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Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy

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Neural Regeneration Research 2024年第9期19卷 2057-2067页

作者： Bismark Gatica-Garcia Michael j.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando j.Espadas-Alvarez Manuel A.Fernandez-Parrilla juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas jaime Santoyo-Salazar Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Laboratorio de Patogénesis Molecular Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Red de Medicina para la Educación y Desarrollo y la Investigación Científica de Iztacala(Red MEDICI) Carrera Médico CirujanoFacultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla de BazMéxico Nanoparticle Therapy Institute AguascalientesMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Escuela Nacional de Medicina y Homeopatía Instituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCiudad de MéxicoMéxico Departamento de Biología Molecular y Biotecnología Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de MéxicoCiudad de MéxicoMéxico Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa de Nanociencias y Nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,thus replicating several clinical features of Parkinson’s disease,a typicalα-*** Nurr1 repressesα-synuclein,we evaluated whether unilateral transfected of rNurr1-V5 transgene via neurotensin-polyplex to the substantia nigra on day 30 after unilateralβ-sitosterolβ-D-glucoside lesion could affect bilateral neuropathology and sensorimotor deficits on day 30 *** study found that rNurr1-V5 expression but not that of the green fluorescent protein(the negative control)reducedβ-sitosterolβ-D-glucoside-induced ***,a bilateral increase in tyrosine hydroxylase-positive cells and arborization occurred in the substantia nigra and increased tyrosine hydroxylase-positive ramifications in the *** addition,tyrosine hydroxylase-positive cells displayed less senescence markerβ-galactosidase and more neuron-cytoskeleton markerβIII-tubulin and brain-derived neurotrophic factor.A significant decrease in activated microglia(positive to ionized calcium-binding adaptor molecule 1)and neurotoxic astrocytes(positive to glial fibrillary acidic protein and complement component 3)and increased neurotrophic astrocytes(positive to glial fibrillary acidic protein and S100 calcium-binding protein A10)also occurred in the substantia *** effects followed the bilateral reduction inα-synuclein aggregates in the nigrostriatal system,improving sensorimotor *** results show that unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neurodegeneration(senescence and loss of neuron-cytoskeleton and tyrosine hydroxylase-positive cells),neuroinflammation(activated microglia,neurotoxic astrocytes),α-synuclein aggregation,and sensorimotor *** neurotrophic astrocytes and

关键词： A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates

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Endoscopic and anesthetic feasibility of EUS and ERCP combined in a single session versus two different sessions

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World journal of Gastrointestinal Endoscopy 2011年第3期3卷 57-61页

作者： juan j vila Marcos Kutz Silvia Goi Miriam Ostiz Edurne Amorena Carlos Prieto Cristina Rodriguez Ignacio Fernández-Urien Francisco j jiménez Endoscopy Unit Gastroenterology DepartmentComplejo Hospitalario de Navarra

AIM:To discuss the feasibility of single session endoscopic ultrasonography(EUS) to discuss and endoscopic retrograde cholangiopancreatography(ERCP) ***:Retrospective endoscopic and anesthetic outcome comparison of performing both EUS and ERCP in a single endoscopic session(Group Ⅰ) versus performing each procedure in two different sessions(Group Ⅱ) was *** following variables were evaluated:epidemiological variables,American Society of Anesthesiologists Physical Status Classification(ASA) level,procedural time,propofol dose,anesthetic complications,endoscopic complications and diagnostic yield,and therapeutic procedures on both groups.T-student,ChiSquare and Fisher test were used for ***:We included 39 patients in Group Ⅰ(mean age:69.85 ± 9.25;27 men) and 46 in Group Ⅱ(mean age:67.46 ± 12.57;25 men).Procedural time did not differ significantly between both groups(Group Ⅰvs Group Ⅱ:93 ± 32.78 vs 98.98 ± 38.17;P >0.05) but the dose of propofol differed(Group Ⅰ vs Group Ⅱ:322.28 ± 250.54 mg vs 516.96 ± 289.06 mg;P = 0.001).Three patients had normal findings on both *** anesthetic complications [O2 desaturation(2),broncoaspiration(1)] and 9 endoscopic complications [pancreatitis(6),bleeding(1),perforation(1),cholangitis(1)] occurred without significant differences between both groups(P > 0.05).We did not find any significant difference regarding age,sex,ASA scale level,diagnostic yield or therapeutic maneuvers between both ***:The performance of EUS and ERCP in a single session offers a similar diagnostic and therapeutic yield,does not entail a higher complication risk and requires a significantly smaller dose of propofol for sedation compared with performing each exploration in a different session.

关键词： Endosonography Endoscopic Retrograde Cholangiopancreatography Feasibility Studies Endoscopy Gastrointestinal Anesthesia

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Endoscopic ultrasonography and idiopathic acute pancreatitis

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World journal of Gastrointestinal Endoscopy 2010年第4期2卷 107-111页

作者： juan j vila Endoscopy Unit Gastroenterology DepartmentHospital de NavarraPamplona 31008Spain

Idiopathic acute pancreatitis is a diagnostic challenge for *** possibility of finding a cause for pancreatitis usually relies on how far the diagnostic study is *** explorations such as endoscopic retrograde cholangiopancreatography and endoscopic ultrasonography can help to determine the cause of ***,microscopic bile examination and magnetic resonance cholangiopancreatography can also be helpful in the work up of these *** this article an approximation to the diagnostic approach to patients with idiopathic acute pancreatitis is made,taking into account the reported evidence with which to choose between the different available explorations.

关键词： Endosonography Cholangiopancreatograp hy Endoscopic retrograde Cholangiopancreatography Magnetic resonance Microscopic bile examination Idiopathic pancreatitis Acute Diagnosis

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Endoscopic ultrasound-guided drainage of pelvic collections and abscesses

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World journal of Gastrointestinal Endoscopy 2010年第6期2卷 223-227页

作者： Ignacio Fernandez-Urien juan j vila Francisco javierjimenez Endoscopy Unit Gastroenterology DepartmentHospital de Navarra

Pelvic abscesses are usually the end stage in the progression of an *** may occur from surgical complications,generalized abdominal infections such as appendicitis or diverticulitis,or from localized infections such as pelvic inflammatory disease or inflammatory bowel *** surgery has been considered as the treatment of choice by some authors,pelvic abscesses can be managed by non-invasive methods such as ultrasound and computed tomography-guided *** development of therapeutic linear echoendoscopes has allowed the endoscopist to perform therapeutic ***,endoscopic ultrasonography(EUS)-guided drainage of pelvic collections has been demonstrated to be feasible,efficient and *** allows the endoscopist to insert stents and drainage catheters into the abscess cavity which drains through the large *** article reviews technique, current results and future prospects of EUS-guided drainage of pelvic lesions.

关键词： Endoscopic ultrasound Abscess Collection Pelvis Drainage

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Pancreatic pseudocyst drainage guided by endoscopic ultrasound

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World journal of Gastrointestinal Endoscopy 2010年第6期2卷 193-197页

作者： juan j vila David Carral Ignacio Fernández-Urien Endoscopy Unit Gastroenterology DepartmentHospital de Navarra Endoscopy Unit Gastroenterology DepmentComplejo Hospitalario Xeral-Calde

Pancreatic pseudocysts can be managed conservatively in the majority of patients but some of them will require surgical,endoscopic or percutaneous drainage. Endoscopic drainage represents an efficient modality of drainage with a high resolution rate and lower morbidity and mortality than the surgical or percutaneous *** this article we review the endoscopic pseudocyst drainage procedure with special emphasis on technical details.

关键词： Endosonography Pancreatic pseudocyst Drainage Endoscopy Digestive system Therapeutics

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Advances in the endoscopic management of pancreatic collections

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World journal of Gastrointestinal Endoscopy 2015年第4期7卷 381-388页

作者： David Ruiz-Clavijo Belen González de la Higuera juan j vila Biliary and Pancreatic diseases Unit Gastroenterology DepartmentComplejo Hospitalario deNavarra 31008 Pamp-lona Spain Biliary and Pancreatic diseases Unit Gastroenterology DepartmentComplejo Hospitalario deNavarra 31008 Pamp-lona Spain Biliary and Pancreatic diseases Unit Gastroenterology DepartmentComplejo Hospitalario deNavarra 31008 Pamplona Spain

Treatment of pancreatic collections has experienced great progress in recent years with the emergence of alternative minimally invasive techniques comparing to the classic surgical treatment. Such techniques have been shown to improve outcomes of morbidity vs surgical treatment. The recent emergence of endoscopic drainage is noteworthy. The advent of endoscopic ultrasonography has been crucial for treatment of these specific lesions. They can be characterized, their relationships with neighboring structures can be evaluated and the drainage guided by this technique has been clearly improved compared with the conventional endoscopic drainage. Computed tomography is the technique of choice to characterize the recently published new classification of pancreatic collections. For this reason, the radiologist's role establishing and classifying in a rigorously manner the collections according to the new nomenclature is essential to making therapeutic decisions. Ideal scenario for comprehensive treatment of these collections would be those centers with endoscopic ultrasound and interventional radiology expertise together with hepatobiliopancreatic surgery. This review describes the different types of pancreatic collections: acute peripancreatic fluid collection, pancreatic pseudocysts, acute necrotic collection and walled-off necrosis; the indications and the contraindications for endoscopic drainage, the drainage technique and their outcomes. The integrated management of pancreatic collections according to their type and evolution time is discussed.

关键词： Pancreatic collection Endosonography Drainage Pancreatic duct Endoscopic retrogradecholangiopancreatografic

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Endosonography-guided cholangiopancreatography as a salvage drainage procedure for obstructed biliary and pancreatic ducts

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World journal of Gastrointestinal Endoscopy 2010年第6期2卷 212-222页

作者： Manuel Perez-Miranda Carlos de la Serna Pilar Diez-Redondo juan j vila Endoscopy Unit.Hospital Universitario Rio Hortega Endoscopy Unit Gastroenterology DepartmentHospital de Navarra

Endoscopic ultrasound allows transmural access to the bile or pancreatic ducts and subsequent contrast injection to provide ductal drainage under fluoroscopy using endoscopic retrograde cholangiopancreatography (ERCP)-based *** patient specifics and operator techniques result in six possible variant approaches to this procedure,known as endosonography-guided cholangiopancreatography(ESCP). ESCP has been in clinical use for a decade now,with over 300 cases *** has become established as a salvage procedure after failed ERCP in the palliation of malignant biliary *** role in the management of clinically severe chronic/relapsing pancreatitis remains under *** review aims to clarify the concepts underlying the use of ESCP and to provide technical tips and a detailed step-by-step procedural description.

关键词： Endosonography Drainage Endoscopy Digestive system Therapeutics Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography

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endoscopic 以后后退 cholangiopancreatography 复杂并发症: 他们怎么能被避免？

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World journal of Gastrointestinal Endoscopy 2012年第6期4卷 241-246页

作者： juan j vila Everson LA Artifon jose Pinhata Otoch Endoscopy Unit Gastroenterology DepartmentComplejo Hospitalario de NavarraPamplona 31008Spain Associate Professor of Surgery University of Sao PauloSao Paulo 04304-030Brazil

Endoscopic retrograde cholangiopancreatography(ERCP) has a significant complication rate which can be lowered by adopting technical variations of proven beneficial effect and prophylactic maneuvers such as pancreatic stenting during ERCP or periprocedural non-steroidal anti-inflammatory drug ***,adoption of these prophylactic maneuvers by endoscopists is not *** this editorial we discuss the beneficial effects of the aforementioned maneuvers.

关键词： Acute necrotizing Anti-inflammatory Agents Catheterization Cholangiopancreatography Complications Endoscopic retrograde Non-steroidal Pancreatitis Stents

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Z-line examination by the PillCam^(TM) SB:Prospective comparison of three ingestion protocols

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World journal of Gastroenterology 2010年第1期16卷 63-68页

作者： Ignacio Fernandez-Urien Erika Borobio Inmaculada Elizalde Rebeca Irisarri juan jose vila jesus Maria Urman javier jimenez Department of Gastroenterology Hospital of Navarra

AIM:To evaluate the Z-line visualization by the PillCamTM SB2 using three different ingestion protocols. METHODS:Ninety consecutive patients undergoing small bowel capsule endoscopy(SBCE)between january and May 2008 were included in the study. They swallowed the capsule in the standing(Group A= 30),supine(Group B=30)and right supine positions (Group C=30).Baseline patient characteristics, difficulties in capsule ingestion,esophageal transit times(ETT)and Z-line visualization were noted. RESULTS:No significant differences were found between the groups with regard to baseline patient characteristics,ingestion difficulties and complete SB examinations(P>0.05).At least 1 frame of the Z-line was detected in 15.8%,46.7%and 90%of patients in groups A,B and C,respectively(P<0.001).The average number of Z-line images was 0.21±0.53,3.23 ±6.59 and 5.53±7.55 and the mean%of the Z-linedetected was 71.3,25.1 and 8.3,in groups A,B and C, respectively(both P<0.001).ETT times were longer in the supine group followed by the right supine and the standing groups(median of 237 s vs 64 s and 39 s, respectively;P<0.001). CONCLUSION:Z-line visualization in patients undergoing SBCE can be accurately achieved in most cases when the capsule is swallowed in the right supine position.

关键词： Barrett Capsule endoscopy Esophagus Gastroesophageal reflux disease Ingestion Varices Z-line

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Pancreas sparing duodenectomy in the treatment of primary duodenal neoplasms and other situations with duodenal involvement

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 485-492页

作者： juli Busquets josefina Lopez-Dominguez Ana Gonzalez-Castillo Marina vila Nuria Pelaez Lluis Secanella Emilio Ramos juan Fabregat Department of Hepatobiliary and Pancreatic Surgery Hospital Universitari de BellvitgeResearch Group of Hepato-biliary and Pancreatic DiseasesInstitut d'InvestigacióBiomèdica de Bellvitge-IDIBELLBarcelona UniversityL’Hospitalet de LlobregatBarcelona 08907Spain Department of General Surgery Hospital del MarBarcelona 08907Spain Department of General Surgery Hospital de MataróBarcelona 08907Spain

Background:There are no clearly defined indications for pancreas-preserving *** present study aimed to analyze postoperative morbidity and the outcomes of patients undergoing pancreaspreserving ***:Patients undergoing pancreas-preserving duodenectomy from April 2008 to May 2020 were *** divided the series according to indication:scenario 1,primary duodenal tumors;scenario 2,tumors of another origin with duodenal involvement;and scenario 3,emergency ***:We included 35 *** duodenectomy was performed in 1 patient of adenomatous duodenal polyposis,limited duodenectomy in 7,and third+fourth duodenal portion resection in *** indications for scenario 1 were gastrointestinal stromal tumor(n=13),adenocarcinoma(n=4),neuroendocrine tumor(n=3),duodenal adenoma(n=1),and adenomatous duodenal polyposis(n=1);scenario 2:retroperitoneal desmoid tumor(n=2),recurrence of liposarcoma(n=2),retroperitoneal paraganglioma(n=1),neuroendocrine tumor in pancreatic uncinate process(n=1),and duodenal infiltration due to metastatic adenopathies of a germinal tumor with digestive hemorrhage(n=1);and scenario 3:aortoenteric fistula(n=3),duodenal trauma(n=1),erosive duodenitis(n=1),and biliopancreatic limb ischemia(n=1).Severe complications(Clavien-Dindo≥IIIb)developed in 14%(5/35),and postoperative mortality was 3%(1/35).Conclusions:Pancreas-preserving duodenectomy is useful in the management of primary duodenal tumors,and is a technical option for some tumors with duodenal infiltration or in emergency interventions.

关键词： Duodenectomy Duodenal neoplasms Organ sparing treatments Pancreatic surgery Duodenal diseases

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