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Machine learning and bioinformatics to identify biomarkers in response to Burkholderia pseudomallei infection in mice

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BIOCELL 2024年第4期48卷 613-621页

作者： YAO fang FEI XIA FEIFEI TIAN L EI QU fang YANG juan fang ZHENHONG HU HAICHAO LIU Department of Respiratory and Critical Care Medicine General Hospital of Center Theater of PLAWuhan430070China School of Medicine Wuhan University of Science and TechnologyWuhan430065China School of Life Science and Engineering Southwest Jiaotong UniversityChengdu611756China

Objective:In the realm of Class I pathogens,Burkholderia pseudomallei(BP)stands out for its propensity to induce severe *** the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response ***:mRNA extraction from BP-infected mouse macrophages constituted the initial step of our *** gene expression arrays,the extracted RNA underwent conversion into digital *** percentile shift method facilitated data processing,with the identiﬁcation of genes manifesting signiﬁcant differences accomplished through the application of the ***,a comprehensive analysis involving Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway was conducted on the differentially expressed genes(DEGs).Leveraging the ESTIMATE algorithm,gene signatures were utilized to compute risk scores for gene expression *** vector machine analysis and gene enrichment scores were instrumental in establishing correlations between biomarkers and macrophages,followed by an evaluation of the predictive power of the identiﬁed ***:The functional and pathway associations of the DEGs predominantly centered around G protein-coupled receptors.A noteworthy positive correlation emerged between the blue module,consisting of 416 genes,and the ***4,identiﬁed through support vector machine analysis among intersecting genes,indicated a robust interaction with macrophages,suggesting its potential as a robust ***4 exhibited commendable predictive efﬁcacy,with BP infection inducing its expression in both macrophages and mouse lung *** blotting in macrophages conﬁrmed a signiﬁcant upregulation of FZD4 expression from 0.5 to 24 h *** mouse lung tissue,FZD4 manifested higher expression in the cytoplasm of pulmonary epithelial cells in BP-infected lungs than in the

关键词： Burkholderia pseudomallei Microarray assay Machine learning Bioinformatics FZD4

Decade Milestone Advancement of Defect-Engineered g-C_(3)N_(4) for Solar Catalytic Applications

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Nano-Micro Letters 2024年第4期16卷 153-218页

作者： Shaoqi Hou Xiaochun Gao Xingyue Lv Yilin Zhao Xitao Yin Ying Liu juan fang Xingxing Yu Xiaoguang Ma Tianyi Ma Dawei Su School of Mathematical and Physical Sciences Faculty of ScienceUniversity of Technology Sydney(UTS)SydneyNSW 2007Australia Laboratory of Plasma and Energy Conversion School of Physics and Optoelectronic EngineeringLudong University186 Middle Hongqi RoadYantai 264025People’s Republic of China School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083People’s Republic of China Department of Chemistry The University of Tokyo7‑3‑1 HogoBunkyoTokyoJapan School of Science STEM CollegeRMIT UniversityMelbourneVIC 3000Australia

Over the past decade, graphitic carbon nitride(g-C_(3)N_(4)) has emerged as a universal photocatalyst toward various sustainable carbo-neutral technologies. Despite solar applications discrepancy, g-C_(3)N_(4) is still confronted with a general fatal issue of insufficient supply of thermodynamically active photocarriers due to its inferior solar harvesting ability and sluggish charge transfer dynamics. Fortunately, this could be significantly alleviated by the “all-in-one” defect engineering strategy, which enables a simultaneous amelioration of both textural uniqueness and intrinsic electronic band structures. To this end, we have summarized an unprecedently comprehensive discussion on defect controls including the vacancy/non-metallic dopant creation with optimized electronic band structure and electronic density, metallic doping with ultraactive coordinated environment(M–N_(x), M–C_(2)N_(2), M–O bonding), functional group grafting with optimized band structure, and promoted crystallinity with extended conjugation π system with weakened interlayered van der Waals interaction. Among them, the defect states induced by various defect types such as N vacancy, P/S/halogen dopants, and cyano group in boosting solar harvesting and accelerating photocarrier transfer have also been emphasized. More importantly, the shallow defect traps identified by femtosecond transient absorption spectra(fs-TAS) have also been highlighted. It is believed that this review would pave the way for future readers with a unique insight into a more precise defective g-C_(3)N_(4) “customization”, motivating more profound thinking and flourishing research outputs on g-C_(3)N_(4)-based photocatalysis.

关键词： Defect engineering g-C_(3)N_(4) Electronic band structures Photocarrier transfer kinetics Defect states

Natural medicine can substitute antibiotics in animal husbandry:protective effects and mechanisms of rosewood essential oil against Salmonella infection

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Chinese Journal of Natural Medicines 2024年第9期22卷 785-796页

作者： WANG Lanqiao fang juan WANG Heng ZHANG Baoyu WANG Nan YAO Xinyu LI He QIU Jiazhang DENG Xuming LENG Bingfeng WANG Jianfeng TAN Wenxi ZHANG Qiaoling State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationInstitute of Zoonosisand College of Veterinary MedicineJilin UniversityChangchun 130062China Shenzhen Beichen Biotech Co. Ltd.Shenzhen 518057China Department of Obstetrics and Gynecology The Second Hospital of Jilin UniversityChangchun 130041China

Aniba rosaeodora essential oil(RO) has been traditionally used in natural medicine as a substitute for antibiotics due to its notable antidepressant and antibacterial properties. Salmonella, a prevalent pathogen in foodborne illnesses, presents a major challenge to current antibiotic treatments. However, the antibacterial efficacy and mechanisms of action of RO against Salmonella spp. remain underexplored. This study aims to elucidate the chemical composition of RO, evaluate its antibacterial activity and mechanisms against Salmonella in vitro, and further delineate its anti-inflammatory mechanisms in vivo during Salmonella infection. Gas chromatography-mass spectrometry(GC-MS) was utilized to characterize the chemical constituents of RO. The antibacterial activity of RO was assessed using minimal inhibitory concentration(MIC) and time-kill assays. Various biochemical assays were employed to uncover the potential bactericidal mechanisms. Additionally, mouse and chick models of Salmonella infection were established to investigate the prophylactic effects of RO treatment. RO exhibited significant antibacterial activity against both Gram-positive and Gram-negative bacteria, with an MIC of 4 mg·mL^(-1) for Salmonella spp. RO treatment resulted in bacterial damage through the disruption of lipid and purine metabolism. Moreover, RO reduced injury and microbial colonization in infected mice and chicks. RO treatment also modulated the host inflammatory response by inhibiting proinflammatory pathways. In conclusion, our findings demonstrate that RO is effective against Salmonella infection, highlighting its potential as an alternative to antibiotics for antibacterial therapy.

关键词： Rosewood essential oil Salmonella Aniba rosaeodora Antibacterial effect Anti-inflammation Anti-infection

Utility of Goal Attainment Scaling(GAS)in evaluating a multicomponent exercise programme for community-dwelling pre-frail older adults

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Family Medicine and Community Health 2024年第1期12卷 36-44页

作者： juan fang Jianping Ren Jinjing Wang Xiantao Qiu Shiyan Zhang Shuang Yuan Liangfeng Wu Lin Xie Le Yu School of Public Health Hangzhou Normal UniversityHangzhouZhejiangChina School of Medicine Huzhou UniversityHuzhouZhejiangChina School of Clinical Medicine Hangzhou Normal UniversityHangzhouZhejiangChina Ziyang Street Community Health Service Center HangzhouZhejiangChina

Objectives This study aimed to investigate the effectiveness of Goal Attainment Scaling(GAS)in assessing an intervention for pre-frail senior ***,the study aimed to explain how the GAS goals were established based on the International Classification of Functioning,Disability and Health(ICF)categories,including body function,activity and participation and environmental *** In this study,220 pre-frail older adults were randomly selected to participate in a controlled *** intervention group engaged in multicomponent exercise three times a week,once at a community health service location and twice at *** control group received advice on physical activity but did not have supervised *** in both groups selected individualised GAS goals from 23 goals developed based on ICF by focus group *** study used generalised estimating equations to analyse the differences between the *** The study included 144 participants,72 in the exercise group and 72 in the control *** top three individualised goals for all participants were vestibular functions(53.5%),pain management(43.1%)and lifting and carrying objects(31.9%).Both groups saw a significant increase in GAS scores at week 8 and week 24 of the intervention(p<0.05),but the exercise group showed a more significant improvement(p<0.05).The participants living alone were associated with lower postintervention improvements in the GAS *** contrast,the participants who were using a smartphone were likely to get higher postintervention improvements in the GAS *** GAS can be a valuable tool for setting and evaluating individualised and meaningful goals in body functions,activity and participation and environmental *** multicomponent exercise interventions can help pre-frail older adults achieve their expected goals as measured by the GAS.

关键词： meaningful goals lifting

热带气旋发展增强过程中龙卷尺度涡旋活动特征

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南京大学学报（自然科学版） 2024年第2期60卷 230-243页

作者：周玥滢方娟中尺度灾害性天气教育部重点实验室南京大学大气科学学院南京210023

观测发现热带气旋(TC)边界层中存在龙卷尺度涡旋(TSV),其引起的相关阵风对近地面具有强烈影响.利用WRF-ARW模型,通过对飓风Earl(2010)进行高分辨率的数值试验模拟,分析了TC边界层龙卷尺度涡旋的时空分布特征以及发生发展的可能原因.Ear... 详细信息

观测发现热带气旋(TC)边界层中存在龙卷尺度涡旋(TSV),其引起的相关阵风对近地面具有强烈影响.利用WRF-ARW模型,通过对飓风Earl(2010)进行高分辨率的数值试验模拟,分析了TC边界层龙卷尺度涡旋的时空分布特征以及发生发展的可能原因.Earl发展增强过程中,TSV数量随着Earl强度的增强而增加,尤其在最强期间表现最为活跃,一方面TC的增强提供了更强的背景场使得TSV更易生成,另一方面更强的背景场使得长生命期的TSV增加,每一时刻同时存在的TSV也就更多.TSV生成区域随Earl的发展从垂直风切左侧逐渐集中至逆风切左侧,且始终位于RMW内侧近地层次级环流上升支和最大垂直涡度位置附近,这里通常满足垂直切变和水平切变不稳定的必要条件,TSV涡度收支分析的结果表明,对TSV生成发展起主要贡献的是与水平风水平切变相关的拉伸项以及与垂直切变相关的扭转项,这意味着TSV的生成与发展可能与垂直切变不稳定和水平切变不稳定有关.

关键词：热带气旋龙卷尺度涡旋垂直切变水平切变

A novel mouse model of calcific aortic valve stenosis

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Animal Models and Experimental Medicine 2024年第4期7卷 523-532页

作者： Ningjing Qian Yaping Wang Wangxing Hu Naifang Cao Yi Qian Jinyong Chen juan fang Dilin Xu Haochang Hu Shuangshuang Yang Dao Zhou Hanyi Dai Dongdong Wei Jian'an Wang Xianbao Liu Department of Cardiology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina State Key Laboratory of Transvascular Implantation Devices China Cardiovascular Key Laboratory of Zhejiang Province HangzhouChina Department of Cardiovascular Surgery The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Endocrinology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouChina Binjiang Institute of Zhejiang University HangzhouChina

Background:Calcific aortic valve stenosis(CAVS)is one of the most challenging heart diseases in clinical with rapidly increasing ***,study of the mecha-nism and treatment of CAVS is hampered by the lack of suitable,robust and efficient models that develop hemodynamically significant stenosis and typical calcium ***,we aim to establish a mouse model to mimic the development and features of ***:The model was established via aortic valve wire injury(AVWI)combined with vitamin D subcutaneous injected in wild type C57/BL6 *** transthoracic echocardiography was applied to evaluate aortic jet peak velocity and mean *** specimens were collected and examined in respect of valve thickening,calcium deposition,collagen accumulation,osteogenic differentiation and ***:Serial transthoracic echocardiography revealed that aortic jet peak velocity and mean gradient increased from 7 days post model establishment in a time depend-ent manner and tended to be stable at 28 *** with the sham group,sim-ple AVWI or the vitamin D group,the hybrid model group showed typical pathological features of CAVS,including hemodynamic alterations,increased aortic valve thicken-ing,calcium deposition,collagen accumulation at 28 *** addition,osteogenic dif-ferentiation,fibrosis and inflammation,which play critical roles in the development of CAVS,were observed in the hybrid ***:We established a novel mouse model of CAVS that could be induced efficiently,robustly and economically,and without genetic *** provides a fast track to explore the underlying mechanisms of CAVS and to identify more effec-tive pharmacological targets.

关键词： animal model calcific aortic valve stenosis valve calcification

不同靶浓度丙泊酚用于老年无痛纤维支气管镜检查患者的临床研究

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中国临床药理学杂志 2024年第18期40卷 2630-2634页

作者：薛艳芝房娟娟肖林张树卿山东大学齐鲁医院德州医院日间手术科山东德州253000

目的分析不同靶浓度丙泊酚与瑞芬太尼靶控输注对老年无痛纤维支气管镜检查患者的影响。方法将行无痛纤维支气管镜检查老年患者分为低剂量组、中剂量组和高剂量组。低剂量组、中剂量组和高剂量组均靶控输注注射用盐酸瑞芬太尼和丙泊酚乳... 详细信息

目的分析不同靶浓度丙泊酚与瑞芬太尼靶控输注对老年无痛纤维支气管镜检查患者的影响。方法将行无痛纤维支气管镜检查老年患者分为低剂量组、中剂量组和高剂量组。低剂量组、中剂量组和高剂量组均靶控输注注射用盐酸瑞芬太尼和丙泊酚乳状注射液,瑞芬太尼效应室靶浓度为3.0ng·mL^(-1),低、中、高剂量组丙泊酚的效应室靶浓度分别为3.0、4.0和5.0μg·mL^(-1),丙泊酚和瑞芬太尼的效应室靶浓度均达到目标靶浓度时开始检查。比较3组患者麻醉效果、麻醉质量(麻醉时间、患者舒适度及操作医师麻醉满意度)、苏醒时间和插管时间,并进行安全性评价。结果低剂量组、中剂量组和高剂量组分别入组31、36和35例。低剂量组、中剂量组和高剂量组的麻醉优良率分别为67.74%(21例/31例)、77.78%(28例/36例)和82.86%(29例/35例),中剂量组和高剂量组的上述指标与低剂量组比较,在统计学上差异均有统计学意义(均P<0.05)。低剂量组、中剂量组和高剂量组的操作医师麻醉满意度分别为(6.13±1.19)、(7.48±1.25)和(6.50±1.07)分,苏醒时间分别为(7.01±1.64)、(7.58±1.30)和(9.42±1.58)min,插管时间分别为(9.94±2.02)、(10.76±1.97)和(13.18±2.25)min,低剂量组和中剂量组的上述指标与高剂量组比较,在统计学上差异均有统计学意义(均P<0.05)。低剂量组、中剂量组和高剂量组患者麻醉时间分别为(31.18±4.26)、(29.96±5.08)和(28.74±5.43)min,舒适度分别为(8.95±0.49)、(9.03±0.41)和(9.12±0.38)分,低血压发生率分别为12.90%、5.56%和14.29%,体动发生率分别为16.13%、8.33%和5.71%,呛咳发生率分别为19.35%、13.89%和11.43%,中剂量组操作医师麻醉满意度显著高于低剂量组和高剂量组,在统计学上差异均有统计学意义(均P<0.05)。结论4.0μg·mL^(-1)效应室靶浓度丙泊酚与3.0ng·mL^(-1)效应室靶浓度瑞芬太尼靶控输注用于老年无痛纤维支气管镜检查的麻醉质量最理想,患者苏醒时间和插管时间最短,且安全性良好。

关键词：丙泊酚乳状注射液注射用盐酸瑞芬太尼靶控输注老年纤维支气管镜麻醉质量插管时间

沙库巴曲缬沙坦与米力农联合治疗难治性心力衰竭患者临床效果观察

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实用中西医结合临床 2024年第4期24卷 102-105页

作者：倪芳娟河南省濮阳县人民医院濮阳457161

目的:探究沙库巴曲缬沙坦联合米力农治疗对难治性心力衰竭(RHF)患者的影响。方法:选择2021年4月至2022年5月收治的90例RHF患者,以随机数字表法分为对照组(接受米力农注射液治疗)45例和观察组(沙库巴曲缬沙坦与米力农治疗)45例。对比两... 详细信息

目的:探究沙库巴曲缬沙坦联合米力农治疗对难治性心力衰竭(RHF)患者的影响。方法:选择2021年4月至2022年5月收治的90例RHF患者,以随机数字表法分为对照组(接受米力农注射液治疗)45例和观察组(沙库巴曲缬沙坦与米力农治疗)45例。对比两组临床疗效、血流动力学指标、心肌损伤情况、心功能指标、生活质量、不良反应。结果:观察组治疗总有效率较对照组高(P0.05)。结论:沙库巴曲缬沙坦联合米力农治疗RHF患者疗效确切,对患者的血流动力学及心肌损伤标志物水平均有积极调节作用,可改善患者心功能,且不良反应较少。

关键词：难治性心力衰竭沙库巴曲缬沙坦米力农

三元软包锂离子电池放电过程扩散诱导应力与热应力对比研究

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储能科学与技术 2024年第4期13卷 1128-1141页

作者：王瑞梓刘训良豆瑞锋周文宁方娟北京科技大学能源与环境工程学院北京科技大学多模式工业储能技术研发中心北京100083

为了明晰锂离子电池在放电过程中产生的扩散诱导应力和热应力对电池的影响,使用Comsol Multiphysics 6.0建立了18.5 Ah软包NCM111锂离子电池的电化学-力-热耦合模型,基于该模型对不同放电倍率下电池的负极颗粒中心表面锂浓度差、扩散诱... 详细信息

为了明晰锂离子电池在放电过程中产生的扩散诱导应力和热应力对电池的影响,使用Comsol Multiphysics 6.0建立了18.5 Ah软包NCM111锂离子电池的电化学-力-热耦合模型,基于该模型对不同放电倍率下电池的负极颗粒中心表面锂浓度差、扩散诱导应力、热应力及膨胀行为进行了仿真分析。扩散诱导应力可通过一维电化学模型及其衍生的颗粒维度进行仿真分析,而热应力则需要通过三维固体力学和传热模型进行仿真。研究结果表明,随着放电倍率的增加,电池产生的扩散诱导应力和热应力都会增大,因此,低放电倍率有助于降低电池产生的应力。负极颗粒产生的扩散诱导应力与颗粒中心表面锂浓度差相关,颗粒中心与表面的锂浓度差随着放电过程的进行逐渐增大。将一维模型中的负极视为由无数负极颗粒组成的线段,放电前期,靠近隔膜端的颗粒中心与表面锂浓度差高于集流体端,放电后期则相反,这个变化发生的转折点在放电深度为60%~70%之间。这也意味着放电前期隔膜端的负极颗粒产生的扩散诱导应力大于集流体端的负极颗粒,也更容易破裂,而放电后期则相反。负极颗粒产生的扩散诱导应力大小为兆帕级,远高于电芯产生的大小为千帕级的热应力。同时,电芯产生的热应力和最大位移与电池温差呈线性关系,随着放电倍率的增加而增大。值得注意的是,与圆柱形电池不同,软包电池的极耳与电芯连接处会产生较大的热应力。本研究对比分析了软包NCM111锂离子电池放电过程产生的扩散诱导应力与热应力,为电极和电芯的制造及应力监测提供理论支撑。

关键词：三元软包锂电池多物理场耦合模型扩散诱导应力热应力