strabismic binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accommodative dysfunctions, accommodative excess was the most common （4 subjects）, followed by accommodative insufficiency （2 subjects）. moderate to severe eye symptoms were found in 13 subjects with ANSBD. CONCLUSION： Significant eye symptoms in VDU users with accommodative and/or non-strabismic binocular dysfunctions often occur and should not be underestimated; therefore, an appropriate evaluation of accommodative and binocular vision status is more important for this population,

关键词： general binocular dysfunctions accommodativedysfunctions non-strabismic binocular dysfunctions eyesymptoms video display unit

EXPERImENTAL STUDY OF mICROSCALE FLOW FOR mICRO mOLECULE LIQUID AND POLYmER SOLUTION

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Journal of Hydrodynamics 2005年第3期17卷 352-357页

作者： LIUZhong-chun YUEXiang-an HOUJi-rui ZHANGLi-juan SchoolofEnergyResources ChinaUniversityofGeoscienceBeijing100083China／／SINOPECExplorationandproductionResearchInstituteBeijing100083China EORcenter ChinaUniversityofPetroleumBeijing102249China

The flow performances of water, white oil and Hydrolyzing Polyacrylamide (HPAm) solution in fused quartz channels and the effect of wettability on the microscale flows have been studied respectively in this paper. The adaptability of classical fluid mechanics in channels with different sizes has been discussed. The results show that water flows in channels of 2μm diameter also have few size effects and white oil flow accord with classical fluid mechanics theory in channels of 25μm diameter too, but polymer solution appears an obvious size effect as diameters of channels decrease to 16μm. The wettability does not produce any influences on the water or white oil flows in channels of 25μm or 50μm diameter. The experimental technology of microscale flows has been first applied for studying the flow performances of pores in low permeability reservoir. This study found a base for deep investigating the percolation mechanism in low permeability reservoirs.

关键词： microscale flow wettability micro molecule liquid polymer solution reservoir pores low permeability

Hepatocellular adenoma in the paediatric population:molecular classification and clinical associations

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World Journal of Gastroenterology 2020年第19期26卷 2294-2304页

作者： Elan Hahn juan Putra Division of Pathology Department of Paediatric Laboratory Medicinethe Hospital for Sick ChildrenToronto M5G 1X8ONCanada Department of Laboratory medicine and Pathobiology University of TorontoToronto M5S 1A8ONCanada

Hepatocellular adenomas(HCAs)represent rare,benign liver tumours occurring predominantly in females taking oral *** children,HCAs comprise less than 5%of hepatic tumours and demonstrate association with various *** contemporary classification of HCAs,based on their distinctive genotypes and clinical phenotypes,includes hepatocyte nuclear factor 1 homeobox alpha-inactivated HCAs,beta-catenin-mutated HCAs,inflammatory HCAs,combined beta-catenin-mutated and inflammatory HCAs,sonic hedgehogactivated HCAs,and unclassified *** children,there is a lack of literature on the characteristics and distribution of HCA *** this review,we summarized different HCA subtypes and the clinicopathologic spectrum of HCAs in the paediatric population.

关键词： Paediatric Hepatocellular adenoma malignant transformation Beta-catenin HNF1A Glycogen storage disorders

Review of Networked microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： Jorge de la Cruz Ying Wu John E.Candelo-Becerra juan C.Vasquez Josep m.Guerrero Center for Research on microgrids(CROm) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on microgrids at UPC(UPC CROm) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on microgrids at AAU(AAU CROm) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

Primary malignant vascular tumors of the liver in children:Angiosarcoma and epithelioid hemangioendothelioma

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World Journal of Gastrointestinal Oncology 2021年第4期13卷 223-230页

作者： Sami Bannoura juan Putra Department of Paediatric Laboratory medicine Hospital for Sick Children555 University AveToronto M5G 1X8OntarioCanada

Primary malignant vascular neoplasms of the liver,angiosarcoma and epithelioid hemangioendothelioma,are extremely rare entities in the pediatric *** Society for the Study of Vascular Anomalies classification system is recommended for the pathologic diagnosis of hepatic vascular lesions in this age *** this article,we highlight the clinicopathologic characteristics of hepatic angiosarcoma and epithelioid hemangioendothelioma in the pediatric *** angiosarcoma in children shows a slight female predominance with an average age of 40 mo at *** distinct histologic features include whorls of atypical spindled cells and eosinophilic globules,in addition to the general findings of *** diagnosis of pediatric hepatic angiosarcoma is not always straightforward,and the diagnostic challenges are discussed in the *** epithelioid hemangioendothelioma also demonstrates a female predominance,but is more commonly identified in adolescents(median age at diagnosis:12 years).Histologically,the lesion is characterized by epithelioid cells and occasional intracytoplasmic lumina with a background of fibromyxoid *** WWTR1-CAmTA1 and YAP1-TFE3 fusions have been associated with epithelioid hemangioendothelioma,there are currently no known signature genetic alterations seen in pediatric hepatic *** in molecular pathology,particularly for pediatric hepatic angiosarcoma,is necessary for a better understanding of the disease biology,diagnosis,and development of targeted therapies.

关键词： Pediatric Hepatic angiosarcoma Epithelioid hemangioendothelioma Infantile hemangioma Liver tumor molecular genetics

Abnormal specific heat at low temperatures and transport properties in mg-Cu-Ag-Gd bulk metallic glass

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Journal of Rare Earths 2023年第2期41卷 277-282页

作者： Qiang Zheng Xiu Su Lingyun Li juan Du Institute of materials School of Materials Science and EngineeringShanghai UniversityShanghai 200072China

We report the pronounced low-temperature specific-heat Cpanomalies in the mg_(59.5)Cu_(22.9)Ag_(6.6)Gd_(11)bulk metallic glass(BmG).The extrapolated electron’s temperature coefficientγ0Kis up to 681.8 mJ/(molGd·K^(2))at 0 K,which is a heavy-fermion-like *** low temperature specific heat indicates an enhancement of the conduction-electron effective mass m*below 7.5 K,suggesting that the mg_(59.5)Cu_(22.9)Ag_(6.6)Gd_(11)BmG is not free-electron-like *** excess specific heat in the mg-based BmG is interpreted with tunneling states and spin glass state(magnetism)which are determined by subtracting electrons’and phonons’contribution to the specific heat below 12 *** Boson peak(BP)temperature is located at 27 K,which is much higher than the reported values of other ***,a BP height of 0.047 mJ/(mol·K^(4))is obtained due to reduced free volume during copper mold casting with a slow cooling *** electrical resistivity was also investigated between 2 and 300 K,which has a negative temperature coefficient of resistivity(TCR)below 35 K(Kondo temperature,TK)and a positive value of 3.9×10^(-4)/K above 35 *** is a minimum at about 35 K for the electrical resistivity,which can be explained by the Kondo *** the resistivity above 35 K,it can be explained by the FaberZiman model due to the T-dependence change of structure factor.

关键词： Specific heat Boson peak Electrical resistivity Bulk metallic glass(BmG) Spin glass behavior Rare earths

Association of residual feed intake with abundance of ruminal bacteria and biopolymer hydrolyzing enzyme activities during the peripartal period and early lactation in Holstein dairy cows

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Journal of Animal Science and Biotechnology 2018年第3期9卷 717-726页

作者： Ahmed A.Elolimy José m.Arroyo FernANDa Batistel michael A.Iakiviak juan J.Loor mammalian Nutri Physio Genomics Department of Animal SciencesUniversity of Illinois Department of Animal Sciences University of Illinois Departamento de Nutrición Animal Instituto de Producción Animal Facultad de Veterinaria Universidad de la Republica Division of Nutritional Sciences Illinois Informatics Institute University of Illinois

Background: Residual feed intake(RFI) in dairy cattle typically calculated at peak lactation is a measure of feed efficiency independent of milk production level. The objective of this study was to evaluate differences in ruminal bacteria, biopolymer hydrolyzing enzyme activities, and overall performance between the most-and the leastefficient dairy cows during the peripartal period. Twenty multiparous Holstein dairy cows with daily ad libitum access to a total mixed ration from d-10 to d 60 relative to the calving date were used. Cows were classified into most-efficient(i.e. with low RFI, n = 10) and least-efficient(i.e. with high RFI, n = 10) based on a linear regression model involving dry matter intake(DmI), fat-corrected milk(FCm), changes in body weight(BW), and metabolic ***: The most-efficient cows had ~ 2.6 kg/d lower DmI at wk 4, 6, 7, and 8 compared with the least-efficient cows. In addition, the most-efficient cows had greater relative abundance of total ruminal bacterial community during the peripartal period. Compared with the least-efficient cows, the most-efficient cows had 4-fold greater relative abundance of Succinivibrio dextrinosolvens at d-10 and d 10 around parturition and tended to have greater abundance of Fibrobacter succinogenes and megaspheara elsdenii. In contrast, the relative abundance of Butyrivibrio proteoclasticus and Streptococcus bovis was lower and Succinimonas amylolytica and Prevotella bryantii tended to be lower in the most-efficient cows around calving. During the peripartal period, the most-efficient cows had lower enzymatic activities of cellulase, amylase, and protease compared with the least-efficient ***: The results suggest that shifts in ruminal bacteria and digestive enzyme activities during the peripartal period could, at least in part, be part of the mechanism associated with better feed efficiency in dairy cows.

关键词： Dairy cows Enzyme activity Peripartal period RFI Rumen bacteria

Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration

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Acta Pharmaceutica Sinica B 2016年第6期6卷 584-592页

作者： Yuqiao Zhang Dali Tian Yuyou Huang Ling Li juan mao juan Tian Jinsong Ding School of Pharmaceutical Sciences Central South University China Resources San-Jiu (Ya’an) Pharmaceutical Co. Ltd.

Shenfu Injection (SFI) is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides (ginsenoside Rg 1, ginsenoside Rbl and ginsenoside Rc) and aconitum alkaloids (benzoylmesaconine and fuziline) were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC mS/mS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of 2-8 mL/kg. (C) 2016 Chinese Pharmaceutical Association and Institute of materia medica, Chinese Academy of medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND

关键词： HPLC-mS/mS Ginsenoside Aconittun alkaloids Phammcokinetics Shenfu Injection Beagle dogs