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World Journal of Gastroenterology 2012年第21期18卷 2689-2694页

作者： Cui-Xia Qiao Xiao-Feng Zhai Chang-Quan Ling Qing-Bo Lang Hui-juan dong Qun Liu Mou-Duo Li Departmentof Traditional Chinese Medicine Changhai Hospital Affiliatedto the Second Military Medical University Shanghai 200433China Department of Graduate School Shanghai Uni-versity of Traditional Chinese Medicine Shanghai 201203China E-Institute of Traditional Chinese MedicineInternal Medicine Shanghai 200433 China

AIM: To investigate and evaluate the change in healthrelated quality of life (HRQoL) by tumor node metastasis (TNM) staging system in patients with hepatocellular carcinoma (HCC). METHODS: A total of 140 patients diagnosed with HCC between June 2008 and April 2009 in our department were enrolled to this study. One hundred and thirty-five (96.5%) patients had liver cirrhosis secondary to hepatitis B virus (HBV) infection, 73 (54.07%) of them being HBV DNA positive; the other etiologies of liver cirrhosis were alcoholic liver disease (1.4%), hepatitis C (1.4%) or cryptogenic (0.7%). All subjects were fully aware of their diagnosis and provided informed consent. HRQoL was assessed before treatment using the functional assessment of cancer therapy-hepatobiliary (FACT-Hep) questionnaire. Descriptive statistics were used to evaluate demographics and disease-specific characteristics of the patients. One-way analysis of variance and independent samples t tests were used to compare the overall FACT-Hep scores and clinically distinct TNM stages. Scores for all FACT-Hep items were analyzed by frequency analyses. The mean scores obtained from the FACT-Hep in different Child-Pugh classes were also evaluated. RESULTS: The mean FACT-Hep scores were reduced significantly from TNM StageⅠto Stage Ⅱ, Stage ⅢA, Stage ⅢB group (687 ± 39.69 vs 547 ± 42.57 vs 387 ± 51.24 vs 177 ± 71.44, P = 0.001). Regarding the physical and emotional well-being subscales, scores decreased gradually from Stage Ⅰ to Stage ⅢB (P = 0.002 vs Stage Ⅰ; P = 0.032 vs Stage Ⅱ; P = 0.033 vs Stage ⅢA). Mean FACT-Hep scores varied by Child-Pugh class, especially in the subscales of physical well-being, functional well-being and the hepatobiliary cancer (P = 0.001 vs Stage I; P = 0.036 vs Stage Ⅱ; P = 0.032 vs Stage ⅢA). For the social and family well-being subscale, only Stage ⅢB scores were significantly lower as compared with Stage Ⅰ scores (P = 0.035). For the subscales of functional well-being and hepatobiliary c

关键词：质量评价身体健康淋巴结肝癌患者系统肿瘤生活

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教育信息化建设背景下“包装印刷”课程混合式教学研究

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印刷与数字媒体技术研究 2023年第4期 103-109页

作者：方遒董娟娟曹慧曹青安徽新闻出版职业技术学院机电信息系合肥230601 安泰新型包装材料有限公司合肥230601

加强教育信息化建设、探索信息化教学方式是实现高等职业教育现代化的必然趋势。本文针对“包装印刷”课程,分析了目前教学模式存在的问题和混合式教学的可行性,构建了基于翻转课堂的线上线下混合式教学模式,并在改革过程中重新搭建线... 详细信息

加强教育信息化建设、探索信息化教学方式是实现高等职业教育现代化的必然趋势。本文针对“包装印刷”课程,分析了目前教学模式存在的问题和混合式教学的可行性,构建了基于翻转课堂的线上线下混合式教学模式,并在改革过程中重新搭建线上课程、加强产教融合并深挖思政元素、融合多种形式教学、重设课程考核方式等。通过教学实施,最终验证了基于翻转课堂的线上线下混合式教学能够取得较好的教学效果,有利于提高人才培养质量。

关键词：教育信息化混合式教学 “包装印刷”课程

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黑龙江多宝山矿集区二道坎银铅锌矿床热液菱锰矿地球化学特征及其指示意义

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吉林大学学报（地球科学版） 2022年第3期52卷 855-865页

作者：董娟袁茂文李成禄山西大同大学建筑与测绘工程学院山西大同037009 中国地质大学(北京)地球科学与资源学院北京100083 黑龙江省地质调查研究总院哈尔滨150036

二道坎银铅锌矿床是黑龙江多宝山矿集区近年新发现的一个三叠纪大型银铅锌矿床.目前,关于该矿床形成机制方面的研究还较少,矿床成因还不太明确.基于此,本次研究选取热液菱锰矿为研究对象,利用光学显微镜和激光剥蚀等离子质谱仪对矿石中... 详细信息

二道坎银铅锌矿床是黑龙江多宝山矿集区近年新发现的一个三叠纪大型银铅锌矿床.目前,关于该矿床形成机制方面的研究还较少,矿床成因还不太明确.基于此,本次研究选取热液菱锰矿为研究对象,利用光学显微镜和激光剥蚀等离子质谱仪对矿石中的菱锰矿矿物学属性及地球化学特征进行了系统研究.结果显示:菱锰矿具有强Eu负异常、Ce正异常、轻稀土元素富集和重稀土元素亏损的特征;轻稀土元素分馏程度明显高于重稀土元素,呈现总体右倾的REE配分曲线.综合来看,二道坎银铅锌矿床中的菱锰矿形成于还原性环境,成矿物质来源具有混源特征,深部成矿物质以及矿区附近的灰岩、炭质页岩对菱锰矿的形成均有重要的贡献.

关键词：多宝山矿集区二道坎银铅锌矿床菱锰矿地球化学

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Transparent organic light-emitting diodes based on Cs_2 CO_3:Ag/Ag composite cathode

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Chinese Science Bulletin 2010年第15期55卷 1479-1482页

作者： LIU Qian DUAN Lian ZHANG DeQiang QIAO juan WANG LiDuo dong GuiFang QIU Yong Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of Chemistry Tsinghua UniversityBeijing 100084 China

The transparent organic light-emitting diodes (TOLEDs) based on Cs 2 CO 3:Ag/Ag composite cathode are reported in this *** show higher efficiency and better stability than the control devices with the Cs 2 CO 3 /Ag *** devices are highly transparent,and show total efficiencies from both sides of the devices comparable with conventional bottom-emitting *** electroluminescence (EL) spectrum from the cathode side of the device is closer to the photoluminescence (PL) spectrum of the light-emitting material than that from the anode *** effect of the cathode Ag thickness on the device performance has been *** is observed that a critical Ag thickness of 15 nm is required to form a good Ag film with high optical transparency and electrical conductivity.

关键词：有机发光二极管复合阴极银膜控制设备器件性能光学透明性光致发光稳定性

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A Comparative miRNAome Analysis Reveals Seven Fiber Initiation-Related and 36 Novel miRNAs in Developing Cotton Ovules

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Molecular Plant 2012年第4期5卷 889-900页

作者： Zheng-Ming Wang Wei Xue Chun-juan dong Long-Guo Jin Shao-Min Bian Chuan Wang Xiu-Yun Wu Jin-Yuan Liu Laboratory of Molecular Biology and MOE Laboratory of Protein Science School of Life SciencesTsinghua UniversityBeijing 100084China

An increasing number of microRNAs （miRNAs） have been shown to play crucial regulatory roles in the process of plant development. Here, we used high-throughput sequencing combined with computational analysis to characterize miRNAomes from the ovules of wild-type upland cotton and a fiberless mutant during fiber initiation. Comparative miR- NAome analysis combined with northern blotting and RACE-PCR revealed seven fiber initiation-related miRNAs expressed in cotton ovules and experimentally validated targets of these miRNAs are involved in different cellular responses and metabolic processes, including transcriptional regulation, auxin and gibberellin signal transduction, actin bundles, and lignin biosynthesis. This paper describes a complex regulatory network consisting of these miRNAs expressed in cotton ovules to coordinate fiber initiation responses. In addition, 36 novel miRNAs and two conserved miRNAs were newly iden- tified, nearly doubling the number of known cotton miRNA families to a total of 78. Furthermore, a chromatin remodeling complex subunit and a pre-mRNA splicing factor are shown for the first time to be miRNA targets. To our knowledge, this study is the first systematic investigation of fiber initiation-related miRNAs and their targets in the developing cotton ovule, deepening our understanding of the important regulatory functions of miRNAs in cotton fiber initiation.

关键词： Cotton ovules fiber initiation high-throughput sequencing molecular characterization newly identifiedmiRNAs.

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Association between sarcopenia and cognitive impairment in community-dwelling population

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Chinese Medical Journal 2021年第6期134卷 725-727页

作者： Hui Zhu Heng-dong Li Bei-Li Feng Lu Zhang Zai-Xing Zheng Yue Zhang dong-juan Wang Zi Xiong Jun-Fei Kang Jia-Chang Jin Jie Lin Hong-Hua Ye Department of Experimental Medical Science HwaMei HospitalUniversity of Chinese Academy of SciencesNingboZhejiang 315010China Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province NingboZhejiang 315010China Department of Cardiology HwaMei HospitalUniversity of Chinese Academy of SciencesNingboZhejiang 315010China

Cognitive impairment is a neurodegenerative change,involving the progression from mild cognitive impairment to dementia.[1]Sarcopenia is often considered geriatric and is characterized by a progressive and generalized decrease in skeletal muscle mass and strength.[2]Interestingly,several common pathogenic mechanisms are involved in both sarcopenia and cognitive *** risk factors for sarcopenia include mitochondrial dysfunction,oxidative stress,chronic inflammation,and hormonal changes,all of which are potential causes of cognitive impairment.[3]Consequently,cognitive impairment may be closely related to *** study aims to examine the relationship between cognitive impairment and sarcopenia among community-dwelling elderly adults.

关键词： impairment inflammation skeletal

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The Herbicidal Activity of Mutant Isolates from Botrytis cinerea

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Agricultural Sciences in China 2006年第8期5卷 622-628页

作者： ZHANG Jin-lin ZHANG Li-hui LIU Ying-chao MA juan LI Chuan dong Jin-gao Mycotoxin Laboratory Hebei Agricultural University Baoding 071001 P.R.China

Fifteen mutant isolates were obtained by ultraviolet mutation from parent isolate Botrytis cinerea BC-4. Among them three mutant isolates, BC4-1, BC4-2, and BC4-15, showed strong herbicidal activity. BC4-1 showed maximum herbicidal activity for inhibition of germination and growth of Digitaria sanguinalis L. and Arnaranthus retroflexus L. The results also showed that herbicidal activity was influenced by differing pH of PD media, with pH value of 4.0 being the optimum. The crude toxin was extracted using chloroform, petroleum ether, and ethyl acetate, respectively, and the ethyl acetate extracts showed the strongest inhibitory activity on the germination and growth of D. sanguinalis L. and A. retroflexus L. Using HPLC, one fraction with an absorption peak at 271 nm was separated from the crude toxin. This fraction could strongly inhibit the growth of D. sanguinalis L. at a concentration of 100 mg L^-1 and could completely inhibit the seed germination of D. sanguinalis L. and A. retroflexus L. at a concentration of 50 mg L^-1 .

关键词： Botrytis cinerea toxin ultraviolet mutation herbicide activity separation and purification

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搬运机械臂液压系统设计和元件选型研究

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现代制造技术与装备 2023年第10期59卷 47-49页

作者：董娟江苏省通州中等专业学校通州226300

液压系统具有配置参数高、运行效能高、应用便捷、简易控制等优势,加强搬运机械臂相关液压系统研究具有重要意义。文章先分析了搬运机械臂液压系统设计,然后介绍了搬运机械臂液压系统的元件选型,以期为相关人员提供有效参考。

关键词：搬运机械臂液压系统系统设计元件选型

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控权与“权”衡:国外派驻监督的历史演进与当代启示

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岭南学刊 2023年第6期 29-33,68页

作者：董娟中共广东省委党校中国特色社会主义研究所广东广州510053

派驻监督是一种由上级监督机关通过设立直属分支机构以强化驻地监管的组织设置。国外的派驻监督尽管具体形式不尽一致,但主要源于集权驱动、控权需要以及监察等目的,具有“分散化”的组织设置、“非嵌入式”组织结构以及“双重”领导体... 详细信息

派驻监督是一种由上级监督机关通过设立直属分支机构以强化驻地监管的组织设置。国外的派驻监督尽管具体形式不尽一致,但主要源于集权驱动、控权需要以及监察等目的,具有“分散化”的组织设置、“非嵌入式”组织结构以及“双重”领导体制等特点,并在实践中对各国的行政区划、职官制度和地方行政等方面产生重要影响。然而,分权冲击引发了国外派驻监督的“废”“立”之变,并造成了各国不同的改革后果。派驻监督不仅是一种监督形式与手段,也是一个复杂的政治过程,需要合理的制度安排和配套措施,这对我国的派驻监督也具有重要的启示意义。

关键词：派驻监督控权改革启示

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“双减”背景下淄博市图书馆少儿阅读推广创新实践

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河南图书馆学刊 2023年第3期43卷 21-23页

作者：董娟淄博市图书馆山东淄博255000

新时期我国“双减”政策的出台落地,明确提出要引导少儿多参加阅读活动,这对少儿群体阅读工作的开展提出了新要求。文章对“双减”政策背景下少儿阅读需求呈现的新特点进行了分析,探讨了淄博市图书馆少儿阅读推广创新实践,并对其完善少... 详细信息

新时期我国“双减”政策的出台落地,明确提出要引导少儿多参加阅读活动,这对少儿群体阅读工作的开展提出了新要求。文章对“双减”政策背景下少儿阅读需求呈现的新特点进行了分析,探讨了淄博市图书馆少儿阅读推广创新实践,并对其完善少儿阅读推广工作提出了建议。

关键词： “双减”政策淄博市图书馆少儿阅读推广

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